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0 0.5 1 1.5 2+ Case 33% Improvement Relative Risk Case (b) 43% Case (c) 20% Exercise for COVID-19  Pitanga et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 4,476 patients in Brazil Fewer cases with higher activity levels (not stat. sig., p=0.052) c19early.org Pitanga et al., Int. J. Environmental .., Oct 2022 Favors exercise Favors inactivity

Leisure Time Physical Activity and SARS-CoV-2 Infection among ELSA-Brasil Participants

Pitanga et al., International Journal of Environmental Research and Public Health, doi:10.3390/ijerph192114155
Oct 2022  
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Exercise for COVID-19
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Retrospective 4,476 participants in Brazil, showing lower risk of COVID-19 cases with a history of physical activity, statistically significant only for those following specific practices to protect against COVID-19.
risk of case, 33.0% lower, OR 0.67, p = 0.05, high activity levels 1,469, low activity levels 1,552, combined results with and without protection practices, RR approximated with OR.
risk of case, 43.0% lower, OR 0.57, p = 0.05, with protection practices, RR approximated with OR.
risk of case, 20.0% lower, OR 0.80, p = 0.46, without protection practices, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pitanga et al., 29 Oct 2022, retrospective, Brazil, peer-reviewed, survey, 11 authors. Contact: pitanga@lognet.com.br (corresponding author).
This PaperExerciseAll
Leisure Time Physical Activity and SARS-CoV-2 Infection among ELSA-Brasil Participants
Francisco José Gondim Pitanga, Maria Da Conceição Almeida, Bruce B Duncan, José Geraldo Mill, Luana Giatti, Maria Del Carmen B Molina, Maria De Jesus Mendes Da Fonseca, Maria Inês Schmidt, Rosane Harter Griep, Sandhi Maria Barreto, Sheila Maria Alvim De Matos
International Journal of Environmental Research and Public Health, doi:10.3390/ijerph192114155
The regular practice of physical activity (PA) can reduce the chance of aggravation of the disease and lower rates of hospitalization and mortality from COVID-19, but few studies have analyzed the association of PA with the risk of infection by SARS-CoV-2. The aim of the study was to analyze the association between PA and self-reported SARS-CoV-2 infection. A longitudinal study was conducted with data from 4476 ELSA-Brasil participants who had their PA analyzed twice, once in 2016-2018 and again in 2020. PA was identified using the IPAQ at both follow-up moments and categorized into four groups: (a) remained physically inactive (reference); (b) remained physically active; (c) became physically active in the second moment; and (d) became physically inactive in the second moment. The variables of age, sex, obesity, hypertension, diabetes and specific protective practices against COVID-19 were tested as possible confounders. Data were analyzed by logistic regression. A 95% confidence interval (CI) was used. Remaining physically active was associated with a 43% reduction in the risk of SARS-CoV-2 infection only among those who used specific practices to protect against COVID-19, OR = 0.57 and CI = 0.32-0.99. The results suggested that regular practice of PA can reduce the risk of SARS-CoV-2 infection, especially among those who have used specific practices to protect against COVID-19 during the pandemic.
Conflicts of Interest: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript or in the decision to publish the results.
References
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Hosmer, Lemeshow, Appled Logistic Regression
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Pitanga, Beck, Pitanga, Pinho Cscortez, Guedes et al., Association between leisure time physical activity and mortality by COVID-19 in the brazilian capitals: An ecological analysis, Rev. Bras. Med. Esporte, doi:10.1590/1517-8692202127062021_0071
Salgado-Aranda, Pérez-Castellano, Núñez-Gil, Orozco, Torres-Esquivel et al., Influence of Baseline Physical Activity as a Modifying Factor on COVID-19 Mortality: A Single-Center, Retrospective Study, Infect. Dis. Ther, doi:10.1007/s40121-021-00418-6
Sallis, Young, Tartof, Sallis, Sall et al., Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: A study in 48 440 adult patients, Br. J. Sports Med, doi:10.1136/bjsports-2021-104080
Schmidt, Griep, Passos, Luft, Goulart et al., Strategies and development of quality assurance and control in the ELSA-Brasil, Rev. Saude Publica, doi:10.1590/S0034-8910.2013047003889
Shimizu, Kimura, Akimoto, Akama, Otsuki et al., Effects of exercise, age and gender on salivary secretory immunoglobulin A in elderly individuals, Exerc. Immunol. Rev
Siu, Campitelli, Kwong, Physical activity and influenza-coded outpatient visits, a population-based cohort study, PLoS ONE, doi:10.1371/journal.pone.0039518
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Zbinden-Foncea, Francaux, Deldicque, Hawley, Does High Cardiorespiratory Fitness Confer Some Protection against Proinflammatory Responses after Infection by SARS-CoV-2?, Obesity, doi:10.1002/oby.22849
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