Diabetes and SARS-CoV-2 Infection: The Potential Role of Antidiabetic Therapy in the Evolution of COVID-19

DOI record: { "DOI": "10.3390/microorganisms11010145", "ISSN": [ "2076-2607" ], "URL": "http://dx.doi.org/10.3390/microorganisms11010145", "abstract": "<jats:p>Diabetes mellitus represents one of the most frequent comorbidities among patients with COVID-19, constituting a risk factor for a more severe prognosis than that of non-diabetic patients. However, the pathophysiological mechanism underlying this unfavorable outcome is still not completely clear. The goal of our study was to evaluate the potential role of antidiabetic therapy in the evolution of COVID-19.</jats:p>", "alternative-id": [ "microorganisms11010145" ], "author": [ { "ORCID": "http://orcid.org/0000-0002-8685-5434", "affiliation": [], "authenticated-orcid": false, "family": "Pinchera", "given": "Biagio", "sequence": "first" }, { "affiliation": [], "family": "Schiano Moriello", "given": "Nicola", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-4378-8366", "affiliation": [], "authenticated-orcid": false, "family": "Buonomo", "given": "Antonio Riccardo", "sequence": "additional" }, { "affiliation": [], "family": "Di Filippo", "given": "Isabella", "sequence": "additional" }, { "affiliation": [], "family": "Tanzillo", "given": "Anastasia", "sequence": "additional" }, { "affiliation": [], "family": "Buzzo", "given": "Giorgio", "sequence": "additional" }, { "affiliation": [], "family": "Villari", "given": "Riccardo", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-5199-8451", "affiliation": [], "authenticated-orcid": false, "family": "Gentile", "given": "Ivan", "sequence": "additional" }, { "affiliation": [], "name": "Federico II COVID Team", "sequence": "additional" } ], "container-title": "Microorganisms", "container-title-short": "Microorganisms", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2023, 1, 6 ] ], "date-time": "2023-01-06T06:48:19Z", "timestamp": 1672987699000 }, "deposited": { "date-parts": [ [ 2023, 1, 6 ] ], "date-time": "2023-01-06T08:04:23Z", "timestamp": 1672992263000 }, "indexed": { "date-parts": [ [ 2023, 1, 7 ] ], "date-time": "2023-01-07T06:06:52Z", "timestamp": 1673071612622 }, "is-referenced-by-count": 0, "issue": "1", "issued": { "date-parts": [ [ 2023, 1, 6 ] ] }, "journal-issue": { "issue": "1", "published-online": { "date-parts": [ [ 2023, 1 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 1, 6 ] ], "date-time": "2023-01-06T00:00:00Z", "timestamp": 1672963200000 } } ], "link": [ { "URL": "https://www.mdpi.com/2076-2607/11/1/145/pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1968", "original-title": [], "page": "145", "prefix": "10.3390", "published": { "date-parts": [ [ 2023, 1, 6 ] ] }, "published-online": { "date-parts": [ [ 2023, 1, 6 ] ] }, "publisher": "MDPI AG", "reference": [ { "DOI": "10.1007/s00125-020-05180-x", "article-title": "Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: The CORONADO study", "author": "Cariou", "doi-asserted-by": "crossref", "first-page": "1500", "journal-title": "Diabetologia", "key": "ref_1", "volume": "63", "year": "2020" }, { "DOI": "10.2337/dc20-0598", "article-title": "Clinical characteristics and risk factors for mortality of COVID-19 patients with diabetes in Wuhan, China: A two-center, retrospective study", "author": "Shi", "doi-asserted-by": "crossref", "first-page": "1382", "journal-title": "Diabetes Care", "key": "ref_2", "volume": "43", "year": "2020" }, { "DOI": "10.1111/dom.14124", "article-title": "Prevalence of comorbidities and their association with mortality in patients with COVID-19: A systematic review and meta-analysis", "author": "Singh", "doi-asserted-by": "crossref", "first-page": "1915", "journal-title": "Diabetes Obes. 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