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c19early.org COVID-19 treatment researchCasirivimab/imdevimabCasirivimab/i.. (more..)
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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 6% Improvement Relative Risk Ventilation -1% Mortality (b) 21% Ventilation (b) 13% Casirivimab/i..  Horby et al.  LATE TREATMENT  RCT Is late treatment with casirivimab/imdevimab beneficial for COVID-19? RCT 9,785 patients in the United Kingdom (September 2020 - May 2021) No significant difference in outcomes seen c19early.org Horby et al., The Lancet, June 2021 Favors casirivimab/im.. Favors control

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Horby et al., The Lancet, doi:10.1016/S0140-6736(22)00163-5 (date from preprint)
Jun 2021  
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16th treatment shown to reduce risk in March 2021
 
*, now known with p = 0.000018 from 28 studies, recognized in 42 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
RCT 9,785 hospitalized patients in the UK showing lower mortality with casirivimab/imdevimab, with statistical significance reached for baseline seronegative patients.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants Haars, Liu, Pochtovyi, Sheward, Tatham, VanBlargan.
risk of death, 6.0% lower, RR 0.94, p = 0.16, treatment 943 of 4,839 (19.5%), control 1,029 of 4,946 (20.8%), NNT 76, all patients.
risk of mechanical ventilation, 1.0% higher, RR 1.01, p = 0.88, treatment 484 of 4,556 (10.6%), control 488 of 4,642 (10.5%), all patients.
risk of death, 21.0% lower, RR 0.79, p = 0.001, treatment 396 of 1,633 (24.2%), control 452 of 1,520 (29.7%), NNT 18, seronegative patients.
risk of mechanical ventilation, 13.0% lower, RR 0.87, p = 0.13, treatment 190 of 1,599 (11.9%), control 202 of 1,484 (13.6%), NNT 58, seronegative patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Horby et al., 16 Jun 2021, Randomized Controlled Trial, United Kingdom, peer-reviewed, 32 authors, study period 18 September, 2020 - 22 May, 2021, average treatment delay 9.0 days.
This PaperCasirivimab/i..All
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[], 'family': 'Ali', 'given': 'Mohammad', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ali', 'given': 'Nayab', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ali', 'given': 'Oudai', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ali', 'given': 'Sakina', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ali', 'given': 'Syed', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alina', 'given': 'Abid', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Aliyuda', 'given': 'Fine', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alizadeh', 'given': 'Katrin', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Jibury', 'given': 'Maithem', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Juboori', 'given': 'Saba', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Khalil', 'given': 'Majid', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alkhusheh', 'given': 'Moutaz', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allan', 'given': 'Fiona', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allanson', 'given': 'Alison', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allcock', 'given': 'Robert', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Eireann', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Kerry', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Louise', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Poppy', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Rebecca', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Sam', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Sharon', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allen', 'given': 'Simon', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allison', 'given': 'Kathryn', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allman', 'given': 'Bethan', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Allsop', 'given': 'Lynne', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Moasseb', 'given': 'Hassan', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Obaidi', 'given': 'Magda', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alomari', 'given': 'Lina', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Rabahi', 'given': 'Akram', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Ramadhani', 'given': 'Bahar', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Saadi', 'given': 'Zayneb', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Alshaer', 'given': 'Inji', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Shahi Salman', 'given': 'Rustam', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Al-Shamkhani', 'given': 'Warkaq', 'sequence': 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[], 'family': 'Anderson', 'given': 'Julie', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Anderson', 'given': 'Laura', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Anderson', 'given': 'Michelle', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Anderson', 'given': 'Nicola', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Anderson', 'given': 'Rachel', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Anderson', 'given': 'Rory', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Anderson', 'given': 'Wendy', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Andreou', 'given': 'Prematie', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Andrews', 'given': 'Angela', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Andrews', 'given': 'Antonette', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Andrews', 'given': 'Jill', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Aneke', 'given': 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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