The Endolysosomal System: The Acid Test for SARS-CoV-2
Daniella Cesar-Silva, Filipe S Pereira-Dutra, Ana Lucia Moraes Moraes Giannini, Cecília Jacques G Jacques G. De Almeida
International Journal of Molecular Sciences, doi:10.3390/ijms23094576
This review aims to describe and discuss the different functions of the endolysosomal system, from homeostasis to its vital role during viral infections. We will initially describe endolysosomal system's main functions, presenting recent data on how its compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for their benefit. It is clear that to succeed, pathogens' evolution favored the establishment of ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies to make the most out of the invaded cell's machinery to produce new viruses and maneuvers to escape the host's defense system.
Conflicts of Interest: The authors declare no conflict of interest.
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'license': [ { 'start': { 'date-parts': [[2022, 4, 20]],
'date-time': '2022-04-20T00:00:00Z',
'timestamp': 1650412800000},
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'abstract': '<jats:p>This review aims to describe and discuss the different functions of the endolysosomal '
'system, from homeostasis to its vital role during viral infections. We will initially '
'describe endolysosomal system’s main functions, presenting recent data on how its '
'compartments are essential for host defense to explore later how SARS-CoV-2 (Severe Acute '
'Respiratory Syndrome Coronavirus 2) and other coronaviruses subvert these organelles for '
'their benefit. It is clear that to succeed, pathogens’ evolution favored the establishment of '
'ways to avoid, escape, or manipulate lysosomal function. The unavoidable coexistence with '
'such an unfriendly milieu imposed on viruses the establishment of a vast array of strategies '
'to make the most out of the invaded cell’s machinery to produce new viruses and maneuvers to '
'escape the host’s defense system.</jats:p>',
'DOI': '10.3390/ijms23094576',
'type': 'journal-article',
'created': {'date-parts': [[2022, 4, 21]], 'date-time': '2022-04-21T05:55:51Z', 'timestamp': 1650520551000},
'page': '4576',
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'is-referenced-by-count': 5,
'title': 'The Endolysosomal System: The Acid Test for SARS-CoV-2',
'prefix': '10.3390',
'volume': '23',
'author': [ {'given': 'Daniella', 'family': 'Cesar-Silva', 'sequence': 'first', 'affiliation': []},
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'authenticated-orcid': False,
'given': 'Filipe S.',
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{ 'given': 'Ana Lucia Moraes',
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'given': 'Cecília Jacques G.',
'family': 'Jacques G. de Almeida',
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