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All Studies   Meta Analysis    Recent:   

Effectiveness of hydrogen peroxide as auxiliary treatment for hospitalized COVID-19 patients in Brazil: preliminary results of a randomized double-blind clinical trial

Di Domênico et al., Epidemiology and Health, doi:10.4178/epih.e2021032
May 2021  
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0 0.5 1 1.5 2+ ICU admission 50% Improvement Relative Risk Improvement 6% Time to discharge 7% Hydrogen Peroxide  Di Domênico et al.  LATE TREATMENT  DB RCT Is late treatment with hydrogen peroxide beneficial for COVID-19? Double-blind RCT 40 patients in Brazil Trial underpowered for serious outcomes c19early.org Di Domênico et al., Epidemiology and H.., May 2021 Favors hydrogen peroxide Favors control
19th treatment shown to reduce risk in May 2021
 
*, now known with p = 0.029 from 7 studies.
Lower risk for viral clearance.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
RCT very late treatment (>10 days from onset) comparing hydrogen peroxide + mint essence with water + mint essence, showing no significant differences.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
risk of ICU admission, 50.0% lower, RR 0.50, p = 1.00, treatment 1 of 20 (5.0%), control 2 of 20 (10.0%), NNT 20.
improvement, 5.7% lower, HR 0.94, p = 0.91, treatment 18, control 17, inverted to make HR<1 favor treatment.
time to discharge, 7.0% lower, relative time 0.93, p = 0.61, treatment mean 3.86 (±1.6) n=18, control mean 4.15 (±1.77) n=17.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Di Domênico et al., 1 May 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Brazil, peer-reviewed, survey, 9 authors, average treatment delay 10.72 days. Contact: pedrocorazza@upf.br.
This PaperHydrogen Per..All
Effectiveness of hydrogen peroxide as auxiliary treatment for hospitalized COVID-19 patients in Brazil: preliminary results of a randomized double-blind clinical trial
Marielle Bazzo Di Domênico, Henrique Cesca, Thales Henrique Jincziwski Ponciano, Renan Brandenburg Dos Santos, Ulysses Lenz, Vinícius Picoli Antunes, Vinicius Webber Godinho, Kauê Collares, Pedro Henrique Corazza
Epidemiology and Health, doi:10.4178/epih.e2021032
OBJECTIVES: To evaluate the effectiveness of hydrogen peroxide (H2O2) in the form of mouthwash and nasal spray as an auxiliary treatment for coronavirus disease 2019 . METHODS: Forty hospitalized patients who tested positive for severe acute respiratory syndrome coronavirus 2 using a reverse-transcription polymerase chain reaction test were evaluated. They were randomly divided into an experimental group (n = 20; gargling with 1.0% H2O2 and nasal wash with 0.5% H2O2) or a control group (n = 20). The solutions were used for 7 days and the patients were monitored every 2 days, for a total of 8 days. At check-ups, patients were asked about their symptoms and possible adverse effects of the solutions. The presence and severity (mild, moderate, or severe) of symptoms were recorded. Data were compared using the Student test and the Fisher exact test (α = 0.05). RESULTS: There was no significant difference between the 2 groups in the length of hospital stay (p = 0.65). The most frequent symptom on day 0 was coughing (72.0% in the experimental group and 76.5% in the control group), which abated over time. There was no significant difference between the groups in the evaluated symptoms. Most (75.0%) of the patients in the experimental group presented a reduction in dyspnea between days 0 and 2. Few patients reported adverse effects from the use of the solutions. CONCLUSIONS: H2O2 as a mouthwash and nasal spray is safe to use. There is insufficient evidence to demonstrate that H2O2 is effective as an auxiliary treatment for hospitalized COVID-19 patients.
CONFLICT OF INTEREST The authors have no conflicts of interest to declare for this study. AUTHOR CONTRIBUTIONS Conceptualization: PHC, MBDD. Data curation: KC. Formal analysis: KC. Funding acquisition: MBDD. Methodology: HC, THJP, RBS, UL, VPA, VWG. Project administration: PHC, MBDD, HC. Writing -original draft: MBDD, PHC, HC. Writing -review & editing: KC, THJP, RBS, UL, VPA, VWG, KC.
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Late treatment
is less effective
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