Vitamin D modulates systemic inflammation in patients with severe COVID-19
Fatemeh Saheb Sharif-Askari, Shirin Hafezi, Narjes Saheb Sharif-Askari, Hawra Ali Hussain Alsayed, Bushra Mdkhana, Balachandar Selvakumar, Mohamad-Hani Temsah, Basema Saddik, Fatme Al Anouti, Rabih Halwani
Life Sciences, doi:10.1016/j.lfs.2022.120909
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References
Bhargava, Sotirchos, Eckstein, Ntranos, Gocke et al., High-dose vitamin D supplementation reduces IL-17-producing CD4+ T-cells and effector-memory CD4+ T-cells in multiple sclerosis patients (S38.001, Neurology
Chauss, Freiwald, Mcgregor, Yan, Wang et al., Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells, Nature Immunology,
doi:10.1038/s41590-021-01080-3
Chen, Hsieh, Wu, Lin, Chen, Dihydroxyvitamin D3
Chen, Yu, Fu, Wang, Chen et al., Vitamin D3 inhibits lipopolysaccharideinduced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit, Scientific Reports,
doi:10.1038/srep10871
Dauletbaev, Herscovitch, Das, Chen, Bernier et al., Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1, British Journal of Pharmacology,
doi:10.1111/bph.13249
Gharibi, Babaloo, Hosseini, Abdollahpour-Alitappeh, Hashemi et al., Targeting STAT3 in cancer and autoimmune diseases, European Journal of Pharmacology,
doi:10.1016/j.ejphar.2020.173107
Goel, Sharif-Askari, Sharif-Askari, Mdkhana, Mahboub et al., SARS-CoVexpression, Frontiers in Pharmacology
Gupta, Hayek, Chan, Mathews, Melamed, Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US, JAMA Internal Medicine,
doi:10.1001/jamainternmed.2020.3596
Kuchipudi, Tellabati, Nelli, White, Perez et al., 18S rRNA is a reliable normalisation gene for real time PCR based on influenza virus infected cells, Virology journal
Li, Tong, Hu, Wang, Lv et al., The relationship between nutritional status and the prognosis of COVID-19: A retrospective analysis of 63 patients, Medicine
Maghbooli, Sahraian, Jamalimoghadamsiahkali, Asadi, Zarei et al., Treatment With 25-Hydroxyvitamin D<sub>3</sub> (Calcifediol) Is Associated With a Reduction in the Blood Neutrophil-to-Lymphocyte Ratio Marker of Disease Severity in Hospitalized Patients With COVID-19: A Pilot Multicenter, Randomized, Placebo-Controlled, Double-Blinded Clinical Trial, Endocrine Practice,
doi:10.1016/j.eprac.2021.09.016
Matsuyama, Kubli, Yoshinaga, Pfeffer, Mak, An aberrant STAT pathway is central to COVID-19, Cell Death & Differentiation,
doi:10.1038/s41418-020-00633-7
Muhammad, Sharif-Askari, Cui, Hamad, Halwani, SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) Gene, Frontiers in Genetics,
doi:10.3389/fgene.2021.622271
Muthian, Raikwar, Rajasingh, Bright, 1,25 dihydroxyvitamin-D3 modulates JAK-STAT pathway in IL-12/IFNγ axis leading to Th1 response in experimental allergic encephalomyelitis, Journal of Neuroscience Research,
doi:10.1002/jnr.20826
Rastogi, Bhansali, Khare, Suri, Yaddanapudi et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study), Postgraduate Medical Journal,
doi:10.1136/postgradmedj-2020-139065
Sharif-Askari, Sharif-Askari, Goel, Hafezi, Assiri et al., SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway, European Journal of Pharmacology,
doi:10.1016/j.ejphar.2021.174374
Zugowski, Lieder, Müller, Gasch, Corvinus et al., STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter,
doi:10.1515/bc.2011.038