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All Studies   Meta Analysis    Recent:   

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

O'Brien et al., NEJM, doi:10.1056/NEJMoa2109682 (press release 4/12/21), NCT04452318
Apr 2021  
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Hospitalization/ER 89% Improvement Relative Risk Symp. case 81% Recovery time 62% Time to viral- 69% Casirivimab/i..  O'Brien et al.  Prophylaxis  DB RCT Is prophylaxis with casirivimab/imdevimab beneficial for COVID-19? Double-blind RCT 1,505 patients in multiple countries (Jul 2020 - Jan 2021) Fewer symptomatic cases (p<0.0001) and faster recovery (p=0.0001) c19early.org O'Brien et al., NEJM, April 2021 Favorscasirivimab/im.. Favorscontrol 0 0.5 1 1.5 2+
17th treatment shown to reduce risk in March 2021
 
*, now with p = 0.00018 from 31 studies, recognized in 45 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Prophylaxis trial reporting lower hospitalization/ER and symptomatic cases, and faster recovery with 1,200mg subcutaneous casirivimab with imdevimab. The same trial has updated results available in1. NCT04452318 (history).
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants2-7.
risk of hospitalization/ER, 88.9% lower, RR 0.11, p = 0.06, treatment 0 of 753 (0.0%), control 4 of 752 (0.5%), NNT 188, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29.
risk of symptomatic case, 81.4% lower, RR 0.19, p < 0.001, treatment 11 of 753 (1.5%), control 59 of 752 (7.8%), NNT 16, day 29.
recovery time, 62.5% lower, relative time 0.37, p < 0.001, treatment 753, control 752, relative time with symptoms.
time to viral-, 69.2% lower, relative time 0.31, p < 0.001, treatment 753, control 752, relative time with high viral load.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
O'Brien et al., 12 Apr 2021, Double Blind Randomized Controlled Trial, multiple countries, peer-reviewed, 36 authors, study period 13 July, 2020 - 28 January, 2021, trial NCT04452318 (history).
This PaperCasirivimab/i..All
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19
Meagan P O’brien, Eduardo Forleo-Neto, Bret J Musser, Flonza Isa, Kuo-Chen Chan, Neena Sarkar, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Peijie Hou, Ingeborg Heirman, John D Davis, Kenneth C Turner, Divya Ramesh, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Yunji Kim, Lisa A Purcell, Alina Baum, Christos A Kyratsous, James Krainson, Richard Perez-Perez, Rizwana Mohseni, Bari Kowal, A Thomas Dicioccio, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos, David M Weinreich
New England Journal of Medicine, doi:10.1056/nejmoa2109682
BACKGROUND REGEN-COV (previously known as REGN-COV2), a combination of the monoclonal antibodies casirivimab and imdevimab, has been shown to markedly reduce the risk of hospitalization or death among high-risk persons with coronavirus disease 2019 (Covid-19). Whether subcutaneous REGEN-COV prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent Covid-19 in persons at high risk for infection because of household exposure to a person with SARS-CoV-2 infection is unknown. METHODS We randomly assigned, in a 1:1 ratio, participants (≥12 years of age) who were enrolled within 96 hours after a household contact received a diagnosis of SARS-CoV-2 infection to receive a total dose of 1200 mg of REGEN-COV or matching placebo administered by means of subcutaneous injection. At the time of randomization, participants were stratified according to the results of the local diagnostic assay for SARS-CoV-2 and according to age. The primary efficacy end point was the development of symptomatic SARS-CoV-2 infection through day 28 in participants who did not have SARS-CoV-2 infection (as measured by reverse-transcriptasequantitative polymerase-chain-reaction assay) or previous immunity (seronegativity). RESULTS Symptomatic SARS-CoV-2 infection developed in 11 of 753 participants in the REGEN-COV group (1.5%) and in 59 of 752 participants in the placebo group (7.8%) (relative risk reduction [1 minus the relative risk], 81.4%; P<0.001). In weeks 2 to 4, a total of 2 of 753 participants in the REGEN-COV group (0.3%) and 27 of 752 participants in the placebo group (3.6%) had symptomatic SARS-CoV-2 infection (relative risk reduction, 92.6%). REGEN-COV also prevented symptomatic and asymptomatic infections overall (relative risk reduction, 66.4%). Among symptomatic infected participants, the median time to resolution of symptoms was 2 weeks shorter with REGEN-COV than with placebo (1.2 weeks and 3.2 weeks, respectively), and the duration of a high viral load (>10 4 copies per milliliter) was shorter (0.4 weeks and 1.3 weeks, respectively). No dose-limiting toxic effects of REGEN-COV were noted. CONCLUSIONS Subcutaneous REGEN-COV prevented symptomatic Covid-19 and asymptomatic SARS-CoV-2 infection in previously uninfected household contacts of infected persons. Among the participants who became infected, REGEN-COV reduced the duration of symptomatic disease and the duration of a high viral load. (Funded by Regeneron Pharmaceuticals and others; ClinicalTrials.gov number, NCT04452318.
Appendix The authors' full names and academic degrees are as follows: Meagan P. O'Brien, M.D., Eduardo Forleo-Neto, M.D., Bret J. Musser, Ph.D., Flonza Isa, M.D., Kuo-Chen Chan, Ph.D., Neena Sarkar, Ph.D., Katharine J. Bar
References
Baum, Fulton, Wloga, Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies, Science
Copin, Baum, Wloga, The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies, Cell
Madewell, Yang, Longini, Jr, Halloran et al., Household transmission of SARS-CoV-2: a systematic review and meta-analysis, JAMA Netw Open
Wang, Nair, Liu, Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7, Nature
Weinreich, Sivapalasingam, Norton, Fact sheet for health care providers: Emergency Use Authorization (EUA) of REGEN-COV (casirivimab and imdevimab)
Weinreich, Sivapalasingam, Norton, REGEN-COV antibody cocktail clinical outcomes study in Covid-19 outpatients, doi:10.1101/2021.05.19
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Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Eduardo', 'family': 'Forleo-Neto', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Bret J.', 'family': 'Musser', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Flonza', 'family': 'Isa', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Kuo-Chen', 'family': 'Chan', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Neena', 'family': 'Sarkar', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Katharine J.', 'family': 'Bar', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Ruanne V.', 'family': 'Barnabas', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Dan H.', 'family': 'Barouch', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Myron S.', 'family': 'Cohen', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Christopher B.', 'family': 'Hurt', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Dale R.', 'family': 'Burwen', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Mary A.', 'family': 'Marovich', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Peijie', 'family': 'Hou', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Ingeborg', 'family': 'Heirman', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6282-1670', 'authenticated-orcid': False, 'given': 'John D.', 'family': 'Davis', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Kenneth C.', 'family': 'Turner', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Divya', 'family': 'Ramesh', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Adnan', 'family': 'Mahmood', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Andrea T.', 'family': 'Hooper', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Jennifer D.', 'family': 'Hamilton', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Yunji', 'family': 'Kim', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Lisa A.', 'family': 'Purcell', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Alina', 'family': 'Baum', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Christos A.', 'family': 'Kyratsous', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'James', 'family': 'Krainson', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Richard', 'family': 'Perez-Perez', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Rizwana', 'family': 'Mohseni', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Bari', 'family': 'Kowal', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'A. Thomas', 'family': 'DiCioccio', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Neil', 'family': 'Stahl', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Leah', 'family': 'Lipsich', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Ned', 'family': 'Braunstein', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'Gary', 'family': 'Herman', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'George D.', 'family': 'Yancopoulos', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}, { 'given': 'David M.', 'family': 'Weinreich', 'sequence': 'additional', 'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., ' 'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., ' 'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., ' 'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the ' 'Departments of Medicine and Microbiology, University of ' 'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global ' 'Health and Epidemiology and the Division of Allergy and ' 'Infectious Diseases, University of Washington, and the Vaccine ' 'and Infectious Diseases...'}]}], 'member': '150', 'reference': [ {'key': 'r1', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2001017'}, {'key': 'r3', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-020-2008-3'}, {'key': 'r4', 'doi-asserted-by': 'publisher', 'DOI': '10.1126/science.abd0831'}, {'key': 'r5', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cell.2021.06.002'}, {'key': 'r6', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-021-03398-2'}, {'key': 'r7', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2035002'}, {'key': 'r12', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamanetworkopen.2020.31756'}], 'container-title': 'New England Journal of Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://www.nejm.org/doi/pdf/10.1056/NEJMoa2109682', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 10, 20]], 'date-time': '2022-10-20T18:06:28Z', 'timestamp': 1666289188000}, 'score': 1, 'resource': {'primary': {'URL': 'http://www.nejm.org/doi/10.1056/NEJMoa2109682'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 9, 23]]}, 'references-count': 7, 'journal-issue': {'issue': '13', 'published-print': {'date-parts': [[2021, 9, 23]]}}, 'alternative-id': ['10.1056/NEJMoa2109682'], 'URL': 'http://dx.doi.org/10.1056/NEJMoa2109682', 'relation': { 'has-preprint': [ { 'id-type': 'doi', 'id': '10.1101/2021.06.14.21258567', 'asserted-by': 'object'}]}, 'ISSN': ['0028-4793', '1533-4406'], 'subject': ['General Medicine'], 'container-title-short': 'N Engl J Med', 'published': {'date-parts': [[2021, 9, 23]]}}
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