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Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial

Brito-Reia et al., German Medical Science GMS Publishing House, doi:10.3205/dgkh000426 (date from preprint), RBR-6c9xnw3
Nov 2021  
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Case 54% Improvement Relative Risk Phthalocyanine  Brito-Reia et al.  Prophylaxis Does phthalocyanine reduce COVID-19 infections? Prospective study of 5,040 patients in Brazil Fewer cases with phthalocyanine (not stat. sig., p=0.076) Brito-Reia et al., German Medical Scie.., Nov 2021 Favorsphthalocyanine Favorscontrol 0 0.5 1 1.5 2+
30th treatment shown to reduce risk in December 2021
*, now with p = 0.00019 from 4 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
Comparison of two similar communities in Brazil, with one using a phthalocyanine derivative mouthwash, suggesting efficacy of the treatment in lowering COVID-19 cases. There was 54% lower risk of confirmed cases during the intervention in the treatment community, compared with 15% higher and 8% lower risk before and after the intervention. Gargle/rinse with 5mL of mouthwash containing phthalocyanine derivative for 1 minute, 3 to 5 times per day.
3 studies use direct respiratory tract administration1-3
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
risk of case, 54.0% lower, RR 0.46, p = 0.08, treatment 6 of 1,153 (0.5%), control 44 of 3,887 (1.1%), NNT 164.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Brito-Reia et al., 15 Nov 2021, prospective, Brazil, peer-reviewed, 7 authors, trial RBR-6c9xnw3. Contact:
This PaperPhthalocyanineAll
Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial Ein viruzides Phthalocyanin-basiertes Mundspül-/Gurgelprotokoll zur Reduzierung des Erkrankungsrisikos durch COVID-19: eine Bevölkerungsstudie
Caroline Verônica, Brito-Reia, Fabiano Vieira, Heitor Marques, Lucas Marques, Costa Alves, Paulo Frazão, Paulo Sérgio Da, PhD. MSc. Silva Santos
Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communi-
Competing interests The authors declare that they have no competing interests.
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Brito-Reia, Population-based virucidal phthalocyanine gargling/rinsing
Brito-Reia, Population-based virucidal phthalocyanine gargling/rinsing
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{ 'type': 'article-journal', 'id': '', 'categories': [ 'COVID-19', 'severe acute respiratory syndrome coronavirus 2', 'antiviral mouthwash', 'population-based study', 'phthalocyanine derivate', 'COVID-19', 'Schweres Akutes Respiratorisches Syndrom-Coronavirus 2', 'antivirale Mundspülung', 'Bevölkerungsstudie', 'Phthalocyanin Derivat', 'Medicine and health'], 'language': 'en', 'author': [ {'family': 'Brito-Reia', 'given': 'Verônica Caroline'}, {'family': 'da Silva Bastos', 'given': 'Roosevelt'}, {'family': 'Vieira Vilhena', 'given': 'Fabiano'}, {'family': 'Marques Honório', 'given': 'Heitor'}, {'family': 'Marques da Costa Alves', 'given': 'Lucas'}, {'family': 'Frazão', 'given': 'Paulo'}, {'family': 'Sérgio da Silva Santos', 'given': 'Paulo'}], 'issued': {'date-parts': [[2022, 12, 6]]}, 'abstract': 'Aim: In this community trial, the objective was to evaluate the incidence of coronavirus ' 'disease-2019 (COVID-19) cases in two similar communities in three distinct phases: 1 (before ' 'the intervention), 2 (during the intervention), and 3 (after the intervention). Methods: The ' 'test community received the oral antiseptic intervention (experimental), while the control ' 'community did not. The official information agency (“Statewise System for Data Analysis”) ' 'provided the number of confirmed COVID-19 cases. Data were analyzed according to the three ' 'phases per epidemiological week (epi) using the R Core Team (2021) program. The relative risk ' 'and 95% confidence intervals between the cumulative incidence values of the test and control ' 'communities were calculated for each period. In the test community, a total of 995 residents ' 'over 10 years of age received two bottles containing 600 ml of mouthwash containing antiviral ' 'phthalocyanine derivative (APD). The participants were asked to gargle/rinse with of 5 mL of ' 'the mouthwash containing ADP 3 to 5 times a day, for 1 min, until the bottles were empty. ' 'Results: In phases 1 and 3, the disease risk between the two communities did not differ ' 'significantly (p>0.05), while in phase 2, the disease risk was 54% lower in the test ' 'community than in the control community. Conclusion: The use of the APD mouthwash protocol ' 'seems to reduce the COVID-19 incidence at the population level, and further studies are ' 'needed to confirm its protective effect under more precisely controlled conditions.', 'DOI': '10.3205/DGKH000426', 'publisher': 'German Medical Science GMS Publishing House', 'title': 'Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of ' 'coronavirus disease-2019: a community trial', 'URL': '', 'copyright': 'Creative Commons Attribution 4.0 International'}
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