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Nutritional Assessment of Critically Ill Children with COVID-19 Admitted to PICU

Mohamed et al., The Medical Journal of Cairo University, doi:10.21608/mjcu.2024.411836
Dec 2024  
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Mortality 80% Improvement Relative Risk Zinc for COVID-19  Mohamed et al.  Sufficiency Are zinc levels associated with COVID-19 outcomes? Retrospective 60 patients in Egypt (June 2023 - May 2024) Lower mortality with higher zinc levels (p=0.0038) c19early.org Mohamed et al., The Medical J. Cairo U.., Dec 2024 Favorszinc Favorscontrol 0 0.5 1 1.5 2+
Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020, now with p = 0.00000032 from 46 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
Retrospective 60 hospitalized pediatric COVID-19 patients showing deficiencies in vitamin D, folic acid (B9), zinc, and selenium associated with higher mortality.
Study covers vitamin D, selenium, zinc, and vitamin B9.
risk of death, 80.5% lower, RR 0.20, p = 0.004, high zinc levels (≥70 µg/dL) 2 of 21 (9.5%), low zinc levels (<70 µg/dL) 19 of 39 (48.7%), NNT 2.6.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mohamed et al., 31 Dec 2024, retrospective, Egypt, peer-reviewed, mean age 5.5, 2 authors, study period 1 June, 2023 - 31 May, 2024.
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Abstract: Med. J. Cairo Univ., Vol. 92, No. 4, Accepted 25/11/2024 DOI: 10.22608/MJCU. 1583-1592, December 2024 www.medicaljournalofcairouniversity.net Nutritional Assessment of Critically Ill Children with COVID-19 Admitted to PICU NAHLA A. MOHAMED, Ph.D.* and HANAN F. MOHAMMED, M.D.** The Department of Pediatrics, El-Galaa Teaching Hospital, General Organization of Teaching Hospitals and Institutes* and Department of Clinical Pathology, El-Galaa Teaching Hospital, General Organization of Teaching Hospital** Abstract Background: Nutrition has important role in the regulation of optimal immune functions, as it provides proper nutrients such as minerals, and vitamins, as well as macronutrients in adequate concentrations to immune system. however, nutritional deficiencies are associated with impaired immune response and have negative impact on human resistance to infection. Aim of Study: Evaluation of the nutritional status of critically ill pediatric patients diagnosed with COVID-19 admitted to PICU and study correlation between nutritional deficiency and outcome. Patients and Methods: This retrospective cohort study of hospitalized patients with COVID-19 enrolled at the pediatric intensive care unit of El-Galaa Teaching Hospital. All confirmed COVID-19 patients have been screened in the period between June 1st, 2023 and may 31th, 2024. The study reviewed the demographic data, anthropometric data, nutritional and medical history, laboratory investigation, duration of hospital stays and outcome of the hospitalized patients during the period of the study. Results: A total of 60 patients with COVID-19 aged 2 to 10 years were evaluated in this study. Non-survivors’ patients with COVID-19 had significantly lower anthropometric measurements (Z score for weight, Z score for height and body mass index Z score) as compared to survivors. There was statistically decrease in folic acid, Vitamin D, Zinc, Selenium (38.3%, 23.3%, 65%, 36.7% respectively) in COVID-19 patients. While severe vitamin D deficiency was reported in 21.7% of patients. There was statistically significant decrease in folic acid, Vitamin D, Zinc, Selenium innon- survivors as compared with survivors’patients. Also, there was statistically significant increase in duration of hospital stay innon-survivors’ patients. Conclusion: Pediatric patients with COVID-19 may have nutritional deficiency in one or more micronutrients that may Correspondence to: Dr. Nahla A. Mohamed, The Department of Pediatrics, El-Galaa Teaching Hospital, General Organization of Teaching Hospitals and Institutes affect their immune response to infection, severity of disease, complications and duration of hospitalization. They will benefit from screening and supplementation of vitamins and trace elements. Key Words: COVID-19 – Selenium – Vitamin D – Zinc folic acid – Micronutrients.
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