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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Viral load, combined 74% Improvement Relative Risk Viral load, E 96% Viral load, S 44% c19early.org/p Natto et al. Povidone-Iod.. for COVID-19 RCT EARLY Favors povidone-iodine Favors saline
The short-term effect of different chlorhexidine forms versus povidone iodine mouth rinse in minimizing the oral SARS-CoV-2 viral load: An open label randomized controlled clinical trial study
Natto et al., Medicine, doi:10.1097/MD.0000000000028925
29 Jul 2022    Source   PDF   Share   Tweet
60 patient RCT comparing chlorhexidine, PVP-I, and saline in Saudi Arabia with a single mouth rinse treatment and PCR testing 5 minutes later, showing statistically significant improvement in Ct value for PVP-I. PVP-I showed greater improvement than saline, without statistical significance.
risk of viral load, 74.0% lower, RR 0.26, p = 0.27, treatment 12, control 12, relative improvement in Ct value, both genes combined.
risk of viral load, 96.2% lower, RR 0.04, p = 0.12, treatment mean 4.43 (±4.78) n=12, control mean 0.17 (±7.67) n=12, relative improvement in Ct value, E gene.
risk of viral load, 44.4% lower, RR 0.56, p = 0.60, treatment mean 3.33 (±5.6) n=12, control mean 1.85 (±7.68) n=12, relative improvement in Ct value, S gene.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Natto et al., 29 Jul 2022, Randomized Controlled Trial, Saudi Arabia, peer-reviewed, 7 authors, this trial compares with another treatment - results may be better when compared to placebo.
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