Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Metformin  COVID-19 treatment studies for Metformin  C19 studies: Metformin  Metformin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 72% Improvement Relative Risk c19early.org/mf Wallace et al. Metformin for COVID-19 Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 8,173 patients in the USA Lower mortality with metformin (p<0.000001) Wallace et al., BMJ Open, doi:10.1136/bmjopen-2021-050051 Favors metformin Favors control
Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study
Wallace et al., BMJ Open, doi:10.1136/bmjopen-2021-050051
Wallace et al., Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based.., BMJ Open, doi:10.1136/bmjopen-2021-050051
Dec 2021   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
Retrospective 9,532 hospitalized COVID+ veterans in the USA, showing lower mortality with metformin use. The study provides results for use before, after, and before+after. Before+after should more accurately represent prophylaxis up to COVID-19 infection (and continued use). Before included use up to 2 years before, and after included use up to 60 days later.
risk of death, 72.0% lower, HR 0.28, p < 0.001, treatment 103 of 1,203 (8.6%), control 1,536 of 6,970 (22.0%), NNT 7.4, adjusted per study, before+after, propensity score weighting, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wallace et al., 31 Dec 2021, retrospective, database analysis, USA, peer-reviewed, 6 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperMetforminAll
Abstract: Original research Association of the patterns of use of medications with mortality of COVID-­19 infection: a hospital-­based observational study Arthur W Wallace,1,2 Piera M Cirillo ‍ ‍,1,3 James C Ryan,1,4 Nickilou Y Krigbaum,1,3 Anusha Badathala,1 Barbara A Cohn1,3 To cite: Wallace AW, Cirillo PM, Ryan JC, et al. Association of the patterns of use of medications with mortality of COVID-­19 infection: a hospital-­based observational study. BMJ Open 2021;11:e050051. doi:10.1136/ bmjopen-2021-050051 ► Prepublication history for this paper is available online. To view these files, please visit the journal online (http://dx.doi.​ org/10.1136/bmjopen-2021-​ 050051). Received 09 February 2021 Accepted 03 December 2021 © Author(s) (or their employer(s)) 2021. Re-­use permitted under CC BY-­NC. No commercial re-­use. See rights and permissions. Published by BMJ. 1 San Franciso Veterans Affairs Medical Center, San Francisco, CA, USA 2 Department of Anesthesiology and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA 3 Child Health and Development Studies, Public Health Institute, Oakland, California, USA 4 Department of Gastroenterology, University of California, San Francisco, San Francisco, CA, USA Correspondence to Dr Arthur W Wallace; a​ rt.​wallace@v​ a.​gov ABSTRACT Objectives SARS-­CoV-­2 enters cells using the ACE2 receptor. Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-­I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury. Here, we describe COVID-­19 survival associated with ACE-­I, ARB and metformin use. Design This is a hospital-­based observational study of patients with COVID-­19 infection using logistic regression with correction for pre-­existing conditions and propensity score weighted Cox proportional hazards models to estimate associations between medication use and mortality. Setting Medical record data from the US Veterans Affairs (VA) were used to identify patients with a reverse transcription PCR diagnosis of COVID-­19 infection, to classify patterns of ACE inhibitors (ACE-­I), ARB, beta blockers, metformin, famotidine and remdesivir use, and, to capture mortality. Participants 9532 hospitalised patients with COVID-­19 infection followed for 60 days were analysed. Outcome measure Death from any cause within 60 days of COVID-­19 diagnosis was examined. Results Discontinuation of ACE-­I was associated with increased risk of death (OR: 1.4; 95% CI 1.2–1.7). Initiating (OR: 0.3; 95% CI 0.2–0.5) or continuous (OR: 0.6; 95% CI 0.5–0.7) ACE-­I was associated with reduced risk of death. ARB and metformin associations were similar in direction and magnitude and also statistically significant. Results were unchanged when accounting for pre-­existing morbidity and propensity score adjustment. Conclusions Recent randomised clinical trials support the safety of continuing ACE-­I and ARB treatment in patients with COVID-­19 where indicated. Our study extends these findings to suggest a possible COVID-­19 survival benefit for continuing or initiating ACE-­I, ARB and metformin medications. Randomised trials are appropriate to confirm or refute the therapeutic potential for ACE-­I, ARBs and metformin.
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit