Analysis of Prior Aspirin Treatment on in-Hospital Outcome of Geriatric COVID-19 Infected Patients

DOI record: { "DOI": "10.3390/medicina58111649", "ISSN": [ "1648-9144" ], "URL": "http://dx.doi.org/10.3390/medicina58111649", "abstract": "<jats:p>Background and Objectives: Aspirin (ASA) is a commonly used antithrombotic drug that has been demonstrated to reduce venous thromboembolism. The aim was to analyze if geriatric COVID-19 patients undergoing a 100 mg/day Aspirin (ASA) treatment prior to hospitalization differ in hospital outcome compared to patients without previous ASA therapy. Materials and Methods: An observational retrospective study was carried out using an anonymized database including geriatric COVID-19 patients (March to April 2020) admitted to Madrid Hospitals Group. A group of COVID-19 patients were treated with low ASA (100 mg/day) prior to COVID-19 infection. Results: Geriatric ASA-treated patients were older (mean age over 70 years; n = 41), had higher frequency of hypertension and hyperlipidemia, and upon admission had higher D-dimer levels than non-ASA-treated patients (mean age over 73 years; n = 160). However, patients under ASA treatment did not show more frequent pulmonary thromboembolism (PE) than non-ASA-treated patients. ASA-treated geriatric COVID-19-infected patients in-hospital &lt; 30 days all-cause mortality was more frequent than in non-ASA-treated COVID-19 patients. In ASA-treated COVID-19-infected geriatric patients, anticoagulant therapy with low molecular weight heparin (LMWH) significantly reduced need of ICU care, but tended to increase in-hospital &lt; 30 days all-cause mortality. Conclusions: Prior treatment with a low dose of ASA in COVID-19-infected geriatric patients increased frequency of in-hospital &lt; 30 days all-cause mortality, although it seemed to not increase PE frequency despite D-dimer levels upon admission being higher than in non-ASA users. In ASA-treated geriatric COVID-19-infected patients, addition of LMWH therapy reduced frequency of ICU care, but tended to increase in-hospital &lt; 30 days all-cause mortality.</jats:p>", "alternative-id": [ "medicina58111649" ], "author": [ { "affiliation": [], "family": "Zekri-Nechar", "given": "Khaoula", "sequence": "first" }, { "affiliation": [], "family": "Barberán", "given": "José", "sequence": "additional" }, { "affiliation": [], "family": "Zamorano-León", "given": "José J.", "sequence": "additional" }, { "affiliation": [], "family": "Durbán", "given": "María", "sequence": "additional" }, { "affiliation": [], "family": "Andrés-Castillo", "given": "Alcira", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-9869-9240", "affiliation": [], "authenticated-orcid": false, "family": "Navarro-Cuellar", "given": "Carlos", "sequence": "additional" }, { "affiliation": [], "family": "López-Farré", "given": "Antonio", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-5551-5181", "affiliation": [], "authenticated-orcid": false, "family": "López-de-Andrés", "given": "Ana", "sequence": "additional" }, { "affiliation": [], "family": "Jiménez-García", "given": "Rodrigo", "sequence": "additional" }, { "affiliation": [], "family": "Martínez-Martínez", "given": "Carlos H.", "sequence": "additional" } ], "container-title": "Medicina", "container-title-short": "Medicina", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 11, 16 ] ], "date-time": "2022-11-16T07:27:34Z", "timestamp": 1668583654000 }, "deposited": { "date-parts": [ [ 2022, 11, 16 ] ], "date-time": "2022-11-16T09:38:26Z", "timestamp": 1668591506000 }, "indexed": { "date-parts": [ [ 2022, 11, 17 ] ], "date-time": "2022-11-17T06:16:42Z", "timestamp": 1668665802322 }, "is-referenced-by-count": 0, "issue": "11", "issued": { "date-parts": [ [ 2022, 11, 15 ] ] }, "journal-issue": { "issue": "11", "published-online": { "date-parts": [ [ 2022, 11 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 11, 15 ] ], "date-time": "2022-11-15T00:00:00Z", "timestamp": 1668470400000 } } ], "link": [ { "URL": "https://www.mdpi.com/1648-9144/58/11/1649/pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1968", "original-title": [], "page": "1649", "prefix": "10.3390", "published": { "date-parts": [ [ 2022, 11, 15 ] ] }, "published-online": { "date-parts": [ [ 2022, 11, 15 ] ] }, "publisher": "MDPI AG", "reference": [ { "DOI": "10.3389/fmed.2021.647917", "article-title": "Risk of Clinically Relevant Venous Thromboembolism in Critically Ill Patients With COVID-19: A Systematic Review and Meta-Analysis", "doi-asserted-by": "crossref", "first-page": "647917", "journal-title": "Front. 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