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0 0.5 1 1.5 2+ Case, SSRI 43% Improvement Relative Risk Case, All 39% Fluvoxamine for COVID-19  Glebov et al.  Prophylaxis Favors fluvoxamine Favors control

Antidepressant drug prescription and incidence of COVID-19 in mental health outpatients: a retrospective cohort study

Glebov et al., BMC Medicine, doi:10.1186/s12916-023-02877-9 (date from preprint)
Dec 2022  
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*, now known with p = 0.00014 from 21 studies, recognized in 3 countries.
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4,000+ studies for 60+ treatments.
Retrospective 5,664 mental health patients in the UK, showing lower risk of COVID-19 cases with recent antidepressant prescriptions overall, and for the subset of patients receiving SSRIs.
risk of case, 43.0% lower, OR 0.57, p = 0.04, adjusted per study, 90 days, SSRI, RR approximated with OR.
risk of case, 39.0% lower, OR 0.61, p = 0.03, adjusted per study, 90 days, all antidepressants, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Glebov et al., 20 Dec 2022, retrospective, United Kingdom, peer-reviewed, 5 authors, study period 1 April, 2020 - 31 December, 2020. Contact:
This PaperFluvoxamineAll
Antidepressant drug prescription and incidence of COVID-19: a retrospective cohort study
Oleg O Glebov, Ph.D Christoph Mueller, Robert Stewart, Dag Aarsland, Gayan Perera
Question Is there an association between prescription of antidepressants and incidence of COVID-19 in the general population? Findings In this retrospective cohort study of mental health outpatients with a recent (1-3 months) antidepressant prescription, there was a statistically significant 40% decrease in positive COVID-19 tests. This association was specifically observed for the most commonly prescribed antidepressant class, Selective Serotonin Reuptake Inhibitors, and remained when adjusted for socioeconomic parameters and physical health. Meaning Antidepressant prescription was associated with lower incidence of COVID-19 in the community, warranting further investigation as prophylactics in prospective clinical studies. .
Authors' Contributions
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Glebov, Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2
Glebov, Understanding SARS-CoV-2 endocytosis for COVID-19 drug repurposing, FEBS J, doi:10.1111/febs.15369
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Honos, Healthy London Partnership
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