Effectiveness of regdanvimab treatment for SARS-CoV-2 delta variant, which exhibited decreased in vitro activity: a nationwide real-world multicenter cohort study
Haein Kim, Young Rock Jang, Ji Yeon Lee, Jae-Hoon Ko, Jee Young Lee, Seongcheol Cho, Yong Dae Lee, Junghoon Song, Miri Hyun, Hyun Ah Kim, Soyoon Hwang, Sangmi Ryou, Yoo Jin Na, Joo-Yeon Lee, Changhee Lee, Nan Young Lee, Seunghwan Shin, Ki Tae Kwon, Jin Yong Kim, Kyong Ran Peck
Frontiers in Cellular and Infection Microbiology, doi:10.3389/fcimb.2023.1192512
Background: Immune-evading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are emerging continuously. The clinical effectiveness of monoclonal antibody agents that exhibit decreased in vitro activity against SARS-CoV-2 variants needs to be elucidated. Methods: A nationwide, multicenter, retrospective cohort study was designed to evaluate the effectiveness of regdanvimab, an anti-SARS-CoV-2 monoclonal antibody agent. Regdanvimab was prescribed in South Korea before and after the emergence of the delta variant, against which the in vitro activity of regdanvimab was decreased but present. Mild to moderate coronavirus 2019 (COVID-19) patients with risk factors for disease progression who were admitted within seven days of symptom onset were screened in four designated hospitals between December 2020 and September 2021. The primary outcomes, O 2 requirements and progression to severe disease within 21 days of admission, were compared between the regdanvimab and supportive care groups, with a subgroup analysis of delta variant-confirmed patients. Results: A total of 2,214 mild to moderate COVID-19 patients were included, of whom 1,095 (49.5%) received regdanvimab treatment. In the analysis of the total Frontiers in Cellular and Infection Microbiology frontiersin.org 01
Ethics statement Review by the Institutional Review Board was exempted because the present investigation was conducted as part of a public health response, and minimal risk was expected to the participating patients.
Author contributions HK, YRJ, JYL, and J-HK have contributed equally to this work and share first authorship. SS, KTK, JYK, and KRP have contributed equally to this work and share corresponding authorship. All authors contributed to the article and approved the submitted version.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1192512/ full#supplementary-material
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