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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 62% Improvement Relative Risk Vitamin D for COVID-19  Anjum et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 140 patients in Pakistan (Mar - Jun 2020) Lower mortality with higher vitamin D levels (p=0.02) c19early.org Anjum et al., Pakistan J. Med. Heal. S.., Jul 2020 Favors vitamin D Favors control

Examine the association between severe vitamin D deficiency and mortality in patients with Covid-19

Anjum et al., Pakistan J. Med. Heal. Sci., 14:3
Jul 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Prospective study of 140 COVID-19 patients in Pakistan, showing significantly higher mortality with vitamin D deficiency.
This is the 7th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 62.5% lower, RR 0.38, p = 0.02, high D levels (≥25nmol/L) 8 of 80 (10.0%), low D levels (<25nmol/L) 16 of 60 (26.7%), NNT 6.0.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Anjum et al., 31 Jul 2020, prospective, Pakistan, peer-reviewed, 6 authors, study period March 2020 - June 2020.
This PaperVitamin DAll
Examine the Association Between Severe Vitamin D Deficiency and Mortality in Patients with Covid-19
Dr Shakeel Anjum, Saima Suleman, Saadullah Afridi, Ghazala Yasmeen, Saleha Afridi, Yar Khan
Aim: To determine the association between severe vitamin D deficiency and mortality in patients presented with covid-19.
References
Asghar, Sohaib, Kazmi, Jawad, Ahmed et al., Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary, Care Hospital of Karachi
Baktash, Hosack, Patel, status and outcomes for hospitalised older patients with COVID-19Postgraduate, Medical Journal Published Online First, doi:10.1136/postgradmedj-2020-138712
Biesalski, Vitamin D deficiency and comorbidities in COVID-19 patients -A fatal relationship?, NFS Journal, doi:.10.1016/j.nfs.2020.06.001
Carpagnano, Di Lecce, Quaranta, Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinol Invest, doi:10.1007/s40618-020-01370-x
Cucinotta, Vanelli, WHO Declares COVID-19 a Pandemic, Acta bio-medica: Atenei Parmensis
D'avolio, Avataneo, Manca, 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients, doi:10.3390/nu12051359
Forrest, Stuhldreher, Prevalence and correlates of vitamin D deficiency in US adults, Nutr Res, doi:10.1016/j.nutres.2010.12.001
Garg, Kim, Whitaker, Hospitalization rates and characteristics of patients hospitalized with laboratoryconfirmed coronavirus disease, COVID-NET
Gheblawi, Wang, Viveiros, Nguyen, Zhong et al., Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2, Circulation research
Grant, Lahore, Mcdonnell, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Gruber-Bzura, Vitamin D and Influenza-Prevention or Therapy?, International journal of molecular sciences
Hastie, Mackay, Ho, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr, doi:10.1016/j.dsx.2020.04.050
Huotari, Herzig, Vitamin D and living in northern latitudes-an endemic risk area for vitamin D deficiency, Int J Circumpolar Health
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res, doi:10.1007/s40520-020-01570-8
Lamers, Beumer, Van Der Vaart, Knoops, Puschhof et al., SARS-CoV-2 productively infects human gut enterocytes, Science
Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLoS ONE, doi:10.1371/journal.pone.0239799
Martineau, Jolliffe, Hooper, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Ortega, Serrano, Pujol, Rangel, Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis, EXCLI journal
Owah, Fan, Dennett, Hagtvedt, Straube, Vitamin D levels and deficiency with different occupations: a systematic review, BMC Public Health
Panarese, Shahini, COVID-19, and vitamin D, Aliment Pharm Ther, doi:10.1111/apt.15752
States, None, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm6915e3
Umhau, Casting sunlight on an epidemic: is vitamin D a critical host factor to prevent COVID-19? MedPage Today
Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, The Lancet respiratory medicine
Xu, Yang, Chen, Luo, Zhang et al., Vitamin D alleviates lipopolysaccharideinduced acute lung injury via regulation of the reninangiotensin system, Molecular medicine reports
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