Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial Ein viruzides Phthalocyanin-basiertes Mundspül-/Gurgelprotokoll zur Reduzierung des Erkrankungsrisikos durch COVID-19: eine Bevölkerungsstudie
Caroline Verônica, Brito-Reia, Fabiano Vieira, Heitor Marques, Lucas Marques, Costa Alves, Paulo Frazão, Paulo Sérgio Da, PhD. MSc. Silva Santos
doi:10.3205/dgkh000426
Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communi-
Competing interests The authors declare that they have no competing interests.
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Brito-Reia, Population-based virucidal phthalocyanine gargling/rinsing
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doi:10.3205/dgkh000395{ 'type': 'article-journal',
'id': 'https://doi.org/10.3205/dgkh000426',
'categories': [ 'COVID-19', 'severe acute respiratory syndrome coronavirus 2', 'antiviral mouthwash',
'population-based study', 'phthalocyanine derivate', 'COVID-19',
'Schweres Akutes Respiratorisches Syndrom-Coronavirus 2', 'antivirale Mundspülung',
'Bevölkerungsstudie', 'Phthalocyanin Derivat', 'Medicine and health'],
'language': 'en',
'author': [ {'family': 'Brito-Reia', 'given': 'Verônica Caroline'},
{'family': 'da Silva Bastos', 'given': 'Roosevelt'},
{'family': 'Vieira Vilhena', 'given': 'Fabiano'},
{'family': 'Marques Honório', 'given': 'Heitor'},
{'family': 'Marques da Costa Alves', 'given': 'Lucas'}, {'family': 'Frazão', 'given': 'Paulo'},
{'family': 'Sérgio da Silva Santos', 'given': 'Paulo'}],
'issued': {'date-parts': [[2022, 12, 6]]},
'abstract': 'Aim: In this community trial, the objective was to evaluate the incidence of coronavirus '
'disease-2019 (COVID-19) cases in two similar communities in three distinct phases: 1 (before '
'the intervention), 2 (during the intervention), and 3 (after the intervention). Methods: The '
'test community received the oral antiseptic intervention (experimental), while the control '
'community did not. The official information agency (“Statewise System for Data Analysis”) '
'provided the number of confirmed COVID-19 cases. Data were analyzed according to the three '
'phases per epidemiological week (epi) using the R Core Team (2021) program. The relative risk '
'and 95% confidence intervals between the cumulative incidence values of the test and control '
'communities were calculated for each period. In the test community, a total of 995 residents '
'over 10 years of age received two bottles containing 600 ml of mouthwash containing antiviral '
'phthalocyanine derivative (APD). The participants were asked to gargle/rinse with of 5 mL of '
'the mouthwash containing ADP 3 to 5 times a day, for 1 min, until the bottles were empty. '
'Results: In phases 1 and 3, the disease risk between the two communities did not differ '
'significantly (p>0.05), while in phase 2, the disease risk was 54% lower in the test '
'community than in the control community. Conclusion: The use of the APD mouthwash protocol '
'seems to reduce the COVID-19 incidence at the population level, and further studies are '
'needed to confirm its protective effect under more precisely controlled conditions.',
'DOI': '10.3205/DGKH000426',
'publisher': 'German Medical Science GMS Publishing House',
'title': 'Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of '
'coronavirus disease-2019: a community trial',
'URL': 'https://www.egms.de/en/journals/dgkh/2022-17/dgkh000426.shtml',
'copyright': 'Creative Commons Attribution 4.0 International'}
