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All Studies   All Outcomes    Recent:   

Molnupiravir: mutagenic, carcinogenic, authorized in the UK

Goldstein, L., TrialSite News
Nov 2021  
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Discussion of concerns with molnupiravir and the MOVe-OUT trial. Author notes that results showing bone marrow toxicity in dogs were mentioned in this preprint1, but removed from the journal version2. Some additional details were provided by the UK regulator:
“Reversible, dose-related bone marrow toxicity affecting all haematopoietic cell lines was observed in dogs at ≥17 mg/kg/day (0.4 times the human NHC exposure at the recommended human dose (RHD)).”3
This article can also be found at4.
Reviews covering molnupiravir for COVID-19 include5-12.
Goldstein et al., 6 Nov 2021, preprint, 1 author.
This PaperMolnupiravirAll
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