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0 0.5 1 1.5 2+ Case 54% Improvement Relative Risk Phthalocyanine  Brito-Reia et al.  Prophylaxis Does phthalocyanine reduce COVID-19 infections? Prospective study of 5,040 patients in Brazil Fewer cases with phthalocyanine (not stat. sig., p=0.076) Brito-Reia et al., German Medical Scie.., Nov 2021 Favors phthalocyanine Favors control

Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial

Brito-Reia et al., German Medical Science GMS Publishing House, doi:10.3205/dgkh000426 (date from preprint), RBR-6c9xnw3
Nov 2021  
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Comparison of two similar communities in Brazil, with one using a phthalocyanine derivative mouthwash, suggesting efficacy of the treatment in lowering COVID-19 cases. There was 54% lower risk of confirmed cases during the intervention in the treatment community, compared with 15% higher and 8% lower risk before and after the intervention. Gargle/rinse with 5mL of mouthwash containing phthalocyanine derivative for 1 minute, 3 to 5 times per day.
3 studies use direct respiratory tract administration Brito-Reia, da Silva Santos, Poleti
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
risk of case, 54.0% lower, RR 0.46, p = 0.08, treatment 6 of 1,153 (0.5%), control 44 of 3,887 (1.1%), NNT 164.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Brito-Reia et al., 15 Nov 2021, prospective, Brazil, peer-reviewed, 7 authors, trial RBR-6c9xnw3.
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AI generated summary. Current AI models can provide useful summaries for non-experts, but may be inaccurate and have limited ability to analyze larger context such as the entire evidence base for phthalocyanine.

A mouthwash containing an antiviral phthalocyanine derivative (APD) was found to significantly reduce the incidence of COVID-19 in a community trial.

  • The article is about a community trial that was conducted in Brazil to evaluate the effectiveness of a mouthwash containing an antiviral phthalocyanine derivative (APD) in reducing the incidence of COVID-19.
  • The trial involved two similar communities, one of which received the APD mouthwash and the other of which did not.
  • The results showed that the incidence of COVID-19 was significantly lower in the community that received the APD mouthwash.
  • The authors concluded that the APD mouthwash may be an effective way to reduce the risk of COVID-19.

Here are some additional details from the article:

  • The APD mouthwash was used twice a day for 1 month.
  • The incidence of COVID-19 was 54% lower in the community that received the APD mouthwash than in the community that did not.
  • The APD mouthwash was well-tolerated by all participants.

The authors of the article note that further studies are needed to confirm the effectiveness of the APD mouthwash in preventing COVID-19. However, the results of this study suggest that it may be an effective way to reduce the risk of this disease.

Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial Ein viruzides Phthalocyanin-basiertes Mundspül-/Gurgelprotokoll zur Reduzierung des Erkrankungsrisikos durch COVID-19: eine Bevölkerungsstudie
Caroline Verônica, Brito-Reia, Fabiano Vieira, Heitor Marques, Lucas Marques, Costa Alves, Paulo Frazão, Paulo Sérgio Da, PhD. MSc. Silva Santos
Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communi-
Competing interests The authors declare that they have no competing interests.
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