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Relationship of anti-SARS-CoV-2 IgG antibodies with Vitamin D and inflammatory markers in COVID-19 patients

Latifi-Pupovci et al., Scientific Reports, doi:10.1038/s41598-022-09785-7
Apr 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Prospective study of 69 COVID+ patients in Kosovo, showing lower vitamin D levels associated with COVID-19 severity.
Latifi-Pupovci et al., 5 Apr 2022, prospective, Kosovo, peer-reviewed, 9 authors.
This PaperVitamin DAll
Relationship of anti-SARS-CoV-2 IgG antibodies with Vitamin D and inflammatory markers in COVID-19 patients
Hatixhe Latifi-Pupovci, Sadie Namani, Artina Pajaziti, Blerina Ahmetaj-Shala, Lindita Ajazaj, Afrim Kotori, Valdete Haxhibeqiri, Valentin Gegaj, Gramoz Bunjaku
Scientific Reports, doi:10.1038/s41598-022-09785-7
Several studies have found an association of COVID-19 disease severity with Vitamin D deficiency and higher levels of anti-SARS-CoV-2 IgGs. The aim of this study was to determine whether levels of Vitamin D and "inflammatory state" influence the magnitude of anti-SARS-CoV-2 IgGs levels in COVID-19 patients. For this purpose, in 67 patients levels of anti-SARS-CoV-2 IgG were measured in week 4 whereas in 52 patients levels of Vitamin D were measured in week 1 after symptom onset. We found that low Vitamin D levels were significantly associated with age and disease severity whereas there was a trend without significance, towards negative correlation of Vitamin D with anti-SARS-CoV-2 IgG. Anti-SARS-CoV-2 IgG were significantly higher in older ages, patients with severe disease, diabetes and those who received corticosteroid and antibiotic therapy. There was a positive correlation of anti-SARS-CoV-2 IgG with IL-6, CRP, LDH, ESR and with percentages of granulocytes. In conclusion, Vitamin D and anti-SARS-CoV-2 IgG share common parameters associated with inflammatory state. However, even though Vitamin D protects against severe forms of COVID-19 it could not directly affect anti-SARS-CoV-2 IgG production. The coronavirus disease 2019 (COVID-19 ) is caused by a new coronavirus which in addition to acute respiratory failure is associated with systemic disorders such as hyperinflammation, hypercoagulation and vasculitis 1 . Although many people exhibit mild 'flu-like' symptoms, in severe responses systemic changes have been attributed to the cytokine storm accompanying severe inflammatory syndrome [2] [3] [4] . Severe forms of COVID-19 have been linked with low levels of circulating 25-hydroxy Vitamin D (25[OH]D) as an expression of Vitamin D (Vit. D) [5] [6] [7] [8] [9] [10] . Vit. D has immunomodulatory activity in response to invasion of bacterial and viral pathogens 11, 12 interacting with its receptor (VDR) in immune cells [13] [14] [15] . In several studies it was shown that severe inflammatory syndrome was accompanied with changes in hematological markers and increased several inflammatory markers such as CRP, LDH, ESR, ferritin etc. 2, [16] [17] [18] . A recent study has shown that in the presence of Vit. D, IL-6 induces higher production of IL-10, a known anti-inflammatory cytokine which is expected to lead to the reduction of inflammatory markers such as CRP 19 . Several studies have shown inverse association between Vit. D and CRP levels [20] [21] [22] . Additionally, high levels of CRP were associated with lowering levels of Vit. D 23 indicating that Vit. D is a negative acute phase reactant. Thus, Vit. D insufficiency could be the cause and effect of high CRP levels in COVID-19 patients. Humoral and cellular immune responses, two wings of adaptive immunity, are crucial in clearing a variety of viral infections 24 , and have been implicated in recovered COVID-19 patients 25, 26 . In several studies disease severity..
Ethics declaration. This study was approved by the Ethics Committee at University Clinical Centre of Kosova (reference no 2548/2020). Written informed consent was obtained from all participants, in accordance with the Declaration of Helsinki. Author contributions Competing interests The authors declare no competing interests.
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' 'https://doi.org/10.1002/eji.202048970 (2020).', 'volume': '50', 'year': '2020'}, { 'DOI': '10.1371/journal.pone.0241104', 'author': 'E Marklund', 'doi-asserted-by': 'publisher', 'issue': '10', 'journal-title': 'PLoS ONE', 'key': '9785_CR62', 'unstructured': 'Marklund, E. et al. Serum-IgG responses to SARS-CoV-2 after mild and ' 'severe COVID-19 infection and analysis of IgG non-responders. PLoS ONE ' '15(10), e0241104. https://doi.org/10.1371/journal.pone.0241104 (2020).', 'volume': '15', 'year': '2020'}, { 'DOI': '10.1007/s11427-020-1805-0', 'author': 'H Ma', 'doi-asserted-by': 'publisher', 'first-page': '482', 'issue': '3', 'journal-title': 'Sci. China Life Sci.', 'key': '9785_CR63', 'unstructured': 'Ma, H. et al. Decline of SARS-CoV-2-specific IgG, IgM and IgA in ' 'convalescent COVID-19 patients within 100 days after hospital discharge. ' 'Sci. China Life Sci. 64(3), 482–485. ' 'https://doi.org/10.1007/s11427-020-1805-0 (2021).', 'volume': '64', 'year': '2021'}], 'reference-count': 63, 'references-count': 63, 'relation': {}, 'resource': {'primary': {'URL': 'https://www.nature.com/articles/s41598-022-09785-7'}}, 'score': 1, 'short-container-title': ['Sci Rep'], 'short-title': [], 'source': 'Crossref', 'subject': ['Multidisciplinary'], 'subtitle': [], 'title': [ 'Relationship of anti-SARS-CoV-2 IgG antibodies with Vitamin D and inflammatory markers in ' 'COVID-19 patients'], 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'volume': '12'}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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