Use of mouthwash and dentifrice containing antimicrobial phthalocyanine derivative for the reduction of clinical symptoms of COVID-19: A randomized triple-blinded clinical trial

{ 'indexed': {'date-parts': [[2023, 4, 15]], 'date-time': '2023-04-15T04:27:39Z', 'timestamp': 1681532859771}, 'reference-count': 35, 'publisher': 'Elsevier BV', 'issue': '4', 'license': [ { 'start': { 'date-parts': [[2022, 12, 1]], 'date-time': '2022-12-01T00:00:00Z', 'timestamp': 1669852800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2022, 12, 1]], 'date-time': '2022-12-01T00:00:00Z', 'timestamp': 1669852800000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-017'}, { 'start': { 'date-parts': [[2022, 12, 1]], 'date-time': '2022-12-01T00:00:00Z', 'timestamp': 1669852800000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-037'}, { 'start': { 'date-parts': [[2022, 12, 1]], 'date-time': '2022-12-01T00:00:00Z', 'timestamp': 1669852800000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-012'}, { 'start': { 'date-parts': [[2022, 12, 1]], 'date-time': '2022-12-01T00:00:00Z', 'timestamp': 1669852800000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-029'}, { 'start': { 'date-parts': [[2022, 12, 1]], 'date-time': '2022-12-01T00:00:00Z', 'timestamp': 1669852800000}, 'content-version': 'stm-asf', 'delay-in-days': 0, 'URL': 'https://doi.org/10.15223/policy-004'}], 'content-domain': { 'domain': [ 'clinicalkey.jp', 'clinicalkey.es', 'clinicalkey.com.au', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2022, 12]]}, 'DOI': '10.1016/j.jebdp.2022.101777', 'type': 'journal-article', 'created': {'date-parts': [[2022, 9, 14]], 'date-time': '2022-09-14T06:29:43Z', 'timestamp': 1663136983000}, 'page': '101777', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 1, 'title': 'USE OF MOUTHWASH AND DENTIFRICE CONTAINING AN ANTIMICROBIAL PHTHALOCYANINE DERIVATIVE FOR THE ' 'REDUCTION OF CLINICAL SYMPTOMS OF COVID-19: A RANDOMIZED TRIPLE-BLIND CLINICAL TRIAL', 'prefix': '10.1016', 'volume': '22', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-1904-5762', 'authenticated-orcid': False, 'given': 'Marcelo Lupion', 'family': 'Poleti', 'sequence': 'first', 'affiliation': []}, {'given': 'Danielle', 'family': 'Gregório', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Alisson Gabriel Idelfonso', 'family': 'Bistaffa', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Karen Barros Parron', 'family': 'Fernandes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fabiano Vieira', 'family': 'Vilhena', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Paulo Sérgio da Silva', 'family': 'Santos', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andréa Name Colado', 'family': 'Simão', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Marcell Alysson Batisti', 'family': 'Lozovoy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Berenice Tomoko', 'family': 'Tatibana', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Thais Maria Freire', 'family': 'Fernandes', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.jebdp.2022.101777_bib0001', 'doi-asserted-by': 'crossref', 'first-page': '454', 'DOI': '10.1016/j.identj.2020.12.027', 'article-title': 'Global neglect of dental coverage in universal health coverage systems ' "and Japan's broad coverage", 'volume': '71', 'author': 'Aida', 'year': '2021', 'journal-title': 'Int Dent J'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0002', 'doi-asserted-by': 'crossref', 'first-page': '892', 'DOI': '10.1038/s41591-021-01296-8', 'article-title': 'SARS-CoV-2 infection of the oral cavity and saliva', 'volume': '27', 'author': 'Huang', 'year': '2021', 'journal-title': 'Nat Med'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0003', 'article-title': 'Periodontal tissues are targets for SARS-CoV-2: a post-mortem study', 'volume': '13', 'author': 'Matuck', 'year': '2020', 'journal-title': 'J Oral Microbiol'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0004', 'doi-asserted-by': 'crossref', 'first-page': '239', 'DOI': '10.1002/path.5679', 'article-title': 'Salivary glands are a target for SARS-CoV-2: a source for saliva ' 'contamination', 'volume': '254', 'author': 'Matuck', 'year': '2021', 'journal-title': 'J Pathol'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0005', 'unstructured': 'Pepsodent WOHD 2021. Bangladesh research summary report 2021: attitudes, ' 'behaviors and experiences of oral health during the covid-19 pandemic. ' 'Accessed 06 September 2022. ' 'https://www.pepsodent.com/sk-eu/content/dam/brands/smile/bd/en/smile_fact_sheet_bangladesh_final-38049334.pdf.'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0006', 'doi-asserted-by': 'crossref', 'first-page': '8', 'DOI': '10.1016/j.fshw.2018.12.001', 'article-title': 'Oral microbiota: a new view of body health', 'volume': '8', 'author': 'Lu', 'year': '2019', 'journal-title': 'Food Science and Human Wellness'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0007', 'first-page': '1', 'article-title': 'Impact of COVID-19 on the oral health of adults in Wuhan and China: ' 'results of a nationwide online cross-sectional questionnaire survey', 'volume': '211', 'author': 'Zhang', 'year': '2021', 'journal-title': 'BMC Oral Health'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0008', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s12903-020-01274-5', 'article-title': 'Oral hygiene habits and possible transmission of COVID-19 among ' 'cohabitants', 'volume': '20', 'author': 'González-Olmo', 'year': '2020', 'journal-title': 'BMC Oral Health'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0009', 'doi-asserted-by': 'crossref', 'first-page': 'e369', 'DOI': '10.4317/jced.57798', 'article-title': 'Does the use of face masks during the COVID-19 pandemic impact on oral ' 'hygiene habits, oral conditions, reasons to seek dental care and ' 'esthetic concerns?', 'volume': '13', 'author': 'Pinzan-Vercelino', 'year': '2021', 'journal-title': 'J Clin Exp Dent'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0010', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.jebdp.2021.101584', 'article-title': 'In vivo evaluation of the virucidal efficacy of chlorhexidine and ' 'povidone-iodine mouthwashes against salivary SARS-CoV-2. A ' 'randomized-controlled clinical trial', 'volume': '21', 'author': 'Elzein', 'year': '2021', 'journal-title': 'J Evid Based Dent Pract'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0011', 'doi-asserted-by': 'crossref', 'first-page': '5059', 'DOI': '10.1007/s00405-021-06873-8', 'article-title': 'Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a ' 'clinical pilot study', 'volume': '278', 'author': 'Schürmann', 'year': '2021', 'journal-title': 'Eur Arch Otorhinolaryngol'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0012', 'doi-asserted-by': 'crossref', 'DOI': '10.1080/20002297.2020.1794363', 'article-title': 'Antiviral mouthwashes: possible benefit for COVID-19 with ' 'evidence-based approach', 'volume': '12', 'author': 'Moosavi', 'year': '2020', 'journal-title': 'J Oral Microbiol'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0013', 'doi-asserted-by': 'crossref', 'first-page': '635', 'DOI': '10.1016/j.adaj.2021.12.007', 'article-title': 'The effect of mouthrinses on severe acute respiratory syndrome ' 'coronavirus 2 viral load: a systematic review', 'volume': '153', 'author': 'Silva', 'year': '2022', 'journal-title': 'J Am Dent Assoc'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0014', 'article-title': 'Toothbrushing with a dentifrice containing antimicrobial phthalocyanine ' 'derivative for the intraoral reduction of viral load of SARS-CoV-2: a ' 'pilot study', 'author': 'Poleti', 'year': '2021', 'journal-title': 'Res Sq. Preprint (version 1)'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0015', 'doi-asserted-by': 'crossref', 'first-page': '269', 'DOI': '10.2147/CCIDE.S315419', 'article-title': 'Virucidal activity of the antiseptic mouthwash and dental gel ' 'containing anionic phthalocyanine derivative: in vitro study', 'volume': '13', 'author': 'Santos', 'year': '2021', 'journal-title': 'Clin Cosmet Investig Dent'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0016', 'doi-asserted-by': 'crossref', 'first-page': '111', 'DOI': '10.31080/ASDS.2020.04.0991', 'article-title': 'A recommendation of PHTALOX mouthwash for preventing infection and ' 'progression of COVID-19', 'volume': '4', 'author': 'Santos', 'year': '2020', 'journal-title': 'Acta Scient Dent Sci'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0017', 'doi-asserted-by': 'crossref', 'first-page': '5059', 'DOI': '10.1007/s00405-021-06873-8', 'article-title': 'Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a ' 'clinical pilot study', 'volume': '278', 'author': 'Schürmann', 'year': '2021', 'journal-title': 'Eur Arch Otorhinolaryngol'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0018', 'doi-asserted-by': 'crossref', 'first-page': '515', 'DOI': '10.1590/S1678-77572010000500015', 'article-title': 'Staining and calculus formation after 0.12% chlorhexidine rinses in ' 'plaque-free and plaque covered surfaces: a randomized trial', 'volume': '18', 'author': 'Zanatta', 'year': '2010', 'journal-title': 'J Appl Oral Sci'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0019', 'first-page': '1', 'article-title': 'Adjuvant use of phthalocyanine derivative for calculus control', 'volume': '12', 'author': 'Santos', 'year': '2021', 'journal-title': 'Int J Case Rep Images'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0020', 'article-title': 'The use of antiviral phthalocyanine mouthwash as a preventive measure ' 'against COVID-19', 'volume': '16', 'author': 'Vilhena', 'year': '2021', 'journal-title': 'GMS Hyg Infect Control'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0021', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1038/s41598-021-99013-5', 'article-title': 'Beneficial effects of a mouthwash containing an antiviral ' 'phthalocyanine derivative on the length of hospital stay for COVID-19: ' 'randomized trial', 'volume': '11', 'author': 'da Silva Santos', 'year': '2021', 'journal-title': 'Sci Rep'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0022', 'doi-asserted-by': 'crossref', 'first-page': '47', 'DOI': '10.2147/CCIDE.S295423', 'article-title': 'A phthalocyanine derivate mouthwash to gargling/rinsing as an option to ' 'reduce clinical symptoms of COVID-19: case series', 'volume': '13', 'author': 'BdF', 'year': '2021', 'journal-title': 'Clin Cosmet Investig Dent'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0023', 'doi-asserted-by': 'crossref', 'first-page': '67', 'DOI': '10.4067/S0718-381X2021000100067', 'article-title': 'Oral manifestation COVID-19 and the rapid resolution of symptoms ' 'post-phtalox treatment: a case series', 'volume': '15', 'author': 'BdF', 'year': '2021', 'journal-title': 'Int J Odontostomat'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0024', 'doi-asserted-by': 'crossref', 'first-page': '28', 'DOI': '10.1016/j.ijsu.2011.10.001', 'article-title': 'CONSORT 2010 explanation and elaboration: updated guidelines for ' 'reporting parallel group randomised trials', 'volume': '10', 'author': 'Moher', 'year': '2012', 'journal-title': 'Int J Surg'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0025', 'doi-asserted-by': 'crossref', 'first-page': '1037', 'DOI': '10.1038/s41591-020-0916-2', 'article-title': 'Real-time tracking of self-reported symptoms to predict potential ' 'COVID-19', 'volume': '26', 'author': 'Menni', 'year': '2020', 'journal-title': 'Nat Med'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0026', 'first-page': '662', 'article-title': 'Advanced statistics: missing data in clinical research – part 1: an ' 'introduction and conceptual framework', 'volume': '14', 'author': 'Haukoos', 'year': '2007', 'journal-title': 'Acad Emerg Med'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0027', 'series-title': 'Critical Thinking in Clinical Research: Applied Theory and Practice ' 'Using Case Studies', 'author': 'Fregni', 'year': '2018'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0028', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.3390/ijms22126527', 'article-title': 'SARS-CoV-2 infection and significance of oral health management in the ' 'era of “the new normal with COVID-19″', 'volume': '22', 'author': 'Imai', 'year': '2021', 'journal-title': 'Int J Mol Sci'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0029', 'doi-asserted-by': 'crossref', 'first-page': 'e14578', 'DOI': '10.1111/dth.14578', 'article-title': 'Oral manifestations of COVID-19 disease: a review article', 'volume': '34', 'author': 'Iranmanesh', 'year': '2021', 'journal-title': 'Dermatol Ther'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0030', 'first-page': '1', 'article-title': 'The impact of oral health status on COVID-19 severity, recovery period ' 'and C-reactive protein values', 'author': 'Kamel', 'year': '2021', 'journal-title': 'Br Dent J'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0031', 'first-page': '1398', 'article-title': 'COVID-19 and Periodontitis: a reality to live with', 'volume': '21', 'author': 'Jafer', 'year': '2020', 'journal-title': 'J Contemp Dent Pract'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0032', 'doi-asserted-by': 'crossref', 'first-page': '971', 'DOI': '10.1038/s41415-020-1747-8', 'article-title': 'Could there be a link between oral hygiene and the severity of ' 'SARS-CoV-2 infections?', 'volume': '228', 'author': 'Sampson', 'year': '2020', 'journal-title': 'Br Dent J'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0033', 'doi-asserted-by': 'crossref', 'first-page': '302', 'DOI': '10.1016/j.amepre.2005.06.013', 'article-title': 'Prevention of upper respiratory tract infections by gargling: a ' 'randomized trial', 'volume': '29', 'author': 'Satomura', 'year': '2005', 'journal-title': 'Am J Prev Med'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0034', 'doi-asserted-by': 'crossref', 'first-page': '32', 'DOI': '10.1159/000057722', 'article-title': 'Prevention of respiratory infections by povidone-iodine gargle', 'volume': '204', 'author': 'Nagatake', 'year': '2002', 'journal-title': 'Dermatology'}, { 'key': '10.1016/j.jebdp.2022.101777_bib0035', 'doi-asserted-by': 'crossref', 'first-page': '1663', 'DOI': '10.1016/j.cgh.2020.04.001', 'article-title': 'Diarrhea during COVID-19 infection: pathogenesis, epidemiology, ' 'prevention, and management', 'volume': '18', 'author': "D'Amico", 'year': '2020', 'journal-title': 'Clin Gastroenterol Hepatol'}], 'container-title': 'Journal of Evidence-Based Dental Practice', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S1532338222001002?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S1532338222001002?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2023, 4, 15]], 'date-time': '2023-04-15T01:27:54Z', 'timestamp': 1681522074000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1532338222001002'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 12]]}, 'references-count': 35, 'journal-issue': {'issue': '4', 'published-print': {'date-parts': [[2022, 12]]}}, 'alternative-id': ['S1532338222001002'], 'URL': 'http://dx.doi.org/10.1016/j.jebdp.2022.101777', 'relation': {}, 'ISSN': ['1532-3382'], 'subject': ['General Dentistry'], 'container-title-short': 'Journal of Evidence-Based Dental Practice', 'published': {'date-parts': [[2022, 12]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'USE OF MOUTHWASH AND DENTIFRICE CONTAINING AN ANTIMICROBIAL PHTHALOCYANINE ' 'DERIVATIVE FOR THE REDUCTION OF CLINICAL SYMPTOMS OF COVID-19: A RANDOMIZED ' 'TRIPLE-BLIND CLINICAL TRIAL', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Journal of Evidence-Based Dental Practice', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.jebdp.2022.101777', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2022 Elsevier Inc. All rights reserved.', 'name': 'copyright', 'label': 'Copyright'}], 'article-number': '101777'}