Oxygen Sparing Effect of Bacteriotherapy in COVID-19
Giancarlo Ceccarelli, Massimiliano Marazzato, Luigi Celani, Francesca Lombardi, Alessandra Piccirilli, Massimo Mancone, Vito Trinchieri, Francesco Pugliese, Claudio M Mastroianni, Gabriella D’ettorre
Nutrients, doi:10.3390/nu13082898
Background: We previously reported that severe COVID-19 patients had higher chances of survival and a reduced risk of developing respiratory failure when administered with the probiotic formulation SLAB51. This study aimed to investigate further bacteriotherapy mechanisms and how early they are activated. Methods: We performed an analysis on the blood oxygenation parameters collected in sixty-nine severe COVID-19 patients requiring non-invasive oxygen therapy and presenting a CT lung involvement ≥50%. Twenty-nine patients received low-molecular-weight heparin, azithromycin and Remdesivir. In addition, forty subjects received SLAB51. Blood gas analyses were performed before the beginning of treatments and at 24 h. Results: The patients receiving only standard therapy needed significantly increased oxygen amounts during the 24 h observation period. Furthermore, they presented lower blood levels of pO 2 , O 2 Hb and SaO 2 than the group also supplemented with oral bacteriotherapy. In vitro data suggest that SLAB51 can reduce nitric oxide synthesis in intestinal cells. Conclusions: SARS-CoV-2 infected patients may present lesions in the lungs compromising their gas exchange capability. The functionality of the organs essential for these patients' survival depends mainly on the levels of pO 2 , O 2 Hb and SaO 2 . SLAB51 contains enzymes that could reduce oxygen consumption in the intestine, making it available for the other organs.
Conflicts of Interest: The authors declare no conflict of interest.
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'abstract': '<jats:p>Background: We previously reported that severe COVID-19 patients had higher chances '
'of survival and a reduced risk of developing respiratory failure when administered with the '
'probiotic formulation SLAB51. This study aimed to investigate further bacteriotherapy '
'mechanisms and how early they are activated. Methods: We performed an analysis on the blood '
'oxygenation parameters collected in sixty-nine severe COVID-19 patients requiring '
'non-invasive oxygen therapy and presenting a CT lung involvement ≥50%. Twenty-nine patients '
'received low-molecular-weight heparin, azithromycin and Remdesivir. In addition, forty '
'subjects received SLAB51. Blood gas analyses were performed before the beginning of '
'treatments and at 24 h. Results: The patients receiving only standard therapy needed '
'significantly increased oxygen amounts during the 24 h observation period. Furthermore, they '
'presented lower blood levels of pO2, O2Hb and SaO2 than the group also supplemented with oral '
'bacteriotherapy. In vitro data suggest that SLAB51 can reduce nitric oxide synthesis in '
'intestinal cells. Conclusions: SARS-CoV-2 infected patients may present lesions in the lungs '
'compromising their gas exchange capability. The functionality of the organs essential for '
'these patients’ survival depends mainly on the levels of pO2, O2Hb and SaO2. SLAB51 contains '
'enzymes that could reduce oxygen consumption in the intestine, making it available for the '
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