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Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

Hasan et al., European Journal of Dentistry, doi:10.1055/s-0042-1753470
Sep 2022  
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Systematic review and meta analysis showing significantly improved viral clearance with both povidone-iodine and chlorhexidine.
2 meta analyses show significant improvements with povidone-iodine for viral load Hasan, Idrees and viral clearance Hasan.
Currently there are 20 povidone-iodine for COVID-19 studies, showing 72% lower mortality [8‑92%], 76% lower hospitalization [-14‑95%], and 45% fewer cases [20‑62%].
This study includes chlorhexidine and povidone-iodine.
Hasan et al., 8 Sep 2022, peer-reviewed, 6 authors.
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Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis
Faizul Hasan, Hsiao-Yean Chiu, Eisner Salamanca, Edi S Ridwan, Bayu S Wiratama, DDS, MDS Hendrik S Budi
European Journal of Dentistry, doi:10.1055/s-0042-1753470
The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reversetranscription polymerase chain reaction (RT-PCR) results (p < 0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.
Conflict of Interest None declared.
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