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Lifestyle, course of COVID-19, and risk of Long-COVID in non-hospitalized patients

Pływaczewska-Jakubowska et al., Frontiers in Medicine, doi:10.3389/fmed.2022.1036556
Oct 2022  
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Moderate/severe case 11% Improvement Relative Risk PASC 14% Exercise  Pływaczewska-Jakubowska et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 1,847 patients in Poland (May 2020 - January 2022) Fewer moderate/severe cases (p=0.3) and lower PASC (p=0.24), not sig. c19early.org Pływaczewska-Jakubowska et al., Fronti.., Oct 2022 Favorsexercise Favorsinactivity 0 0.5 1 1.5 2+
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 68 studies.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 110 treatments. c19early.org
Retrospective 1,847 COVID+ patients in Poland, showing no significant difference in moderate/severe cases with physical activity. Hospitalized patients were excluded.
Study covers exercise and sleep.
risk of moderate/severe case, 11.0% lower, OR 0.89, p = 0.30, high activity levels 490, low activity levels 1,357, adjusted per study, multivariable, model 3, RR approximated with OR.
risk of PASC, 14.0% lower, OR 0.86, p = 0.24, high activity levels 389, low activity levels 1,128, adjusted per study, multivariable, model 3, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pływaczewska-Jakubowska et al., 24 Oct 2022, retrospective, Poland, peer-reviewed, median age 51.0, 5 authors, study period May 2020 - January 2022. Contact: joanna.kapusta@umed.lodz.pl, ma.babicki@gmail.com.
This PaperExerciseAll
Lifestyle, course of COVID-, and risk of Long-COVID in non-hospitalized patients
Zhongwei Huang, Mohammad Javad Nasiri, Abdulqadir J Nashwan, Joanna Kapusta, Magdalena Pływaczewska-Jakubowska, Michał Chudzik, Mateusz Babicki, Piotr Jankowski
Introduction: The coronavirus disease (COVID) pandemic remains a great challenge for the healthcare system. The widely reported prolonged signs and symptoms resulting from severe acute respiratory syndrome coronavirus (SARS-CoV-) infection (Long-COVID) require medical care. The aim of the study was to assess factors, including lifestyle variables, related to the course of COVID-infection and to assess their impact on prolonged symptoms in non-hospitalized patients with COVID-. Methods: A total of , ( men and , women) non-hospitalized participants of the STOP-COVID registry of the PoLoCOV-Study who, following the COVID-, underwent check-up examinations at the cardiology outpatient clinic were included in the analysis. Results: The study participants (median age [ -] years) were evaluated at . ( . -. ) weeks following the diagnosis of COVID-. Female sex (odds ratio [OR] . [ % CI . -. ]), body mass index (BMI; per kg/m : . [ . -. ]), hypertension ( . [ . -. ]), asthma ( . [ . -. ]), stress or overworking ( . [ . -. ]), and nightshift work ( . [ . -. ]) were independently related to the severity of symptoms during acute phase of the COVID-infection. The Long-COVID syndrome was independently related to the female sex ( . [ . -. ]), history of myocardial infarction ( . [ . -. ]), asthma ( . [ . -. ]), and severe course of the acute phase of the COVID-infection ( . [ . -. ]). Conclusion: Female sex, BMI, asthma, hypertension, nightshifts, and stress or overworking are significantly related to the severity of the acute phase of the COVID-infection, while female sex, asthma, history of myocardial infarction, and the severity of symptoms in the acute phase of COVID-are the predictors of Long-COVID in non-hospitalized patients. We did not find an independent relation between Long-COVID and the studied lifestyle factors.
we have also observed an association between higher values of BMI and a symptomatic course of COVID-19. Furthermore, it seems that obesity-related chronic inflammations and processes of immunometabolism not only promote a severe clinical course of acute SARS-CoV-2 infection but also contribute to a Long-COVID-19 syndrome (38) . However, we did not confirm this in Ethics statement The studies involving human participants were reviewed and approved by Bioethics Committee of Lodz Regional Medical Chamber-No. 0115/2021. The patients/participants provided their written informed consent to participate in this study. Author contributions Conceptualization: MC and MP-J. Data curation and methodology: MC, MP-J, and PJ. Formal analysis: MB and JK. Investigation, visualization, and writing-review and editing: MC, MP-J, MB, JK, and PJ. Project administration: MC. Supervision and validation: MC and PJ. All authors have read and agreed to the published version of the manuscript. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer,..
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{ 'indexed': { 'date-parts': [[2022, 10, 25]], 'date-time': '2022-10-25T05:08:47Z', 'timestamp': 1666674527064}, 'reference-count': 54, 'publisher': 'Frontiers Media SA', 'license': [ { 'start': { 'date-parts': [[2022, 10, 24]], 'date-time': '2022-10-24T00:00:00Z', 'timestamp': 1666569600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['frontiersin.org'], 'crossmark-restriction': True}, 'abstract': '<jats:sec><jats:title>Introduction</jats:title><jats:p>The coronavirus disease (COVID) 2019 ' 'pandemic remains a great challenge for the healthcare system. The widely reported prolonged ' 'signs and symptoms resulting from severe acute respiratory syndrome coronavirus 2 ' '(SARS-CoV-2) infection (Long-COVID) require medical care. The aim of the study was to assess ' 'factors, including lifestyle variables, related to the course of COVID-19 infection and to ' 'assess their impact on prolonged symptoms in non-hospitalized patients with ' 'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of ' '1,847 (637 men and 1,210 women) non-hospitalized participants of the STOP-COVID registry of ' 'the PoLoCOV-Study who, following the COVID-19, underwent check-up examinations at the ' 'cardiology outpatient clinic were included in the ' 'analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The study ' 'participants (median age 51 [41–62] years) were evaluated at 13.4 (8.4–23.6) weeks following ' 'the diagnosis of COVID-19. Female sex (odds ratio [OR] 1.46 [95% CI 1.19–1.78]), body mass ' 'index (BMI; per 1 kg/m<jats:sup>2</jats:sup>: 1.02 [1.00–1.04]), hypertension (1.39 ' '[1.07–1.81]), asthma (1.55 [1.06–2.27]), stress or overworking (1.54 [1.25–1.90]), and ' 'nightshift work (1.51 [1.06–2.14]) were independently related to the severity of symptoms ' 'during acute phase of the COVID-19 infection. The Long-COVID syndrome was independently ' 'related to the female sex (1.42 [1.13–1.79]), history of myocardial infarction (2.57 ' '[1.04–6.32]), asthma (1.56 [1.01–2.41]), and severe course of the acute phase of the COVID-19 ' 'infection (2.27 ' '[1.82–2.83]).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Female ' 'sex, BMI, asthma, hypertension, nightshifts, and stress or overworking are significantly ' 'related to the severity of the acute phase of the COVID-19 infection, while female sex, ' 'asthma, history of myocardial infarction, and the severity of symptoms in the acute phase of ' 'COVID-19 are the predictors of Long-COVID in non-hospitalized patients. 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Med.', 'published': {'date-parts': [[2022, 10, 24]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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