All Studies Meta Analysis

Examine the association between severe vitamin D deficiency and mortality in patients with Covid-19

Anjum et al., Pakistan J. Med. Heal. Sci., 14:3

Jul 2020

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.

Lower risk for mortality, ICU, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

Prospective study of 140 COVID-19 patients in Pakistan, showing significantly higher mortality with vitamin D deficiency.

This is the 8th of 211 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 248,027,826 vigintillion).

This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.

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risk of death, 62.5% lower, RR 0.38, p = 0.02, high D levels (≥25nmol/L) 8 of 80 (10.0%), low D levels (<25nmol/L) 16 of 60 (26.7%), NNT 6.0.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Anjum et al., 31 Jul 2020, prospective, Pakistan, peer-reviewed, 6 authors, study period March 2020 - June 2020.

This Paper Vitamin D All

Examine the Association Between Severe Vitamin D Deficiency and Mortality in Patients with Covid-19

Dr Shakeel Anjum, Saima Suleman, Saadullah Afridi, Ghazala Yasmeen, Saleha Afridi, Yar Khan

Aim: To determine the association between severe vitamin D deficiency and mortality in patients presented with covid-19.

References

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Biesalski, Vitamin D deficiency and comorbidities in COVID-19 patients -A fatal relationship?, NFS Journal, doi:.10.1016/j.nfs.2020.06.001

Carpagnano, Di Lecce, Quaranta, Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinol Invest, doi:10.1007/s40618-020-01370-x

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Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLoS ONE, doi:10.1371/journal.pone.0239799

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Xu, Yang, Chen, Luo, Zhang et al., Vitamin D alleviates lipopolysaccharideinduced acute lung injury via regulation of the reninangiotensin system, Molecular medicine reports

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