All Studies Meta Analysis Recent:

Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial

Brito-Reia et al., German Medical Science GMS Publishing House, doi:10.3205/dgkh000426 (date from preprint), RBR-6c9xnw3

Nov 2021

Post
Facebook

Source PDF All Meta

Phthalocyanine

29th treatment shown to reduce risk in December 2021

^*, now known with p = 0.00019 from 4 studies.

Lower risk for ICU admission, hospitalization, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

Comparison of two similar communities in Brazil, with one using a phthalocyanine derivative mouthwash, suggesting efficacy of the treatment in lowering COVID-19 cases. There was 54% lower risk of confirmed cases during the intervention in the treatment community, compared with 15% higher and 8% lower risk before and after the intervention. Gargle/rinse with 5mL of mouthwash containing phthalocyanine derivative for 1 minute, 3 to 5 times per day.

3 studies use direct respiratory tract administration Brito-Reia, da Silva Santos, Poleti

Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects.

Important missing comments or errors? Let us know.

risk of case, 54.0% lower, RR 0.46, p = 0.08, treatment 6 of 1,153 (0.5%), control 44 of 3,887 (1.1%), NNT 164.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

1. Brito-Reia et al., Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial, German Medical Science GMS Publishing House, doi:10.3205/dgkh000426.egms.de, doi.org.

2. da Silva Santos et al., Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: randomised trial, Scientific Reports, doi:10.1038/s41598-021-99013-5.nature.com, doi.org.

3. Poleti et al., Use of mouthwash and dentifrice containing antimicrobial phthalocyanine derivative for the reduction of clinical symptoms of COVID-19: A randomized triple-blinded clinical trial, Journal of Evidence-Based Dental Practice, doi:10.1016/j.jebdp.2022.101777.sciencedirect.com, doi.org.

Brito-Reia et al., 15 Nov 2021, prospective, Brazil, peer-reviewed, 7 authors, trial RBR-6c9xnw3. Contact: veronicabr@usp.br.

This Paper Phthalocyanine All

AI generated summary. Current AI models can provide useful summaries for non-experts, but may be inaccurate and have limited ability to analyze larger context such as the entire evidence base for phthalocyanine.

A mouthwash containing an antiviral phthalocyanine derivative (APD) was found to significantly reduce the incidence of COVID-19 in a community trial.

The article is about a community trial that was conducted in Brazil to evaluate the effectiveness of a mouthwash containing an antiviral phthalocyanine derivative (APD) in reducing the incidence of COVID-19.
The trial involved two similar communities, one of which received the APD mouthwash and the other of which did not.
The results showed that the incidence of COVID-19 was significantly lower in the community that received the APD mouthwash.
The authors concluded that the APD mouthwash may be an effective way to reduce the risk of COVID-19.

Here are some additional details from the article:

The APD mouthwash was used twice a day for 1 month.
The incidence of COVID-19 was 54% lower in the community that received the APD mouthwash than in the community that did not.
The APD mouthwash was well-tolerated by all participants.

The authors of the article note that further studies are needed to confirm the effectiveness of the APD mouthwash in preventing COVID-19. However, the results of this study suggest that it may be an effective way to reduce the risk of this disease.

Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial Ein viruzides Phthalocyanin-basiertes Mundspül-/Gurgelprotokoll zur Reduzierung des Erkrankungsrisikos durch COVID-19: eine Bevölkerungsstudie

Caroline Verônica, Brito-Reia, Fabiano Vieira, Heitor Marques, Lucas Marques, Costa Alves, Paulo Frazão, Paulo Sérgio Da, PhD. MSc. Silva Santos

doi:10.3205/dgkh000426

Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communi-

Competing interests The authors declare that they have no competing interests.

References

Ausina-Márquez, Ferrer, Oral antiseptics against coronavirus: in-vitro and clinical evidence, J Hosp Infect, doi:10.1016/j.jhin.2021.04.004

Brito-Reia, Population-based virucidal phthalocyanine gargling/rinsing

Burton, Clarkson, Goulao, Glenny, Mcbain et al., Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them, Cochrane Database Syst Rev, doi:10.1002/14651858.CD013627.pub2

Carrouel, Conte, Fisher, Gonçalves, Dussart et al., COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression, J Clin Med, doi:10.3390/jcm9041126

Carrouel, Gonçalves, Conte, Campus, Fisher et al., Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2, J Dent Res, doi:10.1177/0022034520967933

Carrouel, Valette, Gadea, Esparcieux, Illes et al., Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial, Clin Microbiol Infect, doi:10.1016/j.cmi.2021.05.028

Casale, Rinaldi, Sabatino, Moffa, Ciccozzi, Could nasal irrigation and oral rinse reduce the risk for COVID-19 infection?, Int J Immunopathol Pharmacol, doi:10.1177/2058738420941757

Chaudhary, Melkonyan, Meethil, Saraswat, Hall et al., Estimating salivary carriage of severe acute respiratory syndrome coronavirus 2 in nonsymptomatic people and efficacy of mouthrinse in reducing viral load: A randomized controlled trial, J Am Dent Assoc, doi:10.1016/j.adaj.2021.05.021

Choudhury, Shabnam, Ahsan, Kabir, Khan et al., Effect of 1?% povidone iodine mouthwash/gargle, nasal and eye drop in COVID -19 patient, Biores Comm, doi:10.3329/brc.v7i1.54245

Da Fonseca Orcina, Vilhena, De Oliveira, Da, Alves et al., A Phthalocyanine Derivate Mouthwash to Gargling/Rinsing as an Option to Reduce Clinical Symptoms of COVID-19: Case Series, Clin Cosmet Investig Dent, doi:10.2147/CCIDE.S295423

Da, Santos, Da Fonseca Orcina, Da, Alves, A recommendation of PHTALOX® mouthwash for preventing infection and progression of COVID-19, Acta Scient Dent Sci, doi:10.31080/ASDS.2020.04.0991

Da, Santos, Da Fonseca Orcina, Machado, Vilhena et al., Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: randomised trial, Sci Rep, doi:10.1038/s41598-021-99013-5

De Almeida, Pronunciate, Grotto, Pugliesi, Guimarães et al., Two hundred days of COVID-19 in São Paulo State, Brazil, Epidemiol Infect, doi:10.1017/S0950268820002927

Eduardo, Corrêa, Heller, Daep, Benitez et al., Salivary SARS-CoV-2 load reduction with mouthwash use: A randomized pilot clinical trial, Heliyon, doi:10.1016/j.heliyon.2021.e07346

Encinar, Menendez, Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2'-O-Methylation of Viral RNA, Viruses, doi:10.3390/v12050525

Fernandes Matuck, Dolhnikoff, Maia, Sendyk, Zarpellon et al., Periodontal tissues are targets for Sars-Cov-2: a post-mortem study, J Oral Microbiol, doi:10.1080/20002297.2020.18481357/8

Fortaleza, Guimarães, Catão, Ferreira, Berg De Almeida et al., The use of health geography modeling to understand early dispersion of COVID-19 in São Paulo, Brazil, PLoS One, doi:10.1371/journal.pone.0245051

Gao, Xu, Sun, Wang, Guo et al., A systematic review of asymptomatic infections with COVID-19, J Microbiol Immunol Infect, doi:10.1016/j.jmii.2020.05.001

Justo, Bueno, Barbosa, Perosa, Carvalho et al., Comparison of viral load between saliva and nasopharyngeal swabs for SARS-CoV2: the role of days of symptoms onset on diagnosis, Mem Inst Oswaldo Cruz, doi:10.1590/0074-02760210018

Konishi, Saito, Ishikawa, Kanai, Igei, How Did Japan Cope with COVID-19? Big Data and Purchasing Behavior, Asian Econ Papers, doi:10.1162/asep_a_00797

Kramer, Eggers, Hübner, Walger, Steinmann et al., Virucidal gargling and virucidal nasal spray, GMS Hyg Infect Control, doi:10.3205/dgkh000373

Lamas, Dios, Rodríguez, Campo Pérez, Alvargonzalez et al., Is povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests, Oral Dis, doi:10.1111/odi.13526

Matuck, Dolhnikoff, Duarte-Neto, Maia, Gomes et al., Salivary glands are a target for SARS-CoV-2: a source for saliva contamination, J Pathol, doi:10.1002/path.5679

Mohamed, Baharom, Sulaiman, Rashid, Early viral clearance among covid-19 patients when gargling with povidone-iodine and essential oils: a pilot clinical trial

Nagatake, Ahmed, Oishi, Prevention of respiratory infections by povidone-iodine gargle, Dermatology, doi:10.1159/000057722

Orcina, Santos, Oral manifestation COVID-19 and the rapid resolution of symptoms post-phtalox treatment: a case series, Int J Odontostomat

Peng, Xu, Li, Cheng, Zhou et al., Transmission routes of 2019-nCoV and controls in dental practice, Int J Oral Sci, doi:10.1038/s41368-020-0075-9

Santos, Da Fonseca Orcina, Reia, Ribeiro, Grotto et al., Virucidal Activity of the Antiseptic Mouthwash and Dental Gel Containing Anionic Phthalocyanine Derivative: In vitro Study, GMS Hygiene and Infection Control, doi:10.2147/CCIDE.S3154196/8

Tashiro, Shaw, COVID-19 Pandemic response in Japan: what is behind the initial flattening of the curve? Sustainability, doi:10.3390/su12135250

Teodoro, Santos, Campos, Koga-Ito, Sibelino et al., PHTALOX® antimicrobial action and cytotoxicity: in vitro study

To, Tsang, Yip, Chan, Wu et al., Consistent Detection of 2019 Novel Coronavirus in Saliva, Clin Infect Dis, doi:10.1093/cid/ciaa149

Vilhena, Reia, Da Fonseca Orcina, Santos, Zangrando et al., The use of antiviral Phthalocyanine mouthwash as a preventive measure against COVID-19, GMS Hyg Infect Control, doi:10.3205/dgkh000395

Wu, Zhao, Yu, Chen, Song et al., A new coronavirus associated with human respiratory disease in China, Nature, doi:10.1038/s41586-020-2008-3

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0