Abstract: medRxiv preprint doi: https://doi.org/10.1101/2023.01.24.23284916; this version posted January 25, 2023. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Real-world effectiveness of molnupiravir, nirmatrelvir-ritonavir, and sotrovimab on preventing hospital admission among higher-risk patients with COVID-19 in Wales: a retrospective cohort study Authors Andrew Evans, Chief Pharmaceutical Officer, Health and Social Services Group, Welsh Government, Cathays Park, Cardiff CF10 3NQ (corresponding author) Andrew.Evans@gov.wales Cathy Qi, Statistician and Research Officer, Population Data Science, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Singleton Park Swansea SA2 8PP Cathy.Qi@swansea.ac.uk Lolu Adebayo, Research Officer, Population Data Science, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Singleton Park Swansea SA2 8PP J.O.Adebayo@swansea.ac.uk Jonathan Underwood, Clinical Academic Research Partnership Fellow, School of Medicine, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN underwoodj7@cardiff.ac.uk James Coulson, Clinical Reader, School of Medicine, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN Coulsonjm@cardiff.ac.uk Rowena Bailey, Senior Research Officer, Population Data Science, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Singleton Park Swansea SA2 8PP r.bailey@swansea.ac.uk Gareth John, Information Systems Development and Design Lead, Information Services Directorate, Digital Health and Care Wales, Tŷ Glan-yr-Afon, 21 Cowbridge Road East, Cardiff CF11 9AD Gareth.John@wales.nhs.uk Adrian Edwards, Professor of General Practice, Division of Population Medicine, Director, PRIME Centre Wales and Wales COVID-19 Evidence Centre. Division of Population Medicine, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, CF14 4YS Edwardsag@cardiff.ac.uk Alison Cooper, Associate Academic Fellow, Wales Covid-19 Evidence Centre. Division of Population Medicine, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, CF14 4YS Coopera8@cardiff.ac.uk Ronan A Lyons, Clinical Professor of Public Health, Population Data Science, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Singleton Park Swansea SA2 8PP r.a.lyons@swansea.ac.uk Ashley Akbari, Associate Professor Population Data Science Research, Population Data Science, Swansea University Medical School, Faculty of Medicine, Health and Life Science, Swansea University, Singleton Park Swansea SA2 8PP a.akbari@swansea.ac.uk NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2023.01.24.23284916; this version posted January 25, 2023. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Abstract Objective To compare the effectiveness of molnupiravir, nirmatrelvir-ritonavir, and sotrovimab with..