Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19 in Taiwan: A Retrospective Study
Hsiang-Ling Lin, Yu-Ning Winter, Lee, Fang-Ju Sun, Ming-Wei Cheng, S U M M A R Y
doi:10.6890/IJGE.202307_17(3).0008
The aim of this study was to investigate the association between famotidine treatment and severity, as well as mortality, for patients with COVID-19. In addition, to investigate whether this association was changed in cases of concomitant treatment with corticosteroids, remdesivir, clarithromycin, low molecular weight heparin, or statin. Material and methods: This is a retrospective cohort study conducted by analyzing electronic medical records of 171 hospitalized patients into the Infectious Disease Ward of a 2068-bed tertiary care medical center, with laboratory-confirmed COVID-19 between May 01, 2021 and August 31, 2021. Patients were classified as receiving famotidine if they were treated with oral drug, at any dose, within ± 7 days of COVID-19 screening and/or hospital admission. Famotidine use was extracted directly from the electronic medical record. Results: Current study failed to identify famotidine as a protective factor associated with a significant reduction in the risk of in-hospital mortality (odds ratio 1.573, 95% confidence interval (CI) 0.464-5.325, p = 0.467) or a significant reduction in the risk of ICU admission (odds ratio 0.547, 95% confidence interval (CI) 0.286-1.045, p = 0.068). However, non-significant trend towards a lower rate of ICU admission in association with famotidine prescription was observed.
Conclusions: The results of this study reflect the real-world use of famotidine does not reduce the risk of in-hospital-mortality or ICU admission of hospitalized COVID-19 patients.
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doi:10.1016/j.apsb.2020.02.008DOI record:
{
"DOI": "10.6890/IJGE.202307_17(3).0008",
"ISSN": "1873-9598",
"URL": "",
"abstract": "Objectives: The aim of this study was to investigate the association between famotidine treatment and severity, as well as mortality, for patients with COVID-19. In addition, to investigate whether this association was changed in cases of concomitant treatment with corticosteroids, remdesivir, clarithromycin, low molecular weight heparin, or statin. Material and methods: This is a retrospective cohort study conducted by analyzing electronic medical records of 171 hospitalized patients into the Infectious Disease Ward of a 2068-bed tertiary care medical center, with laboratory-confirmed COVID-19 between May 01, 2021 and August 31, 2021. Patients were classified as receiving famotidine if they were treated with oral drug, at any dose, within ± 7 days of COVID-19 screening and/or hospital admission. Famotidine use was extracted directly from the electronic medical record. Results: Current study failed to identify famotidine as a protective factor associated with a significant reduction in the risk of in-hospital mortality (odds ratio 1.573, 95% confidence interval (CI) 0.464-5.325, p = 0.467) or a significant reduction in the risk of ICU admission (odds ratio 0.547, 95% confidence interval (CI) 0.286-1.045, p = 0.068). However, non-significant trend towards a lower rate of ICU admission in association with famotidine prescription was observed. Conclusions: The results of this study reflect the real-world use of famotidine does not reduce the risk of in-hospital-mortality or ICU admission of hospitalized COVID-19 patients.",
"author": [
{
"literal": "Hsiang-Ling Lin"
},
{
"literal": "Winter Yu-Ning Lee"
},
{
"literal": "Fang-Ju Sun"
},
{
"literal": "Ming-Wei Cheng"
}
],
"container-title": "International Journal of Gerontology",
"issue": "3",
"issued": {
"date-parts": [
[
"2023",
"7",
"1"
]
]
},
"language": "en",
"page-first": "183",
"title": "Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19 in Taiwan: A Retrospective Study",
"type": "article-journal",
"volume": "17"
}
