Examine the association between severe vitamin D deficiency and mortality in patients with Covid-19

Anjum et al., Pakistan J. Med. Heal. Sci., 14:3, Jul 2020

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 125 studies, recognized in 18 countries.

Lower risk for mortality, ICU, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,700+ studies for 141 treatments. c19early.org

Prospective study of 140 COVID-19 patients in Pakistan, showing significantly higher mortality with vitamin D deficiency.

This is the 8th of 218 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 25,894,433,917 vigintillion).

This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.

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risk of death, 62.5% lower, RR 0.38, p = 0.02, high D levels (≥25nmol/L) 8 of 80 (10.0%), low D levels (<25nmol/L) 16 of 60 (26.7%), NNT 6.0.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Anjum et al., 31 Jul 2020, prospective, Pakistan, peer-reviewed, 6 authors, study period March 2020 - June 2020.

This Paper Vitamin D All

Examine the Association Between Severe Vitamin D Deficiency and Mortality in Patients with Covid-19

Dr Shakeel Anjum, Saima Suleman, Saadullah Afridi, Ghazala Yasmeen, Saleha Afridi, Yar Khan

Aim: To determine the association between severe vitamin D deficiency and mortality in patients presented with covid-19.

References

Asghar, Sohaib, Kazmi, Jawad, Ahmed et al., Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary, Care Hospital of Karachi

Baktash, Hosack, Patel, status and outcomes for hospitalised older patients with COVID-19Postgraduate, Medical Journal Published Online First, doi:10.1136/postgradmedj-2020-138712

Biesalski, Vitamin D deficiency and comorbidities in COVID-19 patients -A fatal relationship?, NFS Journal, doi:.10.1016/j.nfs.2020.06.001

Carpagnano, Di Lecce, Quaranta, Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinol Invest, doi:10.1007/s40618-020-01370-x

Cucinotta, Vanelli, WHO Declares COVID-19 a Pandemic, Acta bio-medica: Atenei Parmensis

D'avolio, Avataneo, Manca, 25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients, doi:10.3390/nu12051359

Forrest, Stuhldreher, Prevalence and correlates of vitamin D deficiency in US adults, Nutr Res, doi:10.1016/j.nutres.2010.12.001

Garg, Kim, Whitaker, Hospitalization rates and characteristics of patients hospitalized with laboratoryconfirmed coronavirus disease, COVID-NET

Gheblawi, Wang, Viveiros, Nguyen, Zhong et al., Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2, Circulation research

Grant, Lahore, Mcdonnell, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988

Gruber-Bzura, Vitamin D and Influenza-Prevention or Therapy?, International journal of molecular sciences

Hastie, Mackay, Ho, Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab Syndr, doi:10.1016/j.dsx.2020.04.050

Huotari, Herzig, Vitamin D and living in northern latitudes-an endemic risk area for vitamin D deficiency, Int J Circumpolar Health

Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res, doi:10.1007/s40520-020-01570-8

Lamers, Beumer, Van Der Vaart, Knoops, Puschhof et al., SARS-CoV-2 productively infects human gut enterocytes, Science

Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PLoS ONE, doi:10.1371/journal.pone.0239799

Martineau, Jolliffe, Hooper, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583

Ortega, Serrano, Pujol, Rangel, Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis, EXCLI journal

Owah, Fan, Dennett, Hagtvedt, Straube, Vitamin D levels and deficiency with different occupations: a systematic review, BMC Public Health

Panarese, Shahini, COVID-19, and vitamin D, Aliment Pharm Ther, doi:10.1111/apt.15752

States, None, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm6915e3

Umhau, Casting sunlight on an epidemic: is vitamin D a critical host factor to prevent COVID-19? MedPage Today

Xu, Shi, Wang, Zhang, Huang et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome, The Lancet respiratory medicine

Xu, Yang, Chen, Luo, Zhang et al., Vitamin D alleviates lipopolysaccharideinduced acute lung injury via regulation of the reninangiotensin system, Molecular medicine reports

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