{ 'indexed': {'date-parts': [[2024, 4, 4]], 'date-time': '2024-04-04T16:38:54Z', 'timestamp': 1712248734696},
'reference-count': 0,
'publisher': 'International Association of Physical Chemists (IAPC)',
'funder': [ { 'DOI': '10.13039/100020473',
'name': 'Badan Riset dan Inovasi Nasional',
'doi-asserted-by': 'publisher',
'award': ['12/II/7/HK/2023']}],
'content-domain': {'domain': [], 'crossmark-restriction': False},
'abstract': '<jats:p>Background and purpose: Scientific research is crucial to develop therapies for '
'various disease severity levels, as modern drugs cause side effects and are difficult to '
'predict. Researchers are exploring herbal alternatives with fewer side effects, particularly '
'propolis, which has been validated through in vitro, in vivo, and clinical studies. This will '
'focus on scientific evidence and its supporting technology for developing new bioactive '
'compounds for chronic diseases. Nanotechnology can improve the delivery and absorption of '
'herbal medicines, which often have poor bioavailability due to their high molecular weight '
'and solubility in water, particularly in oral medicines. This technology can enhance '
"propolis's effects through multi-target therapy and reduce side effects. Experimental "
'approach: All publications related to each section of this review were discovered using the '
'search engines Google Scholar, Scopus, and Pubmed. This was only available for publication '
'between 2013 and 2023. The selected publications were used as references in this review after '
'being thoroughly studied. Key results: Evaluation of propolis active compounds, the '
'classification of propolis nano formulations, design concepts, and mechanisms of action of '
'propolis nano formulation. Additionally, the challenges and prospects for how these insights '
'can be translated into clinical benefits are discussed. Conclusion: In the last ten years, a '
'list of nanoformulation propolis has been reported. This review concludes the difficulties '
'encountered in developing large-scale nanoformulations. To commercialize them, improvements '
'in nano carrier synthesis, standardized evaluation methodology within the framework of '
'strategy process improvement, and Good Manufacturing Practices would be required.</jats:p>',
'DOI': '10.5599/admet.2128',
'type': 'journal-article',
'created': {'date-parts': [[2024, 1, 27]], 'date-time': '2024-01-27T02:47:52Z', 'timestamp': 1706323672000},
'source': 'Crossref',
'is-referenced-by-count': 1,
'title': 'New insights of propolis nanoformulation and its therapeutic potential in human diseases',
'prefix': '10.5599',
'author': [ { 'ORCID': 'http://orcid.org/0000-0001-8761-4723',
'authenticated-orcid': False,
'given': 'Paula Mariana',
'family': 'Kustiawan',
'sequence': 'first',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0001-8566-7960',
'authenticated-orcid': False,
'given': 'Putri Hawa',
'family': 'Syaifie',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0002-1933-9974',
'authenticated-orcid': False,
'given': 'Khalish Arsy Al Khairy',
'family': 'Siregar',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'http://orcid.org/0009-0003-5979-9574',
'authenticated-orcid': False,
'given': 'Delfritama',
'family': 'Ibadillah',
'sequence': 'additional',
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{ 'ORCID': 'http://orcid.org/0000-0002-3621-9659',
'authenticated-orcid': False,
'given': 'Etik',
'family': 'Mardliyati',
'sequence': 'additional',
'affiliation': []}],
'member': '3564',
'published-online': {'date-parts': [[2024, 1, 26]]},
'container-title': 'ADMET and DMPK',
'original-title': [],
'link': [ { 'URL': 'https://pub.iapchem.org/ojs/index.php/admet/article/download/2128/1962',
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'deposited': { 'date-parts': [[2024, 2, 5]],
'date-time': '2024-02-05T02:55:40Z',
'timestamp': 1707101740000},
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'resource': {'primary': {'URL': 'https://pub.iapchem.org/ojs/index.php/admet/article/view/2128'}},
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'URL': 'http://dx.doi.org/10.5599/admet.2128',
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'ISSN': ['1848-7718'],
'subject': [ 'Pharmacology (medical)', 'General Pharmacology, Toxicology and Pharmaceutics',
'Chemistry (miscellaneous)', 'Medicine (miscellaneous)'],
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'published': {'date-parts': [[2024, 1, 26]]}}
