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Treatment with proton pump inhibitors is associated with secondary bacterial infections and sepsis in patients with COVID-19: a retrospective analysis of their joint impact on in-hospital prognosis

Bianconi et al., Annals of Medicine, doi:10.1080/07853890.2024.2399761
Oct 2024  
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Death/ICU -37% Improvement Relative Risk SBI -96% SBS -67% PPIs for COVID-19  Bianconi et al.  Prophylaxis Is prophylaxis with PPIs beneficial for COVID-19? Retrospective 1,087 patients in Italy Higher death/ICU with PPIs (not stat. sig., p=0.091) c19early.org Bianconi et al., Annals of Medicine, Oct 2024 FavorsPPI Favorscontrol 0 0.5 1 1.5 2+
PPIs for COVID-19
1st treatment shown to increase risk in September 2020, now with p = 0.00000012 from 39 studies.
5,100+ studies for 109 treatments. c19early.org
Retrospective 1,087 hospitalized COVID-19 patients showing significantly increased risk of secondary bacterial infections (SBIs) and secondary bacterial sepsis (SBS) sepsis with pre-admission proton pump inhibitor (PPI) use. Combined ICU admission/mortality was higher but without statistical significance.
risk of death/ICU, 37.0% higher, OR 1.37, p = 0.09, treatment 447, control 640, adjusted per study, multivariable, model 5, RR approximated with OR.
risk of miscellaneous, 95.5% higher, OR 1.96, p < 0.001, treatment 447, control 640, adjusted per study, SBI, multivariable, model 5, RR approximated with OR.
risk of miscellaneous, 67.0% higher, OR 1.67, p = 0.002, treatment 447, control 640, adjusted per study, SBS, multivariable, model 5, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bianconi et al., 30 Oct 2024, retrospective, Italy, peer-reviewed, 11 authors.
This PaperPPIsAll
Treatment with proton pump inhibitors is associated with secondary bacterial infections and sepsis in patients with COVID-19: a retrospective analysis of their joint impact on in-hospital prognosis
Vanessa Bianconi, Massimo R Mannarino, Filippo Figorilli, Federica Ricciutelli, Stefania De Carlo, Valentina Zullo, Martina Corba, Amirhossein Sahebkar, Alessia Greco, Rita Lombardini, Rita Paltriccia, Matteo Pirro
Annals of Medicine, doi:10.1080/07853890.2024.2399761
Introduction and objectives. secondary bacterial infections (sBis) contribute to worse in-hospital outcomes in patients with coronavirus disease 2019 . treatment with proton pump inhibitors (PPis) is associated with an increased risk of bacterial infections in different clinical settings. however, the association between PPi treatment prior to hospital admission and the occurrence of either sBis or secondary bacterial sepsis (sBs) as well as their joint impact on clinical outcomes of patients hospitalized for cOViD-19 are not clarified. Patients and methods. We retrospectively analyzed preadmission PPi use, in-hospital occurrence of sBis and sBs, and in-hospital outcomes of a cohort of patients hospitalized for cOViD-19. Results. among 1087 patients, 447 (41%) were on PPi treatment prior to hospital admission. During the hospital stay, 197 (18%) and 223 (20%) patients were diagnosed with sBis and sBs, respectively. the composite endpoint of intensive care unit (icU) admission/in-hospital death was met by 214 (20%) patients. Preadmission PPi treatment was independently associated with up to a 2.1-fold and 1.7-fold increased risk of sBis and sBs, respectively. the occurrence of sBs was independently associated with up to a 2.2-fold increased risk of icU admission/in-hospital death. a significant preadmission PPi treatment x sBs interaction emerged in predicting icU admission/ in-hospital death (F = 5.221, p interaction = 0.023). Conclusions. PPi treatment prior to hospital admission for cOViD-19 is associated with an increased risk of sBis and sBs. in addition, it interacts with sBs in predicting in-hospital prognosis. an appropriate use of PPis may attenuate the risk of adverse clinical outcomes during hospitalization for cOViD-19.
Ethics approval statement this study was conducted according to the guidelines of the Declaration of helsinki and approved by the local ethics committee (ceR Umbria, protocol code: 18342/20/OV; date of approval: 7 May 2020). Author contributions conception and design: V.B. and M.P. analysis and interpretation of the data: V.B., M.R.M., F.F., F.R., s.D., V.Z., M.c., a.s., a.G., R.l., R.P., and M.P. Drafting of the paper: V.B., F.R., and M.P. Revising the paper critically for intellectual content: V.B., M.R.M., a.s., and M.P. Final approval of the version to be published and agreement to be accountable for all aspects of the work: V.B., M.R.M., F.F., F.R., s.D., V.Z., M.c., a.s., a.G., R.l., R.P., and M.P. Disclosure statement the authors declare that they have no conflicts of interest with respect to the research, authorship, and/or publication of this manuscript. No financial or personal relationships with individuals or organizations have influenced or could be perceived to have influenced the work presented in this paper.
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