Prospective study of 140 COVID-19 patients in Pakistan, showing significantly higher mortality with vitamin D deficiency.
This study is excluded in the after exclusion results of meta
unadjusted results with no group details.
Abstract: ORIGINAL ARTICLE
Examine the Association Between Severe Vitamin D Deficiency and
Mortality in Patients with Covid-19
SHAKEEL ANJUM1, SAIMA SULEMAN2, SAADULLAH AFRIDI3, GHAZALA YASMEEN4, MOHAMMAD IKRAM SHAH5,
Assistant Professor in Rheumatology Niazi Medical College, Sargodha
Senior House Officer, Internal Medicine department Shaikh Zayed Hospital, Lahore
Director Sarhad Institute of Health Sciences, Sarhad University, Peshawar
Demonstrator Community Medicine, Sheikh Zayed Medical College, Rahim Yar Khan
Assistant professor (Medicine) Jinnah Medical College Peshawar
Associate Professor Sarhad Institute of Health Sciences, Sarhad University Peshawar
Correspondence to: Dr. Shakeel Anjum, Email: email@example.com. Mobile No: +923316662103
Aim: To determine the association between severe vitamin D deficiency and mortality in patients presented with
Study Design: Prospective/Observational
Place and Duration: Shaikh Zayed Hospital, Rahim Yar Khan during from March 2020 to June 2020.
Materials & Methods: Total 140 patients of both genders diagnosed to have covid-19 were enrolled in this study.
Patients ages were ranging from 15 years to 75 years. Detailed demographics including age, sex, and body mass
index (BMI) were recorded after taking written consent. 5 ml blood sample was taken from all the patients to
examine the vitamin D level. Severe Vitamin D deficiency was defined as 25(OH)D < 25 nmol/L (10 ng/dL).
Association between mortality and severe vitamin D deficiency was examined. Data was analyzed by SPSS 24.0.
Results: Out of 140 patients, 82 (58.57%) were males while 58 (41.43%) were females with mean age
42.46±14.73 years. Severe vitamin D deficiency was observed in 60 (42.86%) patients. Mortality found in 22
(15.71%) patients. Patients with severe vitamin D deficiency had high rate of mortality 16 (26.67%) as compared
to patients with no vitamin D deficiency 6 (7.5%), a significant association was observed between severe vitamin
D deficiency and mortality in patients with covid-19 disease with p-value <0.05.
Conclusion: It is concluded that there was strong relationship between severe vitamin-D deficiency and mortality
in patients with covid-19 disease.
Keywords: Covid-19, Vitamin D Deficiency, Mortality
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