Utilidad de los enjuagues con povidona yodada y peróxido de hidrógeno en pacientes con COVID-19
Daniel Pablo-Marcos, Beatriz Abascal, Lara Lloret, Manuel Gutiérrez Cuadra, Nieves Velasco, Carmen Valero
Enfermedades Infecciosas y Microbiología Clínica, doi:10.1016/j.eimc.2021.10.005
Introduction: Povidone-iodine and hydrogen peroxide could be effective in against SARS-CoV-2. Methods: A "non-interventional trial" in 88 patients (43 ± 17 yrs., 55% men) with SARS-CoV-2 in nasopharyngeal swabs (RT-PCR). 31 received mouth rinses/gargling with povidone-iodine (every 8 h, two consecutive days), 17 with mouth rinses/gargling of hydrogen peroxide, and 40 controls. Were repeated PCR in 3, 11 and 17 days. Results: After intervention the viral load (Log10 copies/ml) remained similar in povidone-iodine (4.3 ± 2.7 copies/ml), hydrogen peroxide (4.6 ± 2.9 copies/ml; p = 0.40) and controls (4.4 ± 3.0 copies/ml). The percentage of patients with a negative result in the second PCR was 27% in povidone-iodine group, 23% in hydrogen peroxide and 32% in controls; in the third PCR, 62%, 54% y 58% respectively; and in the fourth PCR, 81%, 75% y 81%. Conclusion: Our results do not support the clinical usefulness of mouth rinses/gargling with povidoneiodine or hydrogen peroxide in patients with COVID-19.
G Model We only found one other study, without a control group, in 12 hospitalised COVID-19 patients who received H 2 O 2 (1%) mouth rinses, with no change in their oropharyngeal viral load at 30 min 13 . Our study has limitations, as it is not randomised. However, we included a large number of patients with a control group and evaluated the utility of two commonly used oral antiseptics. We conclude that rinses and gargles of PVI and H 2 O 2 do not seem to have a clear utility in reducing the oropharyngeal viral load of SARS-CoV-2. We believe that the recommendation for the use of these and other oral antiseptics should be based on scientific evidence, hence more studies are needed to assess their efficacy in this pandemic.
Conflicts of interest The authors declare that they have no conflicts of interest.
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