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0 0.5 1 1.5 2+ Severe case 15% Improvement Relative Risk c19early.org/mf Pinchera et al. Metformin for COVID-19 Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 43 patients in Italy (November 2021 - May 2022) Study compares with insulin, results vs. placebo may differ Lower severe cases with metformin (p=0.048) Pinchera et al., Microorganisms, doi:10.3390/microorganisms11010145 Favors metformin Favors insulin
Diabetes and SARS-CoV-2 Infection: The Potential Role of Antidiabetic Therapy in the Evolution of COVID-19
Pinchera et al., Microorganisms, doi:10.3390/microorganisms11010145
Pinchera et al., Diabetes and SARS-CoV-2 Infection: The Potential Role of Antidiabetic Therapy in the Evolution of COVID-19, Microorganisms, doi:10.3390/microorganisms11010145
Jan 2023   Source   PDF  
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Retrospective 43 diabetes patients hospitalized for COVID-19 in Italy, showing lower risk of severe cases with metformin vs. insulin.
risk of severe case, 15.2% lower, RR 0.85, p = 0.048, treatment 5 of 19 (26.3%), control 14 of 24 (58.3%), NNT 3.1, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pinchera et al., 6 Jan 2023, retrospective, Italy, peer-reviewed, 9 authors, study period November 2021 - May 2022, this trial compares with another treatment - results may be better when compared to placebo.
Contact: biapin89@virgilio.it (corresponding author).
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Abstract: microorganisms Communication Diabetes and SARS-CoV-2 Infection: The Potential Role of Antidiabetic Therapy in the Evolution of COVID-19 Biagio Pinchera * , Nicola Schiano Moriello, Antonio Riccardo Buonomo , Isabella Di Filippo, Anastasia Tanzillo, Giorgio Buzzo, Riccardo Villari, Ivan Gentile and Federico II COVID Team Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy * Correspondence: biapin89@virgilio.it Abstract: Diabetes mellitus represents one of the most frequent comorbidities among patients with COVID-19, constituting a risk factor for a more severe prognosis than that of non-diabetic patients. However, the pathophysiological mechanism underlying this unfavorable outcome is still not completely clear. The goal of our study was to evaluate the potential role of antidiabetic therapy in the evolution of COVID-19. Keywords: COVID-19; SARS-CoV-2; diabetes; insulin; metformin; mTOR
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