Review of Andrographis paniculata extracts and compounds like andrographolide with antiviral, anti-inflammatory, and immunomodulatory properties that could help treat COVID-19 symptoms and progression. In silico studies suggest these compounds may inhibit SARS-CoV-2 proteins involved in replication and infection. Early in vitro studies also show extracts can prevent infectious virion production. Authors note that the safety profile of standardized A. paniculata preparations seems acceptable from clinical trials for other respiratory infections, with only minor adverse effects reported.
Intharuksa et al., 13 Jul 2022, Thailand, peer-reviewed, 4 authors.
Contact:
warunya@kmpht.ac.th (corresponding author), aekkhaluck.int@cmu.ac.th, wipawadee.y@cmu.ac.th, panee.sirisa-ard@cmu.ac.th.
