The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses
Zack Saud, Victoria J Tyrrell, Andreas Zaragkoulias, Majd B Protty, Evelina Statkute, Anzelika Rubina, Kirsten Bentley, Daniel A White, Patricia Dos Santos Rodrigues, Robert C Murphy, Harald Köfeler, William J Griffiths, Jorge Alvarez-Jarreta, Richard William Brown, Robert G Newcombe, James Heyman, Manon Pritchard, Robert Wj. Mcleod, Arvind Arya, Ceri-Ann Lynch, David Owens, P Vince Jenkins, Niklaas J Buurma, Valerie B O’donnell, David W Thomas, Richard J Stanton
Journal of Lipid Research, doi:10.1016/j.jlr.2022.100208
The lipid envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an essential component of the virus; however, its molecular composition is undetermined. Addressing this knowledge gap could support the design of antiviral agents as well as further our understanding of viralhost protein interactions, infectivity, pathogenicity, and innate immune system clearance.
Supplemental data This article contains supplemental data.
Author contributions
Conflict of interest Venture Life Group plc and Johnson & Johnson provided information on mouthwash formulations employed in the in vitro study. Venture Life Group partfunded the clinical study but had no input in study design, data ysis, or drafting of the article. The authors declare that they have no conflicts of interest with the contents of this article.
Abbreviations ACE2, angiotensin-converting enzyme 2; aPL, aminophospholipid; CE, cholesteryl ester; Cer, ceramide; cmc, critical micelle concentration; COVID-19, coronavirus disease 2019; CPC, cetylpyridinium chloride; CUR, curtain gas; DHCer, dihydroceramide; ER, endoplasmic reticulum; GS1, source gas 1; GS2, source gas 2; HILIC, hydrophilic interaction liquid chromatography; HSV, herpes simplex virus; IPM, isopropyl myristate; IS, ionization voltage; LAE, ethyl lauroyl arginate; LMSD, LIPID MAPS Structure Database; MRM, multiple reaction monitoring; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PFU, plaque-forming unit; PG, phosphatidylglycerol; PI, phosphatidylinositol; PL, phospholipid; PS, phosphatidylserine; PVP-I, povidoneiodine; SARS-CoV2, severe acute respiratory syndrome coronavirus 2; SEC, size-exclusion chromatography; SL, sphingolipid; TAG, triacylglyceride; TEM, temperature; TG, triglyceride; TMPRSS2, transmembrane serine protease 2.
References
Aiyar, Disa, Ao, Ju, Nerurkar et al., Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells, Mol. Cell Biochem
Alpert, Walenga, Kramer, Silski, Davis, Tracheal epithelial cell fatty acid composition modulates prostaglandin E2 and cAMP production, Am. J. Physiol
Alvarez-Jarreta, Rodrigues, Fahy, O'connor, Price et al., LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications, Bioinformatics
Amara, Mercer, Viral apoptotic mimicry, Nat. Rev. Microbiol
Asker, Weiss, Mcclements, Analysis of the interactions of a cationic surfactant (lauric arginate) with an anionic biopolymer (pectin): isothermal titration calorimetry, light scattering, and microelectrophoresis, Langmuir
Astani, Reichling, Schnitzler, Comparative study on the antiviral activity of selected monoterpenes derived from essential oils, Phytother. Res
Birge, Boeltz, Kumar, Carlson, Wanderley et al., Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer, Cell Death Differ
Bohan, Van Ert, Ruggio, Rogers, Badreddine et al., Phosphatidylserine receptors enhance SARS-CoV-2 infection, PLoS Pathog
Brender, Mchenry, Ramamoorthy, Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides?, Front. Immunol
Buurma, Aggregation and reactivity in aqueous solutions of cationic surfactants and aromatic anions across concentration scales, Curr. Opin. Colloid Interf. Sci
Cevik, Tate, Lloyd, Maraolo, Schafers et al., SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis, Lancet Microbe
Chen, Du, Hagemeijer, Takvorian, Pau et al., Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses, Cell
Chow, Howden, Walker, Lee, Bradshaw et al., Antiseptic mouthwash against pharyngeal <em>Neisseria gon-orrhoeae</em>: a randomised controlled trial and an in vitro study, Sex. Transm. Infect
Chow, Williamson, Hocking, Law, Maddaford et al., Antiseptic mouthwash for gonorrhoea prevention (OMEGA): a randomised, double-blind, parallel-group, multicentre trial, Lancet Infect. Dis
Clark, Thomas, Hammond, Aldrovandi, Wilkinson et al., Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation, Proc. Natl. Acad. Sci. U. S. A
Cohen, Lin, Machamer, Identification of a Golgi complex-targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein, J. Virol
Costa, Brites, Vaz, De Santana, Dos Santos et al., Chlorhexidine mouthwash reduces the salivary viral load of SARS-CoV-2: a randomized clinical trial, Oral Dis,
doi:10.1111/odi.14086Da Silva Santos, Da Fonseca Orcina, Machado, Vilhena, Da Costa Alves et al., Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: randomised trial, Sci. Rep
Davies, Buczkowski, Welch, Green, Mawer et al., Effective <em>in-vitro</em> inactivation of SARS-CoV-2 by commercially available mouthwashes, bioRxiv,
doi:10.1101/2020.12.02.408047De Meyer, Smit, Effect of cholesterol on the structure of a phospholipid bilayer, Proc. Natl. Acad. Sci. U. S. A
De Vries, Van Der Loeff, Antiseptic mouthwashes against sexually transmitted infections, Lancet Infect. Dis
Deinhardt-Emmer, Wittschieber, Sanft, Kleemann, Elschner et al., Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage, Elife
Fairley, Zhang, Chow, New thinking on gonorrhoea control in MSM: are antiseptic mouthwashes the answer?, Curr. Opin. Infect. Dis
Feng, Hensley, Mcknight, Hu, Madden et al., A pathogenic picornavirus acquires an envelope by hijacking cellular membranes, Nature
Garoff, Simons, Dobberstein, Assembly of the Semliki Forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro, J. Mol. Biol
Gerl, Sampaio, Urban, Kalvodova, Verbavatz et al., Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane, J. Cell Biol
Ghosh, Dellibovi-Ragheb, Kerviel, Pak, Qiu et al., beta-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway, Cell
Green, Roberts, Tobery, Vincent, Barili et al., In vitro assessment of the virucidal activity of four mouthwashes containing Cetylpyridinium Chloride, ethanol, zinc and a mix of enzyme and proteins against a human coronavirus, bioRxiv,
doi:10.1101/2020.10.28.359257Guti Érrez-García, De, Cerda-Angeles, Cabrera-Licona, Delgado-Enciso et al., Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID-19 in front-line health professionals: a randomized, open-label, controlled trial in a general hospital in Mexico City, Biomed. Rep
Heemskerk, Bevers, Lindhout, Platelet activation and blood coagulation, Thromb. Haemost
Holmstrup, Damgaard, Olsen, Klinge, Flyvbjerg et al., Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician, J. Oral Microbiol
Holtzman, Grunberger, Hunter, Phospholipid fatty acid composition of pulmonary airway epithelial cells: potential substrates for oxygenation, Biochim. Biophys. Acta
Ikonen, Cellular cholesterol trafficking and compartmentalization, Nat. Rev. Mol. Cell Biol
Israelachvili, Mitchell, Ninham, Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers, J. Chem. Society-Faraday Trans. Ii
Joshipura, Munoz-Torres, Morou-Bermudez, Patel, Over-the-counter mouthwash use and risk of pre-diabetes/diabetes, Nitric Oxide
Li, Li, Samuel, Cueto, Li et al., Lysophospholipids and their G proteincoupled receptors in atherosclerosis, Front. Biosci
Liebisch, Fahy, Aoki, Dennis, Durand et al., Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures, J. Lipid Res
Maceyka, Spiegel, Sphingolipid metabolites in inflammatory disease, Nature
Macfarlane, Kawecki, Cunningham, Bovaird, Morgan et al., Mouthwash use in general population: results from adult dental health survey in grampian, Scotland, J. Oral Maxillofac. Res
Madden, Thomas, Blair, Samer, Doyle et al., An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques, bioRxiv,
doi:10.1101/2022.02.25.481974Madjid, Aboshady, Awan, Litovsky, Casscells, Influenza and cardiovascular disease: is there a causal relationship? Tex, Heart Inst. J
Mahmoud, Christian, Tucker, Taha, Scamehorn, Semiequilibrium dialysis study of the solubilization of benzoate anion by aqueous hexadecylpyridinium chloride, J. Phys. Chem
Makide, Uwamizu, Shinjo, Ishiguro, Okutani et al., Novel lysophosphoplipid receptors: their structure and function, J. Lipid Res
Marouf, Cai, Said, Daas, Diab et al., Association between periodontitis and severity of COVID-19 infection: a case-control study, J. Clin. Periodontol
Martinez Lamas, Diz Dios, Perez Rodriguez, Del Campo Perez, Cabrera Alvargonzalez et al., Is povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests, Oral Dis,
doi:10.1111/odi.13526Matsumoto, Kobayashi, Kamata, Role of lysophosphatidylcholine (LPC) in atherosclerosis, Curr. Med. Chem
Mcbride, Li, Machamer, The cytoplasmic tail of the severe acute respiratory syndrome coronavirus spike protein contains a novel endoplasmic reticulum retrieval signal that binds COPI and promotes interaction with membrane protein, J. Virol
Meiller, Silva, Ferreira, Jabra-Rizk, Kelley et al., Efficacy of Listerine Antiseptic in reducing viral contamination of saliva, J. Clin. Periodontol
Meister, Bruggemann, Todt, Conzelmann, Muller et al., Virucidal Efficacy of different Oral Rinses against Severe Acute Respiratory Syndrome Coronavirus 2, J. Infect. Dis
Meng, Hua, Bian, Coronavirus disease 2019 (COVID-19): emerging and future challenges for Dental and Oral Medicine, J. Dent Res
Mercer, Helenius, Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells, Science
Meyers, Robison, Milici, Alam, Quillen et al., Lowering the transmission and spread of human coronavirus, J. Med. Virol
Moller-Tank, Kondratowicz, Davey, Rennert, Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry, J. Virol
Morizono, Chen, Role of phosphatidylserine receptors in enveloped virus infection, J. Virol
Mukhim, Dey, Das, Ismail, Aggregation and adsorption behavior of cetylpyridinium chloride in aqueous sodium salicylate and sodium benzoate solutions, J. Colloid Interf. Sci
Muller, Eick, Moritz, Lussi, Gruber, Cytotoxicity and antimicrobial activity of oral rinses in vitro, Biomed. Res. Int
Nguyen, Yang, Ito, Matte, Shaman et al., Seasonal Influenza infections and Cardiovascular disease mortality, JAMA Cardiol
O'donnell, Thomas, Stanton, Maillard, Murphy et al., Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection, Function (Oxf)
Paidassi, Tacnet-Delorme, Garlatti, Darnault, Ghebrehiwet et al., C1q binds phosphatidylserine and likely acts as a multiligandbridging molecule in apoptotic cell recognition, J. Immunol
Perrier, Bonnin, Desmarets, Danneels, Goffard et al., The C-terminal domain of the MERS coronavirus M protein contains a trans-Golgi network localization signal, J. Biol. Chem
Popkin, Zilka, Dimaano, Fujioka, Rackley et al., Cetylpyridinium Chloride (CPC) exhibits potent, rapid activity against Influenza Viruses in vitro and in vivo, Pathog. Immun
Rihn, Merits, Bakshi, Turnbull, Wickenhagen et al., A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research, PLoS Biol
Rodríguez-Casanovas, Rosa, Bello-Lemus, Rasperini, Acosta-Hoyos, Virucidal activity of different mouthwashes using a novel biochemical assay, Healthcare
Rosing, Cavagni, Gaio, Muniz, Ranzan et al., Efficacy of two mouthwashes with cetylpyridinium chloride: a controlled randomized clinical trial, Braz. Oral Res
Saud, Ponsford, Bentley, Cole, Pandey et al., Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract, Clin. Infect. Dis. ciac,
doi:10.1093/cid/ciac170Shinitzky, Barenholz, Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing dicetylphosphate, J. Biol. Chem
Shishu, Development of novel microemulsion-based topical formulations of acyclovir for the treatment of cutaneous herpetic infections, AAPS PharmSciTech
Simons, Ikonen, Functional rafts in cell membranes, Nature
Smith, Want, O'maille, Abagyan, Siuzdak, XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification, Anal. Chem
Steyer, Maruši Ć, Kolenc, Triglav, A throat lozenge with fixed combination of cetylpyridinium chloride and benzydamine hydrochloride has direct virucidal effect on SARS-CoV-2, COVID
Sud, Fahy, Cotter, Brown, Dennis et al., LMSD: LIPID MAPS structure database, Nucl. Acids Res
Tadakamadla, Boccalari, Rathore, Dolci, Tartaglia et al., In vitro studies evaluating the efficacy of mouth rinses on Sars-Cov-2: A systematic review, J. Infect. Public Health
Thomas, Clark, Hammond, Aldrovandi, Collins et al., Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells, Nat. Protoc
Tooze, Tooze, Fuller, Sorting of progeny coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells, J. Cell Biol
Tooze, Tooze, Warren, Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59, J. Cell Biol
Trypsteen, Van Cleemput, Snippenberg, Gerlo, Vandekerckhove, On the whereabouts of SARS-CoV-2 in the human body: a systematic review, PLoS Pathog
Udell, Zawi, Bhatt, Keshtkar-Jahromi, Gaughran et al., Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis, JAMA
Van Dijck, Tsoumanis, Rotsaert, Vuylsteke, Van Den Bossche et al., Antibacterial mouthwash to prevent sexually transmitted infections in men who have sex with men taking HIV pre-exposure prophylaxis (PReGo): a randomised, placebo-controlled, crossover trial, Lancet Infect. Dis
Van Meer, Lipids of the Golgi membrane, Trends Cell Biol
Vance, Phospholipid synthesis and transport in mammalian cells, Traffic
Welch, Davies, Buczkowski, Hettiarachchi, Green et al., Analysis of inactivation of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents, and fixatives, J. Clin. Microbiol
Xavier, Roca Sergi, Segret Pons, Antiviral use of Cationic Surfactant, NOVACYT
Yang, Radu, Wang, Riedinger, Witte, Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A, Blood
Yoon, Yoon, Song, Yoon, Lim et al., Clinical significance of a high SARS-CoV-2 viral load in the saliva, J. Korean Med. Sci
Zheng, Fan, Yu, Feng, Lou et al., Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, BMJ
{ 'indexed': {'date-parts': [[2024, 6, 14]], 'date-time': '2024-06-14T22:27:34Z', 'timestamp': 1718404054140},
'reference-count': 85,
'publisher': 'Elsevier BV',
'issue': '6',
'license': [ { 'start': { 'date-parts': [[2022, 6, 1]],
'date-time': '2022-06-01T00:00:00Z',
'timestamp': 1654041600000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'},
{ 'start': { 'date-parts': [[2022, 4, 13]],
'date-time': '2022-04-13T00:00:00Z',
'timestamp': 1649808000000},
'content-version': 'vor',
'delay-in-days': 0,
'URL': 'http://creativecommons.org/licenses/by/4.0/'}],
'content-domain': { 'domain': ['jlr.org', 'elsevier.com', 'sciencedirect.com'],
'crossmark-restriction': True},
'published-print': {'date-parts': [[2022, 6]]},
'DOI': '10.1016/j.jlr.2022.100208',
'type': 'journal-article',
'created': {'date-parts': [[2022, 4, 15]], 'date-time': '2022-04-15T05:49:26Z', 'timestamp': 1650001766000},
'page': '100208',
'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy',
'source': 'Crossref',
'is-referenced-by-count': 30,
'title': 'The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted '
'in\xa0vivo by oral rinses',
'prefix': '10.1016',
'volume': '63',
'author': [ {'given': 'Zack', 'family': 'Saud', 'sequence': 'first', 'affiliation': []},
{'given': 'Victoria J.', 'family': 'Tyrrell', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-2290-0128',
'authenticated-orcid': False,
'given': 'Andreas',
'family': 'Zaragkoulias',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0001-8992-9120',
'authenticated-orcid': False,
'given': 'Majd B.',
'family': 'Protty',
'sequence': 'additional',
'affiliation': []},
{'given': 'Evelina', 'family': 'Statkute', 'sequence': 'additional', 'affiliation': []},
{'given': 'Anzelika', 'family': 'Rubina', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-6619-2098',
'authenticated-orcid': False,
'given': 'Kirsten',
'family': 'Bentley',
'sequence': 'additional',
'affiliation': []},
{'given': 'Daniel A.', 'family': 'White', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0003-0768-0013',
'authenticated-orcid': False,
'given': 'Patricia Dos Santos',
'family': 'Rodrigues',
'sequence': 'additional',
'affiliation': []},
{'given': 'Robert C.', 'family': 'Murphy', 'sequence': 'additional', 'affiliation': []},
{'given': 'Harald', 'family': 'Köfeler', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-4129-6616',
'authenticated-orcid': False,
'given': 'William J.',
'family': 'Griffiths',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-0946-0957',
'authenticated-orcid': False,
'given': 'Jorge',
'family': 'Alvarez-Jarreta',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0001-8182-7314',
'authenticated-orcid': False,
'given': 'Richard William',
'family': 'Brown',
'sequence': 'additional',
'affiliation': []},
{'given': 'Robert G.', 'family': 'Newcombe', 'sequence': 'additional', 'affiliation': []},
{'given': 'James', 'family': 'Heyman', 'sequence': 'additional', 'affiliation': []},
{'given': 'Manon', 'family': 'Pritchard', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0003-3221-6896',
'authenticated-orcid': False,
'given': 'Robert WJ.',
'family': 'Mcleod',
'sequence': 'additional',
'affiliation': []},
{'given': 'Arvind', 'family': 'Arya', 'sequence': 'additional', 'affiliation': []},
{'given': 'Ceri-Ann', 'family': 'Lynch', 'sequence': 'additional', 'affiliation': []},
{'given': 'David', 'family': 'Owens', 'sequence': 'additional', 'affiliation': []},
{'given': 'P Vince', 'family': 'Jenkins', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0003-0260-5057',
'authenticated-orcid': False,
'given': 'Niklaas J.',
'family': 'Buurma',
'sequence': 'additional',
'affiliation': []},
{'given': 'Valerie B.', 'family': 'O’Donnell', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0001-7319-5820',
'authenticated-orcid': False,
'given': 'David W.',
'family': 'Thomas',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-6799-1182',
'authenticated-orcid': False,
'given': 'Richard J.',
'family': 'Stanton',
'sequence': 'additional',
'affiliation': []}],
'member': '78',
'reference': [ { 'key': '10.1016/j.jlr.2022.100208_bib1',
'doi-asserted-by': 'crossref',
'first-page': '587',
'DOI': '10.1016/0022-2836(78)90173-0',
'article-title': 'Assembly of the Semliki Forest virus membrane glycoproteins in the '
'membrane of the endoplasmic reticulum in\xa0vitro',
'volume': '124',
'author': 'Garoff',
'year': '1978',
'journal-title': 'J.\xa0Mol. Biol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib2',
'doi-asserted-by': 'crossref',
'first-page': '213',
'DOI': '10.1083/jcb.201108175',
'article-title': 'Quantitative analysis of the lipidomes of the influenza virus envelope '
'and MDCK cell apical membrane',
'volume': '196',
'author': 'Gerl',
'year': '2012',
'journal-title': 'J.\xa0Cell Biol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib3',
'doi-asserted-by': 'crossref',
'first-page': '2329',
'DOI': '10.4049/jimmunol.180.4.2329',
'article-title': 'C1q binds phosphatidylserine and likely acts as a multiligand-bridging '
'molecule in apoptotic cell recognition',
'volume': '180',
'author': 'Paidassi',
'year': '2008',
'journal-title': 'J.\xa0Immunol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib4',
'doi-asserted-by': 'crossref',
'first-page': '5794',
'DOI': '10.1128/JVI.00060-11',
'article-title': 'Identification of a Golgi complex-targeting signal in the cytoplasmic '
'tail of the severe acute respiratory syndrome coronavirus envelope '
'protein',
'volume': '85',
'author': 'Cohen',
'year': '2011',
'journal-title': 'J.\xa0Virol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib5',
'doi-asserted-by': 'crossref',
'first-page': '2418',
'DOI': '10.1128/JVI.02146-06',
'article-title': 'The cytoplasmic tail of the severe acute respiratory syndrome '
'coronavirus spike protein contains a novel endoplasmic reticulum '
'retrieval signal that binds COPI and promotes interaction with membrane '
'protein',
'volume': '81',
'author': 'McBride',
'year': '2007',
'journal-title': 'J.\xa0Virol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib6',
'doi-asserted-by': 'crossref',
'first-page': '14406',
'DOI': '10.1074/jbc.RA119.008964',
'article-title': 'The C-terminal domain of the MERS coronavirus M protein contains a '
'trans-Golgi network localization signal',
'volume': '294',
'author': 'Perrier',
'year': '2019',
'journal-title': 'J.\xa0Biol. Chem.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib7',
'doi-asserted-by': 'crossref',
'first-page': '1215',
'DOI': '10.1083/jcb.105.3.1215',
'article-title': 'Sorting of progeny coronavirus from condensed secretory proteins at the '
'exit from the trans-Golgi network of AtT20 cells',
'volume': '105',
'author': 'Tooze',
'year': '1987',
'journal-title': 'J.\xa0Cell Biol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib8',
'doi-asserted-by': 'crossref',
'first-page': '1475',
'DOI': '10.1083/jcb.106.5.1475',
'article-title': 'Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of '
'mouse hepatitis virus-A59',
'volume': '106',
'author': 'Tooze',
'year': '1988',
'journal-title': 'J.\xa0Cell Biol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib9',
'doi-asserted-by': 'crossref',
'first-page': '29',
'DOI': '10.1016/S0962-8924(97)01196-3',
'article-title': 'Lipids of the Golgi membrane',
'volume': '8',
'author': 'van Meer',
'year': '1998',
'journal-title': 'Trends Cell Biol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib10',
'doi-asserted-by': 'crossref',
'first-page': '461',
'DOI': '10.1038/nrmicro3469',
'article-title': 'Viral apoptotic mimicry',
'volume': '13',
'author': 'Amara',
'year': '2015',
'journal-title': 'Nat. Rev. Microbiol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib11',
'doi-asserted-by': 'crossref',
'first-page': '962',
'DOI': '10.1038/cdd.2016.11',
'article-title': 'Phosphatidylserine is a global immunosuppressive signal in '
'efferocytosis, infectious disease, and cancer',
'volume': '23',
'author': 'Birge',
'year': '2016',
'journal-title': 'Cell Death Differ.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib12',
'doi-asserted-by': 'crossref',
'first-page': '619',
'DOI': '10.1016/j.cell.2015.01.032',
'article-title': 'Phosphatidylserine vesicles enable efficient en bloc transmission of '
'enteroviruses',
'volume': '160',
'author': 'Chen',
'year': '2015',
'journal-title': 'Cell'},
{ 'key': '10.1016/j.jlr.2022.100208_bib13',
'doi-asserted-by': 'crossref',
'first-page': '367',
'DOI': '10.1038/nature12029',
'article-title': 'A\xa0pathogenic picornavirus acquires an envelope by hijacking cellular '
'membranes',
'volume': '496',
'author': 'Feng',
'year': '2013',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.jlr.2022.100208_bib14',
'doi-asserted-by': 'crossref',
'first-page': '531',
'DOI': '10.1126/science.1155164',
'article-title': 'Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter '
'host cells',
'volume': '320',
'author': 'Mercer',
'year': '2008',
'journal-title': 'Science'},
{ 'key': '10.1016/j.jlr.2022.100208_bib15',
'doi-asserted-by': 'crossref',
'first-page': '8327',
'DOI': '10.1128/JVI.01025-13',
'article-title': 'Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry',
'volume': '87',
'author': 'Moller-Tank',
'year': '2013',
'journal-title': 'J.\xa0Virol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib16',
'doi-asserted-by': 'crossref',
'first-page': '4275',
'DOI': '10.1128/JVI.03287-13',
'article-title': 'Role of phosphatidylserine receptors in enveloped virus infection',
'volume': '88',
'author': 'Morizono',
'year': '2014',
'journal-title': 'J.\xa0Virol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib17',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.ppat.1009743',
'article-title': 'Phosphatidylserine receptors enhance SARS-CoV-2 infection',
'volume': '17',
'author': 'Bohan',
'year': '2021',
'journal-title': 'PLoS Pathog.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib18',
'doi-asserted-by': 'crossref',
'first-page': '1986',
'DOI': '10.1194/jlr.R046920',
'article-title': 'Novel lysophosphoplipid receptors: their structure and function',
'volume': '55',
'author': 'Makide',
'year': '2014',
'journal-title': 'J.\xa0Lipid Res.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib19',
'doi-asserted-by': 'crossref',
'first-page': '58',
'DOI': '10.1038/nature13475',
'article-title': 'Sphingolipid metabolites in inflammatory disease',
'volume': '510',
'author': 'Maceyka',
'year': '2014',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.jlr.2022.100208_bib20',
'doi-asserted-by': 'crossref',
'first-page': '186',
'DOI': '10.1055/s-0037-1613209',
'article-title': 'Platelet activation and blood coagulation',
'volume': '88',
'author': 'Heemskerk',
'year': '2002',
'journal-title': 'Thromb. Haemost.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib21',
'doi-asserted-by': 'crossref',
'first-page': '113',
'DOI': '10.1007/s11010-006-9280-x',
'article-title': 'Lysophosphatidylcholine induces inflammatory activation of human '
'coronary artery smooth muscle cells',
'volume': '295',
'author': 'Aiyar',
'year': '2007',
'journal-title': 'Mol. Cell Biochem.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib22',
'doi-asserted-by': 'crossref',
'first-page': '70',
'DOI': '10.2741/4377',
'article-title': 'Lysophospholipids and their G protein-coupled receptors in '
'atherosclerosis',
'volume': '21',
'author': 'Li',
'year': '2016',
'journal-title': 'Front. Biosci. (Landmark Ed.)'},
{ 'key': '10.1016/j.jlr.2022.100208_bib23',
'doi-asserted-by': 'crossref',
'first-page': '3209',
'DOI': '10.2174/092986707782793899',
'article-title': 'Role of lysophosphatidylcholine (LPC) in atherosclerosis',
'volume': '14',
'author': 'Matsumoto',
'year': '2007',
'journal-title': 'Curr. Med. Chem.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib24',
'doi-asserted-by': 'crossref',
'first-page': '1127',
'DOI': '10.1182/blood-2004-05-1916',
'article-title': 'Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the '
'immunoregulatory GPCR G2A',
'volume': '105',
'author': 'Yang',
'year': '2005',
'journal-title': 'Blood'},
{ 'key': '10.1016/j.jlr.2022.100208_bib25',
'article-title': 'Potential role of oral rinses targeting the viral lipid envelope in '
'SARS-CoV-2 infection',
'volume': '1',
'author': "O'Donnell",
'year': '2020',
'journal-title': 'Function (Oxf)'},
{ 'key': '10.1016/j.jlr.2022.100208_bib26',
'doi-asserted-by': 'crossref',
'first-page': '481',
'DOI': '10.1177/0022034520914246',
'article-title': 'Coronavirus disease 2019 (COVID-19): emerging and future challenges for '
'Dental and Oral Medicine',
'volume': '99',
'author': 'Meng',
'year': '2020',
'journal-title': 'J.\xa0Dent Res.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib27',
'article-title': 'In\xa0vitro assessment of the virucidal activity of four mouthwashes '
'containing Cetylpyridinium Chloride, ethanol, zinc and a mix of enzyme '
'and proteins against a human coronavirus',
'author': 'Green',
'year': '2020',
'journal-title': 'bioRxiv'},
{ 'key': '10.1016/j.jlr.2022.100208_bib28',
'article-title': 'Is povidone iodine mouthwash effective against SARS-CoV-2? First in\xa0'
'vivo tests',
'author': 'Martinez Lamas',
'year': '2020',
'journal-title': 'Oral Dis.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib29',
'doi-asserted-by': 'crossref',
'first-page': '1289',
'DOI': '10.1093/infdis/jiaa471',
'article-title': 'Virucidal Efficacy of different Oral Rinses against Severe Acute '
'Respiratory Syndrome Coronavirus 2',
'volume': '222',
'author': 'Meister',
'year': '2020',
'journal-title': 'J.\xa0Infect. Dis.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib30',
'doi-asserted-by': 'crossref',
'first-page': '1605',
'DOI': '10.1002/jmv.26514',
'article-title': 'Lowering the transmission and spread of human coronavirus',
'volume': '93',
'author': 'Meyers',
'year': '2021',
'journal-title': 'J.\xa0Med. Virol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib31',
'doi-asserted-by': 'crossref',
'first-page': '1179',
'DOI': '10.1016/j.jiph.2021.07.020',
'article-title': 'In\xa0vitro studies evaluating the efficacy of mouth rinses on '
'Sars-Cov-2: A systematic review',
'volume': '14',
'author': 'Tadakamadla',
'year': '2021',
'journal-title': 'J.\xa0Infect. Public Health'},
{ 'key': '10.1016/j.jlr.2022.100208_bib32',
'doi-asserted-by': 'crossref',
'first-page': '63',
'DOI': '10.3390/healthcare10010063',
'article-title': 'Virucidal activity of different mouthwashes using a novel biochemical '
'assay',
'volume': '10',
'author': 'Rodríguez-Casanovas',
'year': '2022',
'journal-title': 'Healthcare'},
{ 'key': '10.1016/j.jlr.2022.100208_bib33',
'doi-asserted-by': 'crossref',
'first-page': '19937',
'DOI': '10.1038/s41598-021-99013-5',
'article-title': 'Beneficial effects of a mouthwash containing an antiviral '
'phthalocyanine derivative on the length of hospital stay for COVID-19: '
'randomised trial',
'volume': '11',
'author': 'da Silva Santos',
'year': '2021',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib34',
'doi-asserted-by': 'crossref',
'first-page': '11',
'DOI': '10.3892/br.2021.1494',
'article-title': 'Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water '
'prevents COVID-19 in front-line health professionals: a randomized, '
'open-label, controlled trial in a general hospital in Mexico City',
'volume': '16',
'author': 'Gutiérrez-García',
'year': '2022',
'journal-title': 'Biomed. Rep.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib35',
'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1111/tra.12230',
'article-title': 'Phospholipid synthesis and transport in mammalian cells',
'volume': '16',
'author': 'Vance',
'year': '2015',
'journal-title': 'Traffic'},
{ 'key': '10.1016/j.jlr.2022.100208_bib36',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pbio.3001091',
'article-title': 'A\xa0plasmid DNA-launched SARS-CoV-2 reverse genetics system and '
'coronavirus toolkit for COVID-19 research',
'volume': '19',
'author': 'Rihn',
'year': '2021',
'journal-title': 'PLoS Biol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib37',
'doi-asserted-by': 'crossref',
'first-page': '779',
'DOI': '10.1021/ac051437y',
'article-title': 'XCMS: processing mass spectrometry data for metabolite profiling using '
'nonlinear peak alignment, matching, and identification',
'volume': '78',
'author': 'Smith',
'year': '2006',
'journal-title': 'Anal. Chem.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib38',
'doi-asserted-by': 'crossref',
'first-page': '1478',
'DOI': '10.1093/bioinformatics/btaa856',
'article-title': 'LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery '
'applications',
'volume': '37',
'author': 'Alvarez-Jarreta',
'year': '2021',
'journal-title': 'Bioinformatics'},
{ 'key': '10.1016/j.jlr.2022.100208_bib39',
'doi-asserted-by': 'crossref',
'first-page': '51',
'DOI': '10.1038/nprot.2013.163',
'article-title': 'Identification and quantification of aminophospholipid molecular '
'species on the surface of apoptotic and activated cells',
'volume': '9',
'author': 'Thomas',
'year': '2014',
'journal-title': 'Nat. Protoc.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib40',
'doi-asserted-by': 'crossref',
'first-page': '341',
'DOI': '10.1111/j.1600-051X.2005.00673.x',
'article-title': 'Efficacy of Listerine Antiseptic in reducing viral contamination of '
'saliva',
'volume': '32',
'author': 'Meiller',
'year': '2005',
'journal-title': 'J.\xa0Clin. Periodontol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib41',
'doi-asserted-by': 'crossref',
'first-page': 'D527',
'DOI': '10.1093/nar/gkl838',
'article-title': 'LMSD: LIPID MAPS structure database',
'volume': '35',
'author': 'Sud',
'year': '2007',
'journal-title': 'Nucl. Acids Res.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib42',
'doi-asserted-by': 'crossref',
'first-page': '1539',
'DOI': '10.1194/jlr.S120001025',
'article-title': 'Update on LIPID MAPS classification, nomenclature, and shorthand '
'notation for MS-derived lipid structures',
'volume': '61',
'author': 'Liebisch',
'year': '2020',
'journal-title': 'J.\xa0Lipid Res.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib43',
'doi-asserted-by': 'crossref',
'first-page': '5875',
'DOI': '10.1073/pnas.1222419110',
'article-title': 'Characterization of platelet aminophospholipid externalization reveals '
'fatty acids as molecular determinants that regulate coagulation',
'volume': '110',
'author': 'Clark',
'year': '2013',
'journal-title': 'Proc. Natl. Acad. Sci. U. S. A.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib44',
'doi-asserted-by': 'crossref',
'DOI': '10.1093/cid/ciac170',
'article-title': 'Mechanically ventilated patients shed high titre live SARS-CoV2 for '
'extended periods from both the upper and lower respiratory tract',
'author': 'Saud',
'year': '2022',
'journal-title': 'Clin. Infect. Dis.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib45',
'doi-asserted-by': 'crossref',
'first-page': '116',
'DOI': '10.1021/la803038w',
'article-title': 'Analysis of the interactions of a cationic surfactant (lauric arginate) '
'with an anionic biopolymer (pectin): isothermal titration calorimetry, '
'light scattering, and microelectrophoresis',
'volume': '25',
'author': 'Asker',
'year': '2009',
'journal-title': 'Langmuir'},
{ 'key': '10.1016/j.jlr.2022.100208_bib46',
'doi-asserted-by': 'crossref',
'first-page': 'e13',
'DOI': '10.1016/S2666-5247(20)30172-5',
'article-title': 'SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of '
'viral shedding, and infectiousness: a systematic review and '
'meta-analysis',
'volume': '2',
'author': 'Cevik',
'year': '2021',
'journal-title': 'Lancet Microbe'},
{ 'key': '10.1016/j.jlr.2022.100208_bib47',
'doi-asserted-by': 'crossref',
'first-page': '569',
'DOI': '10.1038/42408',
'article-title': 'Functional rafts in cell membranes',
'volume': '387',
'author': 'Simons',
'year': '1997',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.jlr.2022.100208_bib48',
'doi-asserted-by': 'crossref',
'first-page': '125',
'DOI': '10.1038/nrm2336',
'article-title': 'Cellular cholesterol trafficking and compartmentalization',
'volume': '9',
'author': 'Ikonen',
'year': '2008',
'journal-title': 'Nat. Rev. Mol. Cell Biol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib49',
'doi-asserted-by': 'crossref',
'first-page': '3654',
'DOI': '10.1073/pnas.0809959106',
'article-title': 'Effect of cholesterol on the structure of a phospholipid bilayer',
'volume': '106',
'author': 'de Meyer',
'year': '2009',
'journal-title': 'Proc. Natl. Acad. Sci. U. S. A.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib50',
'doi-asserted-by': 'crossref',
'first-page': '2652',
'DOI': '10.1016/S0021-9258(19)42780-4',
'article-title': 'Dynamics of the hydrocarbon layer in liposomes of lecithin and '
'sphingomyelin containing dicetylphosphate',
'volume': '249',
'author': 'Shinitzky',
'year': '1974',
'journal-title': 'J.\xa0Biol. Chem.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib51',
'doi-asserted-by': 'crossref',
'first-page': '195',
'DOI': '10.3389/fimmu.2012.00195',
'article-title': 'Does cholesterol play a role in the bacterial selectivity of '
'antimicrobial peptides?',
'volume': '3',
'author': 'Brender',
'year': '2012',
'journal-title': 'Front. Immunol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib52',
'doi-asserted-by': 'crossref',
'first-page': '1520',
'DOI': '10.1016/j.cell.2020.10.039',
'article-title': 'beta-Coronaviruses use lysosomes for egress instead of the biosynthetic '
'secretory pathway',
'volume': '183',
'author': 'Ghosh',
'year': '2020',
'journal-title': 'Cell'},
{ 'key': '10.1016/j.jlr.2022.100208_bib53',
'first-page': 'L192',
'article-title': 'Tracheal epithelial cell fatty acid composition modulates prostaglandin '
'E2 and cAMP production',
'volume': '262',
'author': 'Alpert',
'year': '1992',
'journal-title': 'Am. J. Physiol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib54',
'doi-asserted-by': 'crossref',
'first-page': '459',
'DOI': '10.1016/0005-2760(86)90212-2',
'article-title': 'Phospholipid fatty acid composition of pulmonary airway epithelial '
'cells: potential substrates for oxygenation',
'volume': '877',
'author': 'Holtzman',
'year': '1986',
'journal-title': 'Biochim. Biophys. Acta'},
{ 'key': '10.1016/j.jlr.2022.100208_bib55',
'first-page': '4',
'article-title': 'Influenza and cardiovascular disease: is there a causal relationship?',
'volume': '31',
'author': 'Madjid',
'year': '2004',
'journal-title': 'Tex. Heart Inst. J.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib56',
'doi-asserted-by': 'crossref',
'first-page': '274',
'DOI': '10.1001/jamacardio.2016.0433',
'article-title': 'Seasonal Influenza infections and Cardiovascular disease mortality',
'volume': '1',
'author': 'Nguyen',
'year': '2016',
'journal-title': 'JAMA Cardiol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib57',
'doi-asserted-by': 'crossref',
'first-page': '1711',
'DOI': '10.1001/jama.2013.279206',
'article-title': 'Association between influenza vaccination and cardiovascular outcomes '
'in high-risk patients: a meta-analysis',
'volume': '310',
'author': 'Udell',
'year': '2013',
'journal-title': 'JAMA'},
{ 'key': '10.1016/j.jlr.2022.100208_bib58',
'doi-asserted-by': 'crossref',
'first-page': 'm1443',
'DOI': '10.1136/bmj.m1443',
'article-title': 'Viral load dynamics and disease severity in patients infected with '
'SARS-CoV-2 in Zhejiang province, China, January-March 2020: '
'retrospective cohort study',
'volume': '369',
'author': 'Zheng',
'year': '2020',
'journal-title': 'BMJ'},
{ 'key': '10.1016/j.jlr.2022.100208_bib59',
'doi-asserted-by': 'crossref',
'DOI': '10.7554/eLife.60361',
'article-title': 'Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 '
'and the correlation with tissue damage',
'volume': '10',
'author': 'Deinhardt-Emmer',
'year': '2021',
'journal-title': 'Elife'},
{ 'key': '10.1016/j.jlr.2022.100208_bib60',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.ppat.1009037',
'article-title': 'On the whereabouts of SARS-CoV-2 in the human body: a systematic review',
'volume': '16',
'author': 'Trypsteen',
'year': '2020',
'journal-title': 'PLoS Pathog.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib61',
'article-title': 'An immunoPET probe to SARS-CoV-2 reveals early infection of the male '
'genital tract in rhesus macaques',
'author': 'Madden',
'year': '2022',
'journal-title': 'bioRxiv'},
{ 'key': '10.1016/j.jlr.2022.100208_bib62',
'doi-asserted-by': 'crossref',
'first-page': '673',
'DOI': '10.1002/ptr.2955',
'article-title': 'Comparative study on the antiviral activity of selected monoterpenes '
'derived from essential oils',
'volume': '24',
'author': 'Astani',
'year': '2010',
'journal-title': 'Phytother. Res.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib63',
'doi-asserted-by': 'crossref',
'DOI': '10.1128/JCM.01713-20',
'article-title': 'Analysis of inactivation of SARS-CoV-2 by specimen transport media, '
'nucleic acid extraction reagents, detergents, and fixatives',
'volume': '58',
'author': 'Welch',
'year': '2020',
'journal-title': 'J.\xa0Clin. Microbiol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib64',
'doi-asserted-by': 'crossref',
'first-page': '559',
'DOI': '10.1208/s12249-009-9242-1',
'article-title': 'Development of novel microemulsion-based topical formulations of '
'acyclovir for the treatment of cutaneous herpetic infections',
'volume': '10',
'author': 'Shishu',
'year': '2009',
'journal-title': 'AAPS PharmSciTech'},
{ 'key': '10.1016/j.jlr.2022.100208_bib65',
'first-page': '252',
'article-title': 'Cetylpyridinium Chloride (CPC) exhibits potent, rapid activity against '
'Influenza Viruses in\xa0vitro and in\xa0vivo',
'volume': '2',
'author': 'Popkin',
'year': '2017',
'journal-title': 'Pathog. Immun.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib66',
'series-title': 'Antiviral use of Cationic Surfactant',
'author': 'Bonvila Xavier',
'year': '2009'},
{ 'key': '10.1016/j.jlr.2022.100208_bib67',
'doi-asserted-by': 'crossref',
'first-page': '1525',
'DOI': '10.1039/f29767201525',
'article-title': 'Theory of self-assembly of hydrocarbon amphiphiles into micelles and '
'bilayers',
'volume': '72',
'author': 'Israelachvili',
'year': '1976',
'journal-title': 'J.\xa0Chem. Society-Faraday Trans. Ii'},
{ 'key': '10.1016/j.jlr.2022.100208_bib68',
'doi-asserted-by': 'crossref',
'first-page': '435',
'DOI': '10.3390/covid1020037',
'article-title': 'A\xa0throat lozenge with fixed combination of cetylpyridinium chloride '
'and benzydamine hydrochloride has direct virucidal effect on SARS-CoV-2',
'volume': '1',
'author': 'Steyer',
'year': '2021',
'journal-title': 'COVID'},
{ 'key': '10.1016/j.jlr.2022.100208_bib69',
'doi-asserted-by': 'crossref',
'first-page': '5903',
'DOI': '10.1021/j100352a050',
'article-title': 'Semiequilibrium dialysis study of the solubilization of benzoate anion '
'by aqueous hexadecylpyridinium chloride',
'volume': '93',
'author': 'Mahmoud',
'year': '1989',
'journal-title': 'J.\xa0Phys. Chem.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib70',
'doi-asserted-by': 'crossref',
'first-page': '511',
'DOI': '10.1016/j.jcis.2010.06.070',
'article-title': 'Aggregation and adsorption behavior of cetylpyridinium chloride in '
'aqueous sodium salicylate and sodium benzoate solutions',
'volume': '350',
'author': 'Mukhim',
'year': '2010',
'journal-title': 'J.\xa0Colloid Interf. Sci.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib71',
'doi-asserted-by': 'crossref',
'first-page': '69',
'DOI': '10.1016/j.cocis.2017.10.005',
'article-title': 'Aggregation and reactivity in aqueous solutions of cationic surfactants '
'and aromatic anions across concentration scales',
'volume': '32',
'author': 'Buurma',
'year': '2017',
'journal-title': 'Curr. Opin. Colloid Interf. Sci.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib72',
'first-page': 'e2',
'article-title': 'Mouthwash use in general population: results from adult dental health '
'survey in grampian, Scotland',
'volume': '1',
'author': 'Macfarlane',
'year': '2011',
'journal-title': 'J.\xa0Oral Maxillofac. Res.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib73',
'doi-asserted-by': 'crossref',
'first-page': '4019723',
'DOI': '10.1155/2017/4019723',
'article-title': 'Cytotoxicity and antimicrobial activity of oral rinses in\xa0vitro',
'volume': '2017',
'author': 'Muller',
'year': '2017',
'journal-title': 'Biomed. Res. Int.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib74',
'doi-asserted-by': 'crossref',
'first-page': '14',
'DOI': '10.1016/j.niox.2017.09.004',
'article-title': 'Over-the-counter mouthwash use and risk of pre-diabetes/diabetes',
'volume': '71',
'author': 'Joshipura',
'year': '2017',
'journal-title': 'Nitric Oxide'},
{ 'key': '10.1016/j.jlr.2022.100208_bib75',
'doi-asserted-by': 'crossref',
'first-page': 'e47',
'DOI': '10.1590/1807-3107bor-2017.vol31.0047',
'article-title': 'Efficacy of two mouthwashes with cetylpyridinium chloride: a controlled '
'randomized clinical trial',
'volume': '31',
'author': 'Rosing',
'year': '2017',
'journal-title': 'Braz. Oral Res.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib76',
'doi-asserted-by': 'crossref',
'first-page': '483',
'DOI': '10.1111/jcpe.13435',
'article-title': 'Association between periodontitis and severity of COVID-19 infection: a '
'case-control study',
'volume': '48',
'author': 'Marouf',
'year': '2021',
'journal-title': 'J.\xa0Clin. Periodontol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib77',
'doi-asserted-by': 'crossref',
'first-page': '1332710',
'DOI': '10.1080/20002297.2017.1332710',
'article-title': 'Comorbidity of periodontal disease: two sides of the same coin? An '
'introduction for the clinician',
'volume': '9',
'author': 'Holmstrup',
'year': '2017',
'journal-title': 'J.\xa0Oral Microbiol.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib78',
'article-title': 'Clinical significance of a high SARS-CoV-2 viral load in the saliva',
'volume': '35',
'author': 'Yoon',
'year': '2020',
'journal-title': 'J.\xa0Korean Med. Sci.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib79',
'doi-asserted-by': 'crossref',
'DOI': '10.1111/odi.14086',
'article-title': 'Chlorhexidine mouthwash reduces the salivary viral load of SARS-CoV-2: '
'a randomized clinical trial',
'author': 'Costa',
'year': '2021',
'journal-title': 'Oral Dis.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib80',
'article-title': 'Effective <em>in-vitro</em> inactivation of SARS-CoV-2 by commercially '
'available mouthwashes',
'author': 'Davies',
'year': '2020',
'journal-title': 'bioRxiv'},
{ 'key': '10.1016/j.jlr.2022.100208_bib81',
'doi-asserted-by': 'crossref',
'first-page': '657',
'DOI': '10.1016/S1473-3099(20)30778-7',
'article-title': 'Antibacterial mouthwash to prevent sexually transmitted infections in '
'men who have sex with men taking HIV pre-exposure prophylaxis (PReGo): '
'a randomised, placebo-controlled, crossover trial',
'volume': '21',
'author': 'Van Dijck',
'year': '2021',
'journal-title': 'Lancet Infect. Dis.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib82',
'doi-asserted-by': 'crossref',
'first-page': '88',
'DOI': '10.1136/sextrans-2016-052753',
'article-title': 'Antiseptic mouthwash against pharyngeal <em>Neisseria gonorrhoeae</em>: '
'a randomised controlled trial and an in\xa0vitro study',
'volume': '93',
'author': 'Chow',
'year': '2017',
'journal-title': 'Sex. Transm. Infect.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib83',
'doi-asserted-by': 'crossref',
'first-page': '647',
'DOI': '10.1016/S1473-3099(20)30704-0',
'article-title': 'Antiseptic mouthwash for gonorrhoea prevention (OMEGA): a randomised, '
'double-blind, parallel-group, multicentre trial',
'volume': '21',
'author': 'Chow',
'year': '2021',
'journal-title': 'Lancet Infect. Dis.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib84',
'doi-asserted-by': 'crossref',
'first-page': '45',
'DOI': '10.1097/QCO.0000000000000421',
'article-title': 'New thinking on gonorrhoea control in MSM: are antiseptic mouthwashes '
'the answer?',
'volume': '31',
'author': 'Fairley',
'year': '2018',
'journal-title': 'Curr. Opin. Infect. Dis.'},
{ 'key': '10.1016/j.jlr.2022.100208_bib85',
'doi-asserted-by': 'crossref',
'first-page': '583',
'DOI': '10.1016/S1473-3099(20)30839-2',
'article-title': 'Antiseptic mouthwashes against sexually transmitted infections',
'volume': '21',
'author': 'de Vries',
'year': '2021',
'journal-title': 'Lancet Infect. Dis.'}],
'container-title': 'Journal of Lipid Research',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0022227522000414?httpAccept=text/xml',
'content-type': 'text/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://api.elsevier.com/content/article/PII:S0022227522000414?httpAccept=text/plain',
'content-type': 'text/plain',
'content-version': 'vor',
'intended-application': 'text-mining'}],
'deposited': { 'date-parts': [[2022, 6, 24]],
'date-time': '2022-06-24T02:07:25Z',
'timestamp': 1656036445000},
'score': 1,
'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0022227522000414'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2022, 6]]},
'references-count': 85,
'journal-issue': {'issue': '6', 'published-print': {'date-parts': [[2022, 6]]}},
'alternative-id': ['S0022227522000414'],
'URL': 'http://dx.doi.org/10.1016/j.jlr.2022.100208',
'relation': { 'has-preprint': [ { 'id-type': 'doi',
'id': '10.1101/2020.11.13.381079',
'asserted-by': 'object'},
{ 'id-type': 'doi',
'id': '10.1101/2022.02.16.22270842',
'asserted-by': 'object'}]},
'ISSN': ['0022-2275'],
'subject': [],
'container-title-short': 'Journal of Lipid Research',
'published': {'date-parts': [[2022, 6]]},
'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'},
{ 'value': 'The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, '
'and is disrupted in\xa0vivo by oral rinses',
'name': 'articletitle',
'label': 'Article Title'},
{'value': 'Journal of Lipid Research', 'name': 'journaltitle', 'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.jlr.2022.100208',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'article', 'name': 'content_type', 'label': 'Content Type'},
{ 'value': '© 2022 The Authors. Published by Elsevier Inc on behalf of American Society for '
'Biochemistry and Molecular Biology.',
'name': 'copyright',
'label': 'Copyright'}],
'article-number': '100208'}
