Antiviral efficacy of Andrographis paniculata and andrographolides: A narrative review
Kumarappan Chidambaram
Asian Pacific Journal of Tropical Biomedicine, doi:10.4103/apjtb.apjtb_751_23
The rise of emerging infectious diseases has become notably prominent due to ecological changes and mutations in pathogens. The respiratory illness outbreak caused by the COVID-19 pandemic has spread globally. Natural products contain numerous structures and biological activities, offering ample options for discovering new antiviral drugs with unique targets and mechanisms. Andrographis paniculata has been utilized in Indian Ayurvedic, Swedish, Traditional Thai, and Chinese medicine to alleviate coughs, colds, and influenza symptoms. Early-stage laboratory studies indicate that this herbal extract may reduce inflammation and fever, and boost the body's natural defenses against viruses, potentially leading to symptom relief. This review aims to systematically present clinical trial data about antiviral herbal formulations derived from Andrographis paniculata, delineating the antiviral effects of both natural and synthetic derivatives, along with in silico analyses.
Conflict of interest statement There is no potential conflict of interest during the review.
Publisher's note The Publisher of the Journal remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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