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Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Horby et al., The Lancet, doi:10.1016/S0140-6736(22)00163-5 (date from preprint)

Jun 2021

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Casirivimab/imdevimab

17th treatment shown to reduce risk in March 2021, now with p = 0.00036 from 31 studies, recognized in 45 countries. Efficacy is variant dependent.

Lower risk for hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 109 treatments. c19early.org

RCT 9,785 hospitalized patients in the UK showing lower mortality with casirivimab/imdevimab, with statistical significance reached for baseline seronegative patients.

Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants1-7.

Important missing comments or errors? Let us know.

risk of death, 6.0% lower, RR 0.94, p = 0.16, treatment 943 of 4,839 (19.5%), control 1,029 of 4,946 (20.8%), NNT 76, all patients.

risk of mechanical ventilation, 1.0% higher, RR 1.01, p = 0.88, treatment 484 of 4,556 (10.6%), control 488 of 4,642 (10.5%), all patients.

risk of death, 21.0% lower, RR 0.79, p = 0.001, treatment 396 of 1,633 (24.2%), control 452 of 1,520 (29.7%), NNT 18, seronegative patients.

risk of mechanical ventilation, 13.0% lower, RR 0.87, p = 0.13, treatment 190 of 1,599 (11.9%), control 202 of 1,484 (13.6%), NNT 58, seronegative patients.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

1. Liu et al., Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2, bioRxiv, doi:10.1101/2021.12.14.472719.biorxiv.org, doi.org.

2. Sheward et al., Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron), bioRxiv, doi:10.1101/2021.12.19.473354.biorxiv.org, doi.org.

3. VanBlargan et al., An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by several therapeutic monoclonal antibodies, bioRxiv, doi:10.1101/2021.12.15.472828.biorxiv.org, doi.org.

4. Tatham et al., Lack of Ronapreve (REGN-CoV; casirivimab and imdevimab) virological efficacy against the SARS-CoV 2 Omicron variant (B.1.1.529) in K18-hACE2 mice, bioRxiv, doi:10.1101/2022.01.23.477397.biorxiv.org, doi.org.

5. Pochtovyi et al., In Vitro Efficacy of Antivirals and Monoclonal Antibodies against SARS-CoV-2 Omicron Lineages XBB.1.9.1, XBB.1.9.3, XBB.1.5, XBB.1.16, XBB.2.4, BQ.1.1.45, CH.1.1, and CL.1, Vaccines, doi:10.3390/vaccines11101533.mdpi.com, doi.org.

6. Haars et al., Prevalence of SARS-CoV-2 Omicron Sublineages and Spike Protein Mutations Conferring Resistance against Monoclonal Antibodies in a Swedish Cohort during 2022–2023, Microorganisms, doi:10.3390/microorganisms11102417.mdpi.com, doi.org.

7. Uraki et al., Antiviral efficacy against and replicative fitness of an XBB.1.9.1 clinical isolate, iScience, doi:10.1016/j.isci.2023.108147.sciencedirect.com, doi.org.

Horby et al., 16 Jun 2021, Randomized Controlled Trial, United Kingdom, peer-reviewed, 32 authors, study period 18 September, 2020 - 22 May, 2021, average treatment delay 9.0 days.

This Paper Casirivimab/i..All

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{'given': 'Ritesh', 'family': 'Chaube', 'sequence': 'additional', 'affiliation': []}, {'given': 'Muhammad Y N', 'family': 'Chaudhary', 'sequence': 'additional', 'affiliation': []}, {'given': 'Iram', 'family': 'Chaudhry', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nazia', 'family': 'Chaudhuri', 'sequence': 'additional', 'affiliation': []}, {'given': 'Muhammad', 'family': 'Chaudhury', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anoop', 'family': 'Chauhan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruchi Singh', 'family': 'Chauhan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicola', 'family': 'Chavasse', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vipal', 'family': 'Chawla', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lindsay', 'family': 'Cheater', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Cheaveau', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charlotte', 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{'given': 'Sirjana', 'family': 'Devkota', 'sequence': 'additional', 'affiliation': []}, {'given': 'Usha', 'family': 'Devkota', 'sequence': 'additional', 'affiliation': []}, {'given': 'Prakash', 'family': 'Dey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vishal', 'family': 'Dey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rogin', 'family': 'Deylami', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kevin', 'family': 'Dhaliwal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sundip', 'family': 'Dhani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Amandeep', 'family': 'Dhanoa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mili', 'family': 'Dhar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Devesh', 'family': 'Dhasmana', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ekanjali', 'family': 'Dhillon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Reiss', 'family': 'Dhillon', 'sequence': 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'affiliation': []}, {'given': 'Hayley', 'family': 'Duckles-Leech', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicola', 'family': 'Duff', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emma', 'family': 'Duffield', 'sequence': 'additional', 'affiliation': []}, {'given': 'Helen', 'family': 'Duffy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lionel', 'family': 'Dufour', 'sequence': 'additional', 'affiliation': []}, {'given': 'Annette', 'family': 'Duggan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Parveen', 'family': 'Dugh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Janice', 'family': 'Duignan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Simon', 'family': 'Dummer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andrew', 'family': 'Duncan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christopher', 'family': 'Duncan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fullerton', 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{'given': 'Ciaran', 'family': 'Hart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dominic', 'family': 'Hart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lisa', 'family': 'Hartley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rosemary', 'family': 'Hartley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruth', 'family': 'Hartley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tom', 'family': 'Hartley', 'sequence': 'additional', 'affiliation': []}, {'given': 'William', 'family': 'Hartrey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Phillipa', 'family': 'Hartridge', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stuart', 'family': 'Hartshorn', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heli', 'family': 'Harvala', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Harvey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Angela', 'family': 'Harvey', 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{'given': 'Julius', 'family': 'Labao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Louise', 'family': 'Lacey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nikki', 'family': 'Lack', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emma', 'family': 'Ladlow', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heather', 'family': 'Lafferty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shondipon', 'family': 'Laha', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sushil', 'family': 'Lahane', 'sequence': 'additional', 'affiliation': []}, {'given': 'Clement', 'family': 'Lai', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Lai', 'sequence': 'additional', 'affiliation': []}, {'given': 'Robert', 'family': 'Laing', 'sequence': 'additional', 'affiliation': []}, {'given': 'Inez', 'family': 'Laing-Faiers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emily', 'family': 'Laity', 'sequence': 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{'given': 'Christine', 'family': 'Laycock', 'sequence': 'additional', 'affiliation': []}, {'given': 'Reina', 'family': 'Layug', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maria', 'family': 'Lazo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vietland', 'family': 'Le', 'sequence': 'additional', 'affiliation': []}, {'given': 'Amelia', 'family': 'Lea', 'sequence': 'additional', 'affiliation': []}, {'given': 'William', 'family': 'Lea', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ian', 'family': 'Leadbitter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thomas', 'family': 'Leahy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Richard', 'family': 'Lean', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lorna', 'family': 'Leandro', 'sequence': 'additional', 'affiliation': []}, {'given': 'Darren', 'family': 'Leaning', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sandra', 'family': 'Leason', 'sequence': 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{'given': 'Katarina', 'family': 'Manso', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dina', 'family': 'Mansour', 'sequence': 'additional', 'affiliation': []}, {'given': 'Isheunesu T', 'family': 'Mapfunde', 'sequence': 'additional', 'affiliation': []}, {'given': 'Predeesh', 'family': 'Mappa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hemant', 'family': 'Maraj', 'sequence': 'additional', 'affiliation': []}, {'given': 'Clare', 'family': 'Marchand', 'sequence': 'additional', 'affiliation': []}, {'given': 'Neil', 'family': 'Marcus', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maria', 'family': 'Marecka', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gomathi', 'family': 'Margabanthu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jordi', 'family': 'Margalef', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lavinia', 'family': 'Margarit', 'sequence': 'additional', 'affiliation': []}, {'given': 'Georgios', 'family': 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'Henry', 'family': 'Marshall', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jaimie', 'family': 'Marshall', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jenna', 'family': 'Marshall', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicola', 'family': 'Marshall', 'sequence': 'additional', 'affiliation': []}, {'given': 'Riley', 'family': 'Marshall', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Marshall', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emmeline', 'family': 'Martin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hayley', 'family': 'Martin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hope', 'family': 'Martin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jane', 'family': 'Martin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Karen', 'family': 'Martin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kate', 'family': 'Martin', 'sequence': 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{'given': 'Lucas', 'family': 'Martins Ferreira', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vijay K', 'family': 'Maruthamuthu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gemma', 'family': 'Maryan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roman', 'family': 'Mary-Genetu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sam', 'family': 'Maryosh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vidan', 'family': 'Masani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Diego', 'family': 'Maseda', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sheila', 'family': 'Mashate', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yasaman', 'family': 'Mashhoudi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Al', 'family': 'Mashta', 'sequence': 'additional', 'affiliation': []}, {'given': 'Izhaq', 'family': 'Masih', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sanna', 'family': 'Masih', 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'affiliation': []}, {'given': 'Alison J', 'family': 'Matthews', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heather', 'family': 'Matthews', 'sequence': 'additional', 'affiliation': []}, {'given': 'Helen', 'family': 'Matthews', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fiona', 'family': 'Maxton', 'sequence': 'additional', 'affiliation': []}, {'given': 'Adam', 'family': 'Maxwell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Veronica', 'family': 'Maxwell', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'May', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joanne', 'family': 'May', 'sequence': 'additional', 'affiliation': []}, {'given': 'Philippa', 'family': 'May', 'sequence': 'additional', 'affiliation': []}, {'given': 'Irving', 'family': 'Mayanagao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matthew', 'family': 'Maycock', 'sequence': 'additional', 'affiliation': []}, {'given': 'Graham', 'family': 'Mayers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Victoria', 'family': 'Maynard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shelley', 'family': 'Mayor', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ibreaheim', 'family': 'Mazen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andrea', 'family': 'Mazzella', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nyambura', 'family': 'Mburu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eleanor', 'family': 'McAleese', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'McAlinden', 'sequence': 'additional', 'affiliation': []}, {'given': 'Audrey', 'family': 'McAlpine', 'sequence': 'additional', 'affiliation': []}, {'given': 'Graeme', 'family': 'McAlpine', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jonathan', 'family': 'McAndrew', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hamish', 'family': 'McAuley', 'sequence': 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'Alexandra', 'family': 'McCarrick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Brendan', 'family': 'McCarron', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eoghan', 'family': 'McCarthy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michelle', 'family': 'McCarthy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Natalie', 'family': 'McCarthy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sinead', 'family': 'McCaughey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gareth', 'family': 'McChlery', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tara', 'family': 'McClay', 'sequence': 'additional', 'affiliation': []}, {'given': 'Beverley', 'family': 'McClelland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Declan', 'family': 'McClintock', 'sequence': 'additional', 'affiliation': []}, {'given': 'Patricia', 'family': 'McCormack', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jacqueline', 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{'given': 'Sam', 'family': 'McDonald', 'sequence': 'additional', 'affiliation': []}, {'given': 'Damhnaic', 'family': 'McDonald', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rowan', 'family': 'McDougall', 'sequence': 'additional', 'affiliation': []}, {'given': 'Irene', 'family': 'McEleavy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Julie', 'family': 'McEntee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Evanna', 'family': 'McEvoy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruth', 'family': 'McEwen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Margaret', 'family': 'McFadden', 'sequence': 'additional', 'affiliation': []}, {'given': 'Denise', 'family': 'McFarland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Margaret', 'family': 'McFarland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rachel', 'family': 'McFarland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Erin', 'family': 'McGarry', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lorcan', 'family': 'McGarvey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laura', 'family': 'McGenily', 'sequence': 'additional', 'affiliation': []}, {'given': 'Clodagh', 'family': 'McGettigan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michael', 'family': 'McGettrick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christopher', 'family': 'McGhee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fiona', 'family': 'McGill', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'McGinnity', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hannah', 'family': 'McGivern', 'sequence': 'additional', 'affiliation': []}, {'given': 'Neil', 'family': 'McGlinchey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Phil', 'family': 'McGlone', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deborah', 'family': 'McGlynn', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire', 'family': 'McGoldrick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Clare', 'family': 'McGoldrick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elizabeth', 'family': 'McGough', 'sequence': 'additional', 'affiliation': []}, {'given': 'Brendan', 'family': 'McGrath', 'sequence': 'additional', 'affiliation': []}, {'given': 'Amanda', 'family': 'McGregor', 'sequence': 'additional', 'affiliation': []}, {'given': 'Annemarie', 'family': 'McGregor', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heather', 'family': 'McGuinness', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sean', 'family': 'McGuire', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tara', 'family': 'McHugh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Caroline', 'family': 'McInnes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Neil', 'family': 'McInnes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Karen', 'family': 'McIntyre', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mhairi', 'family': 'McIntyre', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lorna', 'family': 'McKay', 'sequence': 'additional', 'affiliation': []}, {'given': 'Conor P', 'family': 'McKeag', 'sequence': 'additional', 'affiliation': []}, {'given': 'Madeleine', 'family': 'McKee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joseph', 'family': 'McKeever', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shirley', 'family': 'McKenna', 'sequence': 'additional', 'affiliation': []}, {'given': 'Donogh', 'family': 'McKeogh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Caroline', 'family': 'McKerr', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anthony M', 'family': 'McKie', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laura', 'family': 'Mckie', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gerard', 'family': 'McKnight', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heather', 'family': 'McLachlan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andrew', 'family': 'McLaren', 'sequence': 'additional', 'affiliation': []}, {'given': 'Barbara', 'family': 'McLaren', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicola', 'family': 'McLarty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maria', 'family': 'McLaughlin', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'McLay', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mary', 'family': 'McLeish', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tina', 'family': 'McLennan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stewart', 'family': 'McLure', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne-Marie', 'family': 'McMahon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Genevieve', 'family': 'McMahon', 'sequence': 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'Lynne', 'family': 'McNeil', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire', 'family': 'McNeill', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shea', 'family': 'McNeill', 'sequence': 'additional', 'affiliation': []}, {'given': 'Una', 'family': 'McNelis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Melanie', 'family': 'McNulty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roisin', 'family': 'McNulty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christopher', 'family': 'McParland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mark', 'family': 'McPhail', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'McQueen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna', 'family': 'McSkeane', 'sequence': 'additional', 'affiliation': []}, {'given': 'Denise', 'family': 'McSorland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gini', 'family': 'McTaggart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jacqueline', 'family': 'McTaggart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joanna', 'family': 'Mead', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emma', 'family': 'Meadows', 'sequence': 'additional', 'affiliation': []}, {'given': 'Olivia', 'family': 'Meakin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ben', 'family': 'Mearns', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claire', 'family': 'Mearns', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kim', 'family': 'Mears', 'sequence': 'additional', 'affiliation': []}, {'given': 'William', 'family': 'Mears', 'sequence': 'additional', 'affiliation': []}, {'given': 'Manjula', 'family': 'Meda', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ayren', 'family': 'Mediana', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ross', 'family': 'Medine', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thomas', 'family': 'Medveczky', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sharon', 'family': 'Meehan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emily', 'family': 'Meeks', 'sequence': 'additional', 'affiliation': []}, {'given': 'Abbi', 'family': 'Megan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nevan', 'family': 'Meghani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Salim', 'family': 'Meghjee', 'sequence': 'additional', 'affiliation': []}, {'given': 'Amina', 'family': 'Mehar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rohan', 'family': 'Mehra', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Meiring', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rayane', 'family': 'Mejri', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sabina', 'family': 'Melander', 'sequence': 'additional', 'affiliation': []}, {'given': 'Adriana-Stefania', 'family': 'Melinte', 'sequence': 'additional', 'affiliation': []}, {'given': 'Francesca', 'family': 'Mellor', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samantha', 'family': 'Mellor', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zoe', 'family': 'Mellor', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katrina', 'family': 'Mellows', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vladimir', 'family': 'Melnic', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Melville', 'sequence': 'additional', 'affiliation': []}, {'given': 'Julie', 'family': 'Melville', 'sequence': 'additional', 'affiliation': []}, {'given': 'Helen', 'family': 'Membrey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mark', 'family': 'Mencias', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cheryl', 'family': 'Mendonca', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexander', 'family': 'Mentzer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dan', 'family': 'Menzies', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sue', 'family': 'Mepham', 'sequence': 'additional', 'affiliation': []}, {'given': 'Oliver', 'family': 'Mercer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Pauline', 'family': 'Mercer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Arwa', 'family': 'Merchant', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fatema', 'family': 'Merchant', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mihaela', 'family': 'Mercioniu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Megan', 'family': 'Meredith', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marta', 'family': 'Merida Morillas', 'sequence': 'additional', 'affiliation': []}, {'given': 'Blair', 'family': 'Merrick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jack', 'family': 'Merritt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Simon', 'family': 'Merritt', 'sequence': 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{'given': 'Jagrul', 'family': 'Miah', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nahima', 'family': 'Miah', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gabriela', 'family': 'Mic', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dariush', 'family': 'Micallef', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Michael', 'sequence': 'additional', 'affiliation': []}, {'given': 'Angiy', 'family': 'Michael', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shery', 'family': 'Michael', 'sequence': 'additional', 'affiliation': []}, {'given': 'Natalia', 'family': 'Michalak', 'sequence': 'additional', 'affiliation': []}, {'given': 'Loredana', 'family': 'Michalca-Mason', 'sequence': 'additional', 'affiliation': []}, {'given': 'Janet', 'family': 'Middle', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hayley', 'family': 'Middleton', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jennifer T', 'family': 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'family': 'Morselli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gordon', 'family': 'Mortem', 'sequence': 'additional', 'affiliation': []}, {'given': 'Valerie', 'family': 'Mortland', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chelsea', 'family': 'Morton', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gordon', 'family': 'Morton', 'sequence': 'additional', 'affiliation': []}, {'given': 'Priti', 'family': 'Morzaria', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'Moss', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charlotte', 'family': 'Moss', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Moss', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stuart', 'family': 'Moss', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicki', 'family': 'Motherwell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Johanna', 'family': 'Mouland', 'sequence': 'additional', 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'affiliation': []}, {'given': 'Adrian', 'family': 'Palfreeman', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deepshikha', 'family': 'Palit', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alistair', 'family': 'Palmer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lynne', 'family': 'Palmer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ian', 'family': 'Pamphlett', 'sequence': 'additional', 'affiliation': []}, {'given': 'Daniel', 'family': 'Pan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anmol', 'family': 'Pandey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nithya', 'family': 'Pandian', 'sequence': 'additional', 'affiliation': []}, {'given': 'Krishnaa', 'family': 'Pandya', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tej', 'family': 'Pandya', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Panes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yee Wei', 'family': 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{'given': 'Ponmurugan', 'family': 'Ponnusamy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Suresh', 'family': 'Ponnusamy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aravind', 'family': 'Ponnuswamy', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Inês', 'family': 'Ponte Bettencourt dos Reis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Suman', 'family': 'Pooboni', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alice', 'family': 'Poole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lynda', 'family': 'Poole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michele', 'family': 'Poole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sharon', 'family': 'Poon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tajinder', 'family': 'Poonian', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Porter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jo', 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'affiliation': []}, {'given': 'Jyothi', 'family': 'Rajeswary', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jeyanthy', 'family': 'Rajkanna', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gayathri', 'family': 'Rajmohan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruth', 'family': 'Rallan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katherine', 'family': 'Ralston', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maximilian', 'family': 'Ralston', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matsa', 'family': 'Ram', 'sequence': 'additional', 'affiliation': []}, {'given': 'Balaji', 'family': 'Ramabhadran', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fathima', 'family': 'Ramali', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed', 'family': 'Ramali', 'sequence': 'additional', 'affiliation': []}, {'given': 'Athimalaipet', 'family': 'Ramanan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shashikira', 'family': 'Ramanna', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maheshi', 'family': 'Ramasamy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Irfah', 'family': 'Rambe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dhanishta', 'family': 'Ramdin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jozel', 'family': 'Ramirez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mylah', 'family': 'Ramirez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Geshwin', 'family': 'Ramnarain', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lidia', 'family': 'Ramos', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tommy', 'family': 'Rampling', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shanthi', 'family': 'Ramraj', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alex', 'family': 'Ramshaw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aleem', 'family': 'Rana', 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'Rajesh', 'family': 'Rankhelawon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anita', 'family': 'Rao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sandhya', 'family': 'Rao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sanjay', 'family': 'Rao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deepak', 'family': 'Rao', 'sequence': 'additional', 'affiliation': []}, {'given': 'Althaf A', 'family': 'Rasheed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Khalid', 'family': 'Rashid', 'sequence': 'additional', 'affiliation': []}, {'given': 'Simbisai', 'family': 'Ratcliff', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sam', 'family': 'Ratcliffe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sophy', 'family': 'Ratcliffe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sanjeev', 'family': 'Rath', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohmad I', 'family': 'Rather', 'sequence': 'additional', 'affiliation': []}, {'given': 'Selina', 'family': 'Rathore', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aravinden', 'family': 'Ratnakumar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jonathan', 'family': 'Ratoff', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deepa', 'family': 'Rattehalli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jason', 'family': 'Raw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rachael', 'family': 'Raw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hywel', 'family': 'Rawlins', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gautam', 'family': 'Ray', 'sequence': 'additional', 'affiliation': []}, {'given': 'Adam', 'family': 'Raymond-White', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dana', 'family': 'Raynard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicola', 'family': 'Rayner', 'sequence': 'additional', 'affiliation': []}, {'given': 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[]}, {'given': 'John', 'family': 'Reed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andrew', 'family': 'Rees', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Rees', 'sequence': 'additional', 'affiliation': []}, {'given': 'Martyn', 'family': 'Rees', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Rees', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stephanie', 'family': 'Rees', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tabitha', 'family': 'Rees', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fiona', 'family': 'Regan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Karen', 'family': 'Regan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Susan', 'family': 'Regan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kanchan', 'family': 'Rege', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ahmed', 'family': 'Rehan', 'sequence': 'additional', 'affiliation': []}, {'given': 'A', 'family': 'Rehman', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shoib', 'family': 'Rehman', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zainab', 'family': 'Rehman', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ada', 'family': 'Reid', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andrew', 'family': 'Reid', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Reid', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jeremy', 'family': 'Reid', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sharon', 'family': 'Reid', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mkyla', 'family': 'Reilly', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christina', 'family': 'Reith', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alda', 'family': 'Remegoso', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dinakaran', 'family': 'Rengan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stephen', 'family': 'Renshaw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Remya', 'family': 'Renu Vattekkat', 'sequence': 'additional', 'affiliation': []}, {'given': 'Henrik', 'family': 'Reschreiter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mark', 'family': 'Revels', 'sequence': 'additional', 'affiliation': []}, {'given': 'Glynis', 'family': 'Rewitzky', 'sequence': 'additional', 'affiliation': []}, {'given': 'Severine', 'family': 'Rey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charles', 'family': 'Reynard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dominic', 'family': 'Reynish', 'sequence': 'additional', 'affiliation': []}, {'given': 'Peter', 'family': 'Reynolds', 'sequence': 'additional', 'affiliation': []}, {'given': 'Piero', 'family': 'Reynolds', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jonathan', 'family': 'Rhodes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Naghma', 'family': 'Riaz', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emily', 'family': 'Rice', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matthew', 'family': 'Rice', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mel', 'family': 'Rich', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alex', 'family': 'Richards', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'Richards', 'sequence': 'additional', 'affiliation': []}, {'given': 'Liz', 'family': 'Richards', 'sequence': 'additional', 'affiliation': []}, {'given': 'Suzanne', 'family': 'Richards', 'sequence': 'additional', 'affiliation': []}, {'given': 'Celia', 'family': 'Richardson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Julie', 'family': 'Richardson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Neil', 'family': 'Richardson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicky', 'family': 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[]}, {'given': 'Linsey', 'family': 'Rigby', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samita', 'family': 'Rijal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hannah', 'family': 'Riley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matthew', 'family': 'Riley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Phil', 'family': 'Riley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Atika', 'family': 'Rimainar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Zwesty V P', 'family': 'Rimba', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dominic', 'family': 'Rimmer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Robert', 'family': 'Rintoul', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andrew', 'family': 'Riordan', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Ripley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Naomi', 'family': 'Rippon', 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{'given': 'David J', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ian', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jane', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Karen', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mark', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicky', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Philip', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rebecca', 'family': 'Roberts', 'sequence': 'additional', 'affiliation': []}, {'given': 'Calum', 'family': 'Robertson', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Robertson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jamie', 'family': 'Robertson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nichola', 'family': 'Robertson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stuart', 'family': 'Robertson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicole', 'family': 'Robin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Caroline', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emma', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gisela', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hannah', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jemima', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kate', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Matthew', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ryan', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sandra', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexandra', 'family': 'Robinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Steve', 'family': 'Robson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lisa', 'family': 'Roche', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samantha', 'family': 'Roche', 'sequence': 'additional', 'affiliation': []}, {'given': 'Natalie', 'family': 'Rodden', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alistair', 'family': 'Roddick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jack', 'family': 'Roddy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marion', 'family': 'Roderick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'Rodger', 'sequence': 'additional', 'affiliation': []}, {'given': 'Faye', 'family': 'Rodger', 'sequence': 'additional', 'affiliation': []}, {'given': 'Megan', 'family': 'Rodger', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alicia', 'family': 'Rodgers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deirdre', 'family': 'Rodgers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Natasha', 'family': 'Rodgers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Penny', 'family': 'Rodgers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rocio', 'family': 'Rodriguez-Belmonte', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicholas', 'family': 'Roe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charles', 'family': 'Roehr', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gill', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jason', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joanne', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'John', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Leigh', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lindsay', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michaela', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paula', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Susan', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thomas', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paula', 'family': 'Rogers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sakib', 'family': 'Rokadiya', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lee', 'family': 'Rollins', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jennifer', 'family': 'Rollo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Catherine', 'family': 'Rolls', 'sequence': 'additional', 'affiliation': []}, {'given': 'Atal', 'family': 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{'given': 'Alex', 'family': 'Rothman', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joanne', 'family': 'Rothwell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lindsay', 'family': 'Roughley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kathryn', 'family': 'Rowan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Neil', 'family': 'Rowan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stephen', 'family': 'Rowan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna', 'family': 'Rowe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Cathy', 'family': 'Rowe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Louise', 'family': 'Rowe-Leete', 'sequence': 'additional', 'affiliation': []}, {'given': 'Benjamin', 'family': 'Rowlands', 'sequence': 'additional', 'affiliation': []}, {'given': 'Megan', 'family': 'Rowley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Subarna', 'family': 'Roy', 'sequence': 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'affiliation': []}, {'given': 'Jeyakumar', 'family': 'Selwyn', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gary', 'family': 'Semple', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nandini', 'family': 'Sen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Seema', 'family': 'Sen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aditya', 'family': 'Sengupta', 'sequence': 'additional', 'affiliation': []}, {'given': 'Niladri', 'family': 'Sengupta', 'sequence': 'additional', 'affiliation': []}, {'given': 'Susana', 'family': 'Senra', 'sequence': 'additional', 'affiliation': []}, {'given': 'HoJan', 'family': 'Senya', 'sequence': 'additional', 'affiliation': []}, {'given': 'Niranjan', 'family': 'Setty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Abigail', 'family': 'Seward', 'sequence': 'additional', 'affiliation': []}, {'given': 'Teswaree', 'family': 'Sewdin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jack', 'family': 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'Charles', 'family': 'Sharp', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gemma', 'family': 'Sharp', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paula', 'family': 'Sharratt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Phoebe', 'family': 'Sharratt', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katherine', 'family': 'Sharrocks', 'sequence': 'additional', 'affiliation': []}, {'given': 'Serene', 'family': 'Shashaa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Christopher', 'family': 'Shaw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Daisy', 'family': 'Shaw', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Shaw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Deborah', 'family': 'Shaw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Joanne', 'family': 'Shaw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jonathon', 'family': 'Shaw', 'sequence': 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'family': 'Sohal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roy', 'family': 'Soiza', 'sequence': 'additional', 'affiliation': []}, {'given': 'Olajumoke', 'family': 'Solademi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Babak', 'family': 'Soleimani', 'sequence': 'additional', 'affiliation': []}, {'given': 'Amanda', 'family': 'Solesbury', 'sequence': 'additional', 'affiliation': []}, {'given': 'Reanne', 'family': 'Solly', 'sequence': 'additional', 'affiliation': []}, {'given': 'Louise', 'family': 'Solomon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Subash', 'family': 'Somalanka', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Chandrashekaraiah', 'family': 'Somashekar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Raj', 'family': 'Sonia', 'sequence': 'additional', 'affiliation': []}, {'given': 'Shiu-Ching', 'family': 'Soo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Pavandeep', 'family': 'Soor', 'sequence': 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[]}, {'given': 'Thomas', 'family': 'Southworth', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jason', 'family': 'Sowter', 'sequence': 'additional', 'affiliation': []}, {'given': 'Claudia', 'family': 'Spalding', 'sequence': 'additional', 'affiliation': []}, {'given': 'Enti', 'family': 'Spata', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katie', 'family': 'Spears', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mark', 'family': 'Spears', 'sequence': 'additional', 'affiliation': []}, {'given': 'Michelle', 'family': 'Spence', 'sequence': 'additional', 'affiliation': []}, {'given': 'Branwell', 'family': 'Spencer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gisele', 'family': 'Spencer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sue', 'family': 'Spencer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Tom', 'family': 'Spencer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Helen', 'family': 'Spickett', 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{'given': 'Shiva', 'family': 'Sreenivasan', 'sequence': 'additional', 'affiliation': []}, {'given': 'K', 'family': 'Sri Paranthamen', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ramesh', 'family': 'Srinivasan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Asha', 'family': 'Srirajamadhuveeti', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vino', 'family': 'Srirathan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sybil', 'family': 'Stacpoole', 'sequence': 'additional', 'affiliation': []}, {'given': 'Louise', 'family': 'Stadon', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jocasta', 'family': 'Staines', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nikki', 'family': 'Staines', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katie', 'family': 'Stammers', 'sequence': 'additional', 'affiliation': []}, {'given': 'Roxana', 'family': 'Stanciu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Grazyna', 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{'given': 'Claire', 'family': 'Stewart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Colin', 'family': 'Stewart', 'sequence': 'additional', 'affiliation': []}, {'given': 'McKenna', 'family': 'Stewart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rachel', 'family': 'Stewart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Richard', 'family': 'Stewart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jo', 'family': 'Stickley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gemma', 'family': 'Stiller', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Stirrup', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sarah', 'family': 'Stock', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alexander', 'family': 'Stockdale', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lynne', 'family': 'Stockham', 'sequence': 'additional', 'affiliation': []}, {'given': 'Paul', 'family': 'Stockton', 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{'given': 'Jane', 'family': 'Stratton', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sam', 'family': 'Straw', 'sequence': 'additional', 'affiliation': []}, {'given': 'Dieter', 'family': 'Streit', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emma', 'family': 'Stride', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sally', 'family': 'Stringer', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sophia', 'family': 'Strong-Sheldrake', 'sequence': 'additional', 'affiliation': []}, {'given': 'Siske', 'family': 'Struik', 'sequence': 'additional', 'affiliation': []}, {'given': 'Carmel', 'family': 'Stuart', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna', 'family': 'Stubbs', 'sequence': 'additional', 'affiliation': []}, {'given': 'Harrison', 'family': 'Stubbs', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ann', 'family': 'Sturdy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sharon', 'family': 'Sturney', 'sequence': 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{'given': 'Sorrell', 'family': 'Tilbey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Amanda', 'family': 'Tiller', 'sequence': 'additional', 'affiliation': []}, {'given': 'John', 'family': 'Timerick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elizabeth', 'family': 'Timlick', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alison', 'family': 'Timmis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hayley', 'family': 'Timms', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne-Marie', 'family': 'Timoroksa', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samakomva', 'family': 'Tinashe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Heather', 'family': 'Tinkler', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marianne', 'family': 'Tinkler', 'sequence': 'additional', 'affiliation': []}, {'given': 'Myat', 'family': 'Tin Trafford', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jacqui', 'family': 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{'given': 'Jo', 'family': 'Tomlinson', 'sequence': 'additional', 'affiliation': []}, {'given': 'James', 'family': 'Tonkin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ivan', 'family': 'Tonna', 'sequence': 'additional', 'affiliation': []}, {'given': 'Catherine', 'family': 'Toohey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Kirsty', 'family': 'Topham', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mathew', 'family': 'Topping', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruhaif', 'family': 'Tousis', 'sequence': 'additional', 'affiliation': []}, {'given': 'Peter', 'family': 'Tovey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Gareth', 'family': 'Towersey', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jill', 'family': 'Townley', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alain', 'family': 'Townsend', 'sequence': 'additional', 'affiliation': []}, {'given': 'Richard', 'family': 'Tozer', 'sequence': 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Late treatment
is less effective

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