The role of serum vitamin D concentrations in predicting COVID-19 course and outcome

DOI record: { "DOI": "10.5937/afmnai41-42961", "ISSN": [ "0351-6083", "2217-2521" ], "URL": "http://dx.doi.org/10.5937/afmnai41-42961", "abstract": "<jats:p>Introduction/Aim. The coronavirus disease 2019 (COVID-19) pandemic had significant acute and long-term impact on people's health. As the available literature sources have shown that the premorbid conditions affect the course of COVID-19, we aimed to investigate the role of admission vitamin D concentration to predict the outcome of hospitalized COVID-19 patients. Methods. An observational, prospective cohort study was conducted on 329 COVID-19 patients hospitalized at the University Clinical Centre Kragujevac, between October and December 2021. Within 24 hours of admission, vitamin D level was measured from the peripheral venous blood. Medical history data and socio-demographic characteristics were obtained anamnestically and using Health Information System (COMTRADE, Serbia). Lethal outcome and intensive care unit (ICU) admission were considered primary end-points. Results. The prevalence of hypovitaminosis D on admission in our cohort was 27.7%. Both non-survivors and patients requiring ICU admission more frequently had hypovitaminosis D compared to survivors (42,9% versus 21,0%; p &lt; 0,001) and patients on a standard level of care (31,5% verus 25,3%; p = 0,029). Our research showed that vitamin D concentration &lt; 20 ng/mL was an independent predictor of mortality (aOR 2.142 [95% CI 1.226 - 3.744]). However, hypovitaminosis D upon hospital admission did not show a significant impact on ICU admission. Conclusion. Low vitamin D concentration on admission could be a significant predictor of outcome in hospitalized COVID-19 patients.</jats:p>", "author": [ { "affiliation": [ { "id": [ { "asserted-by": "publisher", "id": "https://ror.org/054nax084", "id-type": "ROR" } ] } ], "family": "Božić", "given": "Dunja", "sequence": "first" }, { "affiliation": [ { "id": [ { "asserted-by": "publisher", "id": "https://ror.org/054nax084", "id-type": "ROR" } ] } ], "family": "Stevanović", "given": "Đorđe", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-1770-3733", "affiliation": [ { "id": [ { "asserted-by": "publisher", "id": "https://ror.org/054nax084", "id-type": "ROR" } ] } ], "authenticated-orcid": false, "family": "Poskurica", "given": "Mina", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-7646-5144", "affiliation": [ { "id": [ { "asserted-by": "publisher", "id": "https://ror.org/054nax084", "id-type": "ROR" } ] } ], "authenticated-orcid": false, "family": "Petrović", "given": "Marina", "sequence": "additional" } ], "container-title": "Acta Facultatis Medicae Naissensis", "container-title-short": "Acta fac medic Naissensis", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2024, 7, 9 ] ], "date-time": "2024-07-09T15:15:31Z", "timestamp": 1720538131000 }, "deposited": { "date-parts": [ [ 2024, 7, 9 ] ], "date-time": "2024-07-09T15:16:13Z", "timestamp": 1720538173000 }, "indexed": { "date-parts": [ [ 2024, 7, 10 ] ], "date-time": "2024-07-10T00:02:40Z", "timestamp": 1720569760288 }, "is-referenced-by-count": 0, "issue": "2", "issued": { "date-parts": [ [ 2024 ] ] }, "journal-issue": { "issue": "2", "published-print": { "date-parts": [ [ 2024 ] ] } }, "language": "en", "license": [ { "URL": "http://creativecommons.org/licenses/BY-NC-ND/4.0", "content-version": "unspecified", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 1, 1 ] ], "date-time": "2024-01-01T00:00:00Z", "timestamp": 1704067200000 } } ], "link": [ { "URL": "https://scindeks-clanci.ceon.rs/data/pdf/0351-6083/2024/0351-60832402244B.pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "3964", "original-title": [ "Uloga serumske koncentracije vitamina D u predikciji toka i ishoda COVID-19 infekcije" ], "page": "244-251", "prefix": "10.5937", "published": { "date-parts": [ [ 2024 ] ] }, "published-print": { "date-parts": [ [ 2024 ] ] }, "publisher": "Centre for Evaluation in Education and Science (CEON/CEES)", "reference": [ { "DOI": "10.1007/s11655-021-3313-x", "doi-asserted-by": "crossref", "key": "ref1", "unstructured": "Shi K, Liu Y, Zhang Q, et al. 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