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A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

Intharuksa et al., Molecules, doi:10.3390/molecules27144479
Jul 2022  
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Review of Andrographis paniculata extracts and compounds like andrographolide with antiviral, anti-inflammatory, and immunomodulatory properties that could help treat COVID-19 symptoms and progression. In silico studies suggest these compounds may inhibit SARS-CoV-2 proteins involved in replication and infection. Early in vitro studies also show extracts can prevent infectious virion production. Authors note that the safety profile of standardized A. paniculata preparations seems acceptable from clinical trials for other respiratory infections, with only minor adverse effects reported.
Intharuksa et al., 13 Jul 2022, Thailand, peer-reviewed, 4 authors. Contact: (corresponding author),,,
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{ 'indexed': { 'date-parts': [[2023, 11, 28]], 'date-time': '2023-11-28T02:56:33Z', 'timestamp': 1701140193083}, 'reference-count': 217, 'publisher': 'MDPI AG', 'issue': '14', 'license': [ { 'start': { 'date-parts': [[2022, 7, 13]], 'date-time': '2022-07-13T00:00:00Z', 'timestamp': 1657670400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': ''}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>The COVID-19 pandemic has intensively disrupted global health, economics, and ' 'well-being. Andrographis paniculata (Burm. f.) Nees has been used as a complementary ' 'treatment for COVID-19 in several Asian countries. This review aimed to summarize the ' 'information available regarding A. paniculata and its constituents, to provide critical ' 'points relating to its pharmacological properties, safety, and efficacy, revealing its ' 'potential to serve as a source of lead compounds for COVID-19 drug discovery. A. paniculata ' 'and its active compounds possess favorable antiviral, anti-inflammatory, immunomodulatory, ' 'and antipyretic activities that could be beneficial for COVID-19 treatment. Interestingly, ' 'recent in silico and in vitro studies have revealed that the active ingredients in A. ' 'paniculata showed promising activities against 3CLpro and its virus-specific target protein, ' 'human hACE2 protein; they also inhibit infectious virion production. Moreover, existing ' 'publications regarding randomized controlled trials demonstrated that the use of A. ' 'paniculata alone or in combination was superior to the placebo in reducing the severity of ' 'upper respiratory tract infection (URTI) manifestations, especially as part of early ' 'treatment, without serious side effects. Taken together, its chemical and biological ' 'properties, especially its antiviral activities against SARS-CoV-2, clinical trials on URTI, ' 'and the safety of A. paniculata, as discussed in this review, support the argument that A. ' 'paniculata is a promising natural source for drug discovery regarding COVID-19 ' 'post-infectious treatment, rather than prophylaxis.</jats:p>', 'DOI': '10.3390/molecules27144479', 'type': 'journal-article', 'created': {'date-parts': [[2022, 7, 14]], 'date-time': '2022-07-14T04:12:40Z', 'timestamp': 1657771960000}, 'page': '4479', 'source': 'Crossref', 'is-referenced-by-count': 18, 'title': 'A Comprehensive Review of Andrographis paniculata (Burm. f.) 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