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Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

Hasan et al., European Journal of Dentistry, doi:10.1055/s-0042-1753470
Sep 2022  
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PVP-I for COVID-19
13th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Systematic review and meta analysis showing significantly improved viral clearance with both povidone-iodine and chlorhexidine.
2 meta analyses show significant improvements with povidone-iodine for viral load1,2 and viral clearance1.
Currently there are 21 povidone-iodine for COVID-19 studies, showing 72% lower mortality [8‑92%], 76% lower hospitalization [-14‑95%], and 45% fewer cases [20‑62%].
Study covers chlorhexidine and povidone-iodine.
Hasan et al., 8 Sep 2022, peer-reviewed, 6 authors. Contact: hendrik-s-b@fkg.unair.ac.id.
This PaperPovidone-Iod..All
Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis
Faizul Hasan, Hsiao-Yean Chiu, Eisner Salamanca, Edi S Ridwan, Bayu S Wiratama, DDS, MDS Hendrik S Budi
European Journal of Dentistry, doi:10.1055/s-0042-1753470
The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reversetranscription polymerase chain reaction (RT-PCR) results (p < 0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.
Conflict of Interest None declared.
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'year': '2021', 'journal-title': 'Eur J Dent'}, { 'issue': '08', 'key': 'ref40', 'doi-asserted-by': 'crossref', 'first-page': '924', 'DOI': '10.1016/j.bjoms.2020.08.016', 'article-title': 'Use of mouthwashes against COVID-19 in dentistry', 'volume': '58', 'author': 'A Vergara-Buenaventura', 'year': '2020', 'journal-title': 'Br J Oral Maxillofac Surg'}, { 'issue': '02', 'key': 'ref41', 'doi-asserted-by': 'crossref', 'first-page': '274', 'DOI': '10.1086/524736', 'article-title': 'Chlorhexidine: expanding the armamentarium for infection control and ' 'prevention', 'volume': '46', 'author': 'A M Milstone', 'year': '2008', 'journal-title': 'Clin Infect Dis'}, { 'issue': '02', 'key': 'ref42', 'doi-asserted-by': 'crossref', 'first-page': '85', 'DOI': '10.1002/jemt.20238', 'article-title': 'Chlorhexidine-induced ultrastructural alterations in oral biofilm', 'volume': '68', 'author': 'L Vitkov', 'year': '2005', 'journal-title': 'Microsc Res Tech'}, { 'issue': '05', 'key': 'ref43', 'doi-asserted-by': 'crossref', 'first-page': '308', 'DOI': '10.1016/j.adaj.2017.01.021', 'article-title': 'Chlorhexidine mouthwash as an adjunct to mechanical therapy in chronic ' 'periodontitis: a meta-analysis', 'volume': '148', 'author': 'L FNP da Costa', 'year': '2017', 'journal-title': 'J Am Dent Assoc'}, { 'issue': '01', 'key': 'ref44', 'first-page': '86', 'article-title': 'Chlorhexidine: an effective anticovid mouth rinse', 'volume': '25', 'author': 'A Jain', 'year': '2021', 'journal-title': 'J Indian Soc Periodontol'}, { 'issue': '04', 'key': 'ref45', 'doi-asserted-by': 'crossref', 'first-page': '475', 'DOI': '10.1016/j.ajoms.2021.02.002', 'article-title': 'Virucidal activity of oral care products against SARS-CoV-2 in vitro', 'volume': '33', 'author': 'A Komine', 'year': '2021', 'journal-title': 'J Oral Maxillofac Surg Med Pathol'}, { 'issue': '05', 'key': 'ref46', 'doi-asserted-by': 'crossref', 'first-page': '389', 'DOI': '10.1034/j.1600-0765.2002.00004.x', 'article-title': 'Selection of antimicrobial agents in periodontal therapy', 'volume': '37', 'author': 'J Slots', 'year': '2002', 'journal-title': 'J Periodontal Res'}, { 'issue': '03', 'key': 'ref47', 'first-page': 'CD008676', 'article-title': 'Chlorhexidine mouthrinse as an adjunctive treatment for gingival health', 'volume': '3', 'author': 'P James', 'year': '2017', 'journal-title': 'Cochrane Database Syst Rev'}, { 'issue': '08', 'key': 'ref48', 'first-page': '435', 'article-title': 'Extrinsic stains and management: A new insight', 'volume': '1', 'author': 'S Prathap', 'year': '2013', 'journal-title': 'J Acad Ind Res'}, { 'issue': '03', 'key': 'ref49', 'first-page': 'e410', 'article-title': 'An in vitro analysis model for investigating the staining effect of ' 'various chlorhexidine-based mouthwashes', 'volume': '9', 'author': 'A A Kouadio', 'year': '2017', 'journal-title': 'J Clin Exp Dent'}], 'container-title': 'European Journal of Dentistry', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1753470.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 9, 8]], 'date-time': '2022-09-08T23:12:49Z', 'timestamp': 1662678769000}, 'score': 1, 'resource': {'primary': {'URL': 'http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1753470'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 9, 8]]}, 'references-count': 47, 'URL': 'http://dx.doi.org/10.1055/s-0042-1753470', 'relation': {}, 'ISSN': ['1305-7456', '1305-7464'], 'subject': ['General Dentistry'], 'container-title-short': 'Eur J Dent', 'published': {'date-parts': [[2022, 9, 8]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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