High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients - a randomized, double-blind clinical trial
Sistanizad et al.
, High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients - a..
, European Journal of Integrative Medicine, doi:10.1016/j.eujim.2020.101271
RCT of 30 ventilated ICU patients showing lower mortality with vitamin D treatment, RR 0.36, p = 0.004. Authors do not indicate why the patients were hospitalized or if any of the patients were COVID-19 patients. 300,000 IU intramuscular vitamin D was used.
risk of death, 63.5% lower, RR 0.36, p = 0.004, treatment 5 of 16 (31.2%), control 12 of 14 (85.7%), NNT 1.8.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sistanizad et al., 26 Dec 2020, Randomized Controlled Trial, Iran, peer-reviewed, 8 authors, dosage 300,000IU single dose, intramuscular.
Abstract: European Journal of Integrative Medicine 42 (2021) 101271
Contents lists available at ScienceDirect
European Journal of Integrative Medicine
journal homepage: www.elsevier.com/locate/eujim
High dose vitamin D improves total serum antioxidant capacity and ICU
outcome in critically ill patients - A randomized, double-blind clinical trial
Mohammad Sistanizad a,b, Mehran Kouchek c, MirMohammad Miri c, Sara Salarian c,
Seyedpouzhia Shojaei c, Fatemeh Moeini Vasegh a, Hossein Seiﬁ Kafshgari d,
Roja Qobadighadikolaei e,∗
Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
of Cardiovascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran. Iran
of Critical Care Medicine, Imam Hossein Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
d Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
Department of Clinical Pharmacy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
a r t i c l e
i n f o
Total anti-oxidant Capacity
Randomized controlled trial
a b s t r a c t
Introduction: Mechanical ventilation can increase the rate of free radicals in the systemic circulation due to its
eﬀect on the inﬂammatory system. Previous research has suggested that vitamin D has antioxidant properties.
This study aimed to evaluate the eﬀect of vitamin D on total Antioxidant Capacity (TAC) and its relationship with
ICU patients’ outcomes.
Methods: In this prospective randomized clinical trial, 36 ventilated ICU patients were randomly allocated to
receive either a single intramuscular vitamin D 300,000 IU or its placebo. Serum Vitamin D and TAC were
measured before and on day 7 after the intervention. Clinical Pulmonary Infection Score (CPIS) and sequential
organ failure assessment (SOFA) scores were measured daily for seven days and on days 14 and 28.
Results: Thirty patients completed the study. The results show that injection of vitamin D leads to a signiﬁcant
increase in the mean changes of vitamin D level on the seventh day of the study (+3.5±1.3 vs -0.4±0.2 P=0.00) and
TAC levels (3.2±3.9 vs -2.0±2.6 P=0.00. ICU length of stay was 18.3±8.4 and 25.4±6.6 days in the intervention
and placebo arms of the study. Twelve patients in the placebo group and 5 in the vitamin D group died within
the 28 day study period. The duration of mechanical ventilation was 15.7± 9.3 vs. 22.6± 9.1 days in vitamin D
and placebo arms, respectively.
Conclusion: : Administration of vitamin D may increase TAC levels and decrease the length of stay and duration
of mechanical ventilation in ICU patients.
is less effective
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