Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial
et al., German Medical Science GMS Publishing House, doi:10.3205/dgkh000426, RBR-6c9xnw3, Nov 2021 (preprint)
33rd treatment shown to reduce risk in
December 2021, now with p = 0.00019 from 4 studies.
No treatment is 100% effective. Protocols
combine treatments.
6,300+ studies for
210+ treatments. c19early.org
|
Comparison of two similar communities in Brazil, with one using a phthalocyanine derivative mouthwash, suggesting efficacy of the treatment in lowering COVID-19 cases. There was 54% lower risk of confirmed cases during the intervention in the treatment community, compared with 15% higher and 8% lower risk before and after the intervention. Gargle/rinse with 5mL of mouthwash containing phthalocyanine derivative for 1 minute, 3 to 5 times per day.
Targeted administration to the respiratory tract provides treatment directly
to the typical source of initial SARS-CoV-2 infection and replication, and
allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.
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risk of case, 54.0% lower, RR 0.46, p = 0.08, treatment 6 of 1,153 (0.5%), control 44 of 3,887 (1.1%), NNT 164.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
1.
Poleti et al., Use of mouthwash and dentifrice containing antimicrobial phthalocyanine derivative for the reduction of clinical symptoms of COVID-19: A randomized triple-blinded clinical trial, Journal of Evidence-Based Dental Practice, doi:10.1016/j.jebdp.2022.101777.
Brito-Reia et al., 15 Nov 2021, prospective, Brazil, peer-reviewed, 7 authors, trial RBR-6c9xnw3.
Contact: veronicabr@usp.br.
Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial Ein viruzides Phthalocyanin-basiertes Mundspül-/Gurgelprotokoll zur Reduzierung des Erkrankungsrisikos durch COVID-19: eine Bevölkerungsstudie
doi:10.3205/dgkh000426
Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communi-
Competing interests The authors declare that they have no competing interests.
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DOI record:
{
"DOI": "10.3205/DGKH000426",
"URL": "https://www.egms.de/en/journals/dgkh/2022-17/dgkh000426.shtml",
"abstract": "Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communities in three distinct phases: 1 (before the intervention), 2 (during the intervention), and 3 (after the intervention). Methods: The test community received the oral antiseptic intervention (experimental), while the control community did not. The official information agency (“Statewise System for Data Analysis”) provided the number of confirmed COVID-19 cases. Data were analyzed according to the three phases per epidemiological week (epi) using the R Core Team (2021) program. The relative risk and 95% confidence intervals between the cumulative incidence values of the test and control communities were calculated for each period. In the test community, a total of 995 residents over 10 years of age received two bottles containing 600 ml of mouthwash containing antiviral phthalocyanine derivative (APD). The participants were asked to gargle/rinse with of 5 mL of the mouthwash containing ADP 3 to 5 times a day, for 1 min, until the bottles were empty. Results: In phases 1 and 3, the disease risk between the two communities did not differ significantly (p>0.05), while in phase 2, the disease risk was 54% lower in the test community than in the control community. Conclusion: The use of the APD mouthwash protocol seems to reduce the COVID-19 incidence at the population level, and further studies are needed to confirm its protective effect under more precisely controlled conditions.",
"author": [
{
"family": "Brito-Reia",
"given": "Verônica Caroline"
},
{
"family": "da Silva Bastos",
"given": "Roosevelt"
},
{
"family": "Vieira Vilhena",
"given": "Fabiano"
},
{
"family": "Marques Honório",
"given": "Heitor"
},
{
"family": "Marques da Costa Alves",
"given": "Lucas"
},
{
"family": "Frazão",
"given": "Paulo"
},
{
"family": "Sérgio da Silva Santos",
"given": "Paulo"
}
],
"categories": [
"COVID-19",
"severe acute respiratory syndrome coronavirus 2",
"antiviral mouthwash",
"population-based study",
"phthalocyanine derivate",
"COVID-19",
"Schweres Akutes Respiratorisches Syndrom-Coronavirus 2",
"antivirale Mundspülung",
"Bevölkerungsstudie",
"Phthalocyanin Derivat",
"Medicine and health"
],
"copyright": "Creative Commons Attribution 4.0 International",
"id": "https://doi.org/10.3205/dgkh000426",
"issued": {
"date-parts": [
[
2022,
12,
6
]
]
},
"language": "en",
"publisher": "German Medical Science GMS Publishing House",
"title": "Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial",
"type": "article-journal"
}