Influence of Baseline Physical Activity as a Modifying Factor on COVID-19 Mortality: A Single-Center, Retrospective Study
Ricardo Salgado-Aranda, Nicasio Pérez-Castellano, Ivan Núñez-Gil, A Josué Orozco, Norberto Torres-Esquivel, Jesús Flores-Soler, Ahmed Chamaisse-Akari, Angela Mclnerney, Carlos Vergara-Uzcategui, Lin Wang, Juan J González-Ferrer, David Filgueiras-Rama, Victoria Cañadas-Godoy, Carlos Macaya-Miguel, Julián Pérez-Villacastín
Infectious Diseases and Therapy, doi:10.1007/s40121-021-00418-6
Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a severe respiratory disease with a 3% global mortality. In the absence of effective treatment, controlling of risk factors that predispose to severe disease is essential to reduce coronavirus disease 2019 (COVID-19) mortality. Large observational studies suggest that exercise can reduce the risk of all-cause and disease-specific mortality. The aim of this study was to analyze the influence of the baseline physical activity level on COVID-19 mortality Methods: This is a retrospective cohort study that included patients between 18 and 70 years old, diagnosed with COVID-19 and hospitalized in our center between February 15 and April 15, 2020. After discharge all the patients included in the study were contacted by telephone. Baseline physical activity level was estimated using the Rapid Assessment of Physical Activity Scale questionnaire and patients were divided into two groups for comparison: sedentary patients (group 1) and active patients (group 2). Results: During the study period 552 patients were admitted to our hospital and met the inclusion criteria. Global mortality in group 1 was significantly higher than in group 2 (13.8% vs 1.8%; p \ 0.001). Patients with a sedentary lifestyle had increased COVID-19 mortality independently of other risk factors previously described (hazard ratio 5.91 (1.80-19.41); p = 0.003). Conclusion: A baseline sedentary lifestyle increases the mortality of hospitalized patients with COVID-19. This finding may be of great utility in the prevention of severe COVID-19 disease.
Authorship. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Disclosures. Ricardo Salgado-Aranda, Nicasio Pe ´rez-Castellano, Ivan Nu ´n ˜ez-Gil, A. Josue Órozco, Norberto Torres-Esquivel, Jesu ´s Flores-Soler, Ahmed Chamaisse-Akari, Angela Mclnerney, Carlos Vergara-Uzcategui, Lin Wang, Juan Jose ´Gonza ´lez-Ferrer, David Filgueiras-Rama, Victoria Can ˜adas-Godoy, Carlos Macaya-Miguel, and Julia ´n Pe ´rez-Villacastı ´n declare that they have no conflicts of interest associated with this manuscript. Compliance with Ethics Guidelines. This study has received approval from Clinical Research Ethics Committee of Clinico San Carlos Hospital under registry number ''20/374-E_COVID'' on 11 May 2020; and it was performed in accordance with the Helsinki Declaration of 1964, and its later amendments. All subjects provided informed consent to participate in the study and their consent for publication. Data Availability. The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request. Open Access. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you..
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