Abstract: ORIGINAL ARTICLE Examine the Association Between Severe Vitamin D Deficiency and Mortality in Patients with Covid-19 SHAKEEL ANJUM1, SAIMA SULEMAN2, SAADULLAH AFRIDI3, GHAZALA YASMEEN4, MOHAMMAD IKRAM SHAH5, SALEHA AFRIDI6 1 Assistant Professor in Rheumatology Niazi Medical College, Sargodha Senior House Officer, Internal Medicine department Shaikh Zayed Hospital, Lahore 3 Director Sarhad Institute of Health Sciences, Sarhad University, Peshawar 4 Demonstrator Community Medicine, Sheikh Zayed Medical College, Rahim Yar Khan 5 Assistant professor (Medicine) Jinnah Medical College Peshawar 6 Associate Professor Sarhad Institute of Health Sciences, Sarhad University Peshawar Correspondence to: Dr. Shakeel Anjum, Email: docshakeelanjum@gmail.com. Mobile No: +923316662103 2 ABSTRACT Aim: To determine the association between severe vitamin D deficiency and mortality in patients presented with covid-19. Study Design: Prospective/Observational Place and Duration: Shaikh Zayed Hospital, Rahim Yar Khan during from March 2020 to June 2020. Materials & Methods: Total 140 patients of both genders diagnosed to have covid-19 were enrolled in this study. Patients ages were ranging from 15 years to 75 years. Detailed demographics including age, sex, and body mass index (BMI) were recorded after taking written consent. 5 ml blood sample was taken from all the patients to examine the vitamin D level. Severe Vitamin D deficiency was defined as 25(OH)D < 25 nmol/L (10 ng/dL). Association between mortality and severe vitamin D deficiency was examined. Data was analyzed by SPSS 24.0. Results: Out of 140 patients, 82 (58.57%) were males while 58 (41.43%) were females with mean age 42.46±14.73 years. Severe vitamin D deficiency was observed in 60 (42.86%) patients. Mortality found in 22 (15.71%) patients. Patients with severe vitamin D deficiency had high rate of mortality 16 (26.67%) as compared to patients with no vitamin D deficiency 6 (7.5%), a significant association was observed between severe vitamin D deficiency and mortality in patients with covid-19 disease with p-value <0.05. Conclusion: It is concluded that there was strong relationship between severe vitamin-D deficiency and mortality in patients with covid-19 disease. Keywords: Covid-19, Vitamin D Deficiency, Mortality