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c19early.org COVID-19 treatment researchCasirivimab/imdevimabCasirivimab/i.. (more..)
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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 93% Improvement Relative Risk Death/hospitalization 56% primary Hospitalization 48% Hospitalization/ER 40% SQ vs. IV death 53% SQ vs. IV death/hosp. -71% SQ vs. IV hospitalization -79% SQ vs. IV ER/hosp. 15% Casirivimab/i..  McCreary et al.  LATE TREATMENT Is late treatment with casirivimab/imdevimab beneficial for COVID-19? Prospective study of 2,185 patients in the USA (Jul - Oct 2021) Lower mortality (p=0.009) and death/hosp. (p=0.00031) c19early.org McCreary et al., medRxiv, December 2021 Favors casirivimab/im.. Favors control

Association of subcutaneous or intravenous route of administration of casirivimab and imdevimab monoclonal antibodies with clinical outcomes in COVID-19

McCreary et al., medRxiv, doi:10.1101/2021.11.30.21266756
Dec 2021  
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Prospective study comparing subcutaneous and intravenous casirivimab/imdevimab, and comparing to a PSM matched control set, showing significantly lower mortality and hospitalization with treatment. Controls were matched with EUA-eligible risk factors only, authors were unable to determine symptom severity.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron Liu, Sheward, Tatham, VanBlargan.
risk of death, 93.0% lower, RR 0.07, p = 0.009, treatment 1 of 652 (0.2%), control 29 of 1,304 (2.2%), NNT 48, propensity score matching.
risk of death/hospitalization, 56.0% lower, RR 0.44, p < 0.001, treatment 22 of 652 (3.4%), control 101 of 1,304 (7.7%), NNT 23, propensity score matching, primary outcome.
risk of hospitalization, 48.0% lower, RR 0.52, p = 0.005, treatment 22 of 652 (3.4%), control 85 of 1,304 (6.5%), NNT 32, propensity score matching.
risk of hospitalization/ER, 40.0% lower, RR 0.60, p = 0.003, treatment 40 of 652 (6.1%), control 133 of 1,304 (10.2%), NNT 25, propensity score matching.
SQ vs. IV death, 53.0% lower, RR 0.47, p = 0.52, treatment 1 of 969 (0.1%), control 3 of 1,216 (0.2%), NNT 697, adjusted per study.
SQ vs. IV death/hosp., 71.0% higher, RR 1.71, p = 0.06, treatment 27 of 969 (2.8%), control 21 of 1,216 (1.7%), adjusted per study.
SQ vs. IV hospitalization, 79.0% higher, RR 1.79, p = 0.046, treatment 27 of 969 (2.8%), control 20 of 1,216 (1.6%), adjusted per study.
SQ vs. IV ER/hosp., 15.0% lower, RR 0.85, p = 0.38, treatment 47 of 969 (4.9%), control 71 of 1,216 (5.8%), NNT 101, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
McCreary et al., 1 Dec 2021, prospective, USA, preprint, 27 authors, study period 14 July, 2021 - 26 October, 2021, average treatment delay 6.0 days.
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This PaperCasirivimab/i..All
Association of subcutaneous or intravenous route of administration of casirivimab and imdevimab monoclonal antibodies with clinical outcomes in COVID-19
PharmD, BCPS, BCIDP Erin K Mccreary, J Ryan Bariola, MD Richard J Wadas, Judith A Shovel, Mary Kay Wisniewski, Michelle Adam, BS Debbie Albin, MS Tami Minnier, MD Mark Schmidhofer, MBA Russell Meyers, MD Oscar C Marroquin, MBA Kevin Collins, PhD William Garrard, Lindsay R Berry, PhD Scott Berry, PhD Amy M Crawford, PhD Anna Mcglothlin, MS Kelsey Linstrum, MS Anna Nakayama, MS Stephanie K Montgomery, MD Graham M Snyder, MD Donald M Yealy, MD MPH Derek C Angus, PhD Paula L Kip, MD MSc Christopher W Seymour, MD MPH David T Huang, PhD Kevin E Kip
doi:10.1101/2021.11.30.21266756
Findings: Among 1,956 propensity-matched adults, outpatients who received casirivimab and imdevimab subcutaneously had a 28-day rate of hospitalization or death of 3.4% (n=652) compared to 7.8% (n=1,304) in non-treated controls [risk ratio 0.44 (95% confidence interval: 0.28 to 0.68, p < .001)]. Among 2,185 outpatients who received subcutaneous (n=969) or intravenous (n=1,216) casirivimab and imdevimab, the 28-day rate of hospitalization/death was 2.8% vs. 1.7%, respectively, which resulted in an adjusted risk difference of 1.5% (95% confidence interval: -0.5% to 3.5%, p=.14). The 28-day adjusted risk differences comparing subcutaneous to intravenous route for death, ICU admission, and mechanical ventilation were 0.3% or less, although the 95% confidence intervals were wide. Meaning: Subcutaneously administered casirivimab and imdevimab is associated with reduced hospitalization or death amongst outpatients with mild to moderate COVID-19 compared to no treatment, and has a small, adjusted risk difference compared to patients treated intravenously.
Treated and Nontreated Analysis
References
Austin, An introduction to propensity score methods for reducing the effects of confounding in observational studies, Multivariate Behav Res, doi:10.1080/00273171.2011.568786
Bariola, Mccreary, Wadas, Impact of bamlanivimab monoclonal antibody treatment on hospitalization and mortality among nonhospitalized adults with severe acute respiratory syndrome coronavirus 2 infection, Open Forum Infect Dis, doi:10.1093/ofid/ofab254
Benchimol, Sl, Guttmann, Harron, The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement, PLoS Med
Gov, Uk, Patient information leaflet for Ronapreve
Huang, Mccreary, Bariola, The UPMC OPTIMISE-C19 (OPtimizing Treatment and Impact of Monoclonal antIbodieS through Evaluation for COVID-19) trial: a structured summary of a study protocol for an open-label, pragmatic, comparative effectiveness platform trial with response-adaptive randomization, Trials, doi:10.1186/s13063-021-05316-3
O'brien, Forleo-Neto, Musser, Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19, N Engl J Med, doi:10.1056/NEJMoa2109682
Pfizer, A study of PF-07321332/ritonavir in non-hospitalized low-risk adult participants with COVID-19
Reitz, Seymour, Vates, Strategies to Promote ResiliencY (SPRY): a randomised embedded multifactorial adaptative platform (REMAP) clinical trial protocol to study interventions to improve recovery after surgery in high-risk patients, BMJ Open, doi:10.1136/bmjopen-2020-037690
Rosenbaum, Rubin, The Central Role of the Propensity Score in Observational Studies for Causal Effects, Biometrika, doi:10.2307/2335942
Sharp, Corporation, Efficacy and safety of molnupiravir (MK-4482) in nonhospitalized adult participants with COVID-19
Weinreich, Sivapalasingam, Norton, REGEN-COV Antibody Cocktail Clinical Outcomes Study in Covid-19 Outpatients, medRxiv, doi:10.1101/2021.05.19.21257469
Late treatment
is less effective
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