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All Studies   Meta Analysis    Recent:   

COVID-19 severity in relation to sociodemographics and vitamin D use

Abdulateef et al., Open Medicine, doi:10.1515/med-2021-0273
Apr 2021  
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Hospitalization 41% Improvement Relative Risk Vitamin D for COVID-19  Abdulateef et al.  Prophylaxis Is prophylaxis with vitamin D beneficial for COVID-19? Retrospective 427 patients in Iraq (July - August 2020) Lower hospitalization with vitamin D (not stat. sig., p=0.3) c19early.org Abdulateef et al., Open Medicine, April 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Survey of 428 recovered COVID-19 patients in Iraq, showing fewer hospital visits for patients on prophylactic vitamin C or D. Hospitalization was lower for those on vitamin C, D, or zinc, without statistical significance.
This is the 30th of 122 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 587 sextillion).
30 studies are RCTs, which show efficacy with p=0.0000032.
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Study covers zinc, vitamin C, and vitamin D.
risk of hospitalization, 40.9% lower, RR 0.59, p = 0.30, treatment 6 of 127 (4.7%), control 24 of 300 (8.0%), NNT 31, unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abdulateef et al., 8 Apr 2021, retrospective, Iraq, peer-reviewed, 7 authors, study period July 2020 - August 2020, dosage varies.
This PaperVitamin DAll
COVID-19 severity in relation to sociodemographics and vitamin D use
Darya Saeed Abdulateef, Heshu Sulaiman Rahman, Jamal Mahmood Salih, Sangar Mahmoud Osman, Trifa Abdalla Mahmood, Shirwan Hama Salih Omer, Rana Adnan Ahmed
Open Medicine, doi:10.1515/med-2021-0273
Most COVID-19 cases are treated as outpatients, while the majority of studies on COVID-19 focus on inpatients. Little is known about the self-reporting and selfrating of the disease's symptoms, and the associations of prophylactic use of dietary supplements with COVID-19 severity have not been addressed. The aims of this study are to evaluate COVID-19 severity and to relate them to sociodemographic characteristics and prophylactic dietary supplements. An observational patient-based study conducted through an online questionnaire on recovered COVID-19 patients. The patients were assessed for several severity parameters, sociodemographic parameters, and prophylactic dietary supplement use. A total of 428 patients were evaluated. Age and presence of comorbidities had positive associations with the severity parameters. The severe infection group had the highest proportion of patients stressed about COVID-19 (P < 0.05). Cigarette, but not hookah, smoking was significantly associated with less severe symptoms. Vitamin D negatively predicted disease severity (P < 0.05). In conclusion, stress, age, and presence of comorbidities were the most important positive predictors of COVID-19 severity, while prophylactic vitamin D use and smoking were significant negative predictors. The use of protective measures and other prophylactic dietary supplements was not significantly associated with symptom severity.
Conflict of interest: There is no conflict of interest. Data availability statement: The SPSS file that contains the data of all patients who enrolled in the final analysis was uploaded to Figshare data repository website and its link will be available upon reasonable request. Appendix
References
Abdulateef, Ali, Abdulateef, Mohesh, Smoking knowledge, attitude, and practices among health care professionals from Sulaymaniyah City/Iraq
Annweiler, Corvaisier, Gautier, Dubée, Legrand et al., Vitamin d supplementation associated to better survival in hospitalized frail elderly covid-19 patients: The geria-covid quasi-experimental study, Nutrients, doi:10.3390/nu12113377
Azize, Sadiq, Othman, Impact of coronavirus on the life status of Kurdish people living in Kurdistan Region of Iraq, Kurd J Appl Res, doi:10.24017/covid.6
Benelli, Buscarini, Canetta, Piana, Merli et al., SARS-COV-2 comorbidity network and outcome in hospitalized patients in Crema, MedRxiv, doi:10.1101/2020.04.14.20053090
Biancatelli, Berrill, Marik, The antiviral properties of vitamin C, Expert Rev Anti Infect Ther, doi:10.1080/14787210.2020.1706483
Boterman, Urban-rural polarisation in times of the corona outbreak? The early demographic and geographic patterns of the SARS-CoV-2 epidemic in the Netherlands, Tijdschr Voor Econ En Soc Geogr, doi:10.1111/tesg.12437
Boé, Vandivier, Burnham, Moss, Alcohol abuse and pulmonary disease, J Leukoc Biol, doi:10.1189/jlb.0209087
Burke, Killerby, Newton, Ashworth, Berns et al., Symptom profiles of a convenience sample of patients with COVID-19 -United States, January, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm6928a2
Cao, Chen, He, Xie, Chen, Clinical features and outcomes of COVID-19 patients with gastrointestinal symptoms, Crit Care, doi:10.1186/s13054-020-03034-x
Cao, Tu, Cheng, Yu, Liu et al., Clinical features and short-term outcomes of 102 patients with coronavirus disease 2019 in Wuhan, China, Clin Infect Dis, doi:10.1093/cid/ciaa243
Carr, Rosengrave, Bayer, Chambers, Mehrtens et al., Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes, Crit Care, doi:10.1186/s13054-017-1891-y
Chen, Wu, Chen, Yang, Chen, Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study, BMJ, doi:10.1136/bmj.m1091
Chu, Akl, Duda, Solo, Yaacoub et al., Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis, Lancet, doi:10.1016/S0140-6736(20)31142-9
Connolly, Keil, Ali, Extended urbanisation and the spatialities of infectious disease: demographic change, infrastructure and governance, Urban Stud, doi:10.1177/0042098020910873
Dabbagh, UCLA UCLA Electronic theses and dissertations title current trends of substance use in Iraq: Examining data COVID-19, sociodemographics, and dietary supplements  605 from the 2014 Iraqi National household survey of alcohol and drug use
Dancer, Parekh, Lax, Souza, Zheng et al., Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS), Thorax, doi:10.1136/thoraxjnl-2014-206680
Dixon, Peters, The effect of obesity on lung function, Expert Rev Respir Med, doi:10.1080/17476348.2018.1506331
Douglas, Hemilä, Chalker, Treacy, Vitamin C for preventing and treating the common cold, Cochrane Data Syst Rev, doi:10.1002/14651858.CD000980.pub3
Du, Tu, Zhu, Mu, Wang et al., Clinical features of 85 fatal cases of COVID-19 from Wuhan: A retrospective observational study, Am J Respir Crit Care Med, doi:10.1164/rccm.202003-0543OC
Ferguson, Laydon, Nedjati-Gilani, Imai, Baguelin, Of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand, doi:10.25561/77482
Fowler, Truwit, Hite, Morris, Dewilde et al., Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: The CITRIS-ALI randomized clinical trial, JAMA -J Am Med Assoc. American Medical Association, doi:10.1001/jama.2019.11825
Fujii, Luethi, Young, Frei, Eastwood et al., Effect of Vitamin C, Hydrocortisone, and Thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the vitamins randomized clinical trial, JAMA -J Am Med Assoc. American Medical Association, doi:10.1001/jama.2019.22176
Gombart, Pierre, Maggini, A review of micronutrients and the immune system-working in harmony to reduce the risk of infection, Nutrients, doi:10.3390/nu12010236
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Guan, Liang, Zhao, Liang, Chen et al., Comorbidity and its impact on 1,590 patients with Covid-19 in China: a nationwide analysis, Eur Respir J, doi:10.1183/13993003.00547-2020
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of 2019 novel coronavirus infection in China, N Engl J Med, doi:10.1056/NEJMoa2002032
Guo, Active smoking is associated with severity of coronavirus disease 2019 (COVID-19): an update of a meta-analysis, Tob Induc Dis, doi:10.18332/tid/121915
Guo, Smoking links to the severity of Covid-19: An update of a meta-analysis, J Med Virol, doi:10.1002/jmv.25967
He, Lau, Wu, Deng, Wang et al., Temporal dynamics in viral shedding and transmissibility of COVID-19, Nat Med, doi:10.1038/s41591-020-0869-5
Hemilä, Chalker, Vitamin C can shorten the length of stay in the ICU: a meta-analysis, Nutrients, doi:10.3390/nu11040708
Hemilä, Chalker, Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: A metaregression analysis, J Intensive Care, doi:10.1186/s40560-020-0432-y
Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, doi:10.1016/S0140-6736(20)30183-5
Huang, Ye, Lu, Kong, Zhu et al., Effects of fat distribution on lung function in young adults, J Physiol Anthropol, doi:10.1186/s40101-019-0198-x
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res, doi:10.1007/s40520-020-01570-8
Israel, Feldhamer, Lahad, Levin-Zamir, Lavie, Smoking and the risk of COVID-19 in a large observational population study, doi:10.1101/2020.06.01.20118877v2
Jain, Yuan, Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis, Int J Public Health, doi:10.1007/s00038-020-01390-7
Jing, Liu, Zhang, Fang, Yuan et al., Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study, Lancet Infect Dis, doi:10.1016/s1473-3099(20)30471-0
Jolliffe, Griffiths, Martineau, Vitamin D in the prevention of acute respiratory infection: Systematic review of clinical studies, J Steroid Biochem Mol Biol, doi:10.1016/j.jsbmb.2012.11.017
Jones, Mühlemann, Veith, Zuchowski, Hofmann et al., An analysis of SARS-CoV-2 viral load by patient age
Kashiouris, 'heureux, Cable, Fisher, Leichtle et al., The emerging role of vitamin C as a treatment for sepsis, Nutrients, doi:10.3390/nu12020292
Krieger, Higgins, Housing and health: Time again for public health action, Am J Public Health, doi:10.2105/AJPH.92.5.758
Lauer, Grantz, Bi, Jones, Zheng et al., The incubation period of coronavirus disease 2019 (CoVID-19) from publicly reported confirmed cases: Estimation and application, Ann Intern Med, doi:10.7326/M20-0504
Lippi, Henry, Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19), Eur J Intern Med, doi:10.1016/j.ejim.2020.03.014
Ma, Shan, Zhang, Li, Yang et al., Potential utilities of mask-wearing and instant hand hygiene for fighting SARS-CoV-2, J Med Virol, doi:10.1002/jmv.25805
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Melo Lc Ost, Silva, Da, Obesity and lung function: a systematic review, Einstein, doi:10.1590/S1679-45082014RW2691
Qian, Yang, Ma, Wang, Li et al., COVID-19 transmission within a family cluster by presymptomatic carriers in China, Clin Infect Dis, doi:10.1093/cid/ciaa316
Quan, Huang, Qing, Ping, Liang et al., COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis, J Med Virol, doi:10.1002/jmv.25757
Saez, Tobias, Varga, Barceló, Effectiveness of the measures to flatten the epidemic curve of COVID-19. The case of Spain, Sci Total Env, doi:10.1016/j.scitotenv.2020.138761
Sattar, Mcinnes, Mcmurray, Obesity is a risk factor for severe COVID-19 Infection: multiple potential mechanisms, Circulation, doi:10.1161/CIRCULATIONAHA.120.047659
Seiler, Fagundes, Christian, The impact of everyday stressors on the immune system and health, doi:10.1007/978-3-030-16996-1_6
Shim, Tariq, Choi, Lee, Chowell, Transmission potential and severity of COVID-19 in South Korea, Int J Infect Dis, doi:10.1016/j.ijid.2020.03.031
Silva, Moreira, Martins, COVID-19 and smoking: A high-risk association, Cad Saude Pub, doi:10.1590/0102-311X00072020
Simonnet, Chetboun, Poissy, Raverdy, Noulette et al., High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation, Obesity, doi:10.1002/oby.22831
Solá, Junqué, Estruch, Monforte, Torres et al., High alcohol intake as a risk and prognostic factor for community-acquired pneumonia, Arch Intern Med, doi:10.1001/archinte.1995.00430150137014
Sommer, Sweeney, Functional and Mechanistic Integration of Infection and the Metabolic Syndrome, Korean Diabetes J, doi:10.4093/kdj.2010.34.2.71
Song, Yun, Noh, Cheong, Kim, Covid-19 in South Korea -challenges of subclinical manifestations, N Engl J Med, doi:10.1056/NEJMc2001801
Stahre, Vaneenwyk, Siegel, Njai, Housing insecurity and the association with health outcomes and unhealthy behaviors, Washington State, Prev Chronic Dis, doi:10.5888/pcd12.140511
Storper, Scott, Current debates in urban theory: a critical assessment, Urban Stud, doi:10.1177/0042098016634002
Stutt, Retkute, Bradley, Gilligan, Colvin, A modelling framework to assess the likely effectiveness of facemasks in combination with 'lock-down' in managing the COVID-19 pandemic, Proc R Soc A Math Phys Eng Sci, doi:10.1098/rspa.2020.0376
Tenforde, Kim, Lindsell, Rose, Shapiro et al., risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network-United States
Vardavas, Nikitara, COVID-19 and smoking: a systematic review of the evidence, Tob Induc Dis, doi:10.18332/tid/119324
Walsh, Bowles, Evans, Vitamin D in obesity, Curr Opin Endocrinol Diabetes Obes, doi:10.1097/MED.0000000000000371
Wessels, Rolles, Rink, The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis, Front Immunol, doi:10.3389/fimmu.2020.01712
Xie, Covassin, Fan, Singh, Gao et al., Association between hypoxemia and mortality in patients with COVID-19, Mayo Clin Proc, doi:10.1016/j.mayocp.2020.04.006
Young, Ong, Kalimuddin, Low, Tan et al., Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore, JAMA, doi:10.1001/jama.2020.3204
Zhang, Li, Zhang, Wang, Molina, Identifying airborne transmission as the dominant route for the spread of COVID-19, Proc Natl Acad Sci, doi:10.1073/pnas.2009637117
Zádori, Váncsa, Farkas, Hegyi, Erőss et al., The negative impact of comorbidities on the disease course of COVID-19, Intensive Care Med, doi:10.1007/s00134-020-06161-9
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SARS-COV-2 comorbidity network and outcome in hospitalized ' 'patients in Crema, Italy. MedRxiv. 2020;2020.04.14.20053090. ' '10.1101/2020.04.14.20053090.', 'DOI': '10.1101/2020.04.14.20053090'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_009', 'doi-asserted-by': 'crossref', 'unstructured': 'Smoking and COVID-19. n.d. ' 'https://www.who.int/news-room/commentaries/detail/smoking-and-covid-19 ' '(accessed August 21, 2020).', 'DOI': '10.53127/tblg-2021-A014'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_010', 'doi-asserted-by': 'crossref', 'unstructured': 'Lippi G, Henry BM. Active smoking is not associated with severity of ' 'coronavirus disease 2019 (COVID-19). Eur J Intern Med. 2020;75:107–8. ' '10.1016/j.ejim.2020.03.014.', 'DOI': '10.1016/j.ejim.2020.03.014'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_011', 'doi-asserted-by': 'crossref', 'unstructured': 'Guo F-R. Active smoking is associated with severity of coronavirus ' 'disease 2019 (COVID-19): an update of a meta-analysis. Tob Induc Dis. ' '2020;18:37. 10.18332/tid/121915.', 'DOI': '10.18332/tid/121915'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_012', 'doi-asserted-by': 'crossref', 'unstructured': 'Guo FR. Smoking links to the severity of Covid-19: An update of a ' 'meta-analysis. J Med Virol. 2020;92:2304–5. 10.1002/jmv.25967.', 'DOI': '10.1002/jmv.25967'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_013', 'doi-asserted-by': 'crossref', 'unstructured': 'Da Silva ALO, Moreira JC, Martins SR. COVID-19 and smoking: A high-risk ' 'association. Cad Saude Pub. 2020;36:72020. 10.1590/0102-311X00072020.', 'DOI': '10.1590/0102-311x00072020'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_014', 'doi-asserted-by': 'crossref', 'unstructured': 'Vardavas CI, Nikitara K. COVID-19 and smoking: a systematic review of ' 'the evidence. Tob Induc Dis. 2020;18:20. 10.18332/tid/119324.', 'DOI': '10.18332/tid/119324'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_015', 'unstructured': 'Increased risk of COVID-19 infection amongst smokers and amongst ' 'waterpipe users\u2009–\u2009WHO FCTC Secretariat’s Knowledge Hub on ' 'waterpipes. n.d. https://untobaccocontrol.org/kh/waterpipes/covid-19/ ' '(accessed August 21, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_016', 'doi-asserted-by': 'crossref', 'unstructured': 'Fernández Solá J, Junqué A, Estruch R, Monforte R, Torres A, Urbano ' 'Márquez A. High alcohol intake as a risk and prognostic factor for ' 'community-acquired pneumonia. Arch Intern Med. 1995;155:1649–54. ' '10.1001/archinte.1995.00430150137014.', 'DOI': '10.1001/archinte.1995.00430150137014'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_017', 'doi-asserted-by': 'crossref', 'unstructured': 'Boé DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary ' 'disease. J Leukoc Biol. 2009;86:1097–104. 10.1189/jlb.0209087.', 'DOI': '10.1189/jlb.0209087'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_018', 'unstructured': 'Drinking alcohol does not prevent or treat coronavirus infection and may ' 'impair immune function | National Institute on Alcohol Abuse and ' 'Alcoholism (NIAAA). n.d. ' 'https://www.niaaa.nih.gov/news-events/news-noteworthy/drinking-alcohol-does-not-prevent-or-treat-coronavirus-infection ' '(accessed August 22, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_019', 'unstructured': 'Dabbagh R. UCLA UCLA Electronic theses and dissertations title current ' 'trends of substance use in Iraq: Examining data from the 2014 Iraqi ' 'National household survey of alcohol and drug use; 2017.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_020', 'unstructured': 'Mental Health and Coping During COVID-19 | CDC. n.d. ' 'https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/managing-stress-anxiety.html ' '(accessed August 22, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_021', 'unstructured': 'The Implications of COVID-19 for Mental Health and Substance Use | KFF. ' 'n.d. ' 'https://www.kff.org/coronavirus-covid-19/issue-brief/the-implications-of-covid-19-for-mental-health-and-substance-use/ ' '(accessed August 22, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_022', 'unstructured': 'Situation Report-44. n.d.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_023', 'doi-asserted-by': 'crossref', 'unstructured': 'Storper M, Scott AJ. Current debates in urban theory: a critical ' 'assessment. Urban Stud. 2016;53:1114–36. 10.1177/0042098016634002.', 'DOI': '10.1177/0042098016634002'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_024', 'doi-asserted-by': 'crossref', 'unstructured': 'Connolly C, Keil R, Ali SH. Extended urbanisation and the spatialities ' 'of infectious disease: demographic change, infrastructure and ' 'governance. Urban Stud. 2020;58:245–63. 10.1177/0042098020910873.', 'DOI': '10.1177/0042098020910873'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_025', 'doi-asserted-by': 'crossref', 'unstructured': 'Stahre M, VanEenwyk J, Siegel P, Njai R. Housing insecurity and the ' 'association with health outcomes and unhealthy behaviors, Washington ' 'State, 2011. Prev Chronic Dis. 2015;12:E109. 10.5888/pcd12.140511.', 'DOI': '10.5888/pcd12.140511'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_026', 'doi-asserted-by': 'crossref', 'unstructured': 'Krieger J, Higgins DL. Housing and health: Time again for public health ' 'action. Am J Public Health. 2002;92:758–68. 10.2105/AJPH.92.5.758.', 'DOI': '10.2105/AJPH.92.5.758'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_027', 'doi-asserted-by': 'crossref', 'unstructured': 'Shim E, Tariq A, Choi W, Lee Y, Chowell G. Transmission potential and ' 'severity of COVID-19 in South Korea. Int J Infect Dis. 2020;93:339–44. ' '10.1016/j.ijid.2020.03.031.', 'DOI': '10.1016/j.ijid.2020.03.031'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_028', 'doi-asserted-by': 'crossref', 'unstructured': 'Saez M, Tobias A, Varga D, Barceló MA. Effectiveness of the measures to ' 'flatten the epidemic curve of COVID-19. The case of Spain. Sci Total ' 'Env. 2020;727:138761. 10.1016/j.scitotenv.2020.138761.', 'DOI': '10.1016/j.scitotenv.2020.138761'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_029', 'doi-asserted-by': 'crossref', 'unstructured': 'Jing Q-L, Liu M-J, Zhang Z-B, Fang L-Q, Yuan J, Zhang A-R, et al. ' 'Household secondary attack rate of COVID-19 and associated determinants ' 'in Guangzhou, China: a retrospective cohort study. Lancet Infect Dis. ' '2020;20:1141–50. 10.1016/s1473-3099(20)30471-0.', 'DOI': '10.1016/S1473-3099(20)30471-0'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_030', 'doi-asserted-by': 'crossref', 'unstructured': 'Qian G, Yang N, Ma AHY, Wang L, Li G, Chen X, et al. COVID-19 ' 'transmission within a family cluster by presymptomatic carriers in ' 'China. Clin Infect Dis. 2020;71:861–2. 10.1093/cid/ciaa316.', 'DOI': '10.1093/cid/ciaa316'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_031', 'doi-asserted-by': 'crossref', 'unstructured': 'He X, Lau EHY, Wu P, Deng X, Wang J, Hao X, et al. Temporal dynamics in ' 'viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:672–5. ' '10.1038/s41591-020-0869-5.', 'DOI': '10.1038/s41591-020-0869-5'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_032', 'unstructured': 'Q&A: Tips for health and safety at the workplace in the context of ' 'COVID-19. n.d. ' 'https://www.who.int/news-room/q-a-detail/q-a-tips-for-health-and-safety-at-the-workplace-in-the-context-of-covid-19?gclid=EAIaIQobChMI-rGE2cXw6gIVgdeyCh3AXAWtEAAYASAAEgLFpvD_BwE ' '(accessed August 21, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_033', 'unstructured': 'Social Distancing, Quarantine, and Isolation. n.d. ' 'https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/social-distancing.html ' '(accessed August 20, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_034', 'doi-asserted-by': 'crossref', 'unstructured': 'Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ, et al. ' 'Physical distancing, face masks, and eye protection to prevent ' 'person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic ' 'review and meta-analysis. Lancet. 2020;395:1973–87. ' '10.1016/S0140-6736(20)31142-9.', 'DOI': '10.1016/j.jvs.2020.07.040'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_035', 'doi-asserted-by': 'crossref', 'unstructured': 'Zhang R, Li Y, Zhang AL, Wang Y, Molina MJ. Identifying airborne ' 'transmission as the dominant route for the spread of COVID-19. Proc Natl ' 'Acad Sci USA. 2020;117:14857–63. 10.1073/pnas.2009637117.', 'DOI': '10.1073/pnas.2009637117'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_036', 'unstructured': 'Ferguson NM, Laydon D, Nedjati-Gilani G, Imai N, Ainslie K, Baguelin M, ' 'et al. Of non-pharmaceutical interventions (NPIs) to reduce COVID-19 ' 'mortality and healthcare demand. n.d. 10.25561/77482.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_037', 'doi-asserted-by': 'crossref', 'unstructured': 'Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The ' 'incubation period of coronavirus disease 2019 (CoVID-19) from publicly ' 'reported confirmed cases: Estimation and application. Ann Intern Med. ' '2020;172:577–82. 10.7326/M20-0504.', 'DOI': '10.7326/M20-0504'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_038', 'doi-asserted-by': 'crossref', 'unstructured': 'Ma Q, Shan H, Zhang H, Li G, Yang R, Chen J. Potential utilities of ' 'mask‐wearing and instant hand hygiene for fighting SARS‐CoV‐2. J Med ' 'Virol. 2020;92:1567–71. 10.1002/jmv.25805.', 'DOI': '10.1002/jmv.25805'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_039', 'doi-asserted-by': 'crossref', 'unstructured': 'Gombart AF, Pierre A, Maggini S. A review of micronutrients and the ' 'immune system–working in harmony to reduce the risk of infection. ' 'Nutrients. 2020;12:236. 10.3390/nu12010236.', 'DOI': '10.3390/nu12010236'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_040', 'doi-asserted-by': 'crossref', 'unstructured': 'Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et ' 'al. Evidence that Vitamin D supplementation could reduce risk of ' 'influenza and COVID-19 infections and deaths. Nutrients. 2020;12:988. ' '10.3390/nu12040988.', 'DOI': '10.3390/nu12040988'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_041', 'doi-asserted-by': 'crossref', 'unstructured': 'Dancer RCA, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, et al. ' 'Vitamin D deficiency contributes directly to the acute respiratory ' 'distress syndrome (ARDS). Thorax. 2015;70:617–24. ' '10.1136/thoraxjnl-2014-206680.', 'DOI': '10.1136/thoraxjnl-2014-206680'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_042', 'doi-asserted-by': 'crossref', 'unstructured': 'Jolliffe DA, Griffiths CJ, Martineau AR. Vitamin D in the prevention of ' 'acute respiratory infection: Systematic review of clinical studies. J ' 'Steroid Biochem Mol Biol. 2013;136:321–9. 10.1016/j.jsbmb.2012.11.017.', 'DOI': '10.1016/j.jsbmb.2012.11.017'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_043', 'doi-asserted-by': 'crossref', 'unstructured': 'Colunga Biancatelli RML, Berrill M, Marik PE. The antiviral properties ' 'of vitamin C. Expert Rev Anti Infect Ther. 2020;18:99–101. ' '10.1080/14787210.2020.1706483.', 'DOI': '10.1080/14787210.2020.1706483'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_044', 'doi-asserted-by': 'crossref', 'unstructured': 'Kashiouris MG, L’heureux M, Cable CA, Fisher BJ, Leichtle SW, Fowler AA. ' 'The emerging role of vitamin C as a treatment for sepsis. Nutrients. ' '2020;12:292. 10.3390/nu12020292.', 'DOI': '10.3390/nu12020292'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_045', 'unstructured': 'Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, et al. ' 'Effect of Vitamin C, Hydrocortisone, and Thiamine vs hydrocortisone ' 'alone on time alive and free of vasopressor support among patients with ' 'septic shock: the vitamins randomized clinical trial. JAMA\u2009–\u2009J ' 'Am Med Assoc. American Medical Association 2020;323:423–31. ' '10.1001/jama.2019.22176.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_046', 'doi-asserted-by': 'crossref', 'unstructured': 'Fowler AA, Truwit JD, Hite RD, Morris PE, Dewilde C, Priday A, et al. ' 'Effect of vitamin C infusion on organ failure and biomarkers of ' 'inflammation and vascular injury in patients with sepsis and severe ' 'acute respiratory failure: The CITRIS-ALI randomized clinical trial. ' 'JAMA\u2009–\u2009J Am Med Assoc. American Medical Association ' '2019;322:1261–70. 10.1001/jama.2019.11825.', 'DOI': '10.1001/jama.2019.11825'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_047', 'doi-asserted-by': 'crossref', 'unstructured': 'Douglas RM, Hemilä H, Chalker E, Treacy B. Vitamin C for preventing and ' 'treating the common cold. Cochrane Data Syst Rev. 2007;(3):CD000980. ' '10.1002/14651858.CD000980.pub3.', 'DOI': '10.1002/14651858.CD000980.pub3'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_048', 'doi-asserted-by': 'crossref', 'unstructured': 'Hemilä H, Chalker E. Vitamin C can shorten the length of stay in the ' 'ICU: a meta-analysis. Nutrients. 2019;11:708. 10.3390/nu11040708.', 'DOI': '10.3390/nu11040708'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_049', 'doi-asserted-by': 'crossref', 'unstructured': 'Hemilä H, Chalker E. Vitamin C may reduce the duration of mechanical ' 'ventilation in critically ill patients: A meta-regression analysis. J ' 'Intensive Care. 2020;8:15. 10.1186/s40560-020-0432-y.', 'DOI': '10.1186/s40560-020-0432-y'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_050', 'unstructured': 'Zinc\u2009–\u2009Consumer. n.d. ' 'https://ods.od.nih.gov/factsheets/Zinc-Consumer/ (accessed August 28, ' '2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_051', 'unstructured': 'Council of State and Territorial Epidemiologists, Interim-20-ID-01 TS. ' 'Standardized surveillance case definition and national notification for ' '2019 novel coronavirus disease (COVID-19). Infect Dis Comm. n.d. ' 'https://cdn.ymaws.com/www.cste.org/resource/resmgr/2020ps/interim-20-id-01_covid-19.pdf ' '(accessed August 28, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_052', 'unstructured': 'Visual Analogue Scale\u2009–\u2009Physiopedia. n.d. ' 'https://www.physio-pedia.com/Visual_Analogue_Scale (accessed August 28, ' '2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_053', 'unstructured': 'Burke RM, Killerby ME, Newton S, Ashworth CE, Berns AL, Brennan S, et ' 'al. Symptom profiles of a convenience sample of patients with ' 'COVID-19\u2009–\u2009United States, January–April 2020. MMWR Morb Mortal ' 'Wkly Rep. 2020;69:904–8. 10.15585/mmwr.mm6928a2.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_054', 'doi-asserted-by': 'crossref', 'unstructured': 'Song JY, Yun JG, Noh JY, Cheong HJ, Kim WJ. Covid-19 in South Korea\u2009' '–\u2009challenges of subclinical manifestations. N Engl J Med. ' '2020;382:1858–9. 10.1056/NEJMc2001801.', 'DOI': '10.1056/NEJMc2001801'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_055', 'doi-asserted-by': 'crossref', 'unstructured': 'Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics ' 'of 2019 novel coronavirus infection in China. N Engl J Med. ' '2020;382:1708–20. 10.1056/NEJMoa2002032.', 'DOI': '10.1056/NEJMoa2002032'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_056', 'doi-asserted-by': 'crossref', 'unstructured': 'Tenforde MW, Kim SS, Lindsell CJ, Rose EB, Shapiro NI, Clark, D, et al. ' 'Morbidity and mortality weekly report symptom duration and risk factors ' 'for delayed return to usual health among outpatients with COVID-19 in a ' 'multistate health care systems network-United States, Vol. 69; 2020 ' 'March–June.', 'DOI': '10.15585/mmwr.mm6930e1'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_057', 'doi-asserted-by': 'crossref', 'unstructured': 'Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. ' 'Epidemiologic features and clinical course of patients infected with ' 'SARS-CoV-2 in Singapore. JAMA. 2020;323(15):1488–94. ' '10.1001/jama.2020.3204.', 'DOI': '10.1001/jama.2020.3204'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_058', 'doi-asserted-by': 'crossref', 'unstructured': 'Cao C, Chen M, He L, Xie J, Chen X. Clinical features and outcomes of ' 'COVID-19 patients with gastrointestinal symptoms. Crit Care. ' '2020;24:340. 10.1186/s13054-020-03034-x.', 'DOI': '10.1186/s13054-020-03034-x'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_059', 'doi-asserted-by': 'crossref', 'unstructured': 'Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of ' 'patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. ' '2020;395:497–506. 10.1016/S0140-6736(20)30183-5.', 'DOI': '10.1016/S0140-6736(20)30183-5'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_060', 'doi-asserted-by': 'crossref', 'unstructured': 'Du Y, Tu L, Zhu P, Mu M, Wang R, Yang P, et al. Clinical features of 85 ' 'fatal cases of COVID-19 from Wuhan: A retrospective observational study. ' 'Am J Respir Crit Care Med. 2020;201:1372–9. 10.1164/rccm.202003-0543OC.', 'DOI': '10.1164/rccm.202003-0543OC'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_061', 'doi-asserted-by': 'crossref', 'unstructured': 'Sommer P, Sweeney G. Functional and Mechanistic Integration of Infection ' 'and the Metabolic Syndrome. Korean Diabetes J. 2010;34:71. ' '10.4093/kdj.2010.34.2.71.', 'DOI': '10.4093/kdj.2010.34.2.71'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_062', 'doi-asserted-by': 'crossref', 'unstructured': 'Dixon AE, Peters U. The effect of obesity on lung function. Expert Rev ' 'Respir Med. 2018;12:755–67. 10.1080/17476348.2018.1506331.', 'DOI': '10.1080/17476348.2018.1506331'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_063', 'doi-asserted-by': 'crossref', 'unstructured': 'Melo LC ost, Silva MA layd M da, Calles AC arolin do N. Obesity and lung ' 'function: a systematic review. Einstein (Sao Paulo). 2014;12:120–5. ' '10.1590/S1679-45082014RW2691.', 'DOI': '10.1590/S1679-45082014RW2691'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_064', 'doi-asserted-by': 'crossref', 'unstructured': 'Huang L, Ye Z, Lu J, Kong C, Zhu Q, Huang B, et al. Effects of fat ' 'distribution on lung function in young adults. J Physiol Anthropol. ' '2019;38:7. 10.1186/s40101-019-0198-x.', 'DOI': '10.1186/s40101-019-0198-x'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_065', 'doi-asserted-by': 'crossref', 'unstructured': 'Walsh JS, Bowles S, Evans AL. Vitamin D in obesity. Curr Opin Endocrinol ' 'Diabetes Obes. 2017;24:389–94. 10.1097/MED.0000000000000371.', 'DOI': '10.1097/MED.0000000000000371'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_066', 'doi-asserted-by': 'crossref', 'unstructured': 'Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, et al. Association ' 'between hypoxemia and mortality in patients with COVID-19. Mayo Clin ' 'Proc. 2020;95:1138–47. 10.1016/j.mayocp.2020.04.006.', 'DOI': '10.1016/j.mayocp.2020.04.006'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_067', 'doi-asserted-by': 'crossref', 'unstructured': 'Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, et al. Comorbidity ' 'and its impact on 1,590 patients with Covid-19 in China: a nationwide ' 'analysis. Eur Respir J. 2020;55(5):2000547. 10.1183/13993003.00547-2020.', 'DOI': '10.1183/13993003.01227-2020'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_068', 'unstructured': 'Prevalence of Clinical Manifestations and Comorbidities of Coronavirus ' '(COVID-19) Infection: A Meta-Analysis. n.d. ' 'http://www.fortunejournals.com/articles/prevalence-of-clinical-manifestations-and-comorbidities-of-coronavirus-covid19-infection-a-metaanalysis.html ' '(accessed August 27, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_069', 'doi-asserted-by': 'crossref', 'unstructured': 'Jain V, Yuan J-M. Predictive symptoms and comorbidities for severe ' 'COVID-19 and intensive care unit admission: a systematic review and ' 'meta-analysis. Int J Public Health. 2020;65:533–46. ' '10.1007/s00038-020-01390-7.', 'DOI': '10.1007/s00038-020-01390-7'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_070', 'doi-asserted-by': 'crossref', 'unstructured': 'Zádori N, Váncsa S, Farkas N, Hegyi P, Erőss B, Szakó L, et al. The ' 'negative impact of comorbidities on the disease course of COVID-19. ' 'Intensive Care Med. 2020;46:1784–86. 10.1007/s00134-020-06161-9.', 'DOI': '10.1007/s00134-020-06161-9'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_071', 'unstructured': 'Saeed Abdulateef D, Jamil Ali A, Saeed Abdulateef D, Glad Mohesh MI. ' 'Smoking knowledge, attitude, and practices among health care ' 'professionals from Sulaymaniyah City/Iraq. n.d. 10.4137/TUI.s38171.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_072', 'unstructured': 'Israel A, Feldhamer I, Lahad A, Levin-Zamir D, Lavie G. Smoking and the ' 'risk of COVID-19 in a large observational population study. ' 'https://www.medrxiv.org/content/10.1101/2020.06.01.20118877v2.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_073', 'doi-asserted-by': 'crossref', 'unstructured': 'Azize MP, Sadiq CH, Luqman Othman L. Impact of coronavirus on the life ' 'status of Kurdish people living in Kurdistan Region of Iraq. Kurd J Appl ' 'Res. 2020;5:45–53. 10.24017/covid.6.', 'DOI': '10.24017/covid.6'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_074', 'unstructured': 'Severe mental illness and risks from COVID-19\u2009–\u2009CEBM. n.d. ' 'https://www.cebm.net/covid-19/severe-mental-illness-and-risks-from-covid-19/ ' '(accessed August 25, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_075', 'unstructured': 'Seiler A, Fagundes CP, Christian LM. The impact of everyday stressors on ' 'the immune system and health. In: Choukèr A, editor. Stress challenges ' 'and immunity in space. Springer, Cham: Springer Nature Switzerland AG. ' '10.1007/978-3-030-16996-1_6.'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_076', 'unstructured': 'Psychological Stress and Covid-19: Interactions with Gut Microbiome and ' 'Circadian Rhythm in Driving Symptom Severity (18) (PDF). n.d. ' 'https://www.researchgate.net/publication/340418206_Psychological_Stress_and_Covid-19_Interactions_with_Gut_Microbiome_and_Circadian_Rhythm_in_Driving_Symptom_Severity ' '(accessed August 25, 2020).'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_077', 'doi-asserted-by': 'crossref', 'unstructured': 'Stutt ROJH, Retkute R, Bradley M, Gilligan CA, Colvin J. A modelling ' 'framework to assess the likely effectiveness of facemasks in combination ' 'with ‘lock-down’ in managing the COVID-19 pandemic. Proc R Soc A Math ' 'Phys Eng Sci. 2020;476:20200376. 10.1098/rspa.2020.0376.', 'DOI': '10.1098/rspa.2020.0376'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_078', 'doi-asserted-by': 'crossref', 'unstructured': 'Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention ' 'of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. ' '2020;32:1195–8. 10.1007/s40520-020-01570-8.', 'DOI': '10.1007/s40520-020-01570-8'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_079', 'doi-asserted-by': 'crossref', 'unstructured': 'Wessels I, Rolles B, Rink L. The Potential Impact of Zinc ' 'Supplementation on COVID-19 Pathogenesis. Front Immunol. 2020;11:1712. ' '10.3389/fimmu.2020.01712.', 'DOI': '10.3389/fimmu.2020.01712'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_080', 'doi-asserted-by': 'crossref', 'unstructured': 'Annweiler G, Corvaisier M, Gautier J, Dubée V, Legrand E, Sacco G, et ' 'al. Vitamin d supplementation associated to better survival in ' 'hospitalized frail elderly covid-19 patients: The geria-covid ' 'quasi-experimental study. Nutrients. 2020;12:1–12. 10.3390/nu12113377.', 'DOI': '10.3390/nu12113377'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_081', 'doi-asserted-by': 'crossref', 'unstructured': 'Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, ' 'et al. Vitamin D supplementation to prevent acute respiratory tract ' 'infections: Systematic review and meta-analysis of individual ' 'participant data. BMJ. 2017;356:i6583. 10.1136/bmj.i6583.', 'DOI': '10.1136/bmj.i6583'}, { 'key': '2021121004364802217_j_med-2021-0273_ref_082', 'doi-asserted-by': 'crossref', 'unstructured': 'Carr AC, Rosengrave PC, Bayer S, Chambers S, Mehrtens J, Shaw GM. ' 'Hypovitaminosis C and vitamin C deficiency in critically ill patients ' 'despite recommended enteral and parenteral intakes. Crit Care. 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