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0 0.5 1 1.5 2+ Severe case 34% Improvement Relative Risk Case 20% c19early.org/d Israel et al. Vitamin D for COVID-19 Sufficiency Favors vitamin D Favors control
Vitamin D deficiency is associated with higher risks for SARS-CoV-2 infection and COVID-19 severity: a retrospective case–control study
Israel et al., Internal and Emergency Medicine, doi:10.1007/s11739-021-02902-w
10 Sep 2020    Source   PDF   Share   Tweet
Retrospective 41,757 PCR+ patients in Israel and 417,570 matched contols, showing an inverse correlation between vitamin D levels and the risks of SARS-CoV-2 infection and of severe disease in those infected. COM-0046–20.
risk of severe case, 33.9% lower, OR 0.66, p < 0.001, high D levels 423 of 1,036 (40.8%) cases, 509 of 934 (54.5%) controls, NNT 7.3, adjusted per study, inverted to make OR<1 favor high D levels, case control OR, >75 nmol/L vs. <30 nmol/L, multivariable.
risk of case, 19.7% lower, OR 0.80, p < 0.001, high D levels 6,152 of 15,892 (38.7%) cases, 73,810 of 159,193 (46.4%) controls, NNT 39, adjusted per study, inverted to make OR<1 favor high D levels, case control OR, >75 nmol/L vs. <30 nmol/L, among COVID+ cases, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Israel et al., 10 Sep 2020, retrospective, population-based cohort, Israel, peer-reviewed, 9 authors, study period 1 March, 2020 - 31 October, 2020.
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