Association Between the Use of Proton Pump Inhibitors and Severe Clinical Outcomes in COVID-19 Patients: A Retrospective Observational Study

DOI record: { "DOI": "10.7759/cureus.72385", "ISSN": [ "2168-8184" ], "URL": "http://dx.doi.org/10.7759/cureus.72385", "author": [ { "affiliation": [], "family": "Pinto", "given": "Sharon", "sequence": "first" }, { "affiliation": [], "family": "Al Lawati", "given": "Hadia", "sequence": "additional" }, { "affiliation": [], "family": "Al Raisi", "given": "Marwa", "sequence": "additional" }, { "affiliation": [], "family": "Maawali", "given": "Balqees Al", "sequence": "additional" } ], "container-title": "Cureus", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2024, 10, 25 ] ], "date-time": "2024-10-25T17:54:27Z", "timestamp": 1729878867000 }, "deposited": { "date-parts": [ [ 2024, 10, 25 ] ], "date-time": "2024-10-25T17:54:28Z", "timestamp": 1729878868000 }, "indexed": { "date-parts": [ [ 2024, 10, 26 ] ], "date-time": "2024-10-26T04:23:03Z", "timestamp": 1729916583719, "version": "3.28.0" }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 10, 25 ] ] }, "language": "en", "link": [ { "URL": "https://www.cureus.com/articles/310267-association-between-the-use-of-proton-pump-inhibitors-and-severe-clinical-outcomes-in-covid-19-patients-a-retrospective-observational-study", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.7759", "published": { "date-parts": [ [ 2024, 10, 25 ] ] }, "published-print": { "date-parts": [ [ 2024, 10, 25 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1038/s41577-020-0308-3", "article-title": "COVID-19: immunopathology and its implications for therapy", "author": "Cao X", "doi-asserted-by": "publisher", "journal-title": "Nat Rev Immunol", "key": "ref1", "unstructured": "Cao X. 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Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: a systematic review and meta-analysis. Expert Rev Respir Med. 2020, 14:1149-63. 10.1080/17476348.2020.1804365", "volume": "14", "year": "2020" }, { "DOI": "10.5001/omj.2020.60", "article-title": "Epidemiology of COVID-19 infection in Oman: analysis of the first 1304 cases", "author": "Khamis F", "doi-asserted-by": "publisher", "journal-title": "Oman Med J", "key": "ref4", "unstructured": "Khamis F, Al Rashidi B, Al-Zakwani I, Al Wahaibi AH, Al Awaidy ST. Epidemiology of COVID-19 infection in Oman: analysis of the first 1304 cases. Oman Med J. 2020, 35:e145. 10.5001/omj.2020.60", "volume": "35", "year": "2020" }, { "DOI": "10.1016/j.pharmthera.2010.06.003", "article-title": "Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters", "author": "Kuba K", "doi-asserted-by": "publisher", "journal-title": "Pharmacol Ther", "key": "ref5", "unstructured": "Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 2010, 128:119-28. 10.1016/j.pharmthera.2010.06.003", "volume": "128", "year": "2010" }, { "DOI": "10.1053/j.gastro.2020.02.055", "article-title": "Evidence for gastrointestinal infection of SARS-CoV-2", "author": "Xiao F", "doi-asserted-by": "publisher", "journal-title": "Gastroenterology", "key": "ref6", "unstructured": "Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020, 158:1831-3.e3. 10.1053/j.gastro.2020.02.055", "volume": "158", "year": "2020" }, { "DOI": "10.1016/j.ctim.2014.05.006", "article-title": "Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study", "author": "Tang WR", "doi-asserted-by": "publisher", "journal-title": "Complement Ther Med", "key": "ref7", "unstructured": "Tang WR, Chen WJ, Yu CT, Chang YC, Chen CM, Wang CH, Yang SH. Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study. Complement Ther Med. 2014, 22:581-91. 10.1016/j.ctim.2014.05.006", "volume": "22", "year": "2014" }, { "DOI": "10.1093/trstmh/trab042", "article-title": "Gastrointestinal manifestations in COVID-19", "author": "Kariyawasam JC", "doi-asserted-by": "publisher", "journal-title": "Trans R Soc Trop Med Hyg", "key": "ref8", "unstructured": "Kariyawasam JC, Jayarajah U, Riza R, Abeysuriya V, Seneviratne SL. Gastrointestinal manifestations in COVID-19. Trans R Soc Trop Med Hyg. 2021, 115:1362-88. 10.1093/trstmh/trab042", "volume": "115", "year": "2021" }, { "DOI": "10.53350/pjmhs211582206", "article-title": "Prevalence, mechanism, and implications of gastrointestinal symptoms in COVID-19", "author": "Zeb S", "doi-asserted-by": "publisher", "journal-title": "Pak J Med Health Sci", "key": "ref9", "unstructured": "Zeb S, Almani K, Arshad I, et al.. Prevalence, mechanism, and implications of gastrointestinal symptoms in COVID-19. Pak J Med Health Sci. 2021, 15:2206-9. 10.53350/pjmhs211582206", "volume": "15", "year": "2021" }, { "DOI": "10.1136/gutjnl-2020-322248", "article-title": "Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching", "author": "Lee SW", "doi-asserted-by": "publisher", "journal-title": "Gut", "key": "ref10", "unstructured": "Lee SW, Ha EK, Yeniova AÖ, et al.. Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching. Gut. 2021, 70:76-84. 10.1136/gutjnl-2020-322248", "volume": "70", "year": "2021" }, { "DOI": "10.1097/MEG.0000000000002013", "article-title": "Pre-hospitalization proton pump inhibitor use and clinical outcomes in COVID-19", "author": "Ramachandran P", "doi-asserted-by": "publisher", "journal-title": "Eur J Gastroenterol Hepatol", "key": "ref11", "unstructured": "Ramachandran P, Perisetti A, Gajendran M, Jean-Louis F, Bansal P, Dwivedi AK, Goyal H. Pre-hospitalization proton pump inhibitor use and clinical outcomes in COVID-19. 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Drug Res (Stuttg). 2020, 70:484-8. 10.1055/a-1236-3041", "volume": "70", "year": "2020" }, { "DOI": "10.1016/j.dld.2020.10.001", "article-title": "Proton pump inhibitor use is associated with increased risk of severity and mortality from coronavirus disease 2019 (COVID-19) infection", "author": "Hariyanto TI", "doi-asserted-by": "publisher", "journal-title": "Dig Liver Dis", "key": "ref14", "unstructured": "Hariyanto TI, Prasetya IB, Kurniawan A. Proton pump inhibitor use is associated with increased risk of severity and mortality from coronavirus disease 2019 (COVID-19) infection. 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Am J Kidney Dis. 2021, 78:804-15. 10.1053/j.ajkd.2021.07.003", "volume": "78", "year": "2021" }, { "DOI": "10.1016/S2213-8587(21)00089-9", "article-title": "Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study", "author": "Gao M", "doi-asserted-by": "publisher", "journal-title": "Lancet Diabetes Endocrinol", "key": "ref25", "unstructured": "Gao M, Piernas C, Astbury NM, Hippisley-Cox J, O'Rahilly S, Aveyard P, Jebb SA. Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study. Lancet Diabetes Endocrinol. 2021, 9:350-9. 10.1016/S2213-8587(21)00089-9", "volume": "9", "year": "2021" }, { "DOI": "10.1016/j.tmaid.2020.101923", "article-title": "COVID-19 disease severity and mortality determinants: a large population-based analysis in Oman", "author": "Al Wahaibi A", "doi-asserted-by": "publisher", "journal-title": "Travel Med Infect Dis", "key": "ref26", "unstructured": "Al Wahaibi A, Al Rawahi B, Patel PK, Al Khalili S, Al Maani A, Al-Abri S. COVID-19 disease severity and mortality determinants: a large population-based analysis in Oman. 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