Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Therapeutic high-dose vitamin D for vitamin D-deficient severe COVID-19 disease: randomized, double-blind, placebo-controlled study (SHADE-S)

Singh et al., Journal of Public Health, doi:10.1093/pubmed/fdae007 (conference publication 6/1/2022), Shade-S, NCT04952857
Jun 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
0 0.5 1 1.5 2+ Mortality 45% Improvement Relative Risk Recovery 40% Vitamin D  Shade-S  LATE TREATMENT  DB RCT Is late treatment with vitamin D beneficial for COVID-19? Double-blind RCT 90 patients in India (August - December 2021) Lower mortality (p=0.046) and improved recovery (p=0.01) c19early.org Singh et al., J. Public Health, June 2022 Favors vitamin D Favors control
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
RCT 90 vitamin D deficient moderate/severe COVID-19 ARDS patients in India, showing lower mortality with vitamin D treatment. 600,000IU nanoformulation cholecalciferol.
Cholecalciferol was used in this study. Meta analysis shows that late stage treatment with calcitriol / calcifediol (or paricalcitol, alfacalcidol, etc.) is more effective than cholecalciferol: 69% [47‑82%] lower risk vs. 39% [26‑49%] lower risk. Cholecalciferol requires two hydroxylation steps to become activated - first in the liver to calcifediol, then in the kidney to calcitriol. Calcitriol, paricalcitol, and alfacalcidol are active vitamin D analogs that do not require conversion. This allows them to have more rapid onset of action compared to cholecalciferol. The time delay for cholecalciferol to increase serum calcifediol levels can be 2-3 days, and the delay for converting calcifediol to active calcitriol can be up to 7 days.
Bolus treatment is less effective. Pharmacokinetics and the potential side effects of high bolus doses suggest that ongoing treatment spread over time is more appropriate. Research has confirmed that lower dose regular treatment with vitamin D is more effective than intermittent high-dose bolus treatment for various conditions, including rickets and acute respiratory infections1,2. The biological mechanisms supporting these findings involve the induction of enzymes such as 24-hydroxylase and fibroblast growth factor 23 (FGF23) by high-dose bolus treatments. These enzymes play roles in inactivating vitamin D, which can paradoxically reduce levels of activated vitamin D and suppress its activation for extended periods post-dosage. Evidence indicates that 24-hydroxylase activity may remain elevated for several weeks following a bolus dose, leading to reduced levels of the activated form of vitamin D. Additionally, FGF23 levels can increase for at least three months after a large bolus dose, which also contributes to the suppression of vitamin D activation1.
This is the 16th of 29 COVID-19 RCTs for vitamin D, which collectively show efficacy with p=0.000005.
This is the 84th of 120 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 268 sextillion).
risk of death, 45.0% lower, RR 0.55, p = 0.046, treatment 11 of 45 (24.4%), control 20 of 45 (44.4%), NNT 5.0.
risk of no recovery, 40.0% lower, RR 0.60, p = 0.01, treatment 45, control 45.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Singh et al., 1 Jun 2022, Double Blind Randomized Controlled Trial, placebo-controlled, India, peer-reviewed, 15 authors, study period 1 August, 2021 - 10 December, 2021, dosage 600,000IU single dose, trial NCT04952857 (history) (Shade-S). Contact: ajay. ydv2509@gmail.com.
This PaperVitamin DAll
. Nasotracheal vs Orotracheal Intubation and Post-extubation Airway Obstruction in Critically Ill Children: An Open-label Randomized Controlled Trial (Conference Abstract ID: ABS0001)
Suresh Vijay Kumar, Kumar Angurana, Arun Kumar Baranwal, Karthi Nallasamy, Bikash Soumya Sarkar, Ranjan Ray, Souvik Maitra, Dalim Kumar Baidya, Rahul Kumar Anand, Rajeshwari Subramaniam, Damarla Haritha, Shweta Ram Chandankhede, Kumar Pavan, Shrikant Reddy, Pankanti, Ziyokov Joshi, Vijay Mahajan, Tarandeep Singh, Nupur B Patel, Ashwani Suri, Divya Hirolli, Bikash R Ray, Dalim K Baidya, Deependra Kumar, Taran Deep, C H Hanumantharao, G Bhavani Prasad, Masood Mohammed, N Pavan, Kumar Reddy, Kumar Sanjib, Binita Dhar, Panigrahi, Asif Dhar, Anuprasad Binita Ahmed, Rahul Dilip Bhiwgade, Tilotamma Parate, Sarang Suresh Patil, G Tejaswi, Vedaghosh Amara, Souvik Chaudhuri, Harita Krishna, Pradeep Chinnapotahala, Subba Reddy, Swarna Deepak, MC Rahul D Bhiwgade, Bhushan Nischitha, Shobhna Shahare, Bitey, Tarun Yadav, Mayuri Golhar, Abhimanyu Kalita, Brajendra Lahkar, Pallabi Porbodoi, Mohammad Abbas, Harish M Maheshwarappa, S Saurabh Biswal, Kumar Ratnjeet, Urmila Jhamb, Pallavi Goyal, Romit Saxena, Vijay Komal, Sujata Fulmali, M C Mete, Shobhana Nischitha, Rakhee Bitey, Joshi, Deepa Das, Shivkumar Shivanna, Ivan Deepak, Tauro, Sujata Mete, M C Nischitha, Komal Fulmali, Shobhana Bitey, M M Zhurko, V V Larionov, P Darshan, Indira Menon, Sumanth Shivram, Sapna Babu Mandala, Masood Ahmed Chandsha, Tushar Parmar, Pallavi Sahoo, Nikhil Kothari, Shilpa Goyal, Ankur Sharma, Pradeep Bhatia, Vanaja Bolinedi, Mehul Shah, Kavita Shalia, Owais Tisekar, Muraleedharan Raman, M I Sahadullah, Sreeshuba Kurup, S A Ajeesh, Cherian Roy, Arun Rath, Rupali Patnaik, Shakti Bedanta Mishra, Neela Chavhan, Anuja Porwal, Rajesh Gupta, Mrinal Sircar, Abhishek Prajapati, Rachit Patel, Jagdish Varma, Amol Dongre, Bhalendu Vaishnav, Dumini Soren, Mohd Saif Khan, Jay Prakash, Sourabh Kumar, Pradip Kumar Bhattacharya, Amit Kumar, Anuj Clerk, Krunalkumar Patel, Nikita Desai, Himani Garasia, Nilesh Thumar, Priyank Savaj, Rakesh Mangrolia, Bhargav Umaretiya, Pradeep Hg, Hariprasad Kumar, Sameer Kalpakam, Nithya Bansal, Ravindra Suresh, Madhusudan Mehta, Suprith Kalluraya, Chikkabyraiah, Raghusuprith Reddy, S Jakkinaboina, Bini Mol Thampi, Jai Bhagwan, Ashok Anand, Pramod Kadam, Dev Kapil, Mehta, Khokan Debnath, Sandeep Bhapkar, Neha Keswani, Mumbai, Maharashtra, India Wockhardt Ltd, Rangappa Harshavardhan, Ankur Kuri, Sharma
doi:10.5005/jp-journals-10071-23712A.1
Aim and objectives: The data on long-term nasotracheal intubation among mechanically ventilated critically ill children are limited. The purpose of this study was to compare the rate of post-extubation airway obstruction (PEAO) with nasotracheal and orotracheal intubation. Materials and methods: This open-label randomized controlled trial was conducted in the PICU of a tertiary care and teaching hospital in North India from January to December 2020 involving intubated children aged 3 months to 12 years. After written informed consent, children were randomized into nasotracheal and orotracheal intubation groups. Post-extubation, modified Westley's croup score (mWCS) was used at 10-timepoints (0 minutes, 30 minutes, 1, 2, 3, 6, 12, 24, 36, and 48 hours after extubation) to monitor for PEAO. The primary outcome was the rate of PEAO; and secondary outcomes were time taken for intubation, number of intubation attempts, complications during intubation, unplanned extubation, repeated intubations, tube malposition/ displacement, endotracheal tube blockade, ventilator-associated pneumonia, skin trauma, extubation failure/re-intubation, duration of PICU stay, and mortality. Results: Seventy children were randomized into nasotracheal (n = 30) and orotracheal (n = 40) groups. Both the groups were similar in baseline characteristics. The rate of PEAO was similar between nasotracheal and orotracheal groups (10% vs 20%, p = 0.14). The maximum mWCS and mWCS at 10-timepoints were similar in the two groups. The time taken for intubation was significantly longer (85 seconds vs 48 seconds, p < 0.001) in the nasotracheal group, whereas other secondary outcomes were similar in the two groups. Conclusion: The rate of PEAO was not different between nasotracheal and orotracheal groups. Trial registration number and date:
ABSTRACTS CRITICARE -IJCCM2022 DOI: 10.5005/jp-journals-10071-23712A.147 A 32-year-old male was admitted with a history of loss of consciousness for a few minutes following a lightning strike while he was riding on a motorcycle. On arrival, GCS -E4M6V3, was hemodynamically stable, and there were first-degree burns over the face, chest, right thigh, and groin. Whole-body CT scan done showed no injuries except petechial hemorrhages in the left basal ganglia and left frontal lobe. The very next day patient was intubated in view of respiratory distress and shifted to ICU for further management. ECHO showed moderate left ventricle dysfunction and mild elevation of cardiac enzymes. Lab investigations showed elevated CPK (43,865 IU/L) and mild elevation of serum creatinine. Patient muscle power gradually started decreasing and he was not able to move his limbs by day 4. The nerve conduction study was normal. MRI spine with brain showed prevertebral hematoma in the entire cervical region. Multidisciplinary management was carried out. Tracheostomy was done on day 10 and the patient gradually weaned off from mechanical ventilation. In the course of management by the end of 1 month of hospital stay, the patient had gradual improvement in muscle power and tracheostomy was successfully decannulated. The patient got discharged from the hospital. Hemophagocytic Lymphohistiocytosis after COVID-19 Vaccination: A Case Report (Conference Abstract ID: ABS0148) Nitin Rai, Syed Nabeel Muzaffar,..
References
Akahoshi, Nishizaki, Wakasugi, Portal-systemic encephalopathy due to a congenital extrahepatic portosystemic shunt: three cases and literature review, Hepato-Gastroenterology
Alhazzani, Møller, Arabi, Loeb, Gong et al., Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19), Intensive Care Medicine
Amiya, Hirata, Shiroyama, Fatal cytomegalovirus pneumonia in a critically ill patient with COVID-19, Respirol Case Rep
An, Kim, Han, Lee, Lim, Improvement in survival associated with embolisation of spontaneous portosystemic shunt in patients with recurrent hepatic encephalopathy, Aliment Pharmacol Ther
Appleby, Manuelidis, Creutzfeldt-Jacob Disease Fact Sheet
Balc, Pinceaux, Pronier, Herpes simplex virus and cytomegalovirus reactivations among severe COVID-19 patients, Crit Care
Barua, Zaman, Omi, Faruque, Psychological burden of the COVID-19 pandemic and its associated factors among frontline doctors of Bangladesh: a crosssectional study
Bautista-Rodriguez, Sanchez-De-Toledo, Clark, Herberg, Bajolle et al., Multisystem Inflammatory Syndrome in Children: An International Survey, Pediatrics
Berlioux, Robic, Poirson, Métivier, Otal et al., Pre-transjugular intrahepatic portosystemic shunts (TIPS) prediction of post-TIPS overt hepatic encephalopathy: the critical flicker frequency is more accurate than psychometric tests, Bureau C Hepatology
Bhatt, Gething, Brady, The global distribution and burden of dengue, Nature
Bihani, Mittal, Rajat, Drnb, Critical Care Medicine
Chen, Zhou, Dong, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study, Lancet
Chiche, Forel, Roch, Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients, Crit Care Med
Clerk, Patel, Desai, Garasia, Thumar et al., Bhargav Umaretiya References
Coomes, Haghbayan, Interleukin-6 in COVID-19: a systematic review and meta-analysis, Rev Med Virol
Crump, Time for a comprehensive approach to the syndrome of fever in the tropics, Transactions of the Royal Society of Tropical Medicine and Hygiene
Córdoba, New assessment of hepatic encephalopathy, J Hepatol
D'ardes, Boccatonda, Schiavone, A Case of Coinfection with SARS-COV-2 and Cytomegalovirus in the Era of COVID-19, Eur J Case Rep Intern Med
Devasagayam, Wyatt, Leyden, Cerebral venous sinus thrombosis incidence is higher than previously thought, Stroke, doi:10.1161/STROKEAHA.116.013617
Dosi, Patell, Joshi, Diabetic ketoacidosis: an unusual presentation of acromegaly
El-Boghdadly, Pawa, The erector spinae plane block: plane and simple, Anaesthesia
Erem, Ersöz, Acromegaly presenting with diabetic ketoacidosis, associated with retinitis pigmentosa and octreotideinduced bradycardia, Medicine Endocrine
Erquicia, Valls, Barja, Emotional impact of the COVID-19 pandemic on healthcare workers in one of the most important infection outbreaks in Europe, Medicina Clínica
Funk, Lindner, Druml, Metnitz, Schwarz et al., Incidence and prognosis of dysnatremias present on ICU admission, Intensive Care Med
Gambetti, Kong, Zou, Parchi, Chen, Sporadic and familial CJD: classification and characterisation
Ganeshkumar, Murhekar, Poornima, Dengue infection in India: a systematic review and meta-analysis, PLoS Negl Trop Dis
Giusti, Pedroli, Aniello, Badiale, Pietrabissa et al., The Psychological Impact of the COVID-19 Outbreak on Health Professionals: A Cross-Sectional Study, Front Psychol, doi:10.3389/fpsyg.2020.01684
Godo, Diagnosis and Management of Patients with Paroxysmal Sympathetic Hyperactivity following Acute Brain References
Goldstein, Prescribing of potentially harmful drugs to patients admitted to hospital after head injury, J Neurol Neurosurg Psychiatry
Goyal, Choi, Pinheiro, Schenck, Chen et al., Clinical Characteristics of COVID-19 in New York City, N Engl J Med
Grasselli, Zangrillo, Zanella, Antonelli, Cabrini et al., Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy, Jama
Grewal, Singh, Bansal, Sidhu, Gupta et al., Outcome in survivors of out-of-hospital cardiac arrest in a tertiary care center of North India: A prospective observational study, J Pract Cardiovasc Sci
Griffiths, Reeves, Pathogenesis of human cytomegalovirus in the immunocompromised host, Nat Rev Microbiol, doi:10.1038/s41579-021-00582-z
Guérin, Reignier, Richard, Beuret, Gacouin et al., Prone positioning in severe acute respiratory distress syndrome, New England Journal of Medicine
Hanley, Lucas, Youd, Autopsy in suspected COVID-19 cases, J Clin Pathol
Harrison, Textbook of Internal Medicine, American Journal of Haematology, Egyptian Journal of chest Diseases
Hasselqvist-Ax, Mobile-Phone Dispatch of Laypersons for CPR in Out-of-Hospital Cardiac Arrest, N Engl J Med
Herold, Jurinovic, Arnreich, Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19, J Allergy Clin Immunol
Ho, Karmakar, Critchley, Acute pain management of patients with multiple fractured ribs: a focus on regional techniques, Curr Opin Crit Care
Holmberg, Holmberg, Herlitz, Factors modifying the effect of bystander cardiopulmonary resuscitation on survival in out-of-hospital cardiac arrest patients in Sweden, Eur Heart J
Holmberg, Holmberg, Herlitz, Gardelov, Survival after cardiac arrest outside hospital in Sweden. Swedish Cardiac Arrest Registry, Resuscitation
Hong, Wang, Chung, Chen, Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children, Pediatr Neonatol, doi:10.1016/j.pedneo.2020.03.001
Hospital, Huang, Hospital, None
Huang, Wang, Li, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Hyder, Wunderlich, Puvanachandra, Gururaj, Kobusingye, The impact of traumatic brain injuries: a global perspective, Neurorehabilitation
Icnarc, ICNARC Report on COVID-19 in Critical Care
Inoue, Hori, Narumi, Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images, Radiology
Iwasaki, Jakob, Typical and atypical appearances Creutzfeldt-Jakob disease
Jacobi, Schnellhardt, Kulschewski, Ku, Kuefner et al., An unusual case of hyponatraemia, Nephrol Dial Transplant
Jafari, Izadi, Sarrafzadeh, Heidari, Ranjbar et al., Hyponatremia due to pulmonary tuberculosis: Review of 200 cases, Nephrourol Mon
Keddie, Ziff, Chou, Laboratory biomarkers associated with COVID-19 severity and management, Clinical Immunology
Khan, Shah, Mushtaq, Profiling Laboratory Biomarkers Associated with COVID-19 Disease Progression: A Single-Center Experience, International Journal of Microbiology
Kojima, Tatsuno, Inaba, Velligas, Masaki et al., Creutzfeldt-Jakob Disease: A Case Report and Differential Diagnoses
Krieger, Jauss, Jansen, MRI findings in chronic hepatic encephalopathy depend on portosystemic shunt: results of a controlled prospective clinical investigation, J Hepatol
Krieger, Jauss, Jansen, MRI findings in chronic hepatic encephalopathy depend on portosystemic shunt: results of a controlled prospective clinical investigation, J Hepatol
Ksiazek, Erdman, Goldsmith, SW Group A novel coronavirus associated with severe acute respiratory syndrome, N Engl J Med
Kumar, Sasmal, Kohli, Percutaneous Tracheostomy vs Surgical Tracheostomy: An Observational Cohort Study in Intensive Care Unit at Tertiary Care Center
Kumari, Kumar, Patna, None
Kwon, Kwon, Diagnostic challenge of rapidly progressing sporadic Creutzfeldt-Jakob disease, BMJ
Laleman, Simon-Talero, Maleux, Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: A multicenter survey on safety and efficacy, Hepatology
Laleman, Simon-Talero, Maleux, Perez, Ameloot et al., EASL-CLIF-Consortium, Hepatology
Larsen, Eisenberg, Cummins, Hallstrom, Predicting survival from out-of-hospital cardiac arrest: a graphic model, Ann Emerg Med
Li, Guan, Wu, Early transmission dynamics in Wuhan, China, of Novel Coronavirus-infected pneumonia, N Engl J Med
Li, Scherer, Felix, Kuper, Prevalence of depression, anxiety and posttraumatic stress disorder in health care workers during the COVID-19 pandemic: A systematic review and meta-analysis, PLoS One, doi:10.1371/journal.pone.024645
Lopes, De, Silva, Furtado, Macedo et al., Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated d-dimer concentration (ACTION):an open-label, multicentre, randomised, controlled trial, Lancet
Lu, Zhao, Li, Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding, Lancet
Lueck, Mcllwaine, Zeidler, Creutzfeldt-Jakob disease and the eye. II, Ophthalmic and R Coll Ophthalmol
Mackersie, Shackford, Hoyt, Continuous epidural fentanyl analgesia: ventilatory function improvement with routine use in treatment of blunt chest injury, J Trauma
Maeda, Sato, Yoshikawa, Brain MR imaging in patients with hepatic cirrhosis: relationship between high intensity signal in basal ganglia on T1-weighted images and elemental concentrations in brain, Neuroradiology
Magdy, Saad, Khateeb, Comparative evaluation of semi-quantitative CT-severity scoring versus serum lactate dehydrogenase as prognostic biomarkers for disease severity and clinical outcome of COVID-19 patients, Egypt J Radiol Nucl Med
Malik, Patel, Mehta, systematic review and meta-analysisBMJ Evidence-Based Medicine Published Online First
Manix, Kalakoti, Henry, Thakur, Menger et al., Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy
Mcelvanney, Boodhoo, Fig. 2. MRI scan showing a subependymoma of the fourth ventricle. Case report, Eye
Mcgonagle, Sharif, 'regan, The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease, Autoimmun Rev
Medicine, Fever Group ; Singhi, Chaudhary, Varghese, Bhalla et al., Tropical fevers: Management guidelines, Indian J Crit Care Med
Mehndiratta, Bajaj, Gupta, Anand, Tatke et al., Creutzfeldt-Jakob Disease: Report of 10 cases from North India, Neurol India
Middeldorp, Coppens, Tf, Foppen, Vlaar et al., Incidence of venous thromboembolism in hospitalized patients with COVID-19, J Thromb Haemost
Mohan, Mani, Mathew, Hospital, None
Moniz, Brito, Póvoa, SARS-CoV-2 and Cytomegalovirus Co-infections-A Case Series of Critically ill Patients, J Clin Med
Moss, The ancient and the new": is there an interaction between cytomegalovirus and SARS-CoV-2 infection?, Immunity and Ageing
Nagotkar, Shanbag, Dasarwar, Cerebral salt wasting syndrome following neurosurgical intervention in tuberculous meningitis, Indian Pediatr
Nardelli, Gioia, Ridola, Riggio, Radiological Intervention for Shunt Related Encephalopathy, J Clin Exp Hepatol
Netea, Rovina, Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure, Cell Host Microbe
Ojha, Sporadic Creutzfeldt-Jakob disease: A case report and review of literature
Osawa, Singh, Cytomegalovirus infection in critically ill patients: a systematic review, Crit Care, doi:10.1186/cc7875
Palakawong, Arakaki, Diabetic ketoacidosis in acromegaly: A case Report
Pasha, Case Report of Clinically Probable Sporadic Creutzfeldt -Jakob Disease from A Tertiary Care Hospital in South India. Ann Alzheimer, 's Dement Care
Perkins, Jacobs, Vinay, Nadkarni, Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest. A Statement for Healthcare Professionals From a Task Force of the International Liaison Committee on Resuscitation, Resuscitation
Philips, Kumar, Augustine, Shunt occlusion for portosystemic shunt syndrome related refractory hepatic encephalopathy-A single-centre experience in 21 patients from Kerala, Indian J Gastroenterol
Ponti, Maccaferri, Ruini, Biomarkers associated with COVID-19 disease progression, Crit Rev Clin Lab Sci
Prajapati, Manoj, Singh, Hospital, Persistent Hyperbilirubinemia without any Neurological Deficit in Young Patient: A Case Report (Conference Abstract ID: ABS0239), doi:10.5005/jp-journals-10071-23712A.240Introduction
Que, Shi, Deng, Psychological impact of the COVID-19 pandemic on healthcare workers: a crosssectional study in China, General Psychiatry
Rajput, Dhuan, Agarwal, CVST in a young woman taking norethindrone acetate for DUB: a case report and review of literature, J Obstet Gynaecology Can
Ramasamy, Surendran, Global climate change and its potential impact on disease transmission by salinity-tolerant mosquito vectors in coastal zones, Front Physiol
Ramya, Prakash, Devi, Norethisterone induced cerebral venous sinus thrombosis (CVST): a rare case report and review of literature, Int J Reprod Contracept Obstet Gynecol
Rani, Sundararajan, Rajesh, Jeyamurugan, A study on common etiologies of acute febrile illness detectable by microbiological tests in a tertiary care hospital, Int J Curr Microbiol Appl Sci
Razi, Gu, He, Kong, Ahmed, Venousthrom boembolism inpatientswith COVID-19. Aprevalenta ndapreventablecomplicati onofthepandemic, J Interv Med
Riggio, Efrati, Catalano, Pediconi, Mecarelli et al., High prevalence of spontaneous portal-systemic shunts in persistent hepatic encephalopathy: a case-control study, Hepatology
Riggio, Efrati, Catalano, Pediconi, Mecarelli et al., High prevalence of spontaneous portal-systemic shunts in persistent hepatic encephalopathy: a case-control study, Hepatology
Rn Hemangi Sawant, Shah, Krishnan, Surendran, Results with Ranks for FS_ICU 24 at our centre compared to 104 international centres References
Saad, Vascular anatomy and the morphologic and hemodynamic classifications of gastric varices and spontaneous portosystemic shunts relevant to the BRTO procedure, Tech Vasc Interv Radiol
Sai, Ray, Wig, Bhabatosh Das Department of Medicine
Saseedharan, Annapurna, Kadam, Pragmatic COVID-19 Nutrition Protocol, Indian J Nutri
Saseedharan, Pathrose, Making Nutrition Management Scientific, Objective and Simple with the Help of Technology, J Clin Diagn Res
Sattar, Haider, Zia, Cytomegalovirus Hepatitis in an Immunocompetent Patient: A Cause of Fever of Unknown Origin, Cureus
Seeßle, Hippchen, Schnitzler, High rate of HSV-1 reactivation in invasively ventilated COVID-19 patients: Immunological findings, PLoS One
Serji, Mirali, Chablou, Kamaoui, Harroudi, Liver injury secondary to chest tube placement: a case report of conservative management and review of literature, Clin Case Rep, doi:10.1002/ccr3.1280
Shi, Han, Jiang, Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study, Lancet Infect Dis
Si, Su, Jiang, Psychological impact of COVID-19 on medical care workers in China, Infectious Diseases of Poverty
Siddiqi, Libby, Ridker, Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company'
Simón-Talero, Roccarina, Martínez, Lampichler, Baiges et al., Baveno VI-SPSS group from the Baveno Cooperation. Association Between Portosystemic Shunts and Increased Complications and Mortality in Patients With Cirrhosis, Gastroenterology
Steurer, Held, Spaar, Bausch, Zoller et al., A decision aid to rule out pneumonia and reduce unnecessary prescriptions of antibiotics in primary care patients with cough and fever, BMC Med
Sud, Friedrich, Adhikari, Taccone, Mancebo et al., Effect of prone positioning during mechanical ventilation on mortality among References
Tang, Li, Wang, Sun, Abnormal coagulation parameters are associated with poor prognosisin patients with novel coronavirus pneumonia, J Thromb Haemost
Thiruvenkatarajan, Eng, Adhikary, An update on regional analgesia for rib fractures, Current Opinion in Anaesthesiology
Tjendra, Mana, Disease Severity and Outcome in COVID-19 Patients: A Review of Multiple Biomarkers, Arch Pathol Lab Med
Tryc, Goldbecker, Berding, Rümke, Afshar et al., Cirrhosis-related Parkinsonism: prevalence, mechanisms and response to treatments, J Hepatol
Wang, Wang, Ye, Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence, Int J Antimicrob Agents
Watanabe, Portal-systemic encephalopathy in non-cirrhotic patients: Classification of clinical types, diagnosis and treatment, J Gastroenterol Hepatol
Wu, Chen, Cai, Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China, JAMA Intern Med
Wu, Mcgoogan, Characteristics of and important lessons from the coronavirus disease
Xia, Chen, Friedemann, The Course of Mild and Moderate COVID-19 Infections-The Unexpected Long-Lasting Challenge, OFID
Xue, Gan, Wu, Novel serological biomarkers for inflammation in predicting disease severity in patients with COVID-19, Int Immunopharmacol
Yegya-Raman, Aziz, Schneider, Tobia, Leitch et al., Case Report A Case of Sporadic Creutzfeldt-Jakob Disease Presenting as Conversion Disorder
Yoshikawa, Matsumoto, Hamanaka, Nakagawa, A case of manganese-induced parkinsonism in hereditary haemorrhagic telangiectasia, J Neurol Neurosurg Psychiatry
Youmans, Neurological surgery: A comprehensive reference guide to the diagnosis and management of neurosurgical problems
Zhang, Zhu, Jiao, Liu, Liu et al., Ulinastatin treatment for acute respiratory distress syndrome in China: a meta-analysis of randomized controlled trials, BMC Pulmonary Medicine
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Zidi, Zanditenas, Gelu-Siméon, Rangheard, Valla et al., Treatment of chronic portosystemic encephalopathy in cirrhotic patients by embolization of portosystemic shunts, Liver Int
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit