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Home   COVID-19 treatment studies for Casirivimab/imdevimab  COVID-19 treatment studies for Casirivimab/i..  C19 studies: Casirivimab/i..  Casirivimab/i..   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization/ER 89% Improvement Relative Risk Symptomatic case 81% Recovery time 62% Time to viral- 69% c19early.org/r O'Brien et al. NCT04452318 Casirivimab/i.. RCT Prophylaxis Favors casirivimab/im.. Favors control
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19
O'Brien et al., NEJM, doi:10.1056/NEJMoa2109682 (press release 4/12/21), NCT04452318 (history)
12 Apr 2021    Source   PDF   Share   Tweet
Prophylaxis trial reporting lower hospitalization/ER and symptomatic cases, and faster recovery with 1,200mg subcutaneous casirivimab with imdevimab. The same trial has updated results available in [c19regn.com]. NCT04452318 (history).
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of hospitalization/ER, 88.9% lower, RR 0.11, p = 0.06, treatment 0 of 753 (0.0%), control 4 of 752 (0.5%), NNT 188, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29.
risk of symptomatic case, 81.4% lower, RR 0.19, p < 0.001, treatment 11 of 753 (1.5%), control 59 of 752 (7.8%), NNT 16, day 29.
recovery time, 62.5% lower, relative time 0.37, p < 0.001, treatment 753, control 752, relative time with symptoms.
time to viral-, 69.2% lower, relative time 0.31, p < 0.001, treatment 753, control 752, relative time with high viral load.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
O'Brien et al., 12 Apr 2021, Double Blind Randomized Controlled Trial, multiple countries, peer-reviewed, 36 authors, trial NCT04452318 (history).
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