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Evaluation the plausibility of repurpose of levamisole and niclosamide in treatment of covid-19

Abed et al., Journal of Pharmaceutical Technolgy, doi:10.37662/jpt.2022.999481
Dec 2022  
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Review of the plausibility of repurposing levamisole and niclosamide for treatment of COVID-19. Niclosamide, an FDA-approved antihelminthic drug, has shown antiviral activity against various viruses including SARS-CoV, MERS-CoV, and potentially SARS-CoV-2 by preventing viral entry and replication. Authors highlight recent studies suggesting niclosamide may be effective against COVID-19 through modulating endosomal pH and autophagy, with inhaled and injectable formulations under development and clinical trials planned. Levamisole, another antihelminthic drug with immunostimulant effects, has limited studies on COVID-19 but may enhance immunity and interfere with virulence factors.
Reviews covering niclosamide for COVID-19 include1-6.
Abed et al., 1 Dec 2022, peer-reviewed, 2 authors. Contact: ahmbiq8@gmail.com.
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Abstract: REVIEW ARTICLE e-ISSN: 2717-7904 https://doi.org/10.37662/jpt.2022.999481 Evaluation the plausibility of repurpose of levamisole and niclosamide in treatment of Covid-19 Ahmed Badri Abed1* , Safiye Elif Korcan2 Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Uşak University, Uşak, Turkey Uşak Health Training School, Uşak University, Uşak, Turkey 1 2 ARTICLE INFO ABSTRACT Article history: Since the world health organization declared the pandemic of covid 19, many drugs have been tested and re-evaluated to find effective treatment for the novel corona virus infection. Niclosamide and Levamisole which are FDA approved anthelmintic drugs have been evaluated by many researchers and agencies to repurpose of these drugs as additional options for existing treatment strategy used for patients with Covid-19. Hence we are trying in this review to introduce most reports that evaluated the use of Niclosamide and Levamisole for treatment of patients infected with Covid 19. We concluded that the encouraging studies regarding the repurpose of the two drugs may highlighting for further studies that can widening the options for existing treatment strategy used for patients with COVID-19. Received Revised Accepted Online Published 22 Sep 2021 26 Jan 2022 24 Oct 2022 04 Nov 2022 04 Nov 2022 Keywords: Anthelmintic drugs Covid-19 Levamisole Niclosamide SARS-CoV-2 *Corresponding author: ahmbiq8@gmail.com This is an open-access article licensed under the Creative Commons Attribution 4.0 International License (CC-BY).
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