Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All probiotics studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchProbioticsProbiotics (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Paxlovid Meta
Famotidine Meta Quercetin Meta
Favipiravir Meta Remdesivir Meta
Fluvoxamine Meta Thermotherapy Meta
Hydroxychlor.. Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

COVID-19 Pneumonia and Gut Inflammation: The Role of a Mix of Three Probiotic Strains in Reducing Inflammatory Markers and Need for Oxygen Support

Saviano et al., Journal of Clinical Medicine, doi:10.3390/jcm11133758
Jun 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 67% Improvement Relative Risk ICU admission 86% Hospitalization time 26% Probiotics  Saviano et al.  LATE TREATMENT  RCT Is late treatment with probiotics beneficial for COVID-19? RCT 80 patients in Italy Lower ICU admission (p=0.24) and shorter hospitalization (p=0.52), not sig. c19early.org Saviano et al., J. Clinical Medicine, Jun 2022 Favorsprobiotics Favorscontrol 0 0.5 1 1.5 2+
Probiotics for COVID-19
18th treatment shown to reduce risk in March 2021
 
*, now with p = 0.0000013 from 26 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
RCT 80 COVID-19 interstitial pneumonia patients in Italy, 40 treated with probiotics, showing significantly reduced gut inflammatory markers with treatment, and lower ICU admission and mortality, without statistical significance. Bifidobacterium lactis LA 304, lactobacillus salivarius LA 302, and lactobacillus acidophilus LA 201 bid for 10 days.
The immune effects of probiotics are strain-specific.
Although the 67% lower mortality is not statistically significant, it is consistent with the significant 61% lower mortality [37‑76%] from meta analysis of the 8 mortality results to date.
risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 40 (0.0%), control 1 of 40 (2.5%), NNT 40, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 40 (0.0%), control 3 of 40 (7.5%), NNT 13, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
hospitalization time, 26.3% lower, relative time 0.74, p = 0.52, treatment mean 14.0 (±6.0) n=40, control mean 19.0 (±10.0) n=40.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Saviano et al., 28 Jun 2022, Randomized Controlled Trial, Italy, peer-reviewed, mean age 59.8, 9 authors. Contact: veronica.ojetti@policlinicogemelli.it (corresponding author), angela.saviano@policlinicogemelli.it, alessio.migneco@policlinicogemelli.it, flavia.nasella@gmail.com, francesco.franceschi@policlinicogemelli.it, annalisa.potenza@policlinicogemelli.it, claudia.tarli@policlinicogemelli.it, valentina.siciliano@policlinicogemelli.it, carminepetruzziello@live.it.
This PaperProbioticsAll
COVID-19 Pneumonia and Gut Inflammation: The Role of a Mix of Three Probiotic Strains in Reducing Inflammatory Markers and Need for Oxygen Support
Angela Saviano, Annalisa Potenza, Valentina Siciliano, Carmine Petruzziello, Claudia Tarli, Alessio Migneco, Flavia Nasella, Francesco Franceschi, Veronica Ojetti
Journal of Clinical Medicine, doi:10.3390/jcm11133758
Background: COVID-19 disease, which typically presents with respiratory symptoms, can trigger intestinal inflammation through SARS-CoV-2 replication in the gastrointestinal tract. Supplementation with probiotics may have beneficial effects on gut inflammation due to their analgesic and anti-inflammatory properties. The primary objective of our study was to evaluate the efficacy of a mix of three probiotic strains (Bifidobacterium lactis LA 304, Lactobacillus salivarius LA 302, and Lactobacillus acidophilus LA 201; Lactibiane Iki ® ) in the reduction in fecal calprotectin in patients with COVID-19 pneumonia, compared to a control group. The secondary aim was to evaluate the reduction in oxygen support and length of hospital stay in patients taking the probiotic mix. Patients and Methods: We conducted a prospective randomized controlled trial at Fondazione Policlinico Gemelli, Rome. We enrolled patients with COVID-19 interstitial pneumonia. One group received the probiotic mix twice a day for 10 days in addition to the standard COVID-19 therapy, and a second group received standard COVID-19 therapy without probiotics. We administered oxygen support (through Ventimask or Optiflow ® ) on days (D) 1, 3, 5, 7 and 10, and the level of fecal calprotectin between D3-D5 and D7-D10. Results: A total of 80 patients (44 M/36 F; mean age: 59.8 ± 17.3) were enrolled with a mean value of calprotectin at enrollment of 140 mg/dL. At D7-10, the probiotic group showed a 35% decrease in fecal calprotectin compared to 16% in the control group, a decrease in C-reactive protein (CRP) of 72.7% compared to 62%, and a slight but not significant decrease in oxygen support compared to the control group. Conclusion: Supplementation with a mix of probiotics for 10 days in patients with COVID-19 interstitial pneumonia significantly reduces inflammatory markers.
Institutional Review Board Statement: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Fondazione Policlinico Universitario A. Gemelli Hospital, Rome (authorization #ID3786). Informed Consent Statement: Informed consent was obtained from all subjects involved in the study. Conflicts of Interest: All the authors declare no conflict of interests.
References
Channappanavar, Perlman, Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology, Semin. Immunopathol, doi:10.1007/s00281-017-0629-x
Cristofori, Dargenio, Miniello, Barone, Francavilla, Anti-Inflammatory and Immunomodulatory Effects of Pro-biotics in Gut Inflammation: A Door to the Body, Front. Immunol, doi:10.3389/fimmu.2021.578386
Foligne, Nutten, Grangette, Dennin, Goudercourt et al., Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria, World J. Gastroenterol, doi:10.3748/wjg.v13.i2.236
Gu, Han, Wang, COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission, Gastroenterology, doi:10.1053/j.gastro.2020.02.054
Gutiérrez-Castrellón, Gandara-Martí, Abreu, Nieto-Rufino, López-Orduña et al., Probiotic improves symptomatic and viral clearance in Covid19 outpatients: A randomized, quadruple-blinded, placebo-controlled trial, Gut Microbes, doi:10.1080/19490976.2021.2018899
Hsu, Chia, Lim, The Novel Coronavirus (SARS-CoV-2) Epidemic, Ann. Acad. Med. Singap, doi:10.47102/annals-acadmedsg.202051
Jin, Cai, Cheng, Wang, Wang, A rapid advice guideline for the diagnosis and treatment of 2019 novel coro-navirus (2019-nCoV) infected pneumonia, Mil. Med. Res
Li, Hsu, Chang, Shih, Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Shows a Stronger Anti-Inflammatory Effect than Individual Strains in HT-29 Cells, Nutrients, doi:10.3390/nu11050969
Ojetti, Saviano, Covino, Acampora, Troiani et al., COVID-19 and intestinal inflammation: Role of fecal calprotectin, Dig. Liver Dis, doi:10.1016/j.dld.2020.09.015
Petruzziello, Marannino, Migneco, Brigida, Saviano et al., The efficacy of a mix of three probiotic strains in reducing abdominal pain and inflammatory biomarkers in acute uncomplicated diverticulitis, Eur. Rev. Med. Pharmacol. Sci, doi:10.1016/S1590-8658(20)30782-9
Ren, Wang, Liu, Guo, Dai, When COVID-19 encounters interstitial lung disease: Challenges and management, Zhonghua Jie He He Hu Xi Za Zhi
Sánchez, Delgado, Blanco-Míguez, Lourenço, Gueimonde et al., Probiotics, gut microbiota, and their influence on host health and disease, Mol. Nutr. Food Res, doi:10.1002/mnfr.201600240
Wong, Lui, Sung, Covid-19 and the Digestive System, J. Gastroenterol. Hepatol, doi:10.1111/jgh.15047
Yates, Zaccardi, Islam, Baillie, Malcolm et al., Obesity, chronic disease, age, and in-hospital mortality in patients with COVID-19: Analysis of ISARIC clinical characterisation protocol UK cohort, BMC Infect. Dis, doi:10.1186/s12879-021-06466-0
Ye, Zhang, Wang, Huang, Song, Chest CT manifestations of new coronavirus disease 2019 (COVID-19): A pictorial review, Eur. Radiol, doi:10.1007/s00330-020-06801-0
Zhang, Li, Wang, Tan, Zhang et al., The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases, Front Microbiol, doi:10.3389/fmicb.2020.00301
Zhu, Wei, Niu, The novel coronavirus outbreak in Wuhan, China, Glob. Health Res. Policy, doi:10.1186/s41256-020-00135-6
{ 'indexed': {'date-parts': [[2022, 7, 1]], 'date-time': '2022-07-01T08:43:28Z', 'timestamp': 1656665008906}, 'reference-count': 17, 'publisher': 'MDPI AG', 'issue': '13', 'license': [ { 'start': { 'date-parts': [[2022, 6, 28]], 'date-time': '2022-06-28T00:00:00Z', 'timestamp': 1656374400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Background: COVID-19 disease, which typically presents with respiratory symptoms, can ' 'trigger intestinal inflammation through SARS-CoV-2 replication in the gastrointestinal tract. ' 'Supplementation with probiotics may have beneficial effects on gut inflammation due to their ' 'analgesic and anti-inflammatory properties. The primary objective of our study was to ' 'evaluate the efficacy of a mix of three probiotic strains (Bifidobacterium lactis LA 304, ' 'Lactobacillus salivarius LA 302, and Lactobacillus acidophilus LA 201; Lactibiane Iki®) in ' 'the reduction in fecal calprotectin in patients with COVID-19 pneumonia, compared to a ' 'control group. The secondary aim was to evaluate the reduction in oxygen support and length ' 'of hospital stay in patients taking the probiotic mix. Patients and Methods: We conducted a ' 'prospective randomized controlled trial at Fondazione Policlinico Gemelli, Rome. We enrolled ' 'patients with COVID-19 interstitial pneumonia. One group received the probiotic mix twice a ' 'day for 10 days in addition to the standard COVID-19 therapy, and a second group received ' 'standard COVID-19 therapy without probiotics. We administered oxygen support (through ' 'Ventimask or Optiflow®) on days (D) 1, 3, 5, 7 and 10, and the level of fecal calprotectin ' 'between D3–D5 and D7–D10. Results: A total of 80 patients (44 M/36 F; mean age: 59.8 ± 17.3) ' 'were enrolled with a mean value of calprotectin at enrollment of 140 mg/dl. At D7–10, the ' 'probiotic group showed a 35% decrease in fecal calprotectin compared to 16% in the control ' 'group, a decrease in C-reactive protein (CRP) of 72.7% compared to 62%, and a slight but not ' 'significant decrease in oxygen support compared to the control group. Conclusion: ' 'Supplementation with a mix of probiotics for 10 days in patients with COVID-19 interstitial ' 'pneumonia significantly reduces inflammatory markers.</jats:p>', 'DOI': '10.3390/jcm11133758', 'type': 'journal-article', 'created': {'date-parts': [[2022, 6, 29]], 'date-time': '2022-06-29T05:48:38Z', 'timestamp': 1656481718000}, 'page': '3758', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'COVID-19 Pneumonia and Gut Inflammation: The Role of a Mix of Three Probiotic Strains in ' 'Reducing Inflammatory Markers and Need for Oxygen Support', 'prefix': '10.3390', 'volume': '11', 'author': [ {'given': 'Angela', 'family': 'Saviano', 'sequence': 'first', 'affiliation': []}, {'given': 'Annalisa', 'family': 'Potenza', 'sequence': 'additional', 'affiliation': []}, {'given': 'Valentina', 'family': 'Siciliano', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-1025-1092', 'authenticated-orcid': False, 'given': 'Carmine', 'family': 'Petruzziello', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claudia', 'family': 'Tarli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alessio', 'family': 'Migneco', 'sequence': 'additional', 'affiliation': []}, {'given': 'Flavia', 'family': 'Nasella', 'sequence': 'additional', 'affiliation': []}, {'given': 'Francesco', 'family': 'Franceschi', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8953-0707', 'authenticated-orcid': False, 'given': 'Veronica', 'family': 'Ojetti', 'sequence': 'additional', 'affiliation': []}], 'member': '1968', 'published-online': {'date-parts': [[2022, 6, 28]]}, 'reference': [ { 'key': 'ref1', 'first-page': 'E039', 'article-title': 'When COVID-19 encounters interstitial lung disease: Challenges and ' 'management', 'volume': '43', 'author': 'Ren', 'year': '2020', 'journal-title': 'Zhonghua Jie He He Hu Xi Za Zhi'}, {'key': 'ref2', 'doi-asserted-by': 'publisher', 'DOI': '10.47102/annals-acadmedsg.202051'}, {'key': 'ref3', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00330-020-06801-0'}, {'key': 'ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s41256-020-00135-6'}, { 'key': 'ref5', 'first-page': '4', 'article-title': 'A rapid advice guideline for the diagnosis and treatment of 2019 novel ' 'coro-navirus (2019-nCoV) infected pneumonia', 'volume': '7', 'author': 'Jin', 'year': '2020', 'journal-title': 'Mil. Med. Res.'}, {'key': 'ref6', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/jgh.15047'}, {'key': 'ref7', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s12879-021-06466-0'}, {'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00281-017-0629-x'}, {'key': 'ref9', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.dld.2020.09.015'}, {'key': 'ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fmicb.2020.00301'}, {'key': 'ref11', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1590-8658(20)30782-9'}, {'key': 'ref12', 'doi-asserted-by': 'publisher', 'DOI': '10.1053/j.gastro.2020.02.054'}, {'key': 'ref13', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/mnfr.201600240'}, {'key': 'ref14', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fimmu.2021.578386'}, {'key': 'ref15', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/19490976.2021.2018899'}, {'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.3748/wjg.v13.i2.236'}, {'key': 'ref17', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu11050969'}], 'container-title': 'Journal of Clinical Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/2077-0383/11/13/3758/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 7, 1]], 'date-time': '2022-07-01T08:06:10Z', 'timestamp': 1656662770000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/2077-0383/11/13/3758'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 6, 28]]}, 'references-count': 17, 'journal-issue': {'issue': '13', 'published-online': {'date-parts': [[2022, 7]]}}, 'alternative-id': ['jcm11133758'], 'URL': 'http://dx.doi.org/10.3390/jcm11133758', 'relation': {}, 'ISSN': ['2077-0383'], 'subject': ['General Medicine'], 'container-title-short': 'JCM', 'published': {'date-parts': [[2022, 6, 28]]}}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit