Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19 in Taiwan: A Retrospective Study
Hsiang-Ling Lin, Yu-Ning Winter, Lee, Fang-Ju Sun, Ming-Wei Cheng, S U M M A R Y
doi:10.6890/IJGE.202307_17(3).0008
The aim of this study was to investigate the association between famotidine treatment and severity, as well as mortality, for patients with COVID-19. In addition, to investigate whether this association was changed in cases of concomitant treatment with corticosteroids, remdesivir, clarithromycin, low molecular weight heparin, or statin. Material and methods: This is a retrospective cohort study conducted by analyzing electronic medical records of 171 hospitalized patients into the Infectious Disease Ward of a 2068-bed tertiary care medical center, with laboratory-confirmed COVID-19 between May 01, 2021 and August 31, 2021. Patients were classified as receiving famotidine if they were treated with oral drug, at any dose, within ± 7 days of COVID-19 screening and/or hospital admission. Famotidine use was extracted directly from the electronic medical record. Results: Current study failed to identify famotidine as a protective factor associated with a significant reduction in the risk of in-hospital mortality (odds ratio 1.573, 95% confidence interval (CI) 0.464-5.325, p = 0.467) or a significant reduction in the risk of ICU admission (odds ratio 0.547, 95% confidence interval (CI) 0.286-1.045, p = 0.068). However, non-significant trend towards a lower rate of ICU admission in association with famotidine prescription was observed.
Conclusions: The results of this study reflect the real-world use of famotidine does not reduce the risk of in-hospital-mortality or ICU admission of hospitalized COVID-19 patients.
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doi:10.1016/j.apsb.2020.02.008{ 'issue': '3',
'page-first': '183',
'author': [ {'literal': 'Hsiang-Ling Lin'}, {'literal': 'Winter Yu-Ning Lee'}, {'literal': 'Fang-Ju Sun'},
{'literal': 'Ming-Wei Cheng'}],
'ISSN': '1873-9598',
'language': 'en',
'abstract': 'Objectives: The aim of this study was to investigate the association between famotidine '
'treatment and severity, as well as mortality, for patients with COVID-19. In addition, to '
'investigate whether this association was changed in cases of concomitant treatment with '
'corticosteroids, remdesivir, clarithromycin, low molecular weight heparin, or statin. '
'Material and methods: This is a retrospective cohort study conducted by analyzing electronic '
'medical records of 171 hospitalized patients into the Infectious Disease Ward of a 2068-bed '
'tertiary care medical center, with laboratory-confirmed COVID-19 between May 01, 2021 and '
'August 31, 2021. Patients were classified as receiving famotidine if they were treated with '
'oral drug, at any dose, within ± 7 days of COVID-19 screening and/or hospital admission. '
'Famotidine use was extracted directly from the electronic medical record. Results: Current '
'study failed to identify famotidine as a protective factor associated with a significant '
'reduction in the risk of in-hospital mortality (odds ratio 1.573, 95% confidence interval '
'(CI) 0.464-5.325, p = 0.467) or a significant reduction in the risk of ICU admission (odds '
'ratio 0.547, 95% confidence interval (CI) 0.286-1.045, p = 0.068). However, non-significant '
'trend towards a lower rate of ICU admission in association with famotidine prescription was '
'observed. Conclusions: The results of this study reflect the real-world use of famotidine '
'does not reduce the risk of in-hospital-mortality or ICU admission of hospitalized COVID-19 '
'patients.',
'type': 'article-journal',
'title': 'Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients with COVID-19 in Taiwan: '
'A Retrospective Study',
'URL': '',
'volume': '17',
'container-title': 'International Journal of Gerontology',
'issued': {'date-parts': [['2023', '7', '1']]},
'DOI': '10.6890/IJGE.202307_17(3).0008'}
