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All Studies   Meta Analysis    Recent:   

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan et al., ADMET and DMPK, doi:10.5599/admet.2128
Jan 2024  
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Review of propolis nanoformulations and their therapeutic potential in various human diseases. Authors provide an overview of the chemical composition and biological activities of propolis, noting challenges such as poor bioavailability and solubility. Nanoformulation strategies are discussed as a means to enhance the therapeutic effects of propolis. The review covers pharmacological actions of nanopropolis in diabetes, liver disease, cancer, cardiovascular disease, viral and bacterial infections, inflammation, oral/dental disease, and wound healing. For viral infections, studies showed Thai propolis nanoparticles reduced cytotoxicity, inactivated viral particles, and decreased HSV replication gene expression, while propolis nanofiber exhibited antiviral effects against SARS-CoV-2. Authors highlight the need for further research.
Reviews covering propolis for COVID-19 include Dilokthornsakul, Kustiawan, Ożarowski, Zulhendri, Zullkiflee.
Kustiawan et al., 26 Jan 2024, peer-reviewed, 5 authors. Contact: putri@nano.or.id, etik002@brin.go.id.
This PaperPropolisAll
{ 'DOI': '10.5599/admet.2128', 'ISSN': ['1848-7718'], 'URL': 'http://dx.doi.org/10.5599/admet.2128', 'abstract': '<jats:p>Background and purpose: Scientific research is crucial to develop therapies for ' 'various disease severity levels, as modern drugs cause side effects and are difficult to ' 'predict. Researchers are exploring herbal alternatives with fewer side effects, particularly ' 'propolis, which has been validated through in vitro, in vivo, and clinical studies. This will ' 'focus on scientific evidence and its supporting technology for developing new bioactive ' 'compounds for chronic diseases. Nanotechnology can improve the delivery and absorption of ' 'herbal medicines, which often have poor bioavailability due to their high molecular weight ' 'and solubility in water, particularly in oral medicines. This technology can enhance ' "propolis's effects through multi-target therapy and reduce side effects. Experimental " 'approach: All publications related to each section of this review were discovered using the ' 'search engines Google Scholar, Scopus, and Pubmed. This was only available for publication ' 'between 2013 and 2023. The selected publications were used as references in this review after ' 'being thoroughly studied. Key results: Evaluation of propolis active compounds, the ' 'classification of propolis nano formulations, design concepts, and mechanisms of action of ' 'propolis nano formulation. Additionally, the challenges and prospects for how these insights ' 'can be translated into clinical benefits are discussed. Conclusion: In the last ten years, a ' 'list of nanoformulation propolis has been reported. This review concludes the difficulties ' 'encountered in developing large-scale nanoformulations. To commercialize them, improvements ' 'in nano carrier synthesis, standardized evaluation methodology within the framework of ' 'strategy process improvement, and Good Manufacturing Practices would be required.</jats:p>', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-8761-4723', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Kustiawan', 'given': 'Paula Mariana', 'sequence': 'first'}, { 'ORCID': 'http://orcid.org/0000-0001-8566-7960', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Syaifie', 'given': 'Putri Hawa', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0000-0002-1933-9974', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Siregar', 'given': 'Khalish Arsy Al Khairy', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0009-0003-5979-9574', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Ibadillah', 'given': 'Delfritama', 'sequence': 'additional'}, { 'ORCID': 'http://orcid.org/0000-0002-3621-9659', 'affiliation': [], 'authenticated-orcid': False, 'family': 'Mardliyati', 'given': 'Etik', 'sequence': 'additional'}], 'container-title': 'ADMET and DMPK', 'container-title-short': 'ADMET DMPK', 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': {'date-parts': [[2024, 1, 27]], 'date-time': '2024-01-27T02:47:52Z', 'timestamp': 1706323672000}, 'deposited': { 'date-parts': [[2024, 2, 5]], 'date-time': '2024-02-05T02:55:40Z', 'timestamp': 1707101740000}, 'funder': [ { 'DOI': '10.13039/100020473', 'award': ['12/II/7/HK/2023'], 'doi-asserted-by': 'publisher', 'name': 'Badan Riset dan Inovasi Nasional'}], 'indexed': {'date-parts': [[2024, 4, 4]], 'date-time': '2024-04-04T16:38:54Z', 'timestamp': 1712248734696}, 'is-referenced-by-count': 1, 'issued': {'date-parts': [[2024, 1, 26]]}, 'link': [ { 'URL': 'https://pub.iapchem.org/ojs/index.php/admet/article/download/2128/1962', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://pub.iapchem.org/ojs/index.php/admet/article/download/2128/1962', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '3564', 'original-title': [], 'prefix': '10.5599', 'published': {'date-parts': [[2024, 1, 26]]}, 'published-online': {'date-parts': [[2024, 1, 26]]}, 'publisher': 'International Association of Physical Chemists (IAPC)', 'reference-count': 0, 'references-count': 0, 'relation': {}, 'resource': {'primary': {'URL': 'https://pub.iapchem.org/ojs/index.php/admet/article/view/2128'}}, 'score': 1, 'short-title': [], 'source': 'Crossref', 'subject': [ 'Pharmacology (medical)', 'General Pharmacology, Toxicology and Pharmaceutics', 'Chemistry (miscellaneous)', 'Medicine (miscellaneous)'], 'subtitle': [], 'title': 'New insights of propolis nanoformulation and its therapeutic potential in human diseases', 'type': 'journal-article'}
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