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All Studies   Meta Analysis    Recent:   

Vitamin D levels and COVID-19 severe pneumonia: a prospective case-control study

Cardoso et al., medRxiv, doi:10.1101/2024.06.10.24308690
Jun 2024  
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Severe pneumonia, defici.. 67% Improvement Relative Risk Severe pneumonia, insuffic.. 50% Vitamin D for COVID-19  Cardoso et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 614 patients in Brazil (Apr 2020 - Feb 2022) Lower progression with higher vitamin D levels (p=0.000046) c19early.org Cardoso et al., medRxiv, June 2024 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Prospective case-control study of 614 patients in Brazil showing lower vitamin D levels associated with increased risk of severe COVID-19 pneumonia.
This is the 199th COVID-19 sufficiency study for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 835,162 vigintillion).
severe pneumonia, 66.7% lower, OR 0.33, p < 0.001, high D levels (≥30ng/ml) 83 of 145 (57.2%) cases, 147 of 175 (84.0%) controls, NNT 3.0, adjusted per study, inverted to make OR<1 favor high D levels (≥30ng/ml), case control OR, deficient vs. sufficient, multivariable.
severe pneumonia, 50.0% lower, OR 0.50, p < 0.001, high D levels (≥30ng/mL) 83 of 245 (33.9%) cases, 147 of 279 (52.7%) controls, NNT 5.3, adjusted per study, inverted to make OR<1 favor high D levels (≥30ng/mL), case control OR, insufficient vs. sufficient, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cardoso et al., 11 Jun 2024, prospective, Brazil, preprint, 7 authors, study period April 2020 - February 2022. Contact: joaoguilherme@imip.org.br.
This PaperVitamin DAll
Vitamin D levels and COVID-19 severe pneumonia: a prospective case-control study
Fortunato J Cardoso, Carla A Araujo, Jose Roberto Silva Junior, Angelica Guimaraes, Michelle Viana Taveiro, Jose Natal Figueiroa, Joao G Alves
doi:10.1101/2024.06.10.24308690
Introduction: The hypothesis that a low vitamin D levels is associated with a higher risk for severe COVID-19 has not been completely proven, especially with severe pneumonia. Objective: The goal of this study was to confirm the link between vitamin D levels and COVID-19 severe pneumonia. Methods: This prospective case-control study involved 307 patients who developed severe SARS-CoV-2 pneumonia and were hospitalized in an intensive care unit. Age-and sex-matched controls (307) were selected from the same population; 307 patients with mild to moderate forms of COVID-19 who were not hospitalized. Vitamin D levels were assessed during the duration of the disease. Results: The mean vitamin D level was lower in the severe COVID-19 pneumonia group as compared to the control group; 26.8 ± 7.6 ng/mL vs 28.6 ± 7.4 ng/mL, p<0.002. There were more patients with a sufficient level of vitamin D in the control group as compared to the control group; 127 (20.6%) vs 89 (14.5%), p<0.001. Multivariable analysis showed that a deficient vitamin D level was associated with a higher risk for severe COVID-19 pneumonia (OR=3.0; 95% CI: 1.79, 5.10CI), p<0.001. Conclusion: A sufficient vitamin D level is linked to a lower risk of COVID-19 severe pneumonia.
Competing interests None declared Authors' contributions JGBA and FJC conceived the study. FJC, CAA, JRSJ, and MRT participated in the data collection. JGBA and JNF analyzed the data. JGBA and FJC wrote the main manuscript text. All authors reviewed the manuscript.
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