Supplementary Data — Sodium Bicarbonate reduces COVID-19 risk: real-time meta-analysis of 6 studies

@CovidAnalysis, October 2026, Version 2V2 (V1 2024)
c19early.org
October 2026

Sodium bicarbonate COVID-19 outcomes

StudyImprovementRR · 95% CIOutcomeTreatmentControlRelative Risk
Mody (RCT)64%0.36 · 0.19–0.68no improv.8/3022/30 Soares (ICU)76%0.24 · 0.11–0.54death6/4418/32ICU patients Delić (RCT)23%0.77 · 0.56–1.06death23/4237/52Intubated patients Delić (RCT)20%0.80 · 0.54–1.18death20/4231/52Intubated patients El-Badrawy57%0.43 · 0.09–2.08death3/1273/55 El-Badrawy39%0.61 · 0.20–1.83progression7/1275/55 El-Badrawy19%0.81 · 0.68–0.96no recov.84/12745/55 El-Badrawy73%0.27 · 0.14–0.52no recov.127 (n)55 (n) El-Badrawy66%0.34 · 0.25–0.47recov. time127 (n)55 (n) El-Badr.. (DB RCT)23%0.77 · 0.50–1.18death32/27242/274SODIC El-Badr.. (DB RCT)55%0.45 · 0.23–0.87death12/24727/251SODIC El-Badr.. (DB RCT)79%0.21 · 0.02–1.76death1/1255/130SODIC El-Badr.. (DB RCT)53%0.47 · 0.25–0.88death11/6322/59SODIC El-Badr.. (DB RCT)−23%1.23 · 0.86–1.75death20/2515/23SODIC El-Badr.. (DB RCT)28%0.72 · 0.66–0.80recov. time272 (n)274 (n)SODIC El-Badr.. (DB RCT)33%0.67 · 0.52–0.85no recov.238 (n)229 (n)SODIC Wang (RCT)39%0.61 · 0.46–0.82hosp. time23 (n)32 (n)
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← Sodium
Bicarbonate
reduces riskSodium
Bicarbonate
increases risk →
Fig. S1. All outcomes.
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Fig. S2. Comparison of results for RCTs versus observational studies. For COVID-19 treatments, there is no significant difference between the results of RCTs and observational studies. Observational studies do not systematically over or underestimate efficacy. For high-cost treatments, there is a non-significant trend towards RCTs showing greater efficacy.