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0 0.5 1 1.5 2+ Mortality 79% Improvement Relative Risk Ibuprofen for COVID-19  Kalayan et al.  LATE TREATMENT Is late treatment with ibuprofen + alkalinization beneficial for COVID-19? Retrospective 99 patients in Argentina (June - September 2020) Lower mortality with ibuprofen + alkalinization (p=0.00092) Kalayan et al., European J. Respirator.., Dec 2022 Favors ibuprofen Favors control

Safety and Efficacy of Nebulised Anti-Inflammatory Solution of Alkaline Hypertonic Ibuprofen (AHI) for Treatment of SARS-Cov-2 Infection: A Compassionate Study with a Comparator Arms

Kalayan et al., European Journal of Respiratory Medicine, doi:10.31488/EJRM.132
Dec 2022  
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Retrospective 99 COVID-19 patients in Argentina showing significantly lower mortality with inhaled alkaline hypertonic ibuprofen (AHI) treatment. The treatment has a pH of 8.5. 3 times daily for 7-10 days.
2 studies use direct respiratory tract administration Kalayan, Salva
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Study covers ibuprofen and alkalinization.
risk of death, 79.1% lower, RR 0.21, p < 0.001, treatment 3 of 37 (8.1%), control 24 of 62 (38.7%), NNT 3.3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kalayan et al., 31 Dec 2022, retrospective, Argentina, peer-reviewed, 10 authors, study period June 2020 - September 2020, this trial uses multiple treatments in the treatment arm (combined with alkalinization) - results of individual treatments may vary.
This PaperIbuprofenAll
Safety and Efficacy of Nebulised Anti-Inflammatory Solution of Alkaline Hypertonic Ibuprofen (AHI) for Treatment of SARS-Cov-2 Infection: A Compassionate Study with a Comparator Arms
Galia Kalayan, Ana Carolina Arias Cau, Manuela Del Valle Cabello, Mariela Nuñez, Romina Lumetto, Nicolas Martinez Rios, Luis Argarañas, Néstor García, Roxana Alasino, Dante Beltramo, Roxana Dra, Pabellón Alasino, Ceprocor
European Journal of Respiratory Medicine, doi:10.31488/ejrm.132
Background. This retrospective study evaluates the efficacy of inhalation therapy with alkaline hypertonic ibuprofen (AHI) in COVID-19 positive patients compared to a control group of patients who received conventional treatment. The study was carried out at the Orías Hospital in Jujuy Province, Argentina, from June to September 2020, with final follow-up on September 30. Methods. The study included 99 COVID-19 positive patients with moderate to severe disease (respiratory distress and/or hypoxemia). The control group of 62 patients were treated with the protocols in force at that time, oxygen, dexamethasone and enoxaparin. The group under evaluation comprised 37 patients treated with AH), in addition to standard treatment. Findings. Result shows that the treatment with AHI formulation is safe and effective. The mean respiratory rate (RR) of the patients went from 26.3 before treatment with AHI to 19.8 after treatment. On the other hand, the O2 saturation of patients before treatment with AHI showed a mean of 89.0%; at the end of treatment, the mean was 95.8%. In patients treated with AHI, on day 14, 85% had been discharged, while in patients not treated with AHI, only 36-37% were discharged on day 23. Patients with standard treatment, without AHI, show a mortality of 38.7%, distributed evenly in the 25 days of hospitalization. The mortality of patients treated with AHI was 8.1%, observed within the first 10 days of hospitalization. Interpretation. Results show that nebulization with AHI is an anti-inflammatory therapeutic alternative for the treatment of COVID-19 positive patients.
Declaration of Interests There are no conflicts of interest of the participants of this work to declare. Contributorship Statement Galia Kalayan coordinated the development and data collection; Ana Carolina Arias Cau, Manuela del Valle Cabello, Mariela Nuñez, Romina Lumetto were the ones who collected the data and made their selection; Dante Beltramo, Roxana Alasino, Luis Argañaras, Néstor García and Nicolás Martinez Rios had the idea for the article; Dante Beltramo and Roxana Alasino wrote the article.
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Late treatment
is less effective
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