Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2

{ 'indexed': { 'date-parts': [[2021, 12, 23]], 'date-time': '2021-12-23T06:50:54Z', 'timestamp': 1640242254865}, 'reference-count': 34, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2021, 12, 1]], 'date-time': '2021-12-01T00:00:00Z', 'timestamp': 1638316800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2021, 12, 22]], 'date-time': '2021-12-22T00:00:00Z', 'timestamp': 1640131200000}, 'content-version': 'vor', 'delay-in-days': 21, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'short-container-title': ['Sci Rep'], 'published-print': {'date-parts': [[2021, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Most public health measures to contain the COVID-19 ' 'pandemic are based on preventing the pathogen spread, and the use of oral antiseptics has ' 'been proposed as a strategy to reduce transmission risk. The aim of this manuscript is to ' 'test the efficacy of mouthwashes to reduce salivary viral load in vivo. This is a ' 'multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial that ' 'tests the effect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, ' 'povidone-iodine and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at ' 'baseline and 30, 60 and 120\xa0min after the mouthrinse. A fifth group of patients used ' 'distilled water mouthrinse as a control. Eighty-four participants were recruited and divided ' 'into 12–15 per group. There were no statistically significant changes in salivary viral load ' 'after the use of the different mouthwashes. Although oral antiseptics have shown virucidal ' 'effects in vitro, our data show that salivary viral load in COVID-19 patients was not ' 'affected by the tested treatments. This could reflect that those mouthwashes are not ' 'effective in vivo, or that viral particles are not infective but viral RNA is still detected ' 'by PCR. Viral infectivity studies after the use of mouthwashes are therefore required. ' '(<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" ' 'xlink:href="https://clinicaltrials.gov/ct2/show/NCT04707742">https://clinicaltrials.gov/ct2/show/NCT04707742</jats:ext-link>; ' 'Identifier: NCT04707742)</jats:p>', 'DOI': '10.1038/s41598-021-03461-y', 'type': 'journal-article', 'created': { 'date-parts': [[2021, 12, 22]], 'date-time': '2021-12-22T11:08:57Z', 'timestamp': 1640171337000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': ['Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2'], 'prefix': '10.1038', 'volume': '11', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-4521-1632', 'authenticated-orcid': False, 'given': 'Maria D.', 'family': 'Ferrer', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-7919-5765', 'authenticated-orcid': False, 'given': 'Álvaro Sánchez', 'family': 'Barrueco', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-1523-9415', 'authenticated-orcid': False, 'given': 'Yolanda', 'family': 'Martinez-Beneyto', 'sequence': 'additional', 'affiliation': []}, {'given': 'María V.', 'family': 'Mateos-Moreno', 'sequence': 'additional', 'affiliation': []}, {'given': 'Verónica', 'family': 'Ausina-Márquez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elisa', 'family': 'García-Vázquez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Miguel', 'family': 'Puche-Torres', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maria J. 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