Aspirin use is associated with decreased inpatient mortality in patients with COVID-19: A meta-analysis
Aswin Srinivasan, Jonathan Brown, Pavitra Parimala Krishnamani, Brendon Cornett, MD Ramesh Babu Kesavan, Siva T Sarva, Syed Arman Raza, Waleed Tallat Kayani
American Heart Journal Plus: Cardiology Research and Practice, doi:10.1016/j.ahjo.2022.100191
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Declaration of interests ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: . J o u r n a l P r e -p r o o f
References
Ahmed, Merrell, Ismail, Rationales and uncertainties for aspirin use in COVID-19: a narrative review, Fam Med Community Health,
doi:10.1136/fmch-2020-000741Bianconi, Violi, Fallarino, Is acetylsalicylic acid a safe and potentially useful choice for adult patients with COVID-19?, Drugs
Chow, Khanna, Kethirddy, Aspirin use is associated with decreased mechanical ventilation, intensive care unit admission, and in-hospital mortality in hospitalized patients with coronavirus disease 2019, Anesth Analg
Chow, Rahnavard, Gomberg-Maitland, o u r n a l P r e -p r o o f Journal Pre-proof
Chow, Yin, Yamane, Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID-19: A propensity score-matched analysis, J Thromb Haemost,
doi:10.1111/jth.15517J O U R N A L P R E, -p r o o f
Klok, Kruip, Van Der Meer, Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis, Thromb Res,
doi:10.1016/j.thromres.2020.04.041Mehta, Mcauley, Brown, COVID-19: consider cytokine storm syndromes and immunosuppression, Lancet
Santoro, Nuñez-Gil, Vitale, Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry, Heart,
doi:10.1136/heartjnl-2021-319552{ 'indexed': {'date-parts': [[2022, 8, 11]], 'date-time': '2022-08-11T04:41:29Z', 'timestamp': 1660192889115},
'reference-count': 10,
'publisher': 'Elsevier BV',
'license': [ { 'start': { 'date-parts': [[2022, 8, 1]],
'date-time': '2022-08-01T00:00:00Z',
'timestamp': 1659312000000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'},
{ 'start': { 'date-parts': [[2022, 8, 8]],
'date-time': '2022-08-08T00:00:00Z',
'timestamp': 1659916800000},
'content-version': 'vor',
'delay-in-days': 7,
'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}],
'content-domain': {'domain': ['elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True},
'published-print': {'date-parts': [[2022, 8]]},
'DOI': '10.1016/j.ahjo.2022.100191',
'type': 'journal-article',
'created': {'date-parts': [[2022, 8, 11]], 'date-time': '2022-08-11T04:08:17Z', 'timestamp': 1660190897000},
'page': '100191',
'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy',
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'Aspirin use is associated with decreased inpatient mortality in patients with COVID-19: A '
'meta-analysis',
'prefix': '10.1016',
'author': [ {'given': 'Aswin', 'family': 'Srinivasan', 'sequence': 'first', 'affiliation': []},
{'given': 'Jonathan', 'family': 'Brown', 'sequence': 'additional', 'affiliation': []},
{ 'given': 'Pavitra Parimala',
'family': 'Krishnamani',
'sequence': 'additional',
'affiliation': []},
{'given': 'Brendon', 'family': 'Cornett', 'sequence': 'additional', 'affiliation': []},
{'given': 'Ramesh Babu', 'family': 'Kesavan', 'sequence': 'additional', 'affiliation': []},
{'given': 'Siva T.', 'family': 'Sarva', 'sequence': 'additional', 'affiliation': []},
{'given': 'Syed Arman', 'family': 'Raza', 'sequence': 'additional', 'affiliation': []},
{'given': 'Waleed Tallat', 'family': 'Kayani', 'sequence': 'additional', 'affiliation': []}],
'member': '78',
'reference': [ { 'issue': '4',
'key': '10.1016/j.ahjo.2022.100191_bb0005',
'doi-asserted-by': 'crossref',
'first-page': '571',
'DOI': '10.1161/CIRCRESAHA.120.317447',
'article-title': 'The emerging threat of (Micro)Thrombosis in COVID-19 and its '
'therapeutic implications',
'volume': '127',
'author': 'McFadyen',
'year': '2020',
'journal-title': 'Circ. Res.'},
{ 'key': '10.1016/j.ahjo.2022.100191_bb0010',
'doi-asserted-by': 'crossref',
'first-page': '148',
'DOI': '10.1016/j.thromres.2020.04.041',
'article-title': 'Confirmation of the high cumulative incidence of thrombotic '
'complications in critically ill ICU patients with COVID-19: an updated '
'analysis',
'volume': '191',
'author': 'Klok',
'year': '2020',
'journal-title': 'Thromb. Res.'},
{ 'issue': '2',
'key': '10.1016/j.ahjo.2022.100191_bb0015',
'article-title': 'Rationales and uncertainties for aspirin use in COVID-19: a narrative '
'review',
'volume': '9',
'author': 'Sayed Ahmed',
'year': '2021',
'journal-title': 'Fam. Med. Community Health'},
{ 'issue': '10320',
'key': '10.1016/j.ahjo.2022.100191_bb0020',
'doi-asserted-by': 'crossref',
'first-page': '143',
'DOI': '10.1016/S0140-6736(21)01825-0',
'article-title': 'Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): '
'randomized, controlled, open-label, platform trial',
'volume': '399',
'year': '2022',
'journal-title': 'Lancet'},
{ 'issue': '3',
'key': '10.1016/j.ahjo.2022.100191_bb0025',
'doi-asserted-by': 'crossref',
'DOI': '10.1001/jamanetworkopen.2022.3890',
'article-title': 'N3C consortium and ANCHOR investigators. Association of Early Aspirin '
'use with in-hospital mortality in patients with moderate COVID-19',
'volume': '5',
'author': 'Chow',
'year': '2022',
'journal-title': 'JAMA Netw. Open'},
{ 'issue': '11',
'key': '10.1016/j.ahjo.2022.100191_bb0030',
'doi-asserted-by': 'crossref',
'first-page': '2814',
'DOI': '10.1111/jth.15517',
'article-title': 'Association of prehospital antiplatelet therapy with survival in '
'patients hospitalized with COVID-19: a propensity score-matched '
'analysis',
'volume': '19',
'author': 'Chow',
'year': '2021',
'journal-title': 'J. Thromb. Haemost.'},
{ 'key': '10.1016/j.ahjo.2022.100191_bb0035',
'doi-asserted-by': 'crossref',
'first-page': '930',
'DOI': '10.1213/ANE.0000000000005292',
'article-title': 'Aspirin use is associated with decreased mechanical ventilation, '
'intensive care unit admission, and in-hospital mortality in '
'hospitalized patients with coronavirus disease 2019',
'volume': '132',
'author': 'Chow',
'year': '2021',
'journal-title': 'Anesth. Analg.'},
{ 'key': '10.1016/j.ahjo.2022.100191_bb0040',
'doi-asserted-by': 'crossref',
'first-page': '1383',
'DOI': '10.1007/s40265-020-01365-1',
'article-title': 'Is acetylsalicylic acid a safe and potentially useful choice for adult '
'patients with COVID-19?',
'volume': '80',
'author': 'Bianconi',
'year': '2020',
'journal-title': 'Drugs'},
{ 'key': '10.1016/j.ahjo.2022.100191_bb0045',
'doi-asserted-by': 'crossref',
'first-page': '1033',
'DOI': '10.1016/S0140-6736(20)30628-0',
'article-title': 'COVID-19: consider cytokine storm syndromes and immunosuppression',
'volume': '395',
'author': 'Mehta',
'year': '2020',
'journal-title': 'Lancet'},
{ 'issue': '2',
'key': '10.1016/j.ahjo.2022.100191_bb0050',
'doi-asserted-by': 'crossref',
'first-page': '130',
'DOI': '10.1136/heartjnl-2021-319552',
'article-title': 'Antiplatelet therapy and outcome in COVID-19: the health outcome '
'predictive evaluation registry',
'volume': '108',
'author': 'Santoro',
'year': '2022',
'journal-title': 'Heart'}],
'container-title': 'American Heart Journal Plus: Cardiology Research and Practice',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2666602222001082?httpAccept=text/xml',
'content-type': 'text/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://api.elsevier.com/content/article/PII:S2666602222001082?httpAccept=text/plain',
'content-type': 'text/plain',
'content-version': 'vor',
'intended-application': 'text-mining'}],
'deposited': { 'date-parts': [[2022, 8, 11]],
'date-time': '2022-08-11T04:08:27Z',
'timestamp': 1660190907000},
'score': 1,
'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2666602222001082'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2022, 8]]},
'references-count': 10,
'alternative-id': ['S2666602222001082'],
'URL': 'http://dx.doi.org/10.1016/j.ahjo.2022.100191',
'relation': {},
'ISSN': ['2666-6022'],
'subject': ['General Medicine'],
'container-title-short': 'American Heart Journal Plus: Cardiology Research and Practice',
'published': {'date-parts': [[2022, 8]]},
'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'},
{ 'value': 'Aspirin use is associated with decreased inpatient mortality in patients with '
'COVID-19: A meta-analysis',
'name': 'articletitle',
'label': 'Article Title'},
{ 'value': 'American Heart Journal Plus: Cardiology Research and Practice',
'name': 'journaltitle',
'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.ahjo.2022.100191',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'article', 'name': 'content_type', 'label': 'Content Type'},
{'value': '© 2022 Published by Elsevier Inc.', 'name': 'copyright', 'label': 'Copyright'}],
'article-number': '100191'}
