Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19 in Taiwan: A Retrospective Study
Hsiang-Ling Lin, Yu-Ning Winter, Lee, Fang-Ju Sun, Ming-Wei Cheng, S U M M A R Y
doi:10.6890/IJGE.202307_17(3).0008
The aim of this study was to investigate the association between famotidine treatment and severity, as well as mortality, for patients with COVID-19. In addition, to investigate whether this association was changed in cases of concomitant treatment with corticosteroids, remdesivir, clarithromycin, low molecular weight heparin, or statin. Material and methods: This is a retrospective cohort study conducted by analyzing electronic medical records of 171 hospitalized patients into the Infectious Disease Ward of a 2068-bed tertiary care medical center, with laboratory-confirmed COVID-19 between May 01, 2021 and August 31, 2021. Patients were classified as receiving famotidine if they were treated with oral drug, at any dose, within ± 7 days of COVID-19 screening and/or hospital admission. Famotidine use was extracted directly from the electronic medical record. Results: Current study failed to identify famotidine as a protective factor associated with a significant reduction in the risk of in-hospital mortality (odds ratio 1.573, 95% confidence interval (CI) 0.464-5.325, p = 0.467) or a significant reduction in the risk of ICU admission (odds ratio 0.547, 95% confidence interval (CI) 0.286-1.045, p = 0.068). However, non-significant trend towards a lower rate of ICU admission in association with famotidine prescription was observed.
Conclusions: The results of this study reflect the real-world use of famotidine does not reduce the risk of in-hospital-mortality or ICU admission of hospitalized COVID-19 patients.
References
Anand, Ziebuhr, Wadhwani, Mesters, Hilgenfeld, Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs, Science,
doi:10.1126/science.1085658
Birch, Molinar-Inglis, Trejo, Subcellular hot spots of GPCR signaling promote vascular inflammation, Curr Opin Endocr Metab Res,
doi:10.1016/j.coemr.2020.07.011
Bourinbaiar, Fruhstorfer, The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents, Life Sci,
doi:10.1016/s0024-3205(96)00553-x
Cheung, Hung, Leung, Association between famotidine use and COVID-19 severity in Hong Kong: A territory-wide study, Gastroenterology,
doi:10.1053/j.gastro.2020.05.098
Freedberg, Conigliaro, Wang, Famotidine use is associated with improved clinical outcomes in hospitalized COVID-19 patients: A propensity score matched retrospective cohort study, Gastroenterology,
doi:10.1053/j.gastro.2020.05.053
Ii, Iii, Cannon, Dual-histamine receptor blockade with cetirizine -famotidine reduces pulmonary symptoms in COVID-19 patients, Pulm Pharmacol Ther,
doi:10.1016/j.pupt.2020.101942
Kritas, Ronconi, Caraffa, Gallenga, Ross et al., Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy, J Biol Regul Homeost Agents,
doi:10.23812/20-Editorial-Kritas
Kuno, So, Takahashi, Egorova, The association between famotidine and in-hospital mortality of patients with COVID-19, J Med Virol,
doi:10.1002/jmv.27375
Lai, Shih, Ko, Tang, Hsueh, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges, Int J Antimicrob Agents,
doi:10.1016/j.ijantimicag.2020.105924
Li, Dong, Lei, No evidence indicates famotidine reduces the risk of serious disease in COVID-19 patients after propensity score matching: Meta-analysis and systematic reviews, Dig Dis Sci,
doi:10.1007/s10620-021-07214-9
Shoaibi, Fortin, Weinstein, Berlin, Ryan, Comparative effectiveness of famotidine in hospitalized COVID-19 patients, Am J Gastroenterol,
doi:10.14309/ajg.0000000000001153
Sun, Chen, Hu, Does famotidine reduce the risk of progression to severe disease, death, and intubation for COVID-19 patients? A systemic review and meta-analysis, Dig Dis Sci,
doi:10.1007/s10620-021-06872-z
Wiersinga, Rhodes, Cheng, Peacock, Prescott, Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): A review, JAMA,
doi:10.1001/jama.2020.12839
Wu, Liu, Yang, Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharm Sin B,
doi:10.1016/j.apsb.2020.02.008
{ 'issue': '3',
'page-first': '183',
'author': [ {'literal': 'Hsiang-Ling Lin'}, {'literal': 'Winter Yu-Ning Lee'}, {'literal': 'Fang-Ju Sun'},
{'literal': 'Ming-Wei Cheng'}],
'ISSN': '1873-9598',
'language': 'en',
'abstract': 'Objectives: The aim of this study was to investigate the association between famotidine '
'treatment and severity, as well as mortality, for patients with COVID-19. In addition, to '
'investigate whether this association was changed in cases of concomitant treatment with '
'corticosteroids, remdesivir, clarithromycin, low molecular weight heparin, or statin. '
'Material and methods: This is a retrospective cohort study conducted by analyzing electronic '
'medical records of 171 hospitalized patients into the Infectious Disease Ward of a 2068-bed '
'tertiary care medical center, with laboratory-confirmed COVID-19 between May 01, 2021 and '
'August 31, 2021. Patients were classified as receiving famotidine if they were treated with '
'oral drug, at any dose, within ± 7 days of COVID-19 screening and/or hospital admission. '
'Famotidine use was extracted directly from the electronic medical record. Results: Current '
'study failed to identify famotidine as a protective factor associated with a significant '
'reduction in the risk of in-hospital mortality (odds ratio 1.573, 95% confidence interval '
'(CI) 0.464-5.325, p = 0.467) or a significant reduction in the risk of ICU admission (odds '
'ratio 0.547, 95% confidence interval (CI) 0.286-1.045, p = 0.068). However, non-significant '
'trend towards a lower rate of ICU admission in association with famotidine prescription was '
'observed. Conclusions: The results of this study reflect the real-world use of famotidine '
'does not reduce the risk of in-hospital-mortality or ICU admission of hospitalized COVID-19 '
'patients.',
'type': 'article-journal',
'title': 'Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19 in Taiwan: '
'A Retrospective Study',
'URL': '',
'volume': '17',
'container-title': 'International Journal of Gerontology',
'issued': {'date-parts': [['2023', '7', '1']]},
'DOI': '10.6890/IJGE.202307_17(3).0008'}