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All Studies   Meta Analysis       

Effect of a Single High-Dose Vitamin D3 on the Length of Hospital Stay of Severely 25-Hydroxyvitamin D-Deficient Patients with COVID-19

Dec 2021  
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Mortality 67% Improvement Relative Risk Ventilation 67% ICU admission 50% Hospitalization time 37% Hospitalization, ≥7 days 33% Discharge 12% Vitamin D  Murai et al.  Prophylaxis  DB RCT Is prophylaxis with vitamin D beneficial for COVID-19? Double-blind RCT 32 patients in Brazil Shorter hospitalization with vitamin D (not stat. sig., p=0.27) c19early.org Murai et al., Clinics, December 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Analysis of a subset of patients from Murai et al. with vitamin D < 10 ng/mL, showing improved results with vitamin D treatment, without statistical significance in the small sample.
risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 16 (0.0%), control 1 of 16 (6.2%), NNT 16, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 16 (0.0%), control 1 of 16 (6.2%), NNT 16, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 50.0% lower, RR 0.50, p = 0.65, treatment 2 of 16 (12.5%), control 4 of 16 (25.0%), NNT 8.0.
hospitalization time, 36.8% lower, relative time 0.63, p = 0.27, treatment median 6.0 IQR 14.0 n=16, control median 9.5 IQR 9.2 n=16.
risk of hospitalization, 33.3% lower, RR 0.67, p = 0.27, treatment 8 of 16 (50.0%), control 12 of 16 (75.0%), NNT 4.0, hospitalization ≥7 days.
risk of no hospital discharge, 11.5% lower, HR 0.88, p = 0.76, treatment 16, control 16, inverted to make HR<1 favor treatment.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Murai et al., 31 Dec 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Brazil, peer-reviewed, 5 authors, trial NCT04449718 (history). Contact: rosamariarp@yahoo.com.
This PaperVitamin DAll
Effect of a Single High-Dose Vitamin D3 on the Length of Hospital Stay of Severely 25-Hydroxyvitamin D-Deficient Patients with COVID-19
Igor H Murai, Alan L Fernandes, Leila Antonangelo, Bruno Gualano, Rosa Maria Rodrigues Pereira
Clinics, doi:10.6061/clinics/2021/e3549
Leila Antonangelo 0 0 0 0 -0
References
Amrein, Scherkl, Hoffmann, Neuwersch-Sommeregger, Köstenberger et al., Vitamin D deficiency 2.0: an update on the current status worldwide, Eur J Clin Nutr, doi:10.1038/s41430-020-0558-y
Bassatne, Basbous, Chakhtoura, El Zein, Rahme et al., The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis, Metabolism, doi:10.1016/j.metabol.2021.154753
Bilezikian, Bikle, Hewison, Lazaretti-Castro, Formenti et al., MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19, Eur J Endocrinol, doi:10.1530/EJE-20-0665
Carpagnano, Lecce, Quaranta, Zito, Buonamico et al., Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinol Invest, doi:10.1007/s40618-020-01370-x
Hernández, Nan, Fernandez-Ayala, García-Unzueta, Hernández-Hernández et al., Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection, J Clin Endocrinol Metab, doi:10.1210/clinem/dgaa733
Jevalikar, Mithal, Singh, Sharma, Farooqui et al., Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19, Sci Rep, doi:10.1038/s41598-021-85809-y
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA, doi:10.1001/jama.2020.26848
Reis, Fernandes, Sales, Santos, Santos et al., Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: a multicenter prospective cohort study, Am J Clin Nutr, doi:10.1093/ajcn/nqab151
Stroehlein, Wallqvist, Iannizzi, Mikolajewska, Metzendorf et al., Vitamin D supplementation for the treatment of COVID-19: a living systematic review, Cochrane Database Syst Rev, doi:10.1002/14651858.CD015043
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