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All Studies   Meta Analysis    Recent:   

The role of vitamin D as a preventive strategy in COVID-19 infections: evidence from South Asia

Arambepola et al., Research Square, doi:10.21203/rs.3.rs-3964082/v1
Mar 2024  
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Case 47% Improvement Relative Risk Vitamin D for COVID-19  Arambepola et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 208 patients in India Fewer cases with higher vitamin D levels (not stat. sig., p=0.27) c19early.org Arambepola et al., Research Square, Mar 2024 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Case-control study of 104 hospitalized COVID-19 patients and 104 healthy controls in Sri Lanka, showing significantly lower serum vitamin D levels in cases compared to controls, and in moderate/severe cases compared to mild cases. There was a higher risk of cases with vitamin D deficiency, without statistical significance.
This is the 196th of 204 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 107,767,362 vigintillion).
risk of case, 47.4% lower, OR 0.53, p = 0.27, high D levels (≥50nmol/L) 17 of 104 (16.3%) cases, 30 of 104 (28.8%) controls, NNT 5.6, adjusted per study, inverted to make OR<1 favor high D levels (≥50nmol/L), case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Arambepola et al., 28 Mar 2024, retrospective, India, preprint, 6 authors.
This PaperVitamin DAll
The role of vitamin D as a preventive strategy in COVID-19 infections: evidence from South Asia
Carukshi Arambepola, Ruwanika Seneviratne, Sumedha Wijeratne, Nalika Gunawardena, Ruwan Wijayamuni, Deepika Attygalle
doi:10.21203/rs.3.rs-3964082/v1
Background Regional evidence on prevention of COVID-19 and its sequalae by vitamin D remains inconclusive and sparse. Aim/Objective This study aimed to determine the association between COVID-19 and Vitamin D de ciency among adults in Colombo District, Sri Lanka. Methods A sex-matched case-control study was conducted among 104 RT-PCR-con rmed COVID-19 patients and 104 RT-PCR negative adults recruited from community. Non-fasting blood samples were analysed for serum 25(OH)D using chemiluminescence assay and vitamin D de ciency identi ed (< 50.0nmol/L). Results Cases (34.2; SD = 15.4nmol/L) had signi cantly lower 25(OH)D compared to controls (39.8; SD = 17.8nmol/L) (p = 0.02) which persisted after adjustments (p = 0.02), along with Sinhalese ethnicity (p < 0.001). VDD was signi cantly more prevalent in cases (83.7% vs. 71.2%; crude odds ratio (OR) = 2.1; 95%-CI:1.1,4.1), although not an independent COVID-19 predictor (adjusted OR = 1.9; 95%-CI:0.6,5.7). A signi cantly lower 25(OH)D level was observed in moderate/severe cases (39.7; SD = 12.3nmol/L) vs mild (32.9; SD = 15.8nmol/L) (p = 0.015). Neither low serum concentrations nor de ciency showed an independent relationship with severity (p > 0.05). Diabetes was the sole predictor of COVID-19 severity (p = 0.022). Conclusions Vitamin D has potential as a cost-effective primary, but not secondary, preventive strategy.
References
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Non-fasting blood samples were ' 'analysed for serum 25(OH)D using chemiluminescence assay and vitamin D deficiency identified ' '(&lt;\u200950.0nmol/L).\n' 'Results\n' ' Cases (34.2; SD\u2009=\u200915.4nmol/L) had significantly lower 25(OH)D compared to controls ' '(39.8; SD\u2009=\u200917.8nmol/L) (p\u2009=\u20090.02) which persisted after adjustments ' '(p\u2009=\u20090.02), along with Sinhalese ethnicity (p\u2009&lt;\u20090.001). VDD was ' 'significantly more prevalent in cases (83.7% vs. 71.2%; crude odds ratio (OR)\u2009=\u2009' '2.1; 95%-CI:1.1,4.1), although not an independent COVID-19 predictor (adjusted OR\u2009=\u2009' '1.9; 95%-CI:0.6,5.7). A significantly lower 25(OH)D level was observed in moderate/severe ' 'cases (39.7; SD\u2009=\u200912.3nmol/L) vs mild (32.9; SD\u2009=\u200915.8nmol/L) (p\u2009' '=\u20090.015). Neither low serum concentrations nor deficiency showed an independent ' 'relationship with severity (p\u2009&gt;\u20090.05). Diabetes was the sole predictor of ' 'COVID-19 severity (p\u2009=\u20090.022).\n' 'Conclusions\n' ' Vitamin D has potential as a cost-effective primary, but not secondary, preventive ' 'strategy.</jats:p>', 'DOI': '10.21203/rs.3.rs-3964082/v1', 'type': 'posted-content', 'created': {'date-parts': [[2024, 3, 28]], 'date-time': '2024-03-28T18:19:17Z', 'timestamp': 1711649957000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The role of vitamin D as a preventive strategy in COVID-19 infections: evidence from South Asia', 'prefix': '10.21203', 'author': [ { 'given': 'Carukshi', 'family': 'Arambepola', 'sequence': 'first', 'affiliation': [{'name': 'University of Colombo'}]}, { 'given': 'Ruwanika', 'family': 'Seneviratne', 'sequence': 'additional', 'affiliation': [ { 'name': 'Postgraduate Institute of Medicine, University of Colombo, Sri ' 'Lanka'}]}, { 'given': 'Sumedha', 'family': 'Wijeratne', 'sequence': 'additional', 'affiliation': [{'name': 'University of Colombo'}]}, { 'given': 'Nalika', 'family': 'Gunawardena', 'sequence': 'additional', 'affiliation': [{'name': 'World Health Organization Regional Office for South-East Asia'}]}, { 'given': 'Ruwan', 'family': 'Wijayamuni', 'sequence': 'additional', 'affiliation': [{'name': 'Department of Public Health, Colombo Municipal Council'}]}, { 'given': 'Deepika', 'family': 'Attygalle', 'sequence': 'additional', 'affiliation': [{'name': 'World Bank, South Asia Region'}]}], 'member': '8761', 'reference': [ { 'key': 'ref1', 'doi-asserted-by': 'publisher', 'author': 'Holick MF', 'year': '2011', 'unstructured': 'Holick MF, Binkley NC, Bischoff-Ferrari HA et al. 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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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