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All Studies   Meta Analysis       

Real World Outcomes of Cancer Patients With SARS-CoV-2 Infection Receiving Monoclonal Antibodies

Wilden et al., Journal of the National Comprehensive Cancer Network, doi:10.6004/jnccn.2021.7309
Mar 2022  
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Hospitalization 82% Improvement Relative Risk Casirivimab/i..  Wilden et al.  EARLY TREATMENT Is early treatment with casirivimab/imdevimab beneficial for COVID-19? Retrospective study in the USA (December 2020 - July 2021) Lower hospitalization with casirivimab/imdevimab (p=0.0036) c19early.org Wilden et al., J. the National Compreh.., Mar 2022 Favorscasirivimab/im.. Favorscontrol 0 0.5 1 1.5 2+
17th treatment shown to reduce risk in March 2021, now with p = 0.00018 from 33 studies, recognized in 45 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
Retrospective 395 patients in the USA receiving casirivimab/imdevimab or bamlanivimab, showing lower risk of hospitalization with treatment, statistically significant for casirivimab/imdevimab.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants1-7.
Standard of Care (SOC): SOC for COVID-19 in the study country, the USA, is very poor with very low average efficacy for approved treatments8. Only expensive, high-profit treatments were approved. Low-cost treatments were excluded, reducing the probability of treatment—especially early—due to access and cost barriers, and eliminating complementary and synergistic benefits seen with many low-cost treatments.
Study covers bamlanivimab/etesevimab and casirivimab/imdevimab.
risk of hospitalization, 82.0% lower, OR 0.18, p = 0.004, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wilden et al., 31 Mar 2022, retrospective, USA, peer-reviewed, 9 authors, study period December 2020 - July 2021.
This PaperCasirivimab/i..All
DOI record: { "DOI": "10.6004/jnccn.2021.7309", "ISSN": [ "1540-1405", "1540-1413" ], "URL": "http://dx.doi.org/10.6004/jnccn.2021.7309", "author": [ { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Wilden", "given": "Alexa", "sequence": "first" }, { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Sannareddy", "given": "Aishwarya", "sequence": "additional" }, { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Patel", "given": "Hetal", "sequence": "additional" }, { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Kansagra", "given": "Shraddha", "sequence": "additional" }, { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Kaur", "given": "Gurbakhash", "sequence": "additional" }, { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Ramakrishnan", "given": "Praveen", "sequence": "additional" }, { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Patel", "given": "Prapti", "sequence": "additional" }, { "affiliation": [ { "name": "2 Jacobi Medical Center, Bronx, NY" } ], "family": "Mehta", "given": "Ansh", "sequence": "additional" }, { "affiliation": [ { "name": "1 UT Southwestern Medical Center, Dallas, TX" } ], "family": "Kansagra", "given": "Ankit", "sequence": "additional" } ], "container-title": [ "Journal of the National Comprehensive Cancer Network" ], "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 3, 31 ] ], "date-time": "2022-03-31T11:49:36Z", "timestamp": 1648727376000 }, "deposited": { "date-parts": [ [ 2022, 3, 31 ] ], "date-time": "2022-03-31T11:50:05Z", "timestamp": 1648727405000 }, "indexed": { "date-parts": [ [ 2022, 4, 4 ] ], "date-time": "2022-04-04T00:56:40Z", "timestamp": 1649033800757 }, "is-referenced-by-count": 0, "issn-type": [ { "type": "print", "value": "1540-1405" }, { "type": "electronic", "value": "1540-1413" } ], "issue": "3.5", "issued": { "date-parts": [ [ 2022, 3, 31 ] ] }, "journal-issue": { "issue": "3.5" }, "link": [ { "URL": "https://jnccn.org/view/journals/jnccn/20/3.5/article-pHSR22-178.xml", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://jnccn.org/view/journals/jnccn/20/3.5/article-pHSR22-178.xml", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "4047", "original-title": [], "page": "HSR22-178", "prefix": "10.6004", "published": { "date-parts": [ [ 2022, 3, 31 ] ] }, "published-print": { "date-parts": [ [ 2022, 3, 31 ] ] }, "publisher": "Harborside Press, LLC", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "https://jnccn.org/view/journals/jnccn/20/3.5/article-pHSR22-178.xml" } }, "score": 1, "short-container-title": [], "short-title": [], "source": "Crossref", "subject": [ "Oncology" ], "subtitle": [], "title": [ "HSR22-178: Real World Outcomes of Cancer Patients With SARS-CoV-2 Infection Receiving Monoclonal Antibodies" ], "type": "journal-article", "volume": "20" }
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