Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All andrographolide studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchAndrographolideAndrographol.. (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Paxlovid Meta
Famotidine Meta Quercetin Meta
Favipiravir Meta Remdesivir Meta
Fluvoxamine Meta Thermotherapy Meta
Hydroxychlor.. Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

Intharuksa et al., Molecules, doi:10.3390/molecules27144479
Jul 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Review of Andrographis paniculata extracts and compounds like andrographolide with antiviral, anti-inflammatory, and immunomodulatory properties that could help treat COVID-19 symptoms and progression. In silico studies suggest these compounds may inhibit SARS-CoV-2 proteins involved in replication and infection. Early in vitro studies also show extracts can prevent infectious virion production. Authors note that the safety profile of standardized A. paniculata preparations seems acceptable from clinical trials for other respiratory infections, with only minor adverse effects reported.
Intharuksa et al., 13 Jul 2022, Thailand, peer-reviewed, 4 authors. Contact: warunya@kmpht.ac.th (corresponding author), aekkhaluck.int@cmu.ac.th, wipawadee.y@cmu.ac.th, panee.sirisa-ard@cmu.ac.th.
This PaperAndrographol..All
{ 'indexed': { 'date-parts': [[2023, 11, 28]], 'date-time': '2023-11-28T02:56:33Z', 'timestamp': 1701140193083}, 'reference-count': 217, 'publisher': 'MDPI AG', 'issue': '14', 'license': [ { 'start': { 'date-parts': [[2022, 7, 13]], 'date-time': '2022-07-13T00:00:00Z', 'timestamp': 1657670400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>The COVID-19 pandemic has intensively disrupted global health, economics, and ' 'well-being. Andrographis paniculata (Burm. f.) Nees has been used as a complementary ' 'treatment for COVID-19 in several Asian countries. This review aimed to summarize the ' 'information available regarding A. paniculata and its constituents, to provide critical ' 'points relating to its pharmacological properties, safety, and efficacy, revealing its ' 'potential to serve as a source of lead compounds for COVID-19 drug discovery. A. paniculata ' 'and its active compounds possess favorable antiviral, anti-inflammatory, immunomodulatory, ' 'and antipyretic activities that could be beneficial for COVID-19 treatment. Interestingly, ' 'recent in silico and in vitro studies have revealed that the active ingredients in A. ' 'paniculata showed promising activities against 3CLpro and its virus-specific target protein, ' 'human hACE2 protein; they also inhibit infectious virion production. Moreover, existing ' 'publications regarding randomized controlled trials demonstrated that the use of A. ' 'paniculata alone or in combination was superior to the placebo in reducing the severity of ' 'upper respiratory tract infection (URTI) manifestations, especially as part of early ' 'treatment, without serious side effects. Taken together, its chemical and biological ' 'properties, especially its antiviral activities against SARS-CoV-2, clinical trials on URTI, ' 'and the safety of A. paniculata, as discussed in this review, support the argument that A. ' 'paniculata is a promising natural source for drug discovery regarding COVID-19 ' 'post-infectious treatment, rather than prophylaxis.</jats:p>', 'DOI': '10.3390/molecules27144479', 'type': 'journal-article', 'created': {'date-parts': [[2022, 7, 14]], 'date-time': '2022-07-14T04:12:40Z', 'timestamp': 1657771960000}, 'page': '4479', 'source': 'Crossref', 'is-referenced-by-count': 18, 'title': 'A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as ' 'Potential Lead Compounds for COVID-19 Drug Discovery', 'prefix': '10.3390', 'volume': '27', 'author': [ {'given': 'Aekkhaluck', 'family': 'Intharuksa', 'sequence': 'first', 'affiliation': []}, {'given': 'Warunya', 'family': 'Arunotayanun', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-2832-4464', 'authenticated-orcid': False, 'given': 'Wipawadee', 'family': 'Yooin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Panee', 'family': 'Sirisa-ard', 'sequence': 'additional', 'affiliation': []}], 'member': '1968', 'published-online': {'date-parts': [[2022, 7, 13]]}, 'reference': [ { 'key': 'ref1', 'unstructured': 'WHO Coronavirus (COVID-19) Dashboard\nhttps://covid19.who.int/'}, {'key': 'ref2', 'doi-asserted-by': 'publisher', 'DOI': '10.1073/pnas.2003138117'}, {'key': 'ref3', 'doi-asserted-by': 'publisher', 'DOI': '10.1101/2020.01.31.929042'}, {'key': 'ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30628-0'}, {'key': 'ref5', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fphar.2020.588508'}, {'key': 'ref6', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/life11040348'}, {'key': 'ref7', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/10408398.2018.1501657'}, {'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.4172/2167-0412.1000169'}, { 'key': 'ref9', 'first-page': '473', 'article-title': 'ANDROGRAPHIS Wallich ex Nees in Wallich', 'volume': '19', 'author': 'Jiaqi', 'year': '2011', 'journal-title': 'Fl. China'}, {'key': 'ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.1248/jhs.54.370'}, { 'key': 'ref11', 'series-title': 'WHO Monographs on Selected Medicinal Plants', 'volume': 'Volume 2', 'year': '2002'}, { 'key': 'ref12', 'unstructured': 'Thai National List of Essential Medicine. 2021; pp. 46–47\n' 'https://pubmiddleware.mims.com/resource/document/82AE6301-4B56-473D-A76E-ADA40096A174/pdf/MIMS_1_2022_NLEM_Web.pdf?client=MIMS%20Publication-Topic&email=&country=Thailand&referenceId=Thailand%20National%20List%20of%20Essential%20Medicines%20(NLEM)'}, { 'key': 'ref13', 'first-page': '16', 'article-title': 'Andrographis paniculata (Kalmegh): A Review', 'volume': '1', 'author': 'Mishra', 'year': '2007', 'journal-title': 'Pharm. Rev'}, { 'key': 'ref14', 'series-title': 'Evidence and Rational Based Research on Chinese Drugs', 'first-page': '138', 'article-title': 'Efficacy of Andrographis paniculata in Upper Respiratory Tract ' 'Infectious Diseases and the Mechanism of Action', 'author': 'Panossian', 'year': '2012'}, { 'key': 'ref15', 'series-title': 'Chinese Herbal Medicine: Materia Medica', 'author': 'Bensky', 'year': '1993'}, {'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/14786419.2014.924004'}, { 'key': 'ref17', 'series-title': 'Chinese Drugs of Plant Origin', 'first-page': '1056', 'article-title': 'Andrographis paniculata (Burm. f.) Nees', 'author': 'Tang', 'year': '1992'}, { 'key': 'ref18', 'first-page': '96', 'article-title': 'Andrographolide, the Active Constituent of Andrographis paniculata ' 'Nees. A Preliminary Communication', 'volume': '86', 'author': 'Chakravarti', 'year': '1951', 'journal-title': 'Ind. Med. Gaz'}, {'key': 'ref19', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/1749-8546-5-17'}, {'key': 'ref20', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0021-9673(01)01160-8'}, {'key': 'ref21', 'doi-asserted-by': 'publisher', 'DOI': '10.1248/cpb.42.1216'}, {'key': 'ref22', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/pca.789'}, {'key': 'ref23', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/pca.2800030308'}, {'key': 'ref24', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2014/274905'}, { 'key': 'ref25', 'first-page': '165', 'article-title': 'Variation in morphological characteristics and andrographolide content ' 'in Andrographis paniculata (Burm. f.) Nees of Central India', 'volume': '1', 'author': 'Pandey', 'year': '2010', 'journal-title': 'Iran. J Energy Environ.'}, {'key': 'ref26', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ejmech.2019.05.022'}, {'key': 'ref27', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.sjbs.2019.12.007'}, {'key': 'ref28', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cbi.2020.108984'}, {'key': 'ref29', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.intimp.2020.106206'}, {'key': 'ref30', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.taap.2019.114688'}, {'key': 'ref31', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.acthis.2020.151514'}, {'key': 'ref32', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.biopha.2019.109065'}, {'key': 'ref33', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.biopha.2018.10.054'}, {'key': 'ref34', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/10286020701273627'}, {'key': 'ref35', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/14786419.2013.856907'}, {'key': 'ref36', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s11101-011-9219-z'}, {'key': 'ref37', 'doi-asserted-by': 'publisher', 'DOI': '10.1177/1934578X1300801217'}, {'key': 'ref38', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.carbpol.2019.02.051'}, {'key': 'ref39', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.fitote.2010.03.003'}, {'key': 'ref40', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/np050160u'}, {'key': 'ref41', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/hlca.200690237'}, {'key': 'ref42', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.fitote.2020.104528'}, {'key': 'ref43', 'doi-asserted-by': 'publisher', 'DOI': '10.1039/p19730001247'}, {'key': 'ref44', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/np050211n'}, {'key': 'ref45', 'doi-asserted-by': 'publisher', 'DOI': '10.1248/cpb.32.2117'}, { 'key': 'ref46', 'first-page': '356', 'article-title': 'Chemical constituents isolated from Andrographis paniculata', 'volume': '49B', 'author': 'Kulyal', 'year': '2010', 'journal-title': 'Indian J. Chem.'}, {'key': 'ref47', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0031-9422(03)00051-7'}, {'key': 'ref48', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/14786410410001709197'}, { 'key': 'ref49', 'doi-asserted-by': 'publisher', 'DOI': '10.2306/scienceasia1513-1874.1992.18.187'}, {'key': 'ref50', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cclet.2010.05.002'}, {'key': 'ref51', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.phytol.2019.10.004'}, {'key': 'ref52', 'doi-asserted-by': 'publisher', 'DOI': '10.1177/1934578X1200700417'}, {'key': 'ref53', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.phytochem.2004.05.008'}, {'key': 'ref54', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.2493'}, {'key': 'ref55', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1875-5364(17)30068-7'}, {'key': 'ref56', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2221-1691(13)60123-9'}, { 'key': 'ref57', 'first-page': '435', 'article-title': 'Isolation and structure of two new diterpenoid glucosides from ' 'Andrographis paniculata Nees', 'volume': '17', 'author': 'Hu', 'year': '1982', 'journal-title': 'Acta Pharm. Sin.'}, {'key': 'ref58', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/np0704452'}, {'key': 'ref59', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bioorg.2020.103680'}, {'key': 'ref60', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/j.1744-7909.2006.00308.x'}, {'key': 'ref61', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/10286020802217432'}, {'key': 'ref62', 'doi-asserted-by': 'publisher', 'DOI': '10.1158/1535-7163.MCT-08-0071'}, {'key': 'ref63', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cclet.2010.01.019'}, {'key': 'ref64', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jcb.20464'}, {'key': 'ref65', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.intimp.2007.12.014'}, { 'key': 'ref66', 'first-page': '317', 'article-title': 'Chemical constituents from roots of Andrographis paniculata', 'volume': '46', 'author': 'Xu', 'year': '2011', 'journal-title': 'Yao Xue Xue Bao = Acta Pharm. Sin.'}, {'key': 'ref67', 'doi-asserted-by': 'publisher', 'DOI': '10.1248/cpb.55.455'}, {'key': 'ref68', 'doi-asserted-by': 'publisher', 'DOI': '10.1248/cpb.35.4429'}, {'key': 'ref69', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.phytochem.2011.12.020'}, {'key': 'ref70', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.tetlet.2009.05.097'}, {'key': 'ref71', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0040-4020(01)93918-3'}, {'key': 'ref72', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/169033c0'}, {'key': 'ref73', 'doi-asserted-by': 'publisher', 'DOI': '10.1055/s-2007-971383'}, {'key': 'ref74', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0040-4020(01)90763-X'}, {'key': 'ref75', 'doi-asserted-by': 'publisher', 'DOI': '10.1039/c19680001493'}, {'key': 'ref76', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0031-9422(00)90934-8'}, {'key': 'ref77', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bmcl.2014.03.060'}, {'key': 'ref78', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s11458-008-0034-z'}, {'key': 'ref79', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0031-9422(00)80122-3'}, {'key': 'ref80', 'doi-asserted-by': 'publisher', 'DOI': '10.1177/1934578X1000500115'}, {'key': 'ref81', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00894-020-04599-8'}, {'key': 'ref82', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1778537'}, {'key': 'ref83', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2004.07.008'}, {'key': 'ref84', 'doi-asserted-by': 'publisher', 'DOI': '10.3906/sag-2004-145'}, {'key': 'ref85', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00705-016-3166-3'}, {'key': 'ref86', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/acs.jmedchem.0c00606'}, {'key': 'ref87', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41467-020-18319-6'}, {'key': 'ref88', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s42003-021-02030-3'}, {'key': 'ref89', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s13205-020-02578-7'}, {'key': 'ref90', 'doi-asserted-by': 'publisher', 'DOI': '10.1039/D0RA10529E'}, {'key': 'ref91', 'doi-asserted-by': 'publisher', 'DOI': '10.7717/peerj.11171'}, {'key': 'ref92', 'doi-asserted-by': 'publisher', 'DOI': '10.4103/japtr.JAPTR_84_20'}, {'key': 'ref93', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1760136'}, {'key': 'ref94', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.apsb.2020.02.008'}, {'key': 'ref95', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1777901'}, {'key': 'ref96', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s43094-020-00126-x'}, {'key': 'ref97', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bbrc.2020.08.086'}, {'key': 'ref98', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41586-020-2368-8'}, {'key': 'ref99', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bbrc.2020.08.116'}, {'key': 'ref100', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07391102.2020.1846624'}, {'key': 'ref101', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/acs.jnatprod.0c01324'}, {'key': 'ref102', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s11655-014-1860-0'}, {'key': 'ref103', 'doi-asserted-by': 'publisher', 'DOI': '10.1248/bpb.32.1385'}, {'key': 'ref104', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bmcl.2015.12.100'}, {'key': 'ref105', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.antiviral.2015.03.008'}, {'key': 'ref106', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/0166-3542(88)90001-0'}, {'key': 'ref107', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ejmech.2012.07.030'}, {'key': 'ref108', 'doi-asserted-by': 'publisher', 'DOI': '10.3181/00379727-197-43225'}, {'key': 'ref109', 'doi-asserted-by': 'publisher', 'DOI': '10.1042/bj3380107'}, { 'key': 'ref110', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/1099-1573(200008)14:5<333::AID-PTR584>3.0.CO;2-D'}, {'key': 'ref111', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.1765'}, {'key': 'ref112', 'doi-asserted-by': 'publisher', 'DOI': '10.2174/157340611795564268'}, {'key': 'ref113', 'doi-asserted-by': 'publisher', 'DOI': '10.1248/bpb.31.2018'}, {'key': 'ref114', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/bph.12440'}, {'key': 'ref115', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2015/972067'}, { 'key': 'ref116', 'first-page': '10', 'article-title': 'Anti-Dengue Viral Compounds from Andrographis paniculata by Insilico ' 'Approach', 'volume': '1', 'author': 'Nithya', 'year': '2014', 'journal-title': 'World J. Altern. Med.'}, {'key': 'ref117', 'doi-asserted-by': 'publisher', 'DOI': '10.4103/ayu.AYU_144_17'}, {'key': 'ref118', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/1472-6882-12-3'}, {'key': 'ref119', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/srep14179'}, {'key': 'ref120', 'doi-asserted-by': 'publisher', 'DOI': '10.4103/1995-7645.228436'}, {'key': 'ref121', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijid.2012.05.192'}, {'key': 'ref122', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/01635581.2015.1019630'}, {'key': 'ref123', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41591-020-01202-8'}, {'key': 'ref124', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/np50097a002'}, {'key': 'ref125', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/aps.2009.205'}, {'key': 'ref126', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2004.03.004'}, { 'key': 'ref127', 'first-page': '636', 'article-title': 'Immunostimulant, cerebroprotective & nootropic activities of ' 'Andrographis paniculata leaves extract in normal & type 2 diabetic rats', 'volume': '135', 'author': 'Radhika', 'year': '2012', 'journal-title': 'Indian J. Med. Res.'}, {'key': 'ref128', 'doi-asserted-by': 'publisher', 'DOI': '10.4308/hjb.22.2.67'}, { 'key': 'ref129', 'first-page': '48', 'article-title': 'Immune Modulation Potentials of Aqueous Extract of Andrographis ' 'paniculata Leaves in Male Rat', 'volume': '3', 'author': 'Bukoye', 'year': '2011', 'journal-title': 'Researcher'}, { 'key': 'ref130', 'first-page': '147', 'article-title': 'Modulation of lianbizi injection (andrographolide) on some immune ' 'functions', 'volume': '27', 'author': 'Peng', 'year': '2002', 'journal-title': 'Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China J. Chin. ' 'Mater. Med.'}, {'key': 'ref131', 'doi-asserted-by': 'publisher', 'DOI': '10.1078/094471102321616409'}, {'key': 'ref132', 'doi-asserted-by': 'publisher', 'DOI': '10.1055/s-0029-1185398'}, {'key': 'ref133', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/pca.3011'}, {'key': 'ref134', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s10555-020-09889-4'}, {'key': 'ref135', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fped.2020.576912'}, {'key': 'ref136', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.phrs.2020.104850'}, { 'key': 'ref137', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/(SICI)1099-1573(19980201)12:1<37::AID-PTR186>3.0.CO;2-N'}, {'key': 'ref138', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/np200631v'}, {'key': 'ref139', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/sj.bjp.0706105'}, {'key': 'ref140', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.intimp.2010.08.002'}, {'key': 'ref141', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2010.03.007'}, { 'key': 'ref142', 'first-page': '609', 'article-title': 'Ameliorating effects of Andrographis paniculata extract against ' 'cyclophosphamide-induced toxicity in mice', 'volume': '7', 'author': 'Sheeja', 'year': '2006', 'journal-title': 'Asian Pac. J. Cancer Prev.'}, {'key': 'ref143', 'doi-asserted-by': 'publisher', 'DOI': '10.4103/aja.aja_22_20'}, {'key': 'ref144', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.micinf.2017.08.009'}, {'key': 'ref145', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/cmi.2009.49'}, {'key': 'ref146', 'doi-asserted-by': 'publisher', 'DOI': '10.1021/acs.jnatprod.5b01006'}, {'key': 'ref147', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2006.03.004'}, {'key': 'ref148', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.apsb.2016.02.002'}, {'key': 'ref149', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/j.1440-1681.2011.05633.x'}, {'key': 'ref150', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/molecules26010005'}, {'key': 'ref151', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/0378-8741(91)90178-G'}, { 'key': 'ref152', 'first-page': '121', 'article-title': 'Analgesic, antipyretic, and antiulcerogenic effects of andrographolide', 'volume': '57', 'author': 'Madav', 'year': '1995', 'journal-title': 'Indian J. Pharm. Sci.'}, { 'key': 'ref153', 'first-page': '26', 'article-title': 'Preliminary studies on the pharmacology of the Andrographis product ' 'dihydroandrographolide sodium succinate', 'volume': '8', 'author': 'Deng', 'year': '1978', 'journal-title': 'Newsl. Chin. Herb. Med.'}, {'key': 'ref154', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s12272-009-1902-x'}, { 'key': 'ref155', 'first-page': '437', 'article-title': 'Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in ' 'adults', 'volume': '74', 'author': 'Thamlikitkul', 'year': '1991', 'journal-title': 'J. Med. Assoc. Thail. = Chotmaihet Thangphaet'}, {'key': 'ref156', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0944-7113(00)80054-9'}, {'key': 'ref157', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0944-7113(99)80012-9'}, {'key': 'ref158', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.1359'}, {'key': 'ref159', 'doi-asserted-by': 'publisher', 'DOI': '10.1046/j.1365-2710.2003.00534.x'}, { 'key': 'ref160', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/j.2042-7166.2003.tb05831.x'}, {'key': 'ref161', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0181780'}, {'key': 'ref162', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0944-7113(00)80053-7'}, { 'key': 'ref163', 'first-page': '271', 'article-title': 'Double-blind, placebo-controlled, randomized, pilot clinical trial of ' 'ImmunoGuard®–a standardized fixed combination of Andrographis ' 'paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra ' 'chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with ' 'Familial Mediterranean Fever', 'volume': '10', 'author': 'Amaryan', 'year': '2003', 'journal-title': 'Phytomed. Int. J. Phytother. Phytopharm.'}, {'key': 'ref164', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.phymed.2004.10.004'}, {'key': 'ref165', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0944-7113(97)80051-7'}, {'key': 'ref166', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.2650090804'}, {'key': 'ref167', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.phymed.2009.12.001'}, { 'key': 'ref168', 'series-title': 'Natural Standard Herbal Pharmacotherapy an Evidence Based Approach', 'author': 'Ulbricht', 'year': '2009'}, {'key': 'ref169', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s10067-009-1180-5'}, { 'key': 'ref170', 'first-page': '885', 'article-title': 'Acute hypersensitivity reactions to Andrographis paniculata containing ' 'products, as reported in international pharmacovigilance', 'volume': '31', 'author': 'Farah', 'year': '2008', 'journal-title': 'Drug Saf.'}, {'key': 'ref171', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0944-7113(99)80003-8'}, {'key': 'ref172', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.fct.2009.05.006'}, {'key': 'ref173', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00580-012-1539-x'}, {'key': 'ref174', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.toxrep.2019.05.003'}, { 'key': 'ref175', 'series-title': 'Pharmacology and Applications of Chinese Material Medica', 'first-page': '913', 'article-title': 'Chuanxinlian', 'volume': 'Volume 2', 'author': 'Chang', 'year': '1987'}, {'key': 'ref176', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/BF02857822'}, {'key': 'ref177', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0378-8741(97)00099-8'}, { 'key': 'ref178', 'first-page': '276', 'article-title': 'Hepatoprotective activity of andrographolide from Andrographis ' 'paniculata against carbontetrachloride', 'volume': '92', 'author': 'Handa', 'year': '1990', 'journal-title': 'Indian J. Med. Res.'}, {'key': 'ref179', 'doi-asserted-by': 'publisher', 'DOI': '10.3329/bjms.v8i1.3183'}, { 'key': 'ref180', 'first-page': '34', 'article-title': 'Antifertility effect of Andrographis paniculata in mice', 'volume': '15', 'author': 'Zoha', 'year': '1989', 'journal-title': 'Bangladesh Med. Res. Counc. Bull.'}, { 'key': 'ref181', 'first-page': '91', 'article-title': 'The teratogenic effect of standardised Andrographis paniculata extract ' 'in sprague dawley rats', 'volume': '14', 'author': 'Noordalilati', 'year': '2007', 'journal-title': 'Malays. J. Med. Sci'}, { 'key': 'ref182', 'series-title': 'The Essential Guide to Herbal Safety', 'author': 'Mills', 'year': '2004'}, { 'key': 'ref183', 'doi-asserted-by': 'crossref', 'first-page': '197', 'DOI': '10.1016/bs.irn.2017.02.010', 'article-title': 'Herb–drug interactions of commonly used Chinese medicinal herbs', 'volume': '135', 'author': 'Singh', 'year': '2017', 'journal-title': 'Int. Rev. Neurobiol.'}, {'key': 'ref184', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2016.07.061'}, {'key': 'ref185', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.lfs.2010.12.019'}, {'key': 'ref186', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s11418-011-0516-z'}, {'key': 'ref187', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2011.09.002'}, {'key': 'ref188', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.taap.2007.07.008'}, {'key': 'ref189', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.tox.2010.11.002'}, {'key': 'ref190', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.tiv.2011.09.004'}, {'key': 'ref191', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2005.11.024'}, {'key': 'ref192', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/molecules15053578'}, {'key': 'ref193', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.taap.2014.02.021'}, { 'key': 'ref194', 'doi-asserted-by': 'crossref', 'first-page': '67', 'DOI': '10.1016/j.dmpk.2017.10.005', 'article-title': 'In vitro inhibitory effects of major bioactive constituents of ' 'Andrographis paniculata, Curcuma longa and Silybum marianum on human ' 'liver microsomal morphine glucuronidation: A prediction of potential ' 'herb-drug interactions arising from andrographolide, curcumin and ' 'silybin inhibition in humans', 'volume': '33', 'author': 'Uchaipichat', 'year': '2018', 'journal-title': 'Drug Metab. Pharmacokinet.'}, {'key': 'ref195', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/13880209.2018.1478431'}, {'key': 'ref196', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cbi.2010.01.017'}, {'key': 'ref197', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ejphar.2008.11.011'}, {'key': 'ref198', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2016.11.022'}, {'key': 'ref199', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2015.11.011'}, {'key': 'ref200', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.5556'}, {'key': 'ref201', 'doi-asserted-by': 'publisher', 'DOI': '10.1046/j.1359-4117.2003.01090.x'}, {'key': 'ref202', 'doi-asserted-by': 'publisher', 'DOI': '10.4161/auto.28374'}, {'key': 'ref203', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.intimp.2014.03.015'}, {'key': 'ref204', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bcp.2006.04.019'}, {'key': 'ref205', 'doi-asserted-by': 'publisher', 'DOI': '10.4161/auto.18721'}, {'key': 'ref206', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.canlet.2008.11.015'}, {'key': 'ref207', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.bcp.2016.09.024'}, {'key': 'ref208', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/13880209.2016.1176056'}, { 'key': 'ref209', 'first-page': '4365', 'article-title': 'Anti-proliferative and pro-apoptotic effects from sequenced ' 'combinations of andrographolide and cisplatin on ovarian cancer cell ' 'lines', 'volume': '33', 'author': 'Yunos', 'year': '2013', 'journal-title': 'Anticancer Res.'}, {'key': 'ref210', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jep.2007.10.013'}, {'key': 'ref211', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cbi.2008.10.054'}, {'key': 'ref212', 'doi-asserted-by': 'publisher', 'DOI': '10.3923/ijp.2010.494.499'}, {'key': 'ref213', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jsfa.7739'}, {'key': 'ref214', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.7141'}, {'key': 'ref215', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s11096-020-01153-7'}, {'key': 'ref216', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.sintl.2020.100021'}, { 'key': 'ref217', 'first-page': '269', 'article-title': 'The Efficacy and Safety of Andrographis paniculate Extractfor Treatment ' 'of COVID-19 Patients with Mild Symptoms, Nakhonpathom Hospital', 'volume': '40', 'author': 'Rattanaraksa', 'year': '2022', 'journal-title': 'Reg. 4-5 Med. J.'}], 'container-title': 'Molecules', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/1420-3049/27/14/4479/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 7, 15]], 'date-time': '2022-07-15T06:29:03Z', 'timestamp': 1657866543000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/1420-3049/27/14/4479'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 7, 13]]}, 'references-count': 217, 'journal-issue': {'issue': '14', 'published-online': {'date-parts': [[2022, 7]]}}, 'alternative-id': ['molecules27144479'], 'URL': 'http://dx.doi.org/10.3390/molecules27144479', 'relation': {}, 'ISSN': ['1420-3049'], 'subject': [ 'Chemistry (miscellaneous)', 'Analytical Chemistry', 'Organic Chemistry', 'Physical and Theoretical Chemistry', 'Molecular Medicine', 'Drug Discovery', 'Pharmaceutical Science'], 'container-title-short': 'Molecules', 'published': {'date-parts': [[2022, 7, 13]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit