Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19
Meagan P O’brien, Eduardo Forleo-Neto, Bret J Musser, Flonza Isa, Kuo-Chen Chan, Neena Sarkar, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Peijie Hou, Ingeborg Heirman, John D Davis, Kenneth C Turner, Divya Ramesh, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Yunji Kim, Lisa A Purcell, Alina Baum, Christos A Kyratsous, James Krainson, Richard Perez-Perez, Rizwana Mohseni, Bari Kowal, A Thomas Dicioccio, Neil Stahl, Leah Lipsich, Ned Braunstein, Gary Herman, George D Yancopoulos, David M Weinreich
New England Journal of Medicine, doi:10.1056/nejmoa2109682
BACKGROUND REGEN-COV (previously known as REGN-COV2), a combination of the monoclonal antibodies casirivimab and imdevimab, has been shown to markedly reduce the risk of hospitalization or death among high-risk persons with coronavirus disease 2019 (Covid-19). Whether subcutaneous REGEN-COV prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent Covid-19 in persons at high risk for infection because of household exposure to a person with SARS-CoV-2 infection is unknown.
METHODS We randomly assigned, in a 1:1 ratio, participants (≥12 years of age) who were enrolled within 96 hours after a household contact received a diagnosis of SARS-CoV-2 infection to receive a total dose of 1200 mg of REGEN-COV or matching placebo administered by means of subcutaneous injection. At the time of randomization, participants were stratified according to the results of the local diagnostic assay for SARS-CoV-2 and according to age. The primary efficacy end point was the development of symptomatic SARS-CoV-2 infection through day 28 in participants who did not have SARS-CoV-2 infection (as measured by reverse-transcriptasequantitative polymerase-chain-reaction assay) or previous immunity (seronegativity).
RESULTS Symptomatic SARS-CoV-2 infection developed in 11 of 753 participants in the REGEN-COV group (1.5%) and in 59 of 752 participants in the placebo group (7.8%) (relative risk reduction [1 minus the relative risk], 81.4%; P<0.001). In weeks 2 to 4, a total of 2 of 753 participants in the REGEN-COV group (0.3%) and 27 of 752 participants in the placebo group (3.6%) had symptomatic SARS-CoV-2 infection (relative risk reduction, 92.6%). REGEN-COV also prevented symptomatic and asymptomatic infections overall (relative risk reduction, 66.4%). Among symptomatic infected participants, the median time to resolution of symptoms was 2 weeks shorter with REGEN-COV than with placebo (1.2 weeks and 3.2 weeks, respectively), and the duration of a high viral load (>10 4 copies per milliliter) was shorter (0.4 weeks and 1.3 weeks, respectively). No dose-limiting toxic effects of REGEN-COV were noted.
CONCLUSIONS Subcutaneous REGEN-COV prevented symptomatic Covid-19 and asymptomatic SARS-CoV-2 infection in previously uninfected household contacts of infected persons. Among the participants who became infected, REGEN-COV reduced the duration of symptomatic disease and the duration of a high viral load. (Funded by Regeneron Pharmaceuticals and others; ClinicalTrials.gov number, NCT04452318.
Appendix The authors' full names and academic degrees are as follows: Meagan P. O'Brien, M.D., Eduardo Forleo-Neto, M.D., Bret J. Musser, Ph.D., Flonza Isa, M.D., Kuo-Chen Chan, Ph.D., Neena Sarkar, Ph.D., Katharine J. Bar
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'title': 'Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19',
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'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
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'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
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'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
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'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
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'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
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'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
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'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Dan H.',
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'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
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'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
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'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
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'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
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'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
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'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
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{ 'given': 'Peijie',
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'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Ingeborg',
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'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
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'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
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{ 'given': 'Kenneth C.',
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'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Divya',
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'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Adnan',
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'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Andrea T.',
'family': 'Hooper',
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'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Jennifer D.',
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'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Yunji',
'family': 'Kim',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Lisa A.',
'family': 'Purcell',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Alina',
'family': 'Baum',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Christos A.',
'family': 'Kyratsous',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'James',
'family': 'Krainson',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Richard',
'family': 'Perez-Perez',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Rizwana',
'family': 'Mohseni',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Bari',
'family': 'Kowal',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'A. Thomas',
'family': 'DiCioccio',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Neil',
'family': 'Stahl',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Leah',
'family': 'Lipsich',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Ned',
'family': 'Braunstein',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'Gary',
'family': 'Herman',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'George D.',
'family': 'Yancopoulos',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]},
{ 'given': 'David M.',
'family': 'Weinreich',
'sequence': 'additional',
'affiliation': [ { 'name': 'From Regeneron Pharmaceuticals, Tarrytown, NY (M.P.O., E.F.-N., '
'B.J.M., F.I., K.-C.C., N. Sarkar, P.H., I.H., J.D.D., K.C.T., '
'D.R., A.M., A.T.H., J.D.H., Y.K., L.A.P., A.B., C.A.K., B.K., '
'A.T.D., N. Stahl, L.L., N.B., G.H., G.D.Y., D.M.W.); the '
'Departments of Medicine and Microbiology, University of '
'Pennsylvania, Philadelphia (K.J.B.); the Departments of Global '
'Health and Epidemiology and the Division of Allergy and '
'Infectious Diseases, University of Washington, and the Vaccine '
'and Infectious Diseases...'}]}],
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