Proton pump inhibitor therapy usage and associated hospitalization rates and critical care outcomes of COVID-19 patients

{ 'indexed': {'date-parts': [[2024, 7, 18]], 'date-time': '2024-07-18T09:54:04Z', 'timestamp': 1721296444119}, 'reference-count': 33, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 5, 9]], 'date-time': '2022-05-09T00:00:00Z', 'timestamp': 1652054400000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2022, 5, 9]], 'date-time': '2022-05-09T00:00:00Z', 'timestamp': 1652054400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Proton Pump Inhibitors (PPI) are one of the most ' 'prescribed medications in the United States. However, PPIs have been shown to increase the ' 'risk of enteric infections. Our study aims to evaluate the correlation between PPI and ' 'COVID-19 severity. We performed a retrospective cohort study on patients who tested positive ' 'for SARS-CoV-2 from March to August 2020. Patients were categorized based on PPI user status. ' 'Primary outcomes included need for hospital or ICU admission and 30-day mortality. Secondary ' 'outcomes looked to determine the severity of COVID-19 infection and effect of comorbid ' 'conditions. 2,594 patients were reviewed. The primary outcomes of our study found that ' 'neither active nor past PPI use was associated with increased hospital admission or 30-day ' 'mortality following completion of multivariate analysis. Additionally, there was no ' 'association between COVID-19 infection and the strength of PPI dosing (low, standard, high). ' 'However, the following covariates were independently and significantly associated with ' 'increased admission: age, male gender, diabetes, COPD, composite cardiovascular disease, ' 'kidney disease, and obesity. The following covariates were associated with increased ' 'mortality: age, male gender, COPD, and kidney disease. In conclusion, the high risk features ' 'and comorbidities of PPI users were found to have a stronger correlation to severe COVID-19 ' 'infection and poor outcomes as opposed to the use of PPI therapy.</jats:p>', 'DOI': '10.1038/s41598-022-11680-0', 'type': 'journal-article', 'created': {'date-parts': [[2022, 5, 9]], 'date-time': '2022-05-09T17:23:40Z', 'timestamp': 1652117020000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 8, 'title': 'Proton pump inhibitor therapy usage and associated hospitalization rates and critical care ' 'outcomes of COVID-19 patients', 'prefix': '10.1038', 'volume': '12', 'author': [ {'given': 'Brittney', 'family': 'Shupp', 'sequence': 'first', 'affiliation': []}, {'given': 'Sagar V.', 'family': 'Mehta', 'sequence': 'additional', 'affiliation': []}, {'given': 'Subin', 'family': 'Chirayath', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nishit', 'family': 'Patel', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mina', 'family': 'Aiad', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jared', 'family': 'Sapin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jill', 'family': 'Stoltzfus', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yecheskel', 'family': 'Schneider', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 5, 9]]}, 'reference': [ { 'key': '11680_CR1', 'unstructured': '“CDC COVID Data Tracker.” Centers for disease control and prevention. 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