{ 'indexed': { 'date-parts': [[2023, 11, 28]],
'date-time': '2023-11-28T02:56:33Z',
'timestamp': 1701140193083},
'reference-count': 217,
'publisher': 'MDPI AG',
'issue': '14',
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'date-time': '2022-07-13T00:00:00Z',
'timestamp': 1657670400000},
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'abstract': '<jats:p>The COVID-19 pandemic has intensively disrupted global health, economics, and '
'well-being. Andrographis paniculata (Burm. f.) Nees has been used as a complementary '
'treatment for COVID-19 in several Asian countries. This review aimed to summarize the '
'information available regarding A. paniculata and its constituents, to provide critical '
'points relating to its pharmacological properties, safety, and efficacy, revealing its '
'potential to serve as a source of lead compounds for COVID-19 drug discovery. A. paniculata '
'and its active compounds possess favorable antiviral, anti-inflammatory, immunomodulatory, '
'and antipyretic activities that could be beneficial for COVID-19 treatment. Interestingly, '
'recent in silico and in vitro studies have revealed that the active ingredients in A. '
'paniculata showed promising activities against 3CLpro and its virus-specific target protein, '
'human hACE2 protein; they also inhibit infectious virion production. Moreover, existing '
'publications regarding randomized controlled trials demonstrated that the use of A. '
'paniculata alone or in combination was superior to the placebo in reducing the severity of '
'upper respiratory tract infection (URTI) manifestations, especially as part of early '
'treatment, without serious side effects. Taken together, its chemical and biological '
'properties, especially its antiviral activities against SARS-CoV-2, clinical trials on URTI, '
'and the safety of A. paniculata, as discussed in this review, support the argument that A. '
'paniculata is a promising natural source for drug discovery regarding COVID-19 '
'post-infectious treatment, rather than prophylaxis.</jats:p>',
'DOI': '10.3390/molecules27144479',
'type': 'journal-article',
'created': {'date-parts': [[2022, 7, 14]], 'date-time': '2022-07-14T04:12:40Z', 'timestamp': 1657771960000},
'page': '4479',
'source': 'Crossref',
'is-referenced-by-count': 18,
'title': 'A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as '
'Potential Lead Compounds for COVID-19 Drug Discovery',
'prefix': '10.3390',
'volume': '27',
'author': [ {'given': 'Aekkhaluck', 'family': 'Intharuksa', 'sequence': 'first', 'affiliation': []},
{'given': 'Warunya', 'family': 'Arunotayanun', 'sequence': 'additional', 'affiliation': []},
{ 'ORCID': 'http://orcid.org/0000-0003-2832-4464',
'authenticated-orcid': False,
'given': 'Wipawadee',
'family': 'Yooin',
'sequence': 'additional',
'affiliation': []},
{'given': 'Panee', 'family': 'Sirisa-ard', 'sequence': 'additional', 'affiliation': []}],
'member': '1968',
'published-online': {'date-parts': [[2022, 7, 13]]},
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