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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality -11% Improvement Relative Risk Famotidine for COVID-19  Wallace et al.  Prophylaxis Is prophylaxis with famotidine beneficial for COVID-19? Retrospective 7,944 patients in the USA No significant difference in mortality c19early.org Wallace et al., BMJ Open, December 2021 Favors famotidine Favors control

Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study

Wallace et al., BMJ Open, doi:10.1136/bmjopen-2021-050051
Dec 2021  
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Retrospective 9,532 hospitalized COVID+ veterans in the USA, showing no significant difference in mortality with famotidine use. The study provides results for use before, after, and before+after. Before+after should more accurately represent prophylaxis up to COVID-19 infection (and continued use). Before included use up to 2 years before, and after included use up to 60 days later.
This study includes metformin and famotidine.
risk of death, 11.0% higher, RR 1.11, p = 0.33, treatment 98 of 423 (23.2%), control 1,436 of 7,521 (19.1%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wallace et al., 31 Dec 2021, retrospective, database analysis, USA, peer-reviewed, 6 authors.
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