Conv. Plasma
Nigella Sativa
Peg.. Lambda

All vitamin D studies
Meta analysis
Home COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Recovery time 25% Improvement Relative Risk Vitamin D for COVID-19  Huang et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 46 patients in China (June 2021 - April 2022) Faster recovery with higher vitamin D levels (p=0.02) Huang et al., Frontiers in Medicine, Mar 2023 Favors vitamin D Favors control

Effect of vitamin D status on adult COVID-19 pneumonia induced by Delta variant: A longitudinal, real-world cohort study

Huang et al., Frontiers in Medicine, doi:10.3389/fmed.2023.1121256
Mar 2023  
  Source   PDF   All Studies   Meta AnalysisMeta
Retrospective COVID-19 pneumonia patients in China, showing slower recovery with vitamin D deficiency.
This is the 167th of 185 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 115 vigintillion).
recovery time, 25.0% lower, relative time 0.75, p = 0.02, high D levels (≥20ng/ml) 28, low D levels (<20ng/ml) 18, relative time until resolution of pneumonia.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Huang et al., 24 Mar 2023, retrospective, China, peer-reviewed, 5 authors, study period 14 June, 2021 - 1 April, 2022.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperVitamin DAll
Effect of vitamin D status on adult COVID-19 pneumonia induced by Delta variant: A longitudinal, real-world cohort study
Hua Huang, Jiawei Zheng, Yan Liu, Qunhe Zhou, Denggao Peng
Frontiers in Medicine, doi:10.3389/fmed.2023.1121256
Objective: The effect of vitamin D status on adult COVID-19 pneumonia induced by Delta variant remains to be further explored. Methods: A longitudinal, real-world cohort study was performed. Artificial intelligence (AI) was used to identify and measure pneumonia lesions. All cases with pneumonia were divided into the vitamin D deficiency (VDD) and control groups according to serum 25-hydroxyvitamin D concentration. Lesion dynamics were observed within six time periods after the onset of pneumonia. Results: A total of 161 cases were included, of which 101 (63%) were male and 46 (29%) presented with pneumonia. The median age and baseline 25-hydroxyvitamin D concentrations were 37 years and 21 ng/ml, respectively. Age, fibrinogen, and SARS-CoV-2 IgG titer on admission were independent predictors for the onset of pneumonia. After the onset of pneumonia, patients in the VDD group (n = 18) had higher percentage of fever (33 vs. 7.1%; p = 0.04) than those in the control group (n = 28); the interval of pneumonia resolution was longer (28 vs. 21 days; p = 0.02); lesions progressed more rapidly (p = 0.01) within 3 to 7 days and improved more slowly (p = 0.007) within more than 28 days; notably, simultaneous interleukin-6 (18.7 vs. 14.6 pg/ml; p = 0.04) levels were higher, and cycle thresholds for N gene (22.8 vs. 31.3; p = 0.04) and ORF1ab gene (20.9 vs. 28.7; p = 0.03) were lower within 3 to 7 days. Conclusion: Vitamin D status may have effects on the progression and resolution, but not the onset of Delta variant-induced pneumonia in adults. Computed tomography image diagnosis system based on AI may have promising applications in the surveillance and diagnosis of novel SARS-CoV-2 variantinduced pneumonia.
Ethics statement This investigation involving human participants were reviewed and approved by the Ethics Committee of The Third People's Hospital of Shenzhen (approval number: 2022-123). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. ORF1ab gene in the VDD group was lower (20.9 ± 4.2 vs. 28.7 ± 6.9) than that in the control group within 3 days. Author contributions HH was responsible for methodology, investigation, formal analysis, data curation, writing the original draft, and visualization. JZ and QZ for investigation and data curation. DP for conceptualization, investigation, review and editing, and supervision. YL worked on conceptualization, formal analysis, investigation, and data All authors contributed to the article and approved the submitted version. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary material for..
Alguwaihes, Sabico, Hasanato, Megdad, Albader, Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: a retrospective case-control study in an Arab gulf country, Aging Clin Exp Res, doi:10.1007/s40520-021-01831-0
Askani, Mueller-Peltzer, Madrid, Knoke, Hasic et al., Computed tomographic imaging features of COVID-19 pneumonia caused by the Delta (B.1.617.2) and omicron (B.1.1.529) variant in a German nested cohort pilot study group, Tomography, doi:10.3390/tomography8050202
Attaway, Scheraga, Bhimraj, Biehl, Hatipoğlu, Severe covid-19 pneumonia: pathogenesis and clinical management, BMJ, doi:10.1136/bmj.n436
Bar, Shaw, Choi, Aqui, Fesnak et al., A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia, J Clin Invest, doi:10.1172/JCI155114
Ben-Eltriki, Hopefl, Wright, Deb, Smolders et al., Association between vitamin D status and risk of developing severe COVID-19 infection: a meta-analysis of observational studies, J Am Nutr Assoc, doi:10.1016/j.metabol.2020.154434
Grant, Giovannucci, Greiller, Suri, Jolliffe et al., Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells, J Steroid Biochem Mol Biol, doi:10.1016/j.jsbmb.2018.11.013
Güven, Gültekin, The effect of high-dose parenteral vitamin D3 on COVID-19-related inhospital mortality in critical COVID-19 patients during intensive care unit admission: an observational cohort study, Eur J Clin Nutr, doi:10.1038/s41430-021-00984-5
Holick, Vitamin D deficiency, N Engl J Med, doi:10.1056/NEJMra070553
Karim, Karim, Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic, Lancet, doi:10.1016/S0140-6736(21)02758-6
Li, Guan, Wu, Wang, Zhou et al., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia, N Engl J Med, doi:10.1056/NEJMoa2001316
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Nagpal, Guo, Shin, Lim, Kim et al., Quantitative CT imaging and advanced visualization methods: potential application in novel coronavirus disease 2019 (COVID-19) pneumonia, BJR Open, doi:10.1259/bjro.20200043
Peng, Huang, Liu, Gao, Liu et al., Vitamin D levels and clinical outcomes of SARS-CoV-2 omicron subvariant BA.2 in children: a longitudinal cohort study, J Clin Endocrinol Metab, doi:10.1210/jc.2011-0385
Peng, Liu, Zheng, Lu, Hou et al., Immunological aspects of SARS-CoV-2 infection and the putative beneficial role of vitamin-D, Int J Mol Sci, doi:10.3390/ijms22105251
Razi, Gu, He, Kong, Ahmed et al., Simple prognostic factors and change of inflammatory markers in patients with severe coronavirus disease 2019: a single-center observational study, Acute Med Surg, doi:10.1002/ams2.683
Shah Alam, Czajkowsky, Islam, Ataur, The role of vitamin D in reducing SARS-CoV-2 infection: an update, Int Immunopharmacol, doi:10.1016/j.intimp.2021.107686
Simonovich, Burgos, Scibona, Beruto, Vallone et al., A randomized trial of convalescent plasma in Covid-19 severe pneumonia, N Engl J Med, doi:10.1056/NEJMoa2031304
Simpson, Kay, Abbara, Bhalla, Chung et al., Radiological Society of North America expert consensus document on reporting chest CT findings related to COVID-19: endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA, Radiol Cardiothorac Imaging, doi:10.1148/ryct.2020200152
Toniati, Piva, Cattalini, Garrafa, Regola et al., Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: a single center study of 100 patients in Brescia, Italy, Autoimmun Rev, doi:10.1016/j.autrev.2020.102568
Tsakok, Watson, Saujani, Kong, Xie et al., Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis, Am J Clin Nutr, doi:10.3945/ajcn.111.031070
Yang, Sirajuddin, Zhang, Liu, Teng et al., The role of imaging in 2019 novel coronavirus pneumonia (COVID-19), Eur Radiol, doi:10.1007/s00330-020-06827-4
Yang, Wang, Huang, Dong, Ye et al., Clinical and pulmonary CT characteristics of patients infected with the SARS-CoV-2 omicron variant compared with those of patients infected with the alpha viral strain, Front Public Health, doi:10.3389/fpubh.2022.931480
Yoon, Lee, Kim, Chest CT findings in hospitalized patients with SARS-CoV-2: Delta versus omicron variants, Radiology, doi:10.1148/radiol.220676
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop